当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Retrospective analysis of the association of nodular goiter with primary and secondary hyperparathyroidism.

Retrospective analysis of the association of nodular goiter with primary and secondary hyperparathyroidism.

Abstract：

BACKGROUND:The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified. OBJECTIVE:To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study. METHODS:We retrospectively reviewed all patients referred for parathyroid scintigraphy in the period 1990-1999. A total of 487 patients in the age range 17-65 years were selected for the analysis (339 women and 148 men); group A included 241 patients with primary and group B 246 patients with secondary HPT. RESULTS:A total of 124/241 patients in group A (51.5%), but only 92/246 patients in group B (38.2%) had thyroid disorders (notably nodular goiter) associated with HPT (P=0.0035). Thyroid disorders were evenly distributed throughout the entire 17-65 years age range in group A, but 17-40-year-old patients in group B had significantly fewer thyroid disorders than the older patients of the same group (15.5% compared with 43.3%, P<0.002), as expected in a general population. In patients with primary HPT there was no difference in the prevalence of thyroid disease between women and men, whereas the ratio of women to men in secondary HPT patients with thyroid disease was about 3:1. CONCLUSIONS:These results demonstrate an increased prevalence of nodular goiter in patients with primary rather than secondary HPT, and are consistent with a possible role of increased endogenous calcium concentrations (a hallmark of primary, but not of secondary, HPT) as a goitrogenic factor in patients with HPT.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

dell'Erba L,Baldari S,Borsato N,Bruno G,Calò-Gabrieli G,Carletto M,Ciampolillo A,Dondi M,Erba P,Gerundini P,Lastoria S,Marinelli P,Santoro M,Scarano B,Zagni P,Bagnasco M,Mariani G

doi

10.1530/eje.0.1450429

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

429-34

issue

4

eissn

0804-4643

issn

1479-683X

pii

1450429

journal_volume

145

pub_type

杂志文章,多中心研究

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Associations between thyroid function and mortality: the influence of age.

    abstract：OBJECTIVE:The aim of this study was to investigate the influence of age on the association between thyroid function and mortality. DESIGN:The Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known thyroid disease. METHODS:TSH, free th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-1070

    authors： van de Ven AC,Netea-Maier RT,de Vegt F,Ross HA,Sweep FC,Kiemeney LA,Smit JW,Hermus AR,den Heijer M

    更新日期：2014-08-01 00:00:00

  • IGF receptor gene variants in normal adolescents: effect on stature.

    abstract：OBJECTIVE:IGF1 is essential for human growth and mediates its effects through the type 1 IGF receptor (IGF1R). Our objective was to determine the frequency of certain previously reported IGF1R gene variants in the normal population and their effect on stature. DESIGN:A cross-sectional study was conducted in a populati...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0565

    authors： Kansra AR,Dolan LM,Martin LJ,Deka R,Chernausek SD

    更新日期：2012-12-01 00:00:00

  • Polyglandular autoimmune syndromes.

    abstract：:The polyglandular autoimmune syndromes (PAS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (PAS type I) and a relatively common adult type with (PAS II) or without adrenal failure (PAS III). First clinical manifestation of PAS I usually occurs in childhood, whereas PAS II m...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-09-0044

    authors： Kahaly GJ

    更新日期：2009-07-01 00:00:00

  • Familial neurohypophyseal diabetes insipidus in 13 kindreds and 2 novel mutations in the vasopressin gene.

    abstract：Background:Autosomal dominant neurohypophyseal diabetes insipidus (adNDI) is caused by arginine vasopressin (AVP) deficiency resulting from mutations in the AVP-NPII gene encoding the AVP preprohormone. Aim:To describe the clinical and molecular features of Italian unrelated families with central diabetes insipidus. ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0299

    authors： Patti G,Scianguetta S,Roberti D,Di Mascio A,Balsamo A,Brugnara M,Cappa M,Casale M,Cavarzere P,Cipriani S,Corbetta S,Gaudino R,Iughetti L,Martini L,Napoli F,Peri A,Salerno MC,Salerno R,Passeri E,Maghnie M,Perrotta

    更新日期：2019-09-01 00:00:00

  • A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men.

    abstract：OBJECTIVE:In the absence of widely available measures of determining free and/or bioavailable testosterone (BioT) physicians may use formulae such as the free androgen index (FAI) to estimate free testosterone. We compared the efficacy of calculated markers of androgen status in predicting serum BioT and hypogonadism. ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1510241

    authors： Morris PD,Malkin CJ,Channer KS,Jones TH

    更新日期：2004-08-01 00:00:00

  • Cognition in the adult with childhood-onset GH deficiency.

    abstract：:The GH/IGF1 axis may play an important role in cognitive function. This theory is supported by the finding that both GH and IGF1 receptors are located in several brain areas such as the hippocampus, a brain area that is known to play an essential role in cognitive processes, especially memory and learning. However, th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-08-0279

    authors： van Nieuwpoort IC,Drent ML

    更新日期：2008-12-01 00:00:00

  • Abiraterone acetate treatment lowers 11-oxygenated androgens.

