当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Thyroid function, as assessed by TSH, and future risk of venous thromboembolism: the Tromsø study.

Thyroid function, as assessed by TSH, and future risk of venous thromboembolism: the Tromsø study.

Abstract：

OBJECTIVE:The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. DESIGN:Population-based cohort study. METHODS:TSH was measured in 11 962 subjects aged 25-89 years who participated in Tromsø 4-6 starting in 1994-1995. Incident VTE events were recorded through 31st December 2010. Cox's regression models with TSH as a time-varying covariate were used to calculate hazard ratios (HRs) of VTE by TSH categories (low TSH: <0.05  mU/l; moderately reduced TSH: 0.05-0.19  mU/l; normal TSH: 0.20-4.00  mU/l; moderately elevated TSH: 4.01-5.00  mU/l; and high TSH: >5.00 mU/l) and within the normal range of TSH, modeling TSH as a continuous variable. RESULTS:There were 289 VTEs during 8.2 years of median follow-up. Subjects with low (prevalence: 0.22%) and high (3.01%) TSH had slightly higher risk estimates for VTE than did subjects with normal TSH (multivariable HRs: 2.16, 95% CI 0.69-6.76 and 1.55, 95% CI 0.87-2.77 respectively), but the CIs were wide. Moreover, there was no association between TSH within the normal range and VTE (HR per 1 mU/l increase: 0.95, 95% CI 0.82-1.11). CONCLUSION:Serum levels of TSH within the normal range were not associated with a risk of VTE, whereas low and high TSH levels were rare and associated with a moderately higher risk of VTE. The present findings suggest that only a minor proportion of the VTE risk in the population can be attributed to thyroid dysfunction.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Lerstad G,Enga KF,Jorde R,Brodin EE,Svartberg J,Brækkan SK,Hansen JB

doi

10.1530/EJE-15-0185

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

83-90

issue

1

eissn

0804-4643

issn

1479-683X

pii

EJE-15-0185

journal_volume

173

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Relationship between calcitrophic hormones and blood pressure in elderly subjects.

    abstract：:The relationship between calcitrophic hormones and blood pressure has been investigated in 583 elderly subjects who were untreated for hypertension. Univariate analysis demonstrated that serum parathyroid hormone, calcitriol, albumin and calcium were correlated significantly with mean blood pressure (r = +0.15, +0.10,...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1300446

    authors： St John A,Dick I,Hoad K,Retallack R,Welborn T,Prince R

    更新日期：1994-05-01 00:00:00

  • Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.

    abstract：OBJECTIVE:Anti-inflammatory glucocorticoid (GC) therapy often induces hyperglycemia due to insulin resistance and islet-cell dysfunction. Incretin-based therapies may preserve glucose tolerance and pancreatic islet-cell function. In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-13-0610

    authors： van Genugten RE,van Raalte DH,Muskiet MH,Heymans MW,Pouwels PJ,Ouwens DM,Mari A,Diamant M

    更新日期：2014-02-04 00:00:00

  • Increased carotid intima-media thickness in pre-pubertal children with constitutional leanness and severe obesity: the speculative role of insulin sensitivity, oxidant status, and chronic inflammation.

    abstract：DESIGN:In order to characterize whether different degrees of adipose tissue storage may be associated with markers of early atherosclerosis, we evaluated oxidant-antioxidant status and inflammatory markers and determined carotid intima-media thickness (cIMT) in healthy constitutional lean and obese pre-pubertal childre...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0042

    authors： Giannini C,de Giorgis T,Scarinci A,Cataldo I,Marcovecchio ML,Chiarelli F,Mohn A

    更新日期：2009-07-01 00:00:00

  • Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects.

    abstract：CONTEXT AND OBJECTIVE:Adipokines are involved in the etiopathology of obesity-related disorders. Since the role of adipokine retinol-binding protein-4 (RBP4) in obesity remains uncertain and its relationship with other adipokines and inflammatory markers has not been examined in detail, we investigated the relationship...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0866

    authors： Broch M,Auguet MT,Ramírez R,Olona M,Aguilar C,Megia A,Alcaide MJ,Pastor R,Martínez S,Caubet E,Garcia-España A,Richart C

    更新日期：2009-07-01 00:00:00

  • Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment.

