Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities.

abstract：Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...

journal_title：European journal of endocrinology

authors： Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.

更新日期：2020-03-01 00:00:00

abstract：:Male age-related bone loss is caused, at least in part, by hypogonadism that occurs with advancing age. The study of the effects of sex steroids on bone physiology in men has recently highlighted the central role of estrogens on bone pathophysiology. This review focuses on particular aspects of bone physiology and pat...

journal_title：European journal of endocrinology

authors： Rochira V,Balestrieri A,Madeo B,Zirilli L,Granata AR,Carani C

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances parturition, blocks lactation and changes several hormone receptors in mammary gland and liver. Since IGFs are implicated i...

journal_title：European journal of endocrinology

authors： Rosato R,Lindenbergh-Kortleve D,Neck Jv,Drop S,Jahn G

更新日期：2002-05-01 00:00:00

abstract：:Several bone matrix protein constituents, including the major component collagen type I and the hydroxyapatite binding protein, osteocalcin, have been implicated in the regulation of bone turnover. Cortical bone osteocalcin, collagen and mineral content were studied in autosomal dominant osteopetrosis type I (ADO), a ...

journal_title：European journal of endocrinology

authors： Bollerslev J,Marks SC Jr,Mosekilde L,Lian JB,Stein GS,Mosekilde L

更新日期：1994-06-01 00:00:00

abstract：:Amiodarone (AMD) is a powerful anti-arrhythmic drug used for the treatment of a wide variety of cardiac arrhythmias and its most striking feature is its high iodine content. Thyroid dysfunction is a limiting side-effect of the drug and both AMD-induced hypothyroidism (AIH) and AMD-induced thyrotoxicosis (AIT) are repo...

journal_title：European journal of endocrinology

authors： Pitsiavas V,Smerdely P,Boyages SC

更新日期：1999-03-01 00:00:00

abstract：:This study was designed to ascertain the long-term safety and efficacy profile of the somatostatin analogue octreotide as treatment of refractory acromegaly. Eight patients (aged 21-62 years) with persistent growth hormone (GH) elevation (duration 1-15 years) despite previous therapy were studied. Octreotide was given...

journal_title：European journal of endocrinology

authors： McKnight JA,McCance DR,Sheridan B,Atkinson AB

更新日期：1995-04-01 00:00:00

abstract：:Design Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing's disease (and being eu-, hypo- or hypercortiso...

journal_title：European journal of endocrinology

authors： Hochman C,Cristante J,Geslot A,Salenave S,Sonnet E,Briet C,Bachelot A,Chevalier N,Gilly O,Brue T,Hadjadj S,Kerlan V,Chanson P,Vezzosi D,Chabre O,Drui DD,Castinetti FF

更新日期：2021-01-01 00:00:00

abstract：:CLTA4 is relevant for FOXP3(+)Treg cells, and the link between skewed X chromosome inactivation (XCI) and autoimmunity is recognized. The observation of immune dysregulation polyendocrinopathy enteropathy X-linked syndrome and multiorgan endocrine autoimmune phenomena in various members of one family, associated with ...

journal_title：European journal of endocrinology

authors： Seidel MG,Rami B,Item C,Schober E,Zeitlhofer P,Huber WD,Heitger A,Bodamer OA,Haas OA

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...

journal_title：European journal of endocrinology

authors： Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JA

更新日期：2007-08-01 00:00:00

abstract：AIM:It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship betw...

journal_title：European journal of endocrinology

authors： Guo X,Zhang S,Zhang Q,Liu L,Wu H,Du H,Shi H,Wang C,Xia Y,Liu X,Li C,Sun S,Wang X,Zhou M,Huang G,Jia Q,Zhao H,Song K,Niu K

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Recent observational studies have established progression and recurrence rates of pituitary adenomas. However, it is still unknown how individual pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. The objective of this study was to define a growth model for non-func...

journal_title：European journal of endocrinology

authors： Honegger J,Zimmermann S,Psaras T,Petrick M,Mittelbronn M,Ernemann U,Reincke M,Dietz K

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Postmenopausal estradiol (E(2)) levels vary widely between individuals and this variation is an important determinant of diseases such as osteoporosis. It has been suggested that the estrogen receptor alpha (ESR1) gene may influence peripheral E(2) levels, but the role of common sequence variations in the ESR...

journal_title：European journal of endocrinology

authors： Schuit SC,de Jong FH,Stolk L,Koek WN,van Meurs JB,Schoofs MW,Zillikens MC,Hofman A,van Leeuwen JP,Pols HA,Uitterlinden AG

更新日期：2005-08-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions, such as low energy, increasing energy production and reducing energy waste. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, wi...

journal_title：European journal of endocrinology

authors： López M

更新日期：2017-05-01 00:00:00

abstract：:The identification and sequencing of the ob gene and its product, leptin, in 1994 opened new insights in the study of the mechanisms controlling body weight and led to a surge of research activity. Since its discovery, leptin has been the subject of an enormous amount of work especially within the fields of nutrition,...

journal_title：European journal of endocrinology

authors： Zimmermann-Belsing T,Brabant G,Holst JJ,Feldt-Rasmussen U

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To determine if functional imaging using 11C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHOD...

journal_title：European journal of endocrinology

authors： Koulouri O,Kandasamy N,Hoole AC,Gillett D,Heard S,Powlson AS,O'Donovan DG,Annamalai AK,Simpson HL,Akker SA,Aylwin SJ,Brooke A,Buch H,Levy MJ,Martin N,Morris D,Parkinson C,Tysome JR,Santarius T,Donnelly N,Buscombe

