Effects of growth hormone replacement therapy on levels of cortisol and cortisol-binding globulin in hypopituitary adults.

abstract：OBJECTIVE:Though transsphenoidal surgery remains the first-line treatment of Cushing's disease, recurrence occurs frequently. Conventional radiotherapy and anticortisolic drugs both have adverse effects. Stereotactic radiosurgery needs to be evaluated more precisely. The aim of this study was to determine long-term hor...

journal_title：European journal of endocrinology

authors： Castinetti F,Nagai M,Dufour H,Kuhn JM,Morange I,Jaquet P,Conte-Devolx B,Regis J,Brue T

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Hormone treatment is an important part of gender reassignment therapy in gender dysphoria. Previous data about efficacy and safety are commonly based on small cohorts or they comprise former cohorts under meanwhile obsolet therapy regimes. Our objective was to investigate these topics in a large cohort of ind...

journal_title：European journal of endocrinology

authors： Meyer G,Mayer M,Mondorf A,Fluegel AK,Herrmann E,Bojunga J

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To determine if uterine and ovarian measurements can significantly distinguish between precocious puberty (PP) and premature thelarche (PT) and whether ultrasound has any advantage over the gonadotropin-releasing hormone (GnRH) stimulation test. DESIGN:Prospective. METHODS:One hundred and three girls referr...

journal_title：European journal of endocrinology

authors： de Vries L,Horev G,Schwartz M,Phillip M

更新日期：2006-06-01 00:00:00

abstract：:Little is known about patients with malignant digestive neuroendocrine tumours (MD-NETs). Although their incidence is increasing, MD-NETs remain a rare cancer, representing 1% of digestive cancers. Most MD-NETs are well-differentiated. MD-NET poorly differentiated carcinomas account for 20% of cases on average. Anatom...

journal_title：European journal of endocrinology

authors： Lepage C,Bouvier AM,Faivre J

更新日期：2013-03-15 00:00:00

abstract：:Giant prolactinomas are rare tumours, representing only 2-3% of all prolactin (PRL)-secreting tumours and raising special diagnostic and therapeutic challenges. Based on several considerations developed in this review, their definition should be restricted to pituitary adenomas with a diameter of 40  mm or more, signi...

journal_title：European journal of endocrinology

authors： Maiter D,Delgrange E

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Height variability is largely under genetic control, although identifying the genetic variants involved has been until recently challenging. Smallness for gestational age (SGA) is a risk factor for adult short stature. Genome-wide association studies have identified a single nucleotide polymorphism (SNP) (rs1...

journal_title：European journal of endocrinology

authors： Bouatia-Naji N,Marchand M,Cavalcanti-Proença C,Daghmoun S,Durand E,Tichet J,Marre M,Balkau B,Froguel P,Lévy-Marchal C

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Hyperprolactinemia has been reported to be associated with abnormalities of carbohydrate metabolism. The aim of this study was to evaluate the effects of hyperprolactinemia and bromocriptine (Brc) treatment on endothelial function, insulin sensitivity and inflammatory markers in pre-menopausal women. METHOD...

journal_title：European journal of endocrinology

authors： Yavuz D,Deyneli O,Akpinar I,Yildiz E,Gözü H,Sezgin O,Haklar G,Akalin S

更新日期：2003-09-01 00:00:00

abstract：Objective:With increasing migration to Europe, diabetes diagnosis and treatment of refugees became challenging. To describe the current experience with pediatric refugees in Germany and Austria. Design and Methods:43,137 patients (<21 years) with type 1 diabetes from the diabetes patient follow-up registry (DPV) were ...

journal_title：European journal of endocrinology

authors： Prinz N,Konrad K,Brack C,Hahn E,Herbst A,Icks A,Grulich-Henn J,Jorch N,Kastendieck C,Mönkemöller K,Razum O,Steigleder-Schweiger C,Witsch M,Holl RW

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To stop smoking is commonly associated with significant weight gain, but the mechanisms for this are poorly understood. We assessed the effects of smoking cessation on body weight, insulin sensitivity, β-cell function, and appetite. SUBJECTS AND METHODS:Twenty-seven long-term smokers (n=27; nine females/18 m...

