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Use of radiotherapy after pituitary surgery for non-functioning pituitary adenomas.

Abstract：

:Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack of randomized controlled trials, the use of clinically irrelevant endpoints in most studies on RT, the benign character of the condition, the potential for side effects of RT, and the option to apply RT at a later stage. However, because of its excellent efficacy in inhibiting tumor growth, reducing tumor volume and improving any existing visual defects, and as its side effects seem to be limited compared to the benefits provided, RT keeps a place in the management of NFPAs when a tumor remnant persists, particularly if it is invasive and displays high proliferation markers, if surveillance shows a relevant increase in tumor volume or if the tumor is close to the optic chiasm. The size of the remnant, its vicinity with the optic pathways, and the potential risk to healthy surrounding tissues need to be considered when deciding on an RT procedure.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Chanson P,Dormoy A,Dekkers OM

doi

10.1530/EJE-19-0058

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

D1-D13

issue

1

eissn

0804-4643

issn

1479-683X

pii

EJE-19-0058.R1

journal_volume

181

pub_type

杂志文章,评审

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