    abstract：UNLABELLED:In healthy boys, the pituitary-gonadal axis exhibits diurnal variation in early puberty. Serum testosterone levels are higher during the night and low or immeasurable during the day. These fluctuating levels of circulating androgens in early pubertal boys are difficult to monitor. Prostate specific antigen (...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1360401

    authors： Juul A,Müller J,Skakkebaek NE

    更新日期：1997-04-01 00:00:00

  • A novel HESX1 splice mutation causes isolated GH deficiency by interfering with mRNA processing.

    abstract：OBJECTIVE:Mutations in HESX1 represent a rare cause of GH deficiency (GHD) associated with a broad spectrum of other anomalies. We searched for causative mutations in a cohort of 244 Italian patients affected by combined and isolated GHD (IGHD). METHODS:The HESX1 gene-coding region and exon-intron boundaries were scre...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0047

    authors： Vivenza D,Godi M,Faienza MF,Mellone S,Moia S,Rapa A,Petri A,Bellone S,Riccomagno S,Cavallo L,Giordano M,Bona G

    更新日期：2011-05-01 00:00:00

  • Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome.

    abstract：OBJECTIVES:Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to investigate the assoc...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0432

    authors： Wehr E,Pilz S,Schweighofer N,Giuliani A,Kopera D,Pieber TR,Obermayer-Pietsch B

    更新日期：2009-10-01 00:00:00

  • Use of radiotherapy after pituitary surgery for non-functioning pituitary adenomas.

    abstract：:Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-19-0058

    authors： Chanson P,Dormoy A,Dekkers OM

    更新日期：2019-07-01 00:00:00

  • Distinct effects of pioglitazone and metformin on circulating sclerostin and biochemical markers of bone turnover in men with type 2 diabetes mellitus.

    abstract：OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures and thiazolidinediones (TZDs) increase this risk. TZDs stimulate the expression of sclerostin, a negative regulator of bone formation, in vitro. Abnormal sclerostin production may, therefore, be involved in the pathogenesis of i...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1530/EJE-11-1061

    authors： van Lierop AH,Hamdy NA,van der Meer RW,Jonker JT,Lamb HJ,Rijzewijk LJ,Diamant M,Romijn JA,Smit JW,Papapoulos SE

    更新日期：2012-04-01 00:00:00

  • Do patients with multiple endocrine neoplasia syndrome type 1 benefit from periodical screening?

    abstract：OBJECTIVE:To determine the benefit of periodical clinical screening of carriers of a mutation in the multiple endocrine neoplasia type 1 (MEN-1) gene, because any useful discussion requires more concrete data. DESIGN AND METHODS:Our study population consisted of all the patients with MEN-1 (n=58) who were treated at t...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1490577

    authors： Geerdink EA,Van der Luijt RB,Lips CJ

    更新日期：2003-12-01 00:00:00

  • Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly.

    abstract：INTRODUCTION:In an animal model of acromegaly (PEPCK-hGH transgenic mice), low systemic levels of ghrelin have been observed compared with normal mice. We hypothesized that systemic circulating ghrelin levels are also decreased in humans with active acromegaly and that the contribution of central ghrelin production to ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470195

    authors： van der Toorn FM,Janssen JA,de Herder WW,Broglio F,Ghigo E,van der Lely AJ

    更新日期：2002-08-01 00:00:00

  • Biology of the gonadotropin-releasing hormone system in gynecological cancers.

    abstract：:The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1460001

    authors： Gründker C,Günthert AR,Westphalen S,Emons G

    更新日期：2002-01-01 00:00:00

  • Validity and clinical applicability of the acromegaly quality of life questionnaire, AcroQoL: a 6-month prospective study.

    abstract：OBJECTIVE:Validate the acromegaly quality of life (AcroQoL) questionnaire as a disease-generated questionnaire, which analyses physical and psychological domains, the latter subdivided into appearance and personal relationship sub-scales, to evaluate health-related quality of life (HRQoL) in acromegaly. DESIGN:Prospec...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/eje.1.02214

    authors： Webb SM,Badia X,Surinach NL,Spanish AcroQol Study Group.

