How reliable is the short synacthen test for the investigation of the hypothalamic-pituitary-adrenal axis?

abstract：OBJECTIVE:An increased tendency towards thromboembolic events is observed in patients with Cushing's syndrome. There are much fewer publications available about thromboembolic complications in patients with subclinical Cushing's syndrome (SCS). Therefore, a question arises whether hemostatic disturbances appear in this...

journal_title：European journal of endocrinology

authors： Swiatkowska-Stodulska R,Kaniuka-Jakubowska S,Wisniewski P,Skibowska-Bielinska A,Sworczak K

更新日期：2011-12-01 00:00:00

abstract：:The effects of water deprivation for 3 days were studied in pregnant rats and their fetuses on day 21 of gestation. Maternal water deprivation induced a significant decrease of the body weight in both maternal and fetal rats. This weight loss was accompanied by significant increases in plasma osmolality and haematocri...

journal_title：European journal of endocrinology

authors： Deloof S,De Seze C,Montel V,Chatelain A

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European ...

journal_title：European journal of endocrinology

authors： Giton F,Fiet J,Cornu JN,Cussenot O,Bélanger A,Urien S,Oliva A,Blanchet P,Multigner L

更新日期：2011-12-01 00:00:00

abstract：AIMS:Reported cure rates following trans-sphenoidal surgery for microprolactinoma are variable and recurrence rates in some series are high. We wished to examine the cure rate of trans-sphenoidal surgery for microprolactinoma, and to assess the long-term complications and recurrence rate. DESIGN:A retrospective review...

journal_title：European journal of endocrinology

authors： Turner HE,Adams CB,Wass JA

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVES:Investigation of small numbers of parathyroid tumours by X-chromosome inactivation analysis suggests that the majority of them are monoclonal lesions most likely caused by a somatic mutation. Somatic mutations in the MEN1 gene located on chromosome 11q13 have recently been identified in 12-17% of solitary pa...

journal_title：European journal of endocrinology

authors： Miedlich S,Krohn K,Lamesch P,Müller A,Paschke R

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure. Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vi...

journal_title：European journal of endocrinology

authors： Correa P,Akerstrom G,Westin G

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Herpes simplex virus type 1 (HSV-1)-derived vectors are known to be effective tools to deliver transgenes into normal and neoplastic anterior pituitary (AP) cells in vitro. Our objective was to assess the in vitro and in vivo effects of tsK/beta-gal, a temperature-sensitive HSV-1-derived vector harbouring the...

journal_title：European journal of endocrinology

authors： Bolognani F,Albariño C,Romanowski V,Carri NG,Goya RG

更新日期：2001-10-01 00:00:00

abstract：:CLTA4 is relevant for FOXP3(+)Treg cells, and the link between skewed X chromosome inactivation (XCI) and autoimmunity is recognized. The observation of immune dysregulation polyendocrinopathy enteropathy X-linked syndrome and multiorgan endocrine autoimmune phenomena in various members of one family, associated with ...

journal_title：European journal of endocrinology

authors： Seidel MG,Rami B,Item C,Schober E,Zeitlhofer P,Huber WD,Heitger A,Bodamer OA,Haas OA

更新日期：2012-07-01 00:00:00

abstract：:To investigate a possible association between vitamin D receptor genotype and development of postmenopausal osteoporosis, a longitudinal study from 1977 to 1995 was carried out on women living in Oslo, Norway. One hundred and eighteen premenopausal women born in 1930 were included in a study of pre- and postmenopausal...

journal_title：European journal of endocrinology

authors： Berg JP,Falch JA,Haug E

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To determine the specific morphology of the pituitary gland in children with severe isolated GH deficiency due to GH-1 gene mutations (IGHD type II). DESIGN:The pituitary gland morphology in magnetic resonance imaging (MRI) of children with IGHD type II was analyzed and compared with the findings in a group ...

journal_title：European journal of endocrinology

authors： Binder G,Nagel BH,Ranke MB,Mullis PE

更新日期：2002-12-01 00:00:00

abstract：Aim:To establish pancreatic alpha-cell mass in lean, non-diabetic humans over the adult lifespan, performed as a follow-up study to beta-cell mass across the adult human lifespan. Methods:We examined human pancreatic autopsy tissue from 66 lean, non-diabetic individuals aged from 30 to 102 years, grouped into deciles:...

journal_title：European journal of endocrinology

authors： Moin ASM,Cory M,Gurlo T,Saisho Y,Rizza RA,Butler PC,Butler AE

更新日期：2020-02-01 00:00:00

abstract：:The fast technological development, particularly single nucleotide polymorphism array, array-comparative genomic hybridization, and whole exome sequencing, has led to the discovery of many novel genetic causes of growth failure. In this review we discuss a selection of these, according to a diagnostic classification c...

journal_title：European journal of endocrinology

authors： Wit JM,Oostdijk W,Losekoot M,van Duyvenvoorde HA,Ruivenkamp CA,Kant SG

更新日期：2016-04-01 00:00:00

abstract：:Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria (n = 239), former participants of the randomized controlled trial (RCT) PregMet were invited, 131 p...

journal_title：European journal of endocrinology

authors： Underdal MO,Salvesen Ø,Schmedes A,Andersen MS,Vanky E

更新日期：2019-06-01 00:00:00

abstract：:Puberty is the result of increasing pulsatile secretion of the hypothalamic gonadotropin releasing hormone (GnRH), which stimulates the release of gonadotropins and in turn gonadal activity. In general in females, development of secondary sex characteristics due to the activity of the gonadal axis, i.e., the growth of...

