Abstract：
:Anorexia nervosa is a syndrome, that is collections of symptoms, which is not defined by its etiology. The severe cases are intractable. The syndrome is associated with multiple, profound endocrine alterations which may be adaptive, reactive or etiologic. Adaptive changes potentially may be inappropriate in clinical settings such as inpatient intensive re-nutrition or in a setting with somatic comorbidity. Electrolyte levels must be closely monitored during the refeeding process, and the need for weight gain must be balanced against potentially fatal refeeding complications. An important focus of clinical research should be to identify biomarkers associated with different stages of weight loss and re-nutrition combined with psychometric data. Besides well-established peripheral endocrine actions, several hormones also are released directly to different brain areas, where they may exert behavioral and psychogenic actions that could offer therapeutic targets. We need reliable biomarkers for predicting outcome and to ensure safe re-nutrition, however, first of all we need them to explore the metabolism in anorexia nervosa to open new avenues with therapeutic targets. A breakthrough in our understanding and treatment of this whimsical disease remains. Considering this, the aim of the present review is to provide an updated overview of the many endocrine changes in a clinical perspective.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Støving RKdoi
10.1530/EJE-18-0596subject
Has Abstractpub_date
2019-01-01 00:00:00pages
R9-R27issue
1eissn
0804-4643issn
1479-683Xpii
EJE-18-0596journal_volume
180pub_type
杂志文章,评审abstract：:The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1370200
更新日期：1997-08-01 00:00:00
abstract：CONTEXT AND OBJECTIVE:High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0662
更新日期：2012-02-01 00:00:00
abstract：AIMS:Reported cure rates following trans-sphenoidal surgery for microprolactinoma are variable and recurrence rates in some series are high. We wished to examine the cure rate of trans-sphenoidal surgery for microprolactinoma, and to assess the long-term complications and recurrence rate. DESIGN:A retrospective review...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1400043
更新日期：1999-01-01 00:00:00
abstract：:Bone loss due to menopause, natural or artificial, has been attributed solely to low estrogen. However, in a woman's life, the most precipitous bone loss begins 2 years prior to the last menstrual period, during which time estrogen levels are unperturbed whereas FSH is elevated. Our cell-based and mouse genetic studie...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-10-0397
更新日期：2010-07-01 00:00:00
abstract：Objective:Glucocorticoid treatment of inflammatory disorders is associated with significant adverse effects related to glucocorticoid excess as well as adrenal insufficiency. This necessitates awareness of its use. We therefore investigated trends in systemic glucocorticoid use as well as morbidity and comedications am...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-19-0305
更新日期：2019-09-01 00:00:00
abstract：Objective:Statin therapy has been linked to an increased risk of type 2 diabetes in high-risk populations; however, the pathophysiology of this association remains to be clarified. We investigated glucagon suppression and its relationship with insulin resistance in prediabetic subjects undergoing atorvastatin therapy; ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-19-0173
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0131
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Free fatty acids (FFAs) deplete the intracellular insulin stores of pancreatic beta-cells. It has been suggested that this results from a lipotoxic dysregulation of both insulin secretion and insulin synthesis. In the present study, this hypothesis was tested within a 12-h time-course by directly relating the...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1480481
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:Although vascular mortality is increased in hypopituitary adults on routine replacement, there are limited data on the atherosclerotic process during life in these patients. Measurement of arterial stiffness may provide an index of early vascular changes that predispose to the development of major vascular ac...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1360157
更新日期：1997-02-01 00:00:00
abstract：OBJECTIVE:The molecular mechanisms of TSH receptor (TSHR) activation and intramolecular signal transduction are largely unknown. Deletion of the extracellular domain (ECD) of the TSHR results in increased constitutive activity, which suggests a self-inhibitory interaction between the ECD and the extracellular loops (EC...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.01891
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Cross-sectional studies have shown that more than 50% of patients with congestive heart failure (CHF) have decreased bone mineral density (BMD). There is limited knowledge about the longitudinal changes of BMD and how to treat bone loss in patients with CHF. METHODS:The present study was a prospective, long...