    更新日期：2006-08-01 00:00:00

  • Accuracy of several parameters of hypothalamic-pituitary-adrenal axis activity in predicting before surgery the metabolic effects of the removal of an adrenal incidentaloma.

    abstract：CONTEXT:It is unknown whether the metabolic effects of the removal of an adrenal incidentaloma (AI) can be predicted by the assessment of cortisol hypersecretion before surgery. OBJECTIVE:To evaluate the accuracy of several criteria of hypothalamic-pituitary-adrenal axis activity in predicting the metabolic outcome af...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-10-0602

    authors： Eller-Vainicher C,Morelli V,Salcuni AS,Battista C,Torlontano M,Coletti F,Iorio L,Cairoli E,Beck-Peccoz P,Arosio M,Ambrosi B,Scillitani A,Chiodini I

    更新日期：2010-12-01 00:00:00

  • Functional characterization of four novel PAX8 mutations causing congenital hypothyroidism: new evidence for haploinsufficiency as a disease mechanism.

    abstract：BACKGROUND:Individuals carrying a heterozygous inactivating PAX8 mutation are affected by congenital hypothyroidism (CH), although heterozygous Pax8 knockout mice are not. It has remained unclear whether CH in PAX8 mutation carriers is caused by haploinsufficiency or a dominant negative mechanism. OBJECTIVE:To report ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0410

    authors： Narumi S,Araki S,Hori N,Muroya K,Yamamoto Y,Asakura Y,Adachi M,Hasegawa T

    更新日期：2012-11-01 00:00:00

  • Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism.

    abstract：OBJECTIVE:The treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l. The aim of this cross-sectional, controlled study was to evaluate growth and intellectual outcome in children with persistent SH who have never been treated with levothyroxine. DESIGN AND M...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-0979

    authors： Cerbone M,Bravaccio C,Capalbo D,Polizzi M,Wasniewska M,Cioffi D,Improda N,Valenzise M,Bruzzese D,De Luca F,Salerno M

    更新日期：2011-04-01 00:00:00

  • Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms

    abstract：Objective:Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas; however, their prognosis differs significantly upon their proliferative state, which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expressi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-18-0305

    authors： Grolmusz VK,Kövesdi A,Borks K,Igaz P,Patócs A

    更新日期：2018-10-01 00:00:00

  • Relationship between autoantibodies against glutamic acid decarboxylase, thyroglobulin/thyroid microsome and DNA topoisomerase II in the clinical manifestation of patients with type 1 diabetes mellitus in Taiwan.

    abstract：OBJECTIVE:In a preliminary cross-sectional study, we discovered that DNA topoisomerase II autoantibodies (anti-TopII) were detected in 49.2% of 195 Chinese type 1 diabetes mellitus (type 1 DM) patients with a mean age of 14.5 years and a mean duration of disease of 4.6 years. In order to demonstrate the relationship be...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1420577

    authors： Shiau MY,Tsai ST,Hwang J,Wu CY,Chang YH

    更新日期：2000-06-01 00:00:00

  • Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring.

    abstract：INTRODUCTION:The fetus is most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy. The effects of mild iodine deficiency and subclinical hypothyroidism are poorly known. The present study assesses the association between thyroid hormones (TH)s and urinary iodine concentration (UIC) in healthy pr...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0716

    authors： Alvarez-Pedrerol M,Guxens M,Mendez M,Canet Y,Martorell R,Espada M,Plana E,Rebagliato M,Sunyer J

    更新日期：2009-03-01 00:00:00

  • IL-8 mRNA expression by in situ hybridisation in human pituitary adenomas.

    abstract：:Several cytokines have been shown to be expressed in normal and adenomatous pituitary tissue. Recently, interleukin-8 (IL-8) mRNA was identified by reverse transcription (RT)-PCR in each of a series of 17 pituitary tumours examined. We have investigated further the presence of IL-8 mRNA, using in situ hybridisation in...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1400155

    authors： Suliman ME,Royds JA,Baxter L,Timperley WR,Cullen DR,Jones TH

    更新日期：1999-02-01 00:00:00

  • Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma.

