Abstract:
Objectives:Male hypogonadism is associated with higher risk of co-morbidity and premature mortality. It is, therefore, of utmost importance to identify young men who are at the highest risk of testosterone deficiency and who may benefit from preventive measures. In this context, infertile men constitute a high-risk group. The extent of testosterone replacement therapy (TRT) among infertile men, defined as men who have to undergo assisted reproduction for fatherhood, is currently unknown. Therefore, we evaluated the pattern of prescription of TRT in the years following child conception among men who have fathered children with the help of intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF). Design:By sourcing data from national population registries, hazard ratio (HR) for subsequent TRT was assessed for IVF and ICSI-treated men and compared to those who conceived spontaneously with age Cox regression analysis adjusted for age, educational level and previous intake of medicines for metabolic diseases. Results:ICSI and IVF fathers had increased incidence of newly prescribed TRT compared to fathers conceiving spontaneously (ICSI: HR = 3.81, 95% CI = 3.09-4.69, P < 0.001; IVF: HR = 1.54, 95% CI = 1.15-2.05, P = 0.003). After adjustment for prescription of medication for one or more components of the MetS prior to TRT, the risk estimates attenuated but remained robust both for ICSI-treated (HR = 3.17 (95% CI: 2.56-3.9) and IVF-treated men (HR = 1.06 (95% CI: 1.05-1.07). Conclusion:Men who have to utilise powerful techniques, such as ICSI for fathering children, may be at risk for testosterone deficiency. Routine endocrine evaluation of men seeking fertility treatment is hence warranted.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Elenkov A,Al-Jebari Y,Giwercman YL,Giwercman Adoi
10.1530/EJE-19-0734subject
Has Abstractpub_date
2020-04-01 00:00:00pages
423-428issue
4eissn
0804-4643issn
1479-683Xpii
EJE-19-0734.R2journal_volume
182pub_type
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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journal_title:European journal of endocrinology
pub_type: 杂志文章,meta分析
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-1035
更新日期:2013-05-10 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1340386
更新日期:1996-03-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2001-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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更新日期:2006-01-01 00:00:00
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更新日期:2000-10-01 00:00:00