Abstract：
:The mineralocorticoid receptor (MR), a member of the steroid receptor family, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11beta-hydroxysteroid dehydrogenase. In other tissues MR and the glucocorticoid receptor show overlapping physiological effects or may act together by forming a heterodimer. An additional MR splice variant (MR+4) has been found in different mRNA samples from rat tissues and human white blood cells, thereby implying additional modes of MR-regulated effects. We therefore looked for the presence of these two MR-mRNA isoforms in human classical aldosterone target tissues and various other tissues. MR-mRNA was found in all samples investigated, thereby showing the expression of MR to be more abundant than has been observed thus far. In addition, the MR+4-mRNA variant was also found in all the tissues examined.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Wickert L,Watzka M,Bolkenius U,Bidlingmaier F,Ludwig Mdoi
10.1530/eje.0.1380702subject
Has Abstractpub_date
1998-06-01 00:00:00pages
702-4issue
6eissn
0804-4643issn
1479-683Xjournal_volume
138pub_type
杂志文章abstract：:Paragangliomas (PGLs) are rare vascular, neuroendocrine tumors of paraganglia, which are associated with either sympathetic tissue in adrenal (pheochromocytomas (PCCs)) and extraadrenal (sympathetic paraganglioma (sPGLs)) locations or parasympathetic tissue of the head and neck paragangliomas (HNPGLs). As HNPGLs are u...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-14-0396
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia and inappropriately low PTH concentrations. ADH type 1 is caused by activating mutations in the calcium-sensing receptor (CASR), a G-protein-coupled receptor signaling through α11 (Gα11) and αq (Gαq) subunits. Heterozygous activating mutat...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0109
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Lithium, clinically used in the treatment of bipolar disorders, is well known to induce thyroid growth. However, the mechanism involved is only incompletely characterized. Although it is conventionally believed that thyroid proliferation depends on the thyroid-stimulating hormone (TSH)/cAMP/cAMP response ele...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02038
更新日期：2005-12-01 00:00:00
abstract：:Several lines of evidence suggest that tumor necrosis factor-alpha (TNFalpha) may contribute to the pathogenesis of autoimmune thyroid disease. It is not known, however, whether increased thyroidal TNFalpha levels are associated with changes in thyroid function. The purpose of the present study was to utilize in situ ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1390539
更新日期：1998-11-01 00:00:00
abstract：:Sex steroids are important for the growth and maintenance of both the female and the male skeleton. However, the relative contribution of androgens versus estrogens in the regulation of the male skeleton is unclear. Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the ...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-09-0118
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:The current guidelines for the management of adrenal incidentaloma advise hormonal and radiological follow-up of patients for 2-5 years after the initial diagnosis. However, the vast majority of adrenal incidentaloma are non-functional benign cortical adenomas that require no treatment, so the routine applica...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-15-0199
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:In order to characterize urinary gonadotropin peptide (UGP) as an acute phase reactant, we focused on the UGP levels after surgical operation. DESIGN:Fifty cases of gastrointestinal cancer, 4 cases of cancers of other organs and 13 cases of benign digestive diseases were enrolled into this study. METHODS:UG...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1400555
更新日期：1999-06-01 00:00:00
abstract：:Children with cystic fibrosis (CF) have problems with poor linear growth and inadequate weight gain. Nutritional augmentation has been the mainstay of therapy for improving both weight and height in CF; however, inadequate growth continues to be a problem. Furthermore, protein catabolism has been documented even in no...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.151s081
更新日期：2004-08-01 00:00:00
abstract：:Glycoprotein hormone alpha-subunit (alpha SU) is a recognized product of clinically non-functioning, glycoprotein hormone-secreting and somatotroph adenomas but has not been studied systematically in corticotroph tumours. We have performed immunohistochemistry for alpha SU in a consecutive series of four corticotroph ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1330025
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:Thyroid hormone resistance (RTH) is characterised by variable tissue hyporesponsiveness to thyroid hormone. The disorder is usually caused by mutations in the thyroid hormone receptor beta (TR beta). We describe a large family with this disorder. SUBJECTS AND MEASUREMENT: We identified 36 family members with ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1500425
更新日期：2004-04-01 00:00:00
abstract：:Serum thyrotropin (TSH) concentration circadian rhythm is abolished in many endocrine and non-endocrine diseases. In the present study we have measured serum TSH concentration over 24 h every 2 h in second and third trimester pregnant women. During the 24-h period, serum free thyroxine and free triiodothyronine concen...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1330071
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:Evaluation of the efficiency of somatostatin analogues in the treatment of a mixed luteinizing hormone (LH)-, alpha-subunit-, prolactin (PRL)-secreting pituitary adenoma. DESIGN:A 30-year-old woman, with amenorrhaea-galactorrhaea, presented with a pituitary macroadenoma. The endocrine evaluation showed high ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1450035
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-07-0259