    abstract：CONTEXT AND OBJECTIVE:Arterial stimulation and venous sampling (ASVS) is an important technique for localizing insulinoma. The principle behind ASVS is that insulin secretion is promoted from insulinoma cells by the injection of calcium into the insulinoma-feeding artery. However, the mechanism for ASVS-induced insulin...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0069

    authors： Ono Y,Oda N,Ishihara S,Shimomura A,Hayakawa N,Suzuki A,Horiguchi A,Senda T,Miyakawa S,Itoh M

    更新日期：2008-07-01 00:00:00

  • Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects.

    abstract：OBJECTIVE:Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN:Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg cal...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-08-0339

    authors： Sneve M,Figenschau Y,Jorde R

    更新日期：2008-12-01 00:00:00

  • Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome.

    abstract：OBJECTIVE:The insulin-resistant state of the polycystic ovary syndrome (PCOS) was found to be associated with a decreased glucose transporter GLUT4 expression in the insulin target tissues. This study was performed to explore whether the well-known clinical, hormonal and metabolic efficacy of metformin or rosiglitazone...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-07-0857

    authors： Jensterle M,Janez A,Mlinar B,Marc J,Prezelj J,Pfeifer M

    更新日期：2008-06-01 00:00:00

  • Role of gamma probes in performing minimally invasive parathyroidectomy in patients with primary hyperparathyroidism: optimization of preoperative and intraoperative procedures.

    abstract：OBJECTIVE:In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN:To define the role of intraoperati...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1490007

    authors： Rubello D,Piotto A,Casara D,Muzzio PC,Shapiro B,Pelizzo MR

    更新日期：2003-07-01 00:00:00

  • Long-term clinical data and molecular defects in the STAR gene in five Greek patients.

    abstract：CONTEXT:Steroidogenic acute regulatory (STAR) gene mutations lead to adrenal and gonadal failure. Interesting, though as yet unexplained, features are the formation of ovarian cysts and the potential presence of CNS findings. OBJECTIVE:To report biochemical, genetic, and long-term clinical data in five Greek patients ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0600

    authors： Sertedaki A,Dracopoulou M,Voutetakis A,Stefanaki K,Rontogianni D,Magiakou AM,Kanaka-Gantenbein C,Chrousos G,Dacou-Voutetakis C

    更新日期：2013-02-15 00:00:00

  • MRI T2 signal intensity and tumor response in patients with GH-secreting pituitary macroadenoma: PRIMARYS post-hoc analysis.

    abstract：:Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospect...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-18-0254

    authors： Bonneville F,Rivière LD,Petersenn S,Bevan J,Houchard A,Sert C,Caron PJ,PRIMARYS Study group.

    更新日期：2018-12-01 00:00:00

  • TLR4 gene polymorphisms: evidence for protection against type 2 diabetes but not for diabetes-associated ischaemic heart disease.

    abstract：OBJECTIVE:Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or r...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0280

    authors： Manolakis AC,Kapsoritakis AN,Tiaka EK,Sidiropoulos A,Gerovassili A,Satra M,Vamvakopoulou D,Tsiopoulos F,Papanas N,Skoularigis I,Potamianos SP,Vamvakopoulos N

    更新日期：2011-08-01 00:00:00

  • Thyroid nodules: a review of current guidelines, practices, and prospects.

    abstract：:In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-08-0135

    authors： Gharib H,Papini E,Paschke R

    更新日期：2008-11-01 00:00:00

  • Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trial.

    abstract：OBJECTIVE:We conducted a prospective phase II clinical trial to determine the efficacy of sorafenib in patients with advanced radio-iodine refractory differentiated thyroid cancer. In this article, the long-term results are presented. PATIENTS AND METHODS:Thirty-one patients with progressive metastatic or locally adva...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0405

    authors： Schneider TC,Abdulrahman RM,Corssmit EP,Morreau H,Smit JW,Kapiteijn E

    更新日期：2012-11-01 00:00:00

  • Testosterone replacement therapy in men who conceived with intracytoplasmic sperm injection: nationwide register study.

    abstract：Objectives:Male hypogonadism is associated with higher risk of co-morbidity and premature mortality. It is, therefore, of utmost importance to identify young men who are at the highest risk of testosterone deficiency and who may benefit from preventive measures. In this context, infertile men constitute a high-risk gro...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0734

    authors： Elenkov A,Al-Jebari Y,Giwercman YL,Giwercman A

    更新日期：2020-04-01 00:00:00