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Growth hormone replacement does not increase serum prostate-specific antigen in hypopituitary men over 50 years.

Abstract：

OBJECTIVE:Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance is therefore mandatory, with particular regard to neoplasia. The aim was to examine whether rhGH replacement in hypopituitary adults is associated with changes in serum prostate-specific antigen (PSA) as a surrogate marker of changes in prostatic growth. DESIGN AND METHODS:A prospective longitudinal study was used with a median follow-up of 22 (range 2.5-32) months, in which 41 men aged over 50 years with adult onset hypopituitarism and GH deficiency during rhGH replacement were examined. Serum PSA and IGF-I were measured at baseline and at latest follow-up. RESULTS:Mean serum PSA remained unchanged during rhGH replacement, with a median follow-up of 2 years. No correlation was found between the individual changes in serum IGF-I and changes in serum PSA. CONCLUSIONS:These data are reassuring thus far regarding the safety of GH replacement in relation to the prostate in this patient group.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

le Roux CW,Jenkins PJ,Chew SL,Camacho-Hübner C,Grossman AB,Besser GM,Monson JP

doi

10.1530/eje.0.1470059

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

59-63

issue

1

eissn

0804-4643

issn

1479-683X

pii

14759

journal_volume

147

pub_type

临床试验,杂志文章

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