Cortical bone osteocalcin content and matrix composition in autosomal dominant osteopetrosis type I.

Abstract:

:Several bone matrix protein constituents, including the major component collagen type I and the hydroxyapatite binding protein, osteocalcin, have been implicated in the regulation of bone turnover. Cortical bone osteocalcin, collagen and mineral content were studied in autosomal dominant osteopetrosis type I (ADO), a disorder characterized by diffuse symmetrical osteosclerosis. Iliac crest bone biopsies were obtained from eight patients (mean age 43.0 years, range 17-63 years) and compared with 16 age- and sex-matched normal controls (mean age 44.1 years, range 20-61 years). The osteocalcin level in cortical bone was increased (p < 0.03) in ADO (51.4 +/- 3.9 mg/kg bone) compared with controls (38.0 +/- 3.6 mg/kg bone). Total collagen, protein and calcium expressed per kilogram bone dry weight were without significant difference between patients and controls. The pathogenesis of ADO is most likely not related to cortical bone osteocalcin content, a protein implicated in osteoclast ontogeny and activation. These observations are in contrast to recent observations of reduced bone osteocalcin levels in osteopetrotic mutations in the rat and underscore the interspecies heterogeneity of this disorder.

journal_name

Eur J Endocrinol

authors

Bollerslev J,Marks SC Jr,Mosekilde L,Lian JB,Stein GS,Mosekilde L

doi

10.1530/eje.0.1300592

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

592-4

issue

6

eissn

0804-4643

issn

1479-683X

journal_volume

130

pub_type

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