Soluble α-klotho: a novel serum biomarker for the activity of GH-producing pituitary adenomas.

abstract：:Pituitary tumours express both somatostatin and dopamine receptors. Medical treatment with somatostatin analogues is a cornerstone of GH- and TSH-secreting tumours, while treatment with dopamine agonists is a cornerstone of prolactin-secreting tumours. Dopamine agonists have also demonstrated some efficacy in patients...

journal_title：European journal of endocrinology

authors： Colao A,Filippella M,Pivonello R,Di Somma C,Faggiano A,Lombardi G

更新日期：2007-04-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction...

journal_title：European journal of endocrinology

authors： Nin JW,Ferreira I,Schalkwijk CG,Prins MH,Chaturvedi N,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Modest elevations in circulating IGF-I levels have been suggested to protect against the development of glucose intolerance in insulin-resistant subjects. To further understand the interactions of GH and IGF-I on beta-cell function and post-load glucose tolerance in glucose-intolerant subjects predisposed to ...

journal_title：European journal of endocrinology

authors： Yuen K,Wareham N,Frystyk J,Hennings S,Mitchell J,Fryklund L,Dunger D

更新日期：2004-07-01 00:00:00

abstract：:Previous work has examined potential links between the etiology of GH deficiency (GHD) and the baseline characteristics of the patients including biochemical and psychometric parameters. Using an update of the KIMS pharmaco-epidemiological database (Pfizer International Metabolic Database), we addressed the question h...

journal_title：European journal of endocrinology

authors： Brabant G,Poll EM,Jönsson P,Polydorou D,Kreitschmann-Andermahr I

更新日期：2009-11-01 00:00:00

abstract：:Male age-related bone loss is caused, at least in part, by hypogonadism that occurs with advancing age. The study of the effects of sex steroids on bone physiology in men has recently highlighted the central role of estrogens on bone pathophysiology. This review focuses on particular aspects of bone physiology and pat...

journal_title：European journal of endocrinology

authors： Rochira V,Balestrieri A,Madeo B,Zirilli L,Granata AR,Carani C

更新日期：2006-02-01 00:00:00

abstract：:Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet's effects in patien...

journal_title：European journal of endocrinology

authors： Kawata T,Imanishi Y,Kobayashi K,Kenko T,Wada M,Ishimura E,Miki T,Nagano N,Inaba M,Arnold A,Nishizawa Y

更新日期：2005-10-01 00:00:00

abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

journal_title：European journal of endocrinology

authors： Das S,Fahmy NW,Bourne GA

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia and inappropriately low PTH concentrations. ADH type 1 is caused by activating mutations in the calcium-sensing receptor (CASR), a G-protein-coupled receptor signaling through α11 (Gα11) and αq (Gαq) subunits. Heterozygous activating mutat...

journal_title：European journal of endocrinology

authors： Tenhola S,Voutilainen R,Reyes M,Toiviainen-Salo S,Jüppner H,Mäkitie O

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Chromosomal rearrangements of the RET proto-oncogene is one of the most common molecular events in papillary thyroid carcinoma (PTC). However, their pathogenic role and clinical significance are still debated. This study aimed to investigate the prevalence of RET/PTC rearrangement in a cohort of BRAF WT PTCs ...

journal_title：European journal of endocrinology

authors： Colato C,Vicentini C,Cantara S,Pedron S,Brazzarola P,Marchetti I,Di Coscio G,Chilosi M,Brunelli M,Pacini F,Ferdeghini M

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Many investigators believe that basal adrenal venous sampling (AVS) should be done simultaneously, whereas others opt for sequential AVS for simplicity and reduced cost. This study aimed to evaluate the concordance of sequential and simultaneous AVS methods. DESIGN AND METHODS:Between 1989 and 2015, bilatera...

journal_title：European journal of endocrinology

authors： Almarzooqi MK,Chagnon M,Soulez G,Giroux MF,Gilbert P,Oliva VL,Perreault P,Bouchard L,Bourdeau I,Lacroix A,Therasse E