journal_title：European journal of endocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1530/EJE-06-0614
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVE:Medullary thyroid carcinoma (MTC) occurs sporadically in 75% of patients. Metastatic disease is associated with significantly poorer survival. The aim of this study was to identify prognostic markers for progressive MTC and oncogenic factors associated with response to vandetanib therapy. DESIGN AND METHODS:...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0252
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:IGF1 is essential for human growth and mediates its effects through the type 1 IGF receptor (IGF1R). Our objective was to determine the frequency of certain previously reported IGF1R gene variants in the normal population and their effect on stature. DESIGN:A cross-sectional study was conducted in a populati...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-12-0565
更新日期：2012-12-01 00:00:00
abstract：:Several lines of evidence suggest that tumor necrosis factor-alpha (TNFalpha) may contribute to the pathogenesis of autoimmune thyroid disease. It is not known, however, whether increased thyroidal TNFalpha levels are associated with changes in thyroid function. The purpose of the present study was to utilize in situ ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1390539
更新日期：1998-11-01 00:00:00
abstract：:Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) micrograms/l [median (standard error of m...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1310020
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVE:Very few previous studies have compared the degree of health-related quality of life (HRQL), depression and anxiety of differentiated thyroid cancer patients (DTC) under short-term hypothyroid-ism and levothyroxine treatment. METHODS:Using patient-completed instruments, we examined the frequency of physical ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02047
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Cranial radiation therapy (CRT) is required for successful treatment of a variety of brain tumours in childhood. OBJECTIVE:To investigate whether childhood CRT leads to altered sleep-wakefulness organization in adulthood, and to identify the determinants of such alterations. SUBJECTS AND METHODS:Subjective...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1500503
更新日期：2004-04-01 00:00:00
abstract：:Prostate growth is known to be controlled by steroids such as androgens and estradiol. For this reason steroids (estradiol, adrenal androgens) or steroid inhibitors are commonly used as palliative treatments for prostate carcinoma. In view of the pivotal role played by Ca2+ ions in cell proliferation, we decided to in...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1350367
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVE:The current guidelines for the management of adrenal incidentaloma advise hormonal and radiological follow-up of patients for 2-5 years after the initial diagnosis. However, the vast majority of adrenal incidentaloma are non-functional benign cortical adenomas that require no treatment, so the routine applica...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-15-0199
更新日期：2015-08-01 00:00:00
abstract：:Glucocorticoid treatment causes osteoporosis and growth retardation in humans. Insulin-like growth factor I (IGF-I) stimulates differentiation and replication of cultured osteoblast-like cells and induces longitudinal bone growth in IGF-I-deficient rats. We investigated the influence of subcutaneously infused IGF-I on...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1300387
更新日期：1994-04-01 00:00:00
abstract：:Children with cystic fibrosis (CF) have problems with poor linear growth and inadequate weight gain. Nutritional augmentation has been the mainstay of therapy for improving both weight and height in CF; however, inadequate growth continues to be a problem. Furthermore, protein catabolism has been documented even in no...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.151s081
更新日期：2004-08-01 00:00:00
abstract：:Patients with adrenal insufficiency need lifelong glucocorticoid replacement, but many suffer from poor quality of life, and overall there is increased mortality. Moreover, it appears that use of glucocorticoids at the higher end of the replacement dose range is associated with increased risk for cardiovascular and me...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-08-0874
更新日期：2009-05-01 00:00:00
abstract：:We here investigate the potential rescue of the relative hyposomatotropism of aging and obesity by 3-day pulsatile GHRH infusions (i.v. bolus 0.33 microg/kg every 90 min) in 19 healthy men of varying ages (18 to 66 years) and body compositions (12 to 37% total body fat). Baseline (control) and GHRH-driven pulsatile GH...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1530/eje.0.1390059
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:In the absence of widely available measures of determining free and/or bioavailable testosterone (BioT) physicians may use formulae such as the free androgen index (FAI) to estimate free testosterone. We compared the efficacy of calculated markers of androgen status in predicting serum BioT and hypogonadism. ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1510241
更新日期：2004-08-01 00:00:00
abstract：:Twenty-three patients with active acromegaly underwent serum sampling for growth hormone (GH), insulin and insulin-like growth factor binding protein 1 (IGFBP-1) after placebo or single doses of octreotide or bromocriptine. Integrated 24-h serum GH levels decreased by 90% after octreotide and 49% after bromocriptine. ...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1330195
更新日期：1995-08-01 00:00:00
abstract：:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-11-0454
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02204
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1470059
更新日期：2002-07-01 00:00:00
abstract：:Two experiments were conducted to determine the patterns of LH secretion and to evaluate the LH responses to pulsatile administration of GnRH during early pregnancy in ewes. In experiment 1, pregnant ewes (n=16) were used to determine the concentration of LH in plasma of jugular blood samples collected every 15 min fo...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1410521
更新日期：1999-11-01 00:00:00
abstract：OBJECTIVE:Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance. It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfun...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0555
更新日期：2010-02-01 00:00:00