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVE:Modest elevations in circulating IGF-I levels have been suggested to protect against the development of glucose intolerance in insulin-resistant subjects. To further understand the interactions of GH and IGF-I on beta-cell function and post-load glucose tolerance in glucose-intolerant subjects predisposed to ...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1510039
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether patients with Addison's disease and polyendocrine syndromes have undiagnosed autoimmune polyendocrine syndrome type I (APS I). MATERIALS AND METHODS:Forty patients with clinical manifestations resembling APS I and with autoantibodies typical of this condition were screened for Norwegia...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460519
更新日期：2002-04-01 00:00:00
abstract：OBJECTIVE:Glucocorticoids stimulate several steps in red blood cell (RBC) development; however, little is known on changes in erythroid parameters in patients with Cushing's disease. The aim of this study was to assess both RBC and white blood cell (WBC) parameters in a large cohort of patients with Cushing's disease a...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-13-0824
更新日期：2014-02-04 00:00:00
abstract：OBJECTIVE:Our aim was to compare physical activity and biochemical markers with bone mineral acquisition in rhythmic gymnasts and ballet dancers. METHODS:Weight, height, body mass index, nutritional intake, bone age and menstrual histories were analyzed in nine rhythmic gymnasts, twelve ballet dancers and fourteen con...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1510491
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-produci...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0201
更新日期：2011-07-01 00:00:00
abstract：:Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical s...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-18-0596
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular mortality and morbidity. Little is known about hemostatic features of patients with PHPT. To our knowledge, plasma tissue factor pathway inhibitor (TFPI) and thrombin-activatable fibrinolysis inhibitor (TAFI) levels...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0069
更新日期：2009-05-01 00:00:00
abstract：:Prostate growth is known to be controlled by steroids such as androgens and estradiol. For this reason steroids (estradiol, adrenal androgens) or steroid inhibitors are commonly used as palliative treatments for prostate carcinoma. In view of the pivotal role played by Ca2+ ions in cell proliferation, we decided to in...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1350367
更新日期：1996-09-01 00:00:00
abstract：:Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans). GC signaling follows several consecutive step...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-19-0811
更新日期：2020-02-01 00:00:00
abstract：:The control of prolactin (PRL) secretion by N-methyl-D-aspartate (NMDA) and kainic acid (KA), agonists of NMDA and kainate receptors, and the interactions between NMDA and KA with nitric oxide (NO) were analysed in prepubertal female rats. For this purpose, serum PRL concentrations and hypothalamic and pituitary dopam...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1350464
更新日期：1996-10-01 00:00:00
abstract：OBJECTIVE:The evidence that stress may provoke Graves' hyperthyroidism in genetically susceptible subjects is substantial. Whether exposure to stress is related to the severity of thyrotoxicosis has not been studied. Advancing age is associated with not only less severe Graves' hyperthyroidism but also self-reported st...
journal_title：European journal of endocrinology
pub_type： 杂志文章,多中心研究
doi：10.1530/EJE-08-0573
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Previous studies have suggested that infections are an important cause of death in patients with Addison's disease, but epidemiological studies on the frequency of infections in this population are lacking. OBJECTIVE:To assess and compare the incidence risk of infections in patients with primary adrenal ins...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-12-0879
更新日期：2013-03-15 00:00:00
abstract：BACKGROUND AND AIMS:Ghrelin is an orexigenic 28-amino acid peptide produced by the stomach. Circulating ghrelin levels rise shortly before and fall shortly after every meal. Peptide YY (PYY), an anorexigenic 36-amino acid peptide, is secreted primarily from the intestinal mucosa of the ileum and large intestine. Plasma...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-1033
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Short stature caused by point mutations or deletions of the short stature homeobox (SHOX) gene (SHOX haploinsufficiency (SHI)) is a registered indication for GH treatment. Patients with a SHOX enhancer deletion (SED) have a similar phenotype, but their response to GH is unknown. It is uncertain if duplication...
journal_title：European journal of endocrinology
pub_type： 杂志文章,多中心研究
doi：10.1530/EJE-15-0451
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:Serum IGF-binding protein 2 (IGFBP2) concentrations are reduced in obese humans and increase after a prolonged period of fasting. We investigated the association between IGFBP2 levels and mortality together with other factors that are related to IGFBP2, including the metabolic syndrome and physical function. ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-12-0160
更新日期：2012-07-01 00:00:00
abstract：Objective:Glucocorticoid treatment of inflammatory disorders is associated with significant adverse effects related to glucocorticoid excess as well as adrenal insufficiency. This necessitates awareness of its use. We therefore investigated trends in systemic glucocorticoid use as well as morbidity and comedications am...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-19-0305
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:In a preliminary cross-sectional study, we discovered that DNA topoisomerase II autoantibodies (anti-TopII) were detected in 49.2% of 195 Chinese type 1 diabetes mellitus (type 1 DM) patients with a mean age of 14.5 years and a mean duration of disease of 4.6 years. In order to demonstrate the relationship be...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1420577
更新日期：2000-06-01 00:00:00