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:An increased cardiovascular risk and mortality in hypopituitary patients receiving conventional hormonal treatment without GH replacement have been shown in several studies. Various atherogenic risk factors including endothelial dysfunction - an early event in the atherogenesis - are more expressed in adults...

journal_title：European journal of endocrinology

authors： Hána V,Prázný M,Marek J,Skrha J,Justová V

更新日期：2002-09-01 00:00:00

abstract：:Systematic studies of autosomal dominant osteopetrosis (ADO) were followed by the identification of underlying mutations giving unique possibilities to perform translational studies. What was previously designated ADO1 turned out to be a high bone mass phenotype caused by a missense mutation in the first propeller of ...

journal_title：European journal of endocrinology

authors： Bollerslev J,Henriksen K,Nielsen MF,Brixen K,Van Hul W

更新日期：2013-07-13 00:00:00

abstract：CONTEXT:Although combination therapy of acromegaly with long-acting somatostatin analogs (LA-SSAs) and pegvisomant (PEGV) normalizes insulin-like growth factor-1 (IGF1) levels in the majority of patients, it requires long-term adherence. Switching from combination therapy to monotherapy with weekly PEGV could improve p...

journal_title：European journal of endocrinology

authors： Muhammad A,van der Lely AJ,O'Connor RD,Delhanty PJ,Dal J,Dallenga AH,Feelders RA,Janssen JA,Jorgensen JO,Neggers SJ

更新日期：2016-05-01 00:00:00

abstract：:CLTA4 is relevant for FOXP3(+)Treg cells, and the link between skewed X chromosome inactivation (XCI) and autoimmunity is recognized. The observation of immune dysregulation polyendocrinopathy enteropathy X-linked syndrome and multiorgan endocrine autoimmune phenomena in various members of one family, associated with ...

journal_title：European journal of endocrinology

authors： Seidel MG,Rami B,Item C,Schober E,Zeitlhofer P,Huber WD,Heitger A,Bodamer OA,Haas OA

更新日期：2012-07-01 00:00:00

abstract：:Papillary craniopharyngioma (PCP) is an intracranial tumor that results in high levels of morbidity. We recently demonstrated that the vast majority of these tumors harbor the oncogenic BRAF V600E mutation. The pathologic diagnosis of PCP can now be confirmed using mutation specific immunohistochemistry and targeted g...

journal_title：European journal of endocrinology

authors： Brastianos PK,Santagata S

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified. OBJECTIVE:To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study. METHODS:We ...

journal_title：European journal of endocrinology

authors： dell'Erba L,Baldari S,Borsato N,Bruno G,Calò-Gabrieli G,Carletto M,Ciampolillo A,Dondi M,Erba P,Gerundini P,Lastoria S,Marinelli P,Santoro M,Scarano B,Zagni P,Bagnasco M,Mariani G

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Confirmatory testing of suspected primary aldosteronism (PA) requires an extensive medication switch that can be difficult for patients with severe complicated hypertension and/or refractory hypokalemia. For this reason, we investigated the effect of chronic antihypertensive medication on confirmatory testing...

journal_title：European journal of endocrinology

authors： Solar M,Malirova E,Ballon M,Pelouch R,Ceral J

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Thyroidal production of triiodothyronine (T(3)) is absent in patients who have undergone total thyroidectomy. Therefore, relative T(3) deficiency may occur during postoperative levothyroxine (L-T(4)) therapy. The objective of this study was to evaluate how the individual serum T(3) level changes between preop...

journal_title：European journal of endocrinology

authors： Ito M,Miyauchi A,Morita S,Kudo T,Nishihara E,Kihara M,Takamura Y,Ito Y,Kobayashi K,Miya A,Kubota S,Amino N

更新日期：2012-09-01 00:00:00

abstract：:Two experiments were conducted to determine the patterns of LH secretion and to evaluate the LH responses to pulsatile administration of GnRH during early pregnancy in ewes. In experiment 1, pregnant ewes (n=16) were used to determine the concentration of LH in plasma of jugular blood samples collected every 15 min fo...

