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Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review.

Abstract：

:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while multiple clinical trials using this medication in the treatment of other malignancies are ongoing. As a clinical response to ipilimumab results from immunostimulation, predictably it generates autoimmunity as well, causing immune-related adverse events in the majority of patients. Of those, endocrinopathies are frequently seen, and in particular, autoimmune lymphocytic hypophysitis with anterior panhypopituitarism has been reported a number of times in North America. We present a case of a male referred to our department with manifestations of anterior panhypopituitarism after his third dose of ipilimumab for metastatic malignant melanoma, and we discuss the management of his case in the light of previous reports. We also review the published literature on the presenting symptoms, time to presentation, investigations, imaging, treatment and follow-up of ipilimumab-induced autoimmune lymphocytic hypophysitis.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

doi

10.1530/EJE-12-0167

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

1-5

issue

1

eissn

0804-4643

issn

1479-683X

pii

EJE-12-0167

journal_volume

167

pub_type

杂志文章,评审

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