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Denosumab for bone diseases: translating bone biology into targeted therapy.

Abstract：

:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss such as osteoporosis, rheumatoid arthritis and osteolytic bone metastases. The development and approval of denosumab, a fully MAB against RANKL, has heralded a new era in the treatment of bone diseases by providing a potent, targeted and reversible inhibitor of bone resorption. This article summarises the molecular and cellular biology of the RANKL/RANK system and critically reviews preclinical and clinical studies that have established denosumab as a promising novel therapy for metabolic and malignant bone diseases. We will discuss the potential indications for denosumab along with a critical review of safety and analyse its potential within the concert of established therapies.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Tsourdi E,Rachner TD,Rauner M,Hamann C,Hofbauer LC

doi

10.1530/EJE-11-0454

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

833-40

issue

6

eissn

0804-4643

issn

1479-683X

pii

EJE-11-0454

journal_volume

165

pub_type

杂志文章,评审

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