journal_title：European journal of endocrinology

authors： Stadler M,Tomann L,Storka A,Wolzt M,Peric S,Bieglmayer C,Pacini G,Dickson SL,Brath H,Bech P,Prager R,Korbonits M

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:A sex determining gene(s) has been mapped to a approximately 700 kb region distal to the exons of DMRT1 on 9p. The aim of this study was to examine gonadal developmental status in XX patients hemizygous for the 9p sex determining region. DESIGN:Clinical and molecular studies were performed in an 8-year-old g...

journal_title：European journal of endocrinology

authors： Ogata T,Muroya K,Ohashi H,Mochizuki H,Hasegawa T,Kaji M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

journal_title：European journal of endocrinology

authors： Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To assess the value of the diagnostic whole body (131)I scan after thyroidectomy and (131)I ablation. DESIGN:Retrospective analysis of all patients with differentiated thyroid cancer treated in one centre between 1990 and 2000. RESULTS:A total of 153 consecutive patients who underwent diagnostic scanning fo...

journal_title：European journal of endocrinology

authors： Taylor H,Hyer S,Vini L,Pratt B,Cook G,Harmer C

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Increased reverse tritiodothyronine (T(3)) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T(3) in non-severely ill subjects but its significance remains unclear. PA...

journal_title：European journal of endocrinology

authors： Forestier E,Vinzio S,Sapin R,Schlienger JL,Goichot B

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Circulating IGF1 declines with age while ill-health increases. Controversy remains whether differences in the levels of IGF1 and its binding proteins 1 and 3 (IGFBP1 and IGFBP3) determine health outcomes during ageing. We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular morta...

journal_title：European journal of endocrinology

authors： Yeap BB,Chubb SA,McCaul KA,Ho KK,Hankey GJ,Norman PE,Flicker L

更新日期：2011-05-01 00:00:00

abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

journal_title：European journal of endocrinology

authors： Das S,Fahmy NW,Bourne GA

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CA...

journal_title：European journal of endocrinology

authors： Park YJ,Lee YJ,Choi SI,Chun EJ,Jang HC,Chang HJ

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:To determine the specific morphology of the pituitary gland in children with severe isolated GH deficiency due to GH-1 gene mutations (IGHD type II). DESIGN:The pituitary gland morphology in magnetic resonance imaging (MRI) of children with IGHD type II was analyzed and compared with the findings in a group ...

journal_title：European journal of endocrinology

authors： Binder G,Nagel BH,Ranke MB,Mullis PE

更新日期：2002-12-01 00:00:00

abstract：:Guidelines recommend adults with pituitary disease in whom GH therapy is contemplated, to be tested for GH deficiency (AGHD); however, clinical practice is not uniform. AIMS:1) To record current practice of AGHD management throughout Europe and benchmark it against guidelines; 2) To evaluate educational status of hea...

journal_title：European journal of endocrinology

authors： Martel-Duguech LM,Jorgensen JOL,Korbonits M,Johannsson G,Webb SM,Amadidou F,Mintziori G,Arosio M,Giavoli C,Badiu C,Boschetti M,Ferone D,Ricci Bitti S,Brue T,Albarel F,Cannavò S,Cotta OR,Carvalho D,Salazar D,Christ E

更新日期：2020-12-01 00:00:00

abstract：Background:Autosomal dominant neurohypophyseal diabetes insipidus (adNDI) is caused by arginine vasopressin (AVP) deficiency resulting from mutations in the AVP-NPII gene encoding the AVP preprohormone. Aim:To describe the clinical and molecular features of Italian unrelated families with central diabetes insipidus. ...

journal_title：European journal of endocrinology

authors： Patti G,Scianguetta S,Roberti D,Di Mascio A,Balsamo A,Brugnara M,Cappa M,Casale M,Cavarzere P,Cipriani S,Corbetta S,Gaudino R,Iughetti L,Martini L,Napoli F,Peri A,Salerno MC,Salerno R,Passeri E,Maghnie M,Perrotta

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:In polycystic ovary syndrome (PCOS), insulin resistance (IR) appears with high prevalence and represents the major cause of cardiometabolic complications. Lipin 1beta regulates lipid metabolism and augments insulin sensitivity. The impact of lipin 1beta expression in visceral and subcutaneous adipose tissue o...

