Abstract：
:The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is active even after oral administration, might be useful to restore it. The aim of our study was to verify the effectiveness of oral administration of GHRP-6 in normal elderly subjects and to investigate whether its GH-releasing activity is maintained or vanishes after short-term oral treatment. Seven normal elderly women (aged 65-82 years) were studied. The effect of oral administration of 300 micrograms/kg GHRP-6 on GH secretion was investigated before and after 4 days of treatment with the hexapeptide given twice daily. The GH response to the maximal effective dose of GHRH (1 microgram/kg i.v.) also was studied. Before treatment, oral administration of 300 micrograms/kg GHRP-6 elicited a clear GH rise (peak 10.7 +/- 3.3 micrograms/l; AUC 353.1 +/- 90.6 micrograms.l-1.h-1), which was significantly higher (p < 0.01) than that induced by intravenous GHRH (peak 5.1 +/- 1.5 micrograms/l; AUC 106.5 +/- 43.9 micrograms.l-1.h-1). After 4 days of treatment with GHRP-6, the GH response to the hexapeptide was maintained, with a trend towards an increase (peak 16.8 +/- 2.9 micrograms/l; AUC 499.8 +/- 107.2 micrograms.l-1.h-1). The IGF-I levels were not increased significantly after treatment (77.1 +/- 8.4 vs 84.1 +/- 12.2 micrograms/l).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Ghigo E,Arvat E,Rizzi G,Goffi S,Grottoli S,Mucci M,Boghen MF,Camanni Fdoi
10.1530/eje.0.1310499subject
Has Abstractpub_date
1994-11-01 00:00:00pages
499-503issue
5eissn
0804-4643issn
1479-683Xjournal_volume
131pub_type
临床试验,杂志文章abstract：OBJECTIVE:A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations. DESIGN:Observati...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02101
更新日期：2006-03-01 00:00:00
abstract：Objectives:Adipose tissue (AT) density measurement may provide information about AT quality among people living with HIV. We assessed AT density and evaluated relationships between AT density and immunometabolic biomarker concentrations in men with HIV. Design:Cross-sectional analysis of men enrolled in the Multicente...
journal_title：European journal of endocrinology
pub_type： 杂志文章,多中心研究
doi：10.1530/EJE-19-0296
更新日期：2019-10-01 00:00:00
abstract：OBJECTIVE:In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN:To define the role of intraoperati...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1490007
更新日期：2003-07-01 00:00:00
abstract：:We measured serum concentrations of insulin-like growth factors I and II (IGF-I and IGF-II) by radioimmunoassay in 107 healthy women aged 28-78 years and in 116 women with established osteoporosis. The women with established osteoporosis were randomized to a 1-year double-blind, placebo-controlled treatment with conti...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1320313
更新日期：1995-03-01 00:00:00
abstract：:The objective was to compare the changes in prostaglandin synthesis and metabolism occurring within the fetal membranes that are associated with the onset of parturition and to study the effect of steroid hormones on prostaglandin metabolism. A tissue explant study was made of discs of amnion and chorion obtained from...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1330527
更新日期：1995-11-01 00:00:00
abstract：OBJECTIVE:Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CA...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0014
更新日期：2011-07-01 00:00:00
abstract：:Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-15-0605
更新日期：2016-04-01 00:00:00
abstract：:The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1370200
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:A phase I single centre, open label study of the pharmacokinetics and tolerability of a buccal testosterone tablet (COL 1621) was carried out. DESIGN:Twelve testosterone-deficient males were treated with the buccal tablet twice daily for 7 consecutive days. Multiple blood samples were drawn for testosterone,...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1500057
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:Estimates of the prevalence of hypothyroidism in unselected populations date from the late 1990s. We present an update on the prevalence and incidence of overt hypothyroidism in Piedmont, northwest Italy and examine the association between hypothyroidism and multiple chronic comorbidities. DESIGN AND METHODS...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0559
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVES:High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleot...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0347
更新日期：2016-12-01 00:00:00
abstract：:Congenital generalized lipoatrophy (CGL) is a syndrome with multiple clinical manifestations and complete atrophy of adipose tissue. The exact mechanism of this disease remains unknown. One hypothesis presupposes an abnormal development of adipocytes. Leptin, the adipocyte-specific product of the ob gene, acts as a re...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1400107
更新日期：1999-01-01 00:00:00
abstract：:A pheochromocytoma in a pregnant patient is one of the most threatening medical conditions for mother, fetus, and physician. Although extraordinarily rare with a frequency of 0.002% of all pregnancies, this tumor is notorious for its devastating consequences. As in non-pregnant patients, the signs and symptoms are qui...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-11-0528
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Ghrelin stimulates GH secretion and regulates energy and glucose metabolism. The two circulating isoforms, acyl (AG) and des-acyl (DAG) ghrelin, have distinct metabolic effects and are under active investigation for their therapeutic potentials. However, there is only limited data on the pharmacokinetics of ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1530/EJE-13-0072
更新日期：2013-05-02 00:00:00
