当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Decreasing melatonin and 6-hydroxymelatonin sulfate excretion with advancing gestational age in preterm and term newborn male infants.

Decreasing melatonin and 6-hydroxymelatonin sulfate excretion with advancing gestational age in preterm and term newborn male infants.

Abstract：

:We investigated the ontogeny of melatonin synthesis during fetal maturation by measuring the melatonin (MLT) and 6-hydroxymelatonin sulfate (MLTS) excretion in the urine of male infants aged 2-7 days and gestational age 26-42 weeks. We found a negative correlation between advancing gestational age and the MLT and MLTS excretion expressed as total 24-h amount, ratio of 24-h amount to creatinine and ratio of 24-h amount to body surface area. The ratio of MLT to MLTS was found to be about ten times higher in the study group than in prepubertal children, which might reflect the immaturity of hepatic sulfation capacities. The total amount of excreted MLT and MLTS was only one-tenth the prepubertal values. No day/night differences in MLT and MLTS excretion could be detected. We conclude that the fetal pineal gland is capable of a limited melatonin synthesis from the 26th week of gestation onwards, with decreasing values reaching its nadir around term. This indicates that the amount of fetal MLT excretion is not determined by synthesizing capacities of the pineal gland but by the development of neural connections to the pineal gland.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Commentz JC,Henke A,Dammann O,Hellwege HH,Willig RP

doi

10.1530/eje.0.1350184

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

184-7

issue

2

eissn

0804-4643

issn

1479-683X

journal_volume

135

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women.

    abstract：BACKGROUND:Adaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation. OBJECTIVE:The aim of the study was the assessment of the in...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0579

    authors： Boas M,Forman JL,Juul A,Feldt-Rasmussen U,Skakkebaek NE,Hilsted L,Chellakooty M,Larsen T,Larsen JF,Petersen JH,Main KM

    更新日期：2009-12-01 00:00:00

  • Impaired quality of life and sexual function in overweight and obese men: the European Male Ageing Study.

    abstract：BACKGROUND:Few published data link overweight and obesity with measures of quality of life (QoL) including sexual health in men. OBJECTIVE:To assess the association of overweight/obesity with impairment of physical and psychological QoL and sexual functions in men. DESIGN AND SETTING:Cross-sectional, multicentre surv...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-1129

    authors： Han TS,Tajar A,O'Neill TW,Jiang M,Bartfai G,Boonen S,Casanueva F,Finn JD,Forti G,Giwercman A,Huhtaniemi IT,Kula K,Pendleton N,Punab M,Silman AJ,Vanderschueren D,Lean ME,Wu FC,EMAS group.

    更新日期：2011-06-01 00:00:00

  • Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring.

    abstract：INTRODUCTION:The fetus is most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy. The effects of mild iodine deficiency and subclinical hypothyroidism are poorly known. The present study assesses the association between thyroid hormones (TH)s and urinary iodine concentration (UIC) in healthy pr...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0716

    authors： Alvarez-Pedrerol M,Guxens M,Mendez M,Canet Y,Martorell R,Espada M,Plana E,Rebagliato M,Sunyer J

    更新日期：2009-03-01 00:00:00

  • Clinical characteristics of pain in patients with pituitary adenomas.

    abstract：OBJECTIVE:Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, due to structural and functional properties of the tumour. Our aim was to investigate the clinical characteristics of pain in a large cohort of patients with pituitary disease. DESIGN:In a cross-sectional study, we a...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-14-0375

    authors： Dimopoulou C,Athanasoulia AP,Hanisch E,Held S,Sprenger T,Toelle TR,Roemmler-Zehrer J,Schopohl J,Stalla GK,Sievers C

    更新日期：2014-11-01 00:00:00

  • Retrospective analysis of the association of nodular goiter with primary and secondary hyperparathyroidism.

    abstract：BACKGROUND:The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified. OBJECTIVE:To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study. METHODS:We ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/eje.0.1450429

    authors： dell'Erba L,Baldari S,Borsato N,Bruno G,Calò-Gabrieli G,Carletto M,Ciampolillo A,Dondi M,Erba P,Gerundini P,Lastoria S,Marinelli P,Santoro M,Scarano B,Zagni P,Bagnasco M,Mariani G

    更新日期：2001-10-01 00:00:00

  • Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients.

    abstract：:The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1370503

    authors： Maugendre D,Vérité F,Guilhem I,Genetet B,Allannic H,Delamaire M

    更新日期：1997-11-01 00:00:00

  • Four years' treatment of resistant acromegaly with octreotide.

    abstract：:This study was designed to ascertain the long-term safety and efficacy profile of the somatostatin analogue octreotide as treatment of refractory acromegaly. Eight patients (aged 21-62 years) with persistent growth hormone (GH) elevation (duration 1-15 years) despite previous therapy were studied. Octreotide was given...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1320429

    authors： McKnight JA,McCance DR,Sheridan B,Atkinson AB

    更新日期：1995-04-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Flushing: current concepts.