journal_title：European journal of endocrinology

authors： Al-Gubory KH

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:To compare clinical and humoral parameters before and after surgery in patients with incidental adrenocortical adenomas. DESIGN:Six patients with subclinical Cushing's syndrome and nine with non-functioning adenomas were investigated before and 12 Months after removal of the mass. METHODS:Anthropometric (bo...

journal_title：European journal of endocrinology

authors： Bernini G,Moretti A,Iacconi P,Miccoli P,Nami R,Lucani B,Salvetti A

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Subclinical hypothyroidism occurs in a number of children with Down's syndrome (DS). The reason for the mildly elevated plasma thyrotropin (TSH) concentrations is not known. The present study investigated whether decreased TSH bioactivity plays a role in this phenomenon. DESIGN:A retrospective study of plasm...

journal_title：European journal of endocrinology

authors： Konings CH,van Trotsenburg AS,Ris-Stalpers C,Vulsma T,Wiedijk BM,de Vijlder JJ

更新日期：2001-01-01 00:00:00

abstract：:We studied the roles played by the renin-angiotensin system in inducing hypertension in nine patients with Cushing's syndrome (CS) resulting from adrenocortical adenoma, and compared them with those in patients with primary aldosteronism (PA), renovascular hypertension (RVH) and essential hypertension (EH). In the CS ...

journal_title：European journal of endocrinology

authors： Yasuda G,Shionoiri H,Umemura S,Takasaki I,Ishii M

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Thymic neuroendocrine tumor is the second-most prevalent cause of ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS), which is a rare disease characterized by ectopic ACTH oversecretion from nonpituitary tumors. However, the genetic abnormalities of thymic neuroendocrine tumors with EAS remain largely ...

journal_title：European journal of endocrinology

authors： Li Y,Peng Y,Jiang X,Cheng Y,Zhou W,Su T,Xie J,Zhong X,Song D,Wu L,Fan L,Li M,Hong J,Wang W,Ning G,Cao Y

更新日期：2017-02-01 00:00:00

abstract：:Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospect...

journal_title：European journal of endocrinology

authors： Bonneville F,Rivière LD,Petersenn S,Bevan J,Houchard A,Sert C,Caron PJ,PRIMARYS Study group.

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammator...

journal_title：European journal of endocrinology

authors： Wunder DM,Yared M,Bersinger NA,Widmer D,Kretschmer R,Birkhäuser MH

更新日期：2006-07-01 00:00:00

abstract：:Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans). GC signaling follows several consecutive step...

journal_title：European journal of endocrinology

authors： Vitellius G,Lombes M

更新日期：2020-02-01 00:00:00

abstract：:Evidence suggests that insulin resistance and hyperinsulinaemia are associated with ovarian hyperandrogenism and menstrual irregularities in polycystic ovary syndrome (PCOS). Sixteen obese women with PCOS on a weight-maintaining diet were studied before and after 6 months of therapy with the insulin-sensitizing antidi...

journal_title：European journal of endocrinology

authors： Diamanti-Kandarakis E,Kouli C,Tsianateli T,Bergiele A

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:To determine the frequency of mutant alleles in the CYP21 gene in Spanish girls presenting with precocious pubarche (PP) and to assess the relationships between genotype and endocrine-metabolic variables. DESIGN:Fifty-three unrelated girls with a history of PP (14 prepubertal, 8 pubertal and 31 postmenarchea...

journal_title：European journal of endocrinology

authors： Potau N,Riqué S,Eduardo I,Marcos V,Ibañez L

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Previously, it has been demonstrated that receptor protein tyrosine phosphatase sigma (RPTPsigma) is involved in glucose homeostasis and insulin signaling in several animal models. The aim of this study was to evaluate whether polymorphisms in this gene influence the development of type 2 diabetes (T2D) in hu...

journal_title：European journal of endocrinology

authors： Långberg EC,Gu HF,Nordman S,Efendic S,Ostenson CG

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Flushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying orga...

journal_title：European journal of endocrinology

authors： Huguet I,Grossman A

更新日期：2017-11-01 00:00:00