abstract：OBJECTIVES:We aimed to investigate the relationship between nonalcoholic fatty liver disease (NAFLD), serum adiponectin concentration and brachial-ankle pulse wave velocity (baPWV) as a risk marker for atherosclerosis. METHODS:A total of 213 nonalcoholic subjects (67 males, 146 females) participated in this study. Div...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.01842
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:Evaluation of the efficiency of somatostatin analogues in the treatment of a mixed luteinizing hormone (LH)-, alpha-subunit-, prolactin (PRL)-secreting pituitary adenoma. DESIGN:A 30-year-old woman, with amenorrhaea-galactorrhaea, presented with a pituitary macroadenoma. The endocrine evaluation showed high ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1450035
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:Patients with craniopharyngioma are at an increased risk for cardio- and cerebrovascular mortality. The metabolic syndrome (MetS) is an important cardiometabolic risk factor, but barely studied in patients with craniopharyngioma. We aimed to investigate the prevalence of and risk factors for the MetS and its ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-17-0387
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:In the absence of widely available measures of determining free and/or bioavailable testosterone (BioT) physicians may use formulae such as the free androgen index (FAI) to estimate free testosterone. We compared the efficacy of calculated markers of androgen status in predicting serum BioT and hypogonadism. ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1510241
更新日期：2004-08-01 00:00:00
abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-17-0920
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:Serum concentrations of soluble tumor necrosis factor-alpha (TNF-alpha) receptor 2 (sTNFR2) are associated with insulin resistance. In a recent study, we provided evidence for the existence of a biologically active form of sTNFR2 produced by alternative splicing (DS-TNFR2). We aimed to evaluate whether this c...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02145
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:Multiple types of voltage-activated Ca(2+) channels (T, L, N, P, Q and R type) coordinate a variety of Ca(2+)-dependent processes in neurons and neuroendocrine cells. In insulinoma cell lines as well as in endocrine tissues, the non-L-type alpha1E (Ca(v)2.3) subunit is expressed as the tissue-specific splice ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460881
更新日期：2002-06-01 00:00:00
abstract：:As differentiated (follicular and papillary) thyroid cancer (DTC) may recur years after initial treatment, follow-up of patients with DTC is long term. However, this population has changed, with more individuals being discovered at an earlier stage of disease, so that previous follow-up protocols based mostly on data ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1510539
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:GH deficiency (GHD) and glucocorticoid excess are associated with increased risk of fragility fractures. We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD. DESIGN:Cross-sectional study. METHODS:Fifty-one ad...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-10-0125
更新日期：2010-07-01 00:00:00
abstract：:The GH/IGF1 axis may play an important role in cognitive function. This theory is supported by the finding that both GH and IGF1 receptors are located in several brain areas such as the hippocampus, a brain area that is known to play an essential role in cognitive processes, especially memory and learning. However, th...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-08-0279
更新日期：2008-12-01 00:00:00
abstract：:Bone mineral density (BMD), bone mineral content and body composition were determined in 47 middle-aged (mean age 47.9 +/- 1.1 years) women with Turner's syndrome. Bone mineral density was measured in the forearm, femoral neck and total body. The women investigated had a BMD lower than the normal mean. When expressed ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1320047
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:An inherited profile of genes related to the response to aggressive environmental factors such as viruses and chemicals may be related to an increased susceptibility to Graves' disease (GD). DESIGN AND METHODS:This prospective case-control study was designed to examine the relationship between human herpesvi...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0719
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:To assess the LH response of the pituitary gland to GnRH stimulation in healthy women with a mutant beta-subunit (Trp8 to Arg8 and Ile15 to Thr15). DESIGN:Clinical study. PATIENTS:We studied 40 healthy non-pregnant Japanese women of known zygosity for the LH beta-subunit gene (3 homozygotes for the mutant g...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1430375
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:Though transsphenoidal surgery remains the first-line treatment of Cushing's disease, recurrence occurs frequently. Conventional radiotherapy and anticortisolic drugs both have adverse effects. Stereotactic radiosurgery needs to be evaluated more precisely. The aim of this study was to determine long-term hor...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02323
更新日期：2007-01-01 00:00:00
abstract：:Endogenous pathologic hypercortisolism, or Cushing's syndrome, is associated with poor quality of life, morbidity, and increased mortality. Early diagnosis may mitigate against this natural history of the disorder. The clinical presentation of Cushing's syndrome varies, in part related to the extent and duration of co...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-15-0464
更新日期：2015-10-01 00:00:00
abstract：:In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be repor...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.1.02326
更新日期：2007-02-01 00:00:00