journal_title：European journal of endocrinology

authors： Delemarre EM,Felius B,Delemarre-van de Waal HA

更新日期：2008-12-01 00:00:00

abstract：:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...

journal_title：European journal of endocrinology

authors： Tsourdi E,Rachner TD,Rauner M,Hamann C,Hofbauer LC

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. DESIGN:Population-based cohort study. METHODS:TSH was measured in 1...

journal_title：European journal of endocrinology

authors： Lerstad G,Enga KF,Jorde R,Brodin EE,Svartberg J,Brækkan SK,Hansen JB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Glucocorticoids stimulate several steps in red blood cell (RBC) development; however, little is known on changes in erythroid parameters in patients with Cushing's disease. The aim of this study was to assess both RBC and white blood cell (WBC) parameters in a large cohort of patients with Cushing's disease a...

journal_title：European journal of endocrinology

authors： Ambrogio AG,De Martin M,Ascoli P,Cavagnini F,Pecori Giraldi F

更新日期：2014-02-04 00:00:00

abstract：:In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be repor...

journal_title：European journal of endocrinology

authors： Saeger W,Lüdecke DK,Buchfelder M,Fahlbusch R,Quabbe HJ,Petersenn S

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:To assess whether TCF7L2 single nucleotide polymorphisms rs7903146 C/T and rs11196236 C/T are associated with polycystic ovary syndrome (PCOS) in South Brazilian women. DESIGN:Cross-sectional study. METHODS:Two hundred PCOS patients and 102 non-hirsute, ovulatory controls were genotyped by real-time PCR. Ha...

journal_title：European journal of endocrinology

authors： Ramos RB,Wiltgen D,Spritzer PM

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is defined as hereditary primary hyperparathyroidism without the association of other diseases or tumors. Linkage analyses suggest that different genotypes can lead to the same phenotype of primary hyperparathyroidism. Hereditary syndromes associated with p...

journal_title：European journal of endocrinology

authors： Miedlich S,Lohmann T,Schneyer U,Lamesch P,Paschke R

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:A sex difference in fetal and neonatal pituitary-gonadal function has been well documented. The aim of the following study was to determine sex differences and patterns of basal LH/FSH in the neonatal period. DESIGN:Peripheral venous blood was obtained from 164 healthy full term newborns (91 males, 73 female...

journal_title：European journal of endocrinology

authors： Schmidt H,Schwarz HP

更新日期：2000-08-01 00:00:00

abstract：:Thyroid-stimulating hormone (TSH), like the other pituitary glycoprotein hormones, is produced and secreted as a mixture of isoforms, the majority of which represent differences in oligosaccharide structure and possess different bioactivity. When samples are quantified simultaneously by immunometric assay and bioassay...

journal_title：European journal of endocrinology

authors： Beck-Peccoz P,Persani L

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...

journal_title：European journal of endocrinology

authors： Romero-Kusabara IL,Filho JV,Scalissi NM,Melo KC,Demartino G,Longui CA,Melo MR,Cury AN

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:Transient neonatal hyperthyrotropinemia (TNH) is defined as a neonatal abnormality of thyroid function, which reverts to normal at re-examination after 2 weeks of life. The thyroid function of these infants has not been sufficiently studied in terms of the risk of developing persistent hyperthyrotropinemia (P...

journal_title：European journal of endocrinology

authors： Cuestas E,Gaido MI,Capra RH

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Fetal growth restriction (FGR) has been related to several health risks, which have been generally identified in small-for-gestational age (SGA) individuals. OBJECTIVE:To evaluate the impact of FGR on body composition and hormonal status in infants born either small- or appropriate-for-gestational age (AGA)...

journal_title：European journal of endocrinology

authors： Verkauskiene R,Beltrand J,Claris O,Chevenne D,Deghmoun S,Dorgeret S,Alison M,Gaucherand P,Sibony O,Lévy-Marchal C

更新日期：2007-11-01 00:00:00

abstract：:In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA...

journal_title：European journal of endocrinology

authors： Gharib H,Papini E,Paschke R

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To assess the effect of age on clinical, endocrine and sonographic features associated with polycystic ovary syndrome (PCOS) in normogonadotrophic anovulatory infertile women of reproductive years. DESIGN:Cross-sectional study. METHODS:Four hundred and seventy-two oligo-amenorrhoeic infertile patients, pres...

journal_title：European journal of endocrinology

authors： Bili H,Laven J,Imani B,Eijkemans MJ,Fauser BC

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism (PA) is the most common form of secondary hypertension, while Gitelman's syndrome (GS) is the most common inherited renal tubular disease. However, coexistence of these two diseases has never been previously reported. AIM AND SUBJECTS: The aim of our study was to describe the associatio...

journal_title：European journal of endocrinology

authors： Miao Z,Gao Y,Bindels RJ,Yu W,Lang Y,Chen N,Ren H,Sun F,Li Y,Wang X,Shao L

更新日期：2009-08-01 00:00:00

abstract：CONTEXT:McCune-Albright syndrome (MAS) is a disorder caused by a post-zygotic gain-of-function mutation in the gene encoding the Gs-alpha protein. Sexual precocity, common in girls, has been reported in only 15% of boys, and little is known on the long-term evolution of MAS in males. OBJECTIVE:In a boy with MAS, we st...

journal_title：European journal of endocrinology

authors： De Luca F,Mitchell V,Wasniewska M,Arrigo T,Messina MF,Valenzise M,de Sanctis L,Lahlou N

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

journal_title：European journal of endocrinology

authors： Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

更新日期：2011-04-01 00:00:00