    abstract：OBJECTIVE:Flushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying orga...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-17-0295

    authors： Huguet I,Grossman A

    更新日期：2017-11-01 00:00:00

  • Familial neurohypophyseal diabetes insipidus due to a novel mutation in the arginine vasopressin-neurophysin II gene.

    abstract：BACKGROUND:Familial neurohypophyseal (central) diabetes insipidus (DI) is caused by mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene. The majority of cases is inherited in an autosomal dominant way. In this study, we present the clinical features of a mother and her son with autosomal dominant neuro...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0048

    authors： de Fost M,van Trotsenburg AS,van Santen HM,Endert E,van den Elzen C,Kamsteeg EJ,Swaab DF,Fliers E

    更新日期：2011-07-01 00:00:00

  • The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.

    abstract：OBJECTIVE:Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative genes has been limited. DESIGN AND METHODS:One hundred ten patients with primary CH w...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-17-1017

    authors： Sun F,Zhang JX,Yang CY,Gao GQ,Zhu WB,Han B,Zhang LL,Wan YY,Ye XP,Ma YR,Zhang MM,Yang L,Zhang QY,Liu W,Guo CC,Chen G,Zhao SX,Song KY,Song HD

    更新日期：2018-06-01 00:00:00

  • Prevalence, incidence and associated comorbidities of treated hypothyroidism: an update from a European population.

    abstract：OBJECTIVE:Estimates of the prevalence of hypothyroidism in unselected populations date from the late 1990s. We present an update on the prevalence and incidence of overt hypothyroidism in Piedmont, northwest Italy and examine the association between hypothyroidism and multiple chronic comorbidities. DESIGN AND METHODS...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0559

    authors： Giorda CB,Carnà P,Romeo F,Costa G,Tartaglino B,Gnavi R

    更新日期：2017-05-01 00:00:00

  • A four year dose-response study of recombinant human growth hormone treatment of growth hormone deficient children: effects on growth, bone growth and bone mineralization.

    abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1420042

    authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

    更新日期：2000-01-01 00:00:00

  • Imaging in endocrinology: 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in differentiated thyroid carcinoma: clinical indications and controversies in diagnosis and follow-up.

    abstract：:In recent years, 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-15-0066

    authors： Salvatori M,Biondi B,Rufini V

    更新日期：2015-09-01 00:00:00

  • MECHANISMS IN ENDOCRINOLOGY: An update in the genetic aetiologies of combined pituitary hormone deficiency.

    abstract：:Over the last 5 years, new actors involved in the pathogenesis of combined pituitary hormone deficiency in humans have been reported: they included a member of the immunoglobulin superfamily glycoprotein and ciliary G protein-coupled receptors, as well as new transcription factors and signalling molecules. New modes o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-15-1095

    authors： Castinetti F,Reynaud R,Saveanu A,Jullien N,Quentien MH,Rochette C,Barlier A,Enjalbert A,Brue T

    更新日期：2016-06-01 00:00:00

  • Immunohistochemical detection of GHRH and its receptor splice variant 1 in primary human breast cancers.

    abstract：OBJECTIVE:GHRH is secreted by the hypothalamus and, upon binding to specific GHRH receptors in the pituitary, stimulates growth hormone (GH) production and release from the pituitary. In addition to this neuroendocrine action, accumulated evidence implies additional roles for GHRH in carcinogenesis in non-pituitary tis...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1510391

    authors： Chatzistamou I,Schally AV,Kiaris H,Politi E,Varga J,Kanellis G,Kalofoutis A,Pafiti A,Koutselini H

    更新日期：2004-09-01 00:00:00

  • Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.

    abstract：OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1490343

    authors： Peterhoff M,Sieg A,Brede M,Chao CM,Hein L,Ullrich S

    更新日期：2003-10-01 00:00:00

  • Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease.

    abstract：OBJECTIVE AND DESIGN:Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional in vivo study was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone remodeling in T2D patie...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0860

    authors： Shanbhogue VV,Hansen S,Frost M,Jørgensen NR,Hermann AP,Henriksen JE,Brixen K

    更新日期：2016-02-01 00:00:00

  • Quality of life is decreased in female patients treated for microprolactinoma.

    abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0259

    authors： Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JA

    更新日期：2007-08-01 00:00:00

  • Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia.

    abstract：OBJECTIVE:Activin is a growth and differentiation factor of many cell types, and has recently been implicated in inflammatory processes. Clinical data linking activin and its binding protein, follistatin (FS), are lacking. We measured serum levels of activin and FS in patients diagnosed with septicemia. PATIENTS AND M...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1480559

    authors： Michel U,Ebert S,Phillips D,Nau R

    更新日期：2003-05-01 00:00:00

  • Food intake regulating hormones in adult craniopharyngioma patients.

