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Density of ghrelin-producing cells is higher in the gastric mucosa of morbidly obese patients.

Abstract：

BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-producing cells in the gastric mucosa of morbidly obese and dyspeptic non-obese patients, with and without H. pylori infection. METHODS:Gastric biopsies of the antral and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI >40, 21 with metabolic syndrome (MS)), 17 dyspeptic overweight subjects (25

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Maksud FA,Alves JS,Diniz MT,Barbosa AJ

doi

10.1530/EJE-11-0201

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

57-62

issue

1

eissn

0804-4643

issn

1479-683X

pii

EJE-11-0201

journal_volume

165

pub_type

杂志文章

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