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High IGFBP2 levels are not only associated with a better metabolic risk profile but also with increased mortality in elderly men.

Abstract：

OBJECTIVE:Serum IGF-binding protein 2 (IGFBP2) concentrations are reduced in obese humans and increase after a prolonged period of fasting. We investigated the association between IGFBP2 levels and mortality together with other factors that are related to IGFBP2, including the metabolic syndrome and physical function. DESIGN:A prospective observational study at a clinical research center of 403 independently living elderly men (aged 73-94 years). METHODS:Mortality was registered during 8.6 years of follow-up. Physical performance score (PPS), grip strength (GS), and bone mineral density (BMD) were measured. The measurements taken a baseline were: IGF1; IGFBP1, -2, and -3; IGF1 bioactivity; triiodothyronine (T(3)); and reverse T(3). Further, BMI, insulin sensitivity, cholesterol, inflammatory markers, and albumin levels were also measured. RESULTS:During the follow-up, 180 men died. Higher PPS, GS, and BMD were independently related to a reduced mortality (hazard ratio (HR)=0.87/point, 95% confidence interval (95% CI)=0.82-0.91, P<0.001; HR=0.96/kp, 95% CI 0.94-0.98, P<0.001; and HR=0.21/(g/cm(2)), 95% CI 0.07-0.61, P<0.01). Higher serum IGFBP2 levels were strongly related to mortality (HR=2.26/(mg/l), 95% CI 1.57-3.27, P<0.001). This was independent of comorbidity, physical function, IGF1 bioactivity, and other somatotropic parameters, including BMI and the metabolic syndrome. In addition, IGFBP2 levels were higher in subjects with nonthyroidal illness, and higher IGFBP2 levels were significantly associated with lower albumin concentrations. CONCLUSION:Despite the strong relationship between high IGFBP2 and low physical function, both were strongly and independently related to increased 8-year mortality in elderly men. IGFBP2 may be a useful biomarker integrating the nutritional status, as well as the biological effects of GH, IGF1, and insulin.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

van den Beld AW,Blum WF,Brugts MP,Janssen JA,Grobbee DE,Lamberts SW

doi

10.1530/EJE-12-0160

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

111-7

issue

eissn

0804-4643

issn

1479-683X

pii

EJE-12-0160

journal_volume

167

pub_type

杂志文章

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High IGFBP2 levels are not only associated with a better metabolic risk profile but also with increased mortality in elderly men.