journal_title：European journal of endocrinology

authors： Mlinar B,Pfeifer M,Vrtacnik-Bokal E,Jensterle M,Marc J

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:In an animal model of acromegaly (PEPCK-hGH transgenic mice), low systemic levels of ghrelin have been observed compared with normal mice. We hypothesized that systemic circulating ghrelin levels are also decreased in humans with active acromegaly and that the contribution of central ghrelin production to ...

journal_title：European journal of endocrinology

authors： van der Toorn FM,Janssen JA,de Herder WW,Broglio F,Ghigo E,van der Lely AJ

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVES:The purpose of this population-based prospective cohort study was to examine the effect of hormone therapy (HT) on incidence of diabetes mellitus (DM). DESIGN AND METHODS:Eight thousand four hundred and eighty-three DM-free post-menopausal women aged 52-62 from the population-based Kuopio osteoporosis risk ...

journal_title：European journal of endocrinology

authors： Pentti K,Tuppurainen MT,Honkanen R,Sandini L,Kröger H,Alhava E,Saarikoski S

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Ki-67 labeling index (LI) is currently regarded as a useful prognostic marker of pituitary adenoma (PA) clinical behavior, although its relevance as a reliable clinical indicator is far from being universally accepted, since both validations and criticisms are found in the literature. Minichromosome maintena...

journal_title：European journal of endocrinology

authors： Coli A,Asa SL,Fadda G,Scannone D,Chiloiro S,De Marinis L,Lauretti L,Ranelletti FO,Lauriola L

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance...

journal_title：European journal of endocrinology

authors： le Roux CW,Jenkins PJ,Chew SL,Camacho-Hübner C,Grossman AB,Besser GM,Monson JP

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:Non-thyroidal illness (NTI) is associated with alterations in thyroid hormone metabolism. Whether morphological changes of the thyroid gland accompany NTI is unknown. The aim of the present study was to describe thyroid morphology in patients with lethal non-thyroidal disease. DESIGN:In an autopsy study 267 ...

journal_title：European journal of endocrinology

authors： De Jongh FE,Jöbsis AC,Elte JW

更新日期：2001-03-01 00:00:00

abstract：CONTEXT:Vitamin D deficiency has been identified as a risk factor for a number of autoimmune diseases including type 1 diabetes and multiple sclerosis. OBJECTIVE:We hypothesized that low levels of vitamin D are related to the early stages of autoimmune thyroid disease (AITD). DESIGN:Two case-control studies were perf...

journal_title：European journal of endocrinology

authors： Effraimidis G,Badenhoop K,Tijssen JG,Wiersinga WM

更新日期：2012-07-01 00:00:00

abstract：:Bone mineral density (BMD), bone mineral content and body composition were determined in 47 middle-aged (mean age 47.9 +/- 1.1 years) women with Turner's syndrome. Bone mineral density was measured in the forearm, femoral neck and total body. The women investigated had a BMD lower than the normal mean. When expressed ...

journal_title：European journal of endocrinology

authors： Sylvén L,Hagenfeldt K,Ringertz H

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:17α-Hydroxylase/17,20-lyase deficiency (17OHD) caused by a mutation in the CYP17A1 gene is characterized by hypertension, hypokalemia, and abnormal development of the genitalia. The majority of CYP17A1 mutations are located in the coding sequence, and several intronic splicing site mutations have been report...

journal_title：European journal of endocrinology

authors： Qiao J,Han B,Liu BL,Liu W,Wu JJ,Pan CM,Jiang H,Gu T,Jiang BR,Zhu H,Lu YL,Wu WL,Chen MD,Song HD

更新日期：2011-04-01 00:00:00

abstract：:The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is ac...

journal_title：European journal of endocrinology

authors： Ghigo E,Arvat E,Rizzi G,Goffi S,Grottoli S,Mucci M,Boghen MF,Camanni F

更新日期：1994-11-01 00:00:00

abstract：:To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

journal_title：European journal of endocrinology

authors： Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

更新日期：1995-09-01 00:00:00