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:In the field of fine-needle aspiration cytology, the category of suspicious for malignancy (SM) thyroid lesions, that bears 55-85% risk of malignant histology, is a challenging topic in which morphology alone is not always able to make a correct diagnosis. Recently, immunocytochemistry (ICC) has been referred...

journal_title：European journal of endocrinology

authors： Rossi ED,Martini M,Capodimonti S,Straccia P,Cenci T,Lombardi CP,Pontecorvi A,Larocca LM,Fadda G

更新日期：2013-05-02 00:00:00

abstract：:The polyglandular autoimmune syndromes (PAS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (PAS type I) and a relatively common adult type with (PAS II) or without adrenal failure (PAS III). First clinical manifestation of PAS I usually occurs in childhood, whereas PAS II m...

journal_title：European journal of endocrinology

authors： Kahaly GJ

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-produci...

journal_title：European journal of endocrinology

authors： Maksud FA,Alves JS,Diniz MT,Barbosa AJ

更新日期：2011-07-01 00:00:00

abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

journal_title：European journal of endocrinology

authors： Canalis E

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance...

journal_title：European journal of endocrinology

authors： le Roux CW,Jenkins PJ,Chew SL,Camacho-Hübner C,Grossman AB,Besser GM,Monson JP

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Cranial radiation therapy (CRT) is required for successful treatment of a variety of brain tumours in childhood. OBJECTIVE:To investigate whether childhood CRT leads to altered sleep-wakefulness organization in adulthood, and to identify the determinants of such alterations. SUBJECTS AND METHODS:Subjective...

journal_title：European journal of endocrinology

authors： Van Someren EJ,Swart-Heikens J,Endert E,Bisschop PH,Swaab DF,Bakker PJ,Romijn JA,Fliers E

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:Prolactin is capable of both trophic and lytic actions in rat corpora lutea. In corpora lutea responding to a trophic prolactin signal, the long form of the prolactin receptor is the dominant form and is upregulated by prolactin. We investigated whether mRNA for the short form of the prolactin receptor was do...

journal_title：European journal of endocrinology

authors： Bowen JM,Telleria CM,Towns R,Keyes PL

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammator...

journal_title：European journal of endocrinology

authors： Wunder DM,Yared M,Bersinger NA,Widmer D,Kretschmer R,Birkhäuser MH

更新日期：2006-07-01 00:00:00

abstract：:We investigated the ontogeny of melatonin synthesis during fetal maturation by measuring the melatonin (MLT) and 6-hydroxymelatonin sulfate (MLTS) excretion in the urine of male infants aged 2-7 days and gestational age 26-42 weeks. We found a negative correlation between advancing gestational age and the MLT and MLTS...

journal_title：European journal of endocrinology

authors： Commentz JC,Henke A,Dammann O,Hellwege HH,Willig RP

更新日期：1996-08-01 00:00:00

abstract：:Recombinant human GH has been licensed for use in adult patients with GH deficiency (GHD) for over 15 years. Early weight- and surface area-based dosing regimens were effective but resulted in supraphysiological levels of IGF1 and increased incidence of side effects. Current practice has moved towards individualised r...

journal_title：European journal of endocrinology

authors： Gasco V,Prodam F,Grottoli S,Marzullo P,Longobardi S,Ghigo E,Aimaretti G

更新日期：2013-02-20 00:00:00

abstract：:This study compared plasma concentrations of adrenocorticotropin (ACTH) and cortisol in young men (N = 10, mean age 24.4 years), young women (N = 10, mean age 25.4 years), old men (N = 8, mean age 81.6 years) and old women (N = 8, mean age 83.5 years) under basal resting conditions and after stimulation with either hu...

journal_title：European journal of endocrinology

authors： Born J,Ditschuneit I,Schreiber M,Dodt C,Fehm HL

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis. Diabetes has been shown to have an impact on oxidative stress. The effect of metabolic syndrome (MetS) on oxidative stress and PON-1 has been shown befo...

journal_title：European journal of endocrinology

authors： Tabur S,Torun AN,Sabuncu T,Turan MN,Celik H,Ocak AR,Aksoy N

更新日期：2010-03-01 00:00:00

abstract：:The ob protein, termed leptin, is produced by adipocytes and is thought to act as an afferent satiety signal regulating weight through suppressing appetite and stimulating energy expenditure in humans and/or rodents. Insulin has been found to be a potent stimulator of leptin expression in rodents. It is unclear at pre...

journal_title：European journal of endocrinology

authors： Kiess W,Anil M,Blum WF,Englaro P,Juul A,Attanasio A,Dötsch J,Rascher W

更新日期：1998-05-01 00:00:00

abstract：CONTEXT:Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) and head and neck paragangliomas (HNPGLs), but utility for screening beyond that achieved using standard measurements of normetanephrine and...

journal_title：European journal of endocrinology

authors： Rao D,Peitzsch M,Prejbisz A,Hanus K,Fassnacht M,Beuschlein F,Brugger C,Fliedner S,Langton K,Pamporaki C,Gudziol V,Stell A,Januszewicz A,Timmers HJLM,Lenders JWM,Eisenhofer G

更新日期：2017-08-01 00:00:00

abstract：:Thyrotropin (TSH)-secreting adenomas (TSHomas) are the rarest form of pituitary adenomas, and most endocrinologists will see few cases in a lifetime, if any. In most cases, the diagnostic approach is complicated and cases may be referred after being presented as a syndrome of inappropriate TSH secretion or as a pituit...

journal_title：European journal of endocrinology

authors： Tjörnstrand A,Nyström HF

更新日期：2017-10-01 00:00:00