    abstract：INTRODUCTION:Patients with craniopharyngioma (CP) have disturbances of the hypothalamic-pituitary axis and serious comorbidities such as obesity. We hypothesized that the secretion of hormones regulating the nutritional status is altered in adult patients with CP compared with patients with non-functioning pituitary ad...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-0832

    authors： Roemmler-Zehrer J,Geigenberger V,Störmann S,Losa M,Crippa V,Otto B,Bidlingmaier M,Dimopoulou C,Stalla GK,Schopohl J

    更新日期：2014-03-13 00:00:00

  • Glucocorticoid osteoporosis--mechanisms and management.

    abstract：:Glucocorticoids are potent osteopenic agents, producing negative calcium and bone balance via actions at many sites. The most significant adverse effects of glucocorticoid drugs on the skeleton are probably a direct inhibition of matrix synthesis by the osteoblast, reductions in calcium absorption in both the gut and ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.0.1370209

    authors： Reid IR

    更新日期：1997-09-01 00:00:00

  • Quantification of urinary insulin-like growth factors (IGFs) and IGF binding protein 3 in healthy volunteers before and after stimulation with recombinant human growth hormone.

    abstract：:We examined excretion of urinary insulin-like growth factors I and II (IGF-I and IGF-II) and their major binding protein IGFBP-3 in comparison to their respective serum concentration in nine healthy female volunteers (median age 25 years, range 22-27) under baseline conditions and after stimulation with recombinant hu...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1320433

    authors： Tönshoff B,Blum WF,Vickers M,Kurilenko S,Mehls O,Ritz E

    更新日期：1995-04-01 00:00:00

  • Serum concentrations of LH and FSH in the healthy newborn.

    abstract：OBJECTIVE:A sex difference in fetal and neonatal pituitary-gonadal function has been well documented. The aim of the following study was to determine sex differences and patterns of basal LH/FSH in the neonatal period. DESIGN:Peripheral venous blood was obtained from 164 healthy full term newborns (91 males, 73 female...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430213

    authors： Schmidt H,Schwarz HP

    更新日期：2000-08-01 00:00:00

  • Endothelial function, insulin sensitivity and inflammatory markers in hyperprolactinemic pre-menopausal women.

    abstract：BACKGROUND:Hyperprolactinemia has been reported to be associated with abnormalities of carbohydrate metabolism. The aim of this study was to evaluate the effects of hyperprolactinemia and bromocriptine (Brc) treatment on endothelial function, insulin sensitivity and inflammatory markers in pre-menopausal women. METHOD...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1490187

    authors： Yavuz D,Deyneli O,Akpinar I,Yildiz E,Gözü H,Sezgin O,Haklar G,Akalin S

    更新日期：2003-09-01 00:00:00

  • Serum leptin and C-reactive protein levels in the physiological spontaneous menstrual cycle in reproductive age women.

    abstract：OBJECTIVE:Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammator...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02178

    authors： Wunder DM,Yared M,Bersinger NA,Widmer D,Kretschmer R,Birkhäuser MH

    更新日期：2006-07-01 00:00:00

  • Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs.

    abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1440073

    authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

    更新日期：2001-01-01 00:00:00

  • Serum free insulin-like growth factor-I in growth hormone-deficient adults before and after growth hormone replacement.

    abstract：:The objective of the present study was to compare fasting levels of free IGF-I in serum from patients with adult onset growth hormone deficiency (GHD) and from healthy volunteers, and to examine the effect of GH replacement therapy in GHD on serum free IGF-I. Free IGF-I was measured using separation of free IGF-I by u...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1370132

    authors： Skjaerbaek C,Vahl N,Frystyk J,Hansen TB,Jørgensen JO,Hagen C,Christiansen JS,Orskov H

    更新日期：1997-08-01 00:00:00

  • Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation.

    abstract：BACKGROUND:Nateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the effects of nateglinide on dipeptidyl peptidase-IV (DPP-IV) activity and glucose-dependent insulinotropic polypeptide (GIP) degradation. Research design and method...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-09-0547

    authors： McKillop AM,Duffy NA,Lindsay JR,Green BD,Patterson S,O'Harte FP,Bell PM,Flatt PR

    更新日期：2009-12-01 00:00:00

  • Higher free thyroxine levels are associated with all-cause mortality in euthyroid older men: the Health In Men Study.

    abstract：OBJECTIVE:Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-0306

    authors： Yeap BB,Alfonso H,Hankey GJ,Flicker L,Golledge J,Norman PE,Chubb SA

    更新日期：2013-09-12 00:00:00

  • Influence of gender, age and renal function on plasma adiponectin level: the Tanno and Sobetsu study.

    abstract：DESIGN:The aim of this study was to determine the association between aging and adiponectin level from the aspect of the influence of renal function and sex hormones in humans. METHODS:Serum adiponectin and blood urea nitrogen (BUN) levels were measured in 964 subjects (372 males) aged 60.3+/-12.5 years. Testosterone ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01930

    authors： Isobe T,Saitoh S,Takagi S,Takeuchi H,Chiba Y,Katoh N,Shimamoto K

    更新日期：2005-07-01 00:00:00