    abstract：Context:The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required f...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0905

    authors： Wright C,O'Day P,Alyamani M,Sharifi N,Auchus RJ

    更新日期：2020-04-01 00:00:00

  • Four years' treatment of resistant acromegaly with octreotide.

    abstract：:This study was designed to ascertain the long-term safety and efficacy profile of the somatostatin analogue octreotide as treatment of refractory acromegaly. Eight patients (aged 21-62 years) with persistent growth hormone (GH) elevation (duration 1-15 years) despite previous therapy were studied. Octreotide was given...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1320429

    authors： McKnight JA,McCance DR,Sheridan B,Atkinson AB

    更新日期：1995-04-01 00:00:00

  • A four year dose-response study of recombinant human growth hormone treatment of growth hormone deficient children: effects on growth, bone growth and bone mineralization.

    abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1420042

    authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

    更新日期：2000-01-01 00:00:00

  • Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women.

    abstract：OBJECTIVE:Although fibroblast growth factor 23 (FGF23) has been implicated in the pathogenesis of cardiovascular disease, the relationship between FGF23 and cardiovascular disease has not been well characterized in the general population. The aim of this study was to determine whether serum FGF23 is independently assoc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-11-0577

    authors： Dalal M,Sun K,Cappola AR,Ferrucci L,Crasto C,Fried LP,Semba RD

    更新日期：2011-11-01 00:00:00

  • Diabetes insipidus and use of desmopressin (Minirin) during pregnancy.

    abstract：:With the use of two central health registries in Sweden, the Hospital Discharge Registry and the Medical Birth Registry, we identified 100 infants born of women who had been hospitalized for diabetes insipidus. By checking the medical records of these women, 29 infants were identified whose mothers had diabetes insipi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1320144

    authors： Källén BA,Carlsson SS,Bengtsson BK

    更新日期：1995-02-01 00:00:00

  • Anionic iodotyrosine residues are required for iodothyronine synthesis.

    abstract：:Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxida...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380227

    authors： de Vijlder JJ,den Hartog MT

    更新日期：1998-02-01 00:00:00

  • Serum concentrations of LH and FSH in the healthy newborn.

    abstract：OBJECTIVE:A sex difference in fetal and neonatal pituitary-gonadal function has been well documented. The aim of the following study was to determine sex differences and patterns of basal LH/FSH in the neonatal period. DESIGN:Peripheral venous blood was obtained from 164 healthy full term newborns (91 males, 73 female...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430213

    authors： Schmidt H,Schwarz HP

    更新日期：2000-08-01 00:00:00

  • Radiotherapy for non-functioning pituitary adenomas.

    abstract：:The initial management of large non-functioning pituitary adenomas is surgical debulking. In some cases, postoperative radiotherapy (RT) is administered in order to reduce the likelihood of tumour regrowth. Historically, there have been concerns surrounding a number of potentially significant complications of pituitar...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1440569

    authors： Boelaert K,Gittoes NJ

    更新日期：2001-06-01 00:00:00

  • Association between monoallelic TSHR mutations and congenital hypothyroidism: a statistical approach.

    abstract：OBJECTIVE:Biallelic TSHR mutations cause congenital hypothyroidism (CH). Serum TSH levels of monoallelic mutation carriers range from normal to mildly elevated, and thus the size of its effect remains unclear. The objectives were to examine the association between monoallelic TSHR mutations and positivity at newborn sc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-1049

    authors： Abe K,Narumi S,Suwanai AS,Adachi M,Muroya K,Asakura Y,Nagasaki K,Abe T,Hasegawa T

    更新日期：2018-02-01 00:00:00

  • Observing pretibial myxedema in patients with Graves' disease using digital infrared thermal imaging and high-resolution ultrasonography: for better records, early detection, and further investigation.

    abstract：OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-1095

    authors： Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

    更新日期：2011-04-01 00:00:00

  • Expression of nitric oxide synthase III in human thyroid follicular cells: evidence for increased expression in hyperthyroidism.

    abstract：:Nitric oxide mediates a wide array of cellular functions in many tissues. It is generated by three known isoforms of nitric oxide synthases (NOS). Recently, the endothelial isoform, NOSIII, was shown to be abundantly expressed in the rat thyroid gland and its expression increased in goitrous glands. In this study, we ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360649

    authors： Colin IM,Kopp P,Zbären J,Häberli A,Grizzle WE,Jameson JL

    更新日期：1997-06-01 00:00:00

  • Cross-sectional area of the median nerve is increased in primary autoimmune hypothyroidism and decreases upon treatment with thyroxine.

    abstract：BACKGROUND:The purpose of this study was to assess changes in the cross-sectional area (CSA) of nervus medianus by ultrasound in newly diagnosed primary hypothyroid patients after thyroxine replacement treatment. PATIENTS AND METHODS:The cohort comprised 30 patients with newly diagnosed primary autoimmune hypothyroidi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0397

    authors： Holováčová D,Kužma M,Killinger Z,Payer J

    更新日期：2016-10-01 00:00:00

  • Tumor necrosis factor-alpha decreases thyrotropin-induced 5'-deiodinase activity in FRTL-5 thyroid cells.

    abstract：:Tumor necrosis factor-alpha (TNF-alpha) exerts various effects on many cell types. Acute administration of TNF-alpha to rats decrease hepatic 5'-deiodinase activity (5'D-I) and TNF-alpha has been implicated in the pathogenesis of the low triiodothyronine syndrome in non-thyroidal illness in humans. The thyroid, liver ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1300502

    authors： Ongphiphadhanakul B,Fang SL,Tang KT,Patwardhan NA,Braverman LE

    更新日期：1994-05-01 00:00:00

  • Mineralocorticoid receptor splice variants in different human tissues.

    abstract：:The mineralocorticoid receptor (MR), a member of the steroid receptor family, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11beta-hydroxysteroid dehydrogenase. In other ti...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380702

    authors： Wickert L,Watzka M,Bolkenius U,Bidlingmaier F,Ludwig M

    更新日期：1998-06-01 00:00:00

  • Clinical management of paragangliomas.

    abstract：:Paragangliomas (PGLs) are rare vascular, neuroendocrine tumors of paraganglia, which are associated with either sympathetic tissue in adrenal (pheochromocytomas (PCCs)) and extraadrenal (sympathetic paraganglioma (sPGLs)) locations or parasympathetic tissue of the head and neck paragangliomas (HNPGLs). As HNPGLs are u...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-14-0396

    authors： Corssmit EP,Romijn JA

    更新日期：2014-12-01 00:00:00

  • Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects.

    abstract：OBJECTIVE:Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN:Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg cal...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-08-0339

    authors： Sneve M,Figenschau Y,Jorde R

    更新日期：2008-12-01 00:00:00

  • Transition in endocrinology: induction of puberty.

    abstract：:Puberty is the period during which we attain adult secondary sexual characteristics and reproductive capability. Its onset depends upon reactivation of pulsative GNRH, secretion from its relative quiescence during childhood, on the background of intact potential for pituitary-gonadal function. This review is intended:...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0894

    authors： Dunkel L,Quinton R

    更新日期：2014-06-01 00:00:00

  • The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area.

    abstract：BACKGROUND:The iodine supply of the population in Berlin has normalized during the last 5 Years. Therefore autoimmune thyroiditis has become the most important differential diagnosis in children and adolescents with goiter. OBJECTIVE:The aim of the present study was to define the prevalence of anti-thyroid peroxidase ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1480301

    authors： Kabelitz M,Liesenkötter KP,Stach B,Willgerodt H,Stäblein W,Singendonk W,Jäger-Roman E,Litzenbörger H,Ehnert B,Grüters A

    更新日期：2003-03-01 00:00:00

  • An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action.

    abstract：OBJECTIVE:Serum concentrations of soluble tumor necrosis factor-alpha (TNF-alpha) receptor 2 (sTNFR2) are associated with insulin resistance. In a recent study, we provided evidence for the existence of a biologically active form of sTNFR2 produced by alternative splicing (DS-TNFR2). We aimed to evaluate whether this c...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02145

    authors： Fernández-Real JM,Straczkowski M,Lainez B,Chacón MR,Kowalska I,López-Bermejo A,García-España A,Nikolajuk A,Kinalska I,Ricart W

    更新日期：2006-05-01 00:00:00

  • MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms.

    abstract：:The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the LH receptor ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-18-0396

    authors： Huhtaniemi I

    更新日期：2018-09-01 00:00:00

  • Association between an IGF-I gene polymorphism and body fatness: differences between generations.

    abstract：OBJECTIVE:A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations. DESIGN:Observati...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02101

    authors： Voorhoeve PG,van Rossum EF,Te Velde SJ,Koper JW,Kemper HC,Lamberts SW,de Waal HA

    更新日期：2006-03-01 00:00:00

  • Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans.

    abstract：:Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or le...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1320594

    authors： Dumoulin SC,Perret BP,Bennet AP,Caron PJ

    更新日期：1995-05-01 00:00:00

  • A randomized trial of nicotinamide and vitamin E in children with recent onset type 1 diabetes (IMDIAB IX).

    abstract：OBJECTIVE:Various adjuvant therapies have been introduced along with intensive insulin therapy in patients with recent onset type 1 diabetes. Nicotinamide (NA), administered at diagnosis of the disease, can have beneficial effects on the clinical remission rate, improve metabolic control and preserve or slightly increa...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1500719

    authors： Crinò A,Schiaffini R,Manfrini S,Mesturino C,Visalli N,Beretta Anguissola G,Suraci C,Pitocco D,Spera S,Corbi S,Matteoli MC,Patera IP,Manca Bitti ML,Bizzarri C,Pozzilli P,IMDIAB group.

    更新日期：2004-05-01 00:00:00

  • Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men.

    abstract：BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02204

    authors： Lundin KB,Giwercman YL,Rylander L,Hagmar L,Giwercman A

    更新日期：2006-08-01 00:00:00