当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients.

Anti-pancreatic autoimmunity and Graves' disease: study of a cohort of 600 Caucasian patients.

Abstract：

:The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among subjects at risk of diabetes. Ten were already diabetic at GD diagnosis. Among the 590 non-diabetic patients, 29 had islet cell antibodies (ICA), including 15 with low titre ICA and only 1 ICA-positive subject with a familial history of diabetes. Twenty-four patients had insulin autoantibodies, including three in association with ICA. Glutamic acid decarboxylase (GAD)/64 kDa antibodies were found in 16 of the 150 tested sera, including 13 of the 29 ICA-positive sera. Four ICA-positive patients displayed 37/40 kDa antibodies, including three in association with GAD/64 kDa antibodies. During follow-up, one of the ICA-positive patients developed insulin-dependent diabetes, 14 years after the GD diagnosis. To summarize, this anti-pancreatic autoimmunity study was focused on a large but specific and homogeneous group of subjects at risk for diabetes: recently diagnosed GD patients. This population was characterized by a high prevalence of GAD/64 kDa antibodies but also by a low frequency of evolution towards diabetes and the slowness of the process which could be due to the fact that only a minority of subjects possessed a sufficient combination of anti-pancreatic markers at the same time.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Maugendre D,Vérité F,Guilhem I,Genetet B,Allannic H,Delamaire M

doi

10.1530/eje.0.1370503

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

503-10

issue

5

eissn

0804-4643

issn

1479-683X

journal_volume

137

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Somatic and germline mutations in the pathogenesis of pituitary adenomas.

    abstract：:Pituitary adenomas are frequently occurring neoplasms that produce clinically significant disease in 1:1000 of the general population. The pathogenesis of pituitary tumors is a matter of interest as it could help to improve diagnosis and treatment. Until recently, however, disruptions in relatively few genes were know...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-19-0602

    authors： Vandeva S,Daly AF,Petrossians P,Zacharieva S,Beckers A

    更新日期：2019-12-01 00:00:00

  • BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies.

    abstract：OBJECTIVE:Excess glucocorticoids are known to cause hypertension and cardiovascular disease (CVD). The BclI glucocorticoid receptor (GR) polymorphism increases glucocorticoid sensitivity and is associated with adverse metabolic effects. Previous studies investigating cardiovascular implications have shown inconsistent ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0381

    authors： van Moorsel D,van Greevenbroek MM,Schaper NC,Henry RM,Geelen CC,van Rossum EF,Nijpels G,'t Hart LM,Schalkwijk CG,van der Kallen CJ,Sauerwein HP,Dekker JM,Stehouwer CD,Havekes B

    更新日期：2015-10-01 00:00:00

  • Molecular defects of the CYP21 gene in Spanish girls with isolated precocious pubarche.

    abstract：OBJECTIVE:To determine the frequency of mutant alleles in the CYP21 gene in Spanish girls presenting with precocious pubarche (PP) and to assess the relationships between genotype and endocrine-metabolic variables. DESIGN:Fifty-three unrelated girls with a history of PP (14 prepubertal, 8 pubertal and 31 postmenarchea...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470485

    authors： Potau N,Riqué S,Eduardo I,Marcos V,Ibañez L

    更新日期：2002-10-01 00:00:00

  • Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes.

    abstract：Objective:Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponecti...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0658

    authors： Kampmann FB,Thuesen ACB,Hjort L,Bjerregaard AA,Chavarro JE,Frystyk J,Bjerre M,Tetens I,Olsen SF,Vaag AA,Damm P,Grunnet LG

    更新日期：2019-12-01 00:00:00

  • Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status.

    abstract：OBJECTIVE:Transient neonatal hyperthyrotropinemia (TNH) is defined as a neonatal abnormality of thyroid function, which reverts to normal at re-examination after 2 weeks of life. The thyroid function of these infants has not been sufficiently studied in terms of the risk of developing persistent hyperthyrotropinemia (P...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-0907

    authors： Cuestas E,Gaido MI,Capra RH

    更新日期：2015-04-01 00:00:00

  • Cross-sectional area of the median nerve is increased in primary autoimmune hypothyroidism and decreases upon treatment with thyroxine.

    abstract：BACKGROUND:The purpose of this study was to assess changes in the cross-sectional area (CSA) of nervus medianus by ultrasound in newly diagnosed primary hypothyroid patients after thyroxine replacement treatment. PATIENTS AND METHODS:The cohort comprised 30 patients with newly diagnosed primary autoimmune hypothyroidi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0397

    authors： Holováčová D,Kužma M,Killinger Z,Payer J

    更新日期：2016-10-01 00:00:00

  • A four year dose-response study of recombinant human growth hormone treatment of growth hormone deficient children: effects on growth, bone growth and bone mineralization.

    abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1420042

    authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

    更新日期：2000-01-01 00:00:00

  • Type 2 diabetes from pediatric to geriatric age: analysis of gender and obesity among 120,183 patients from the German/Austrian DPV database.

    abstract：AIM:To characterize the clinical phenotype of type 2 diabetes mellitus (T2DM) with respect to age, gender, and BMI. METHOD:Anonymized data of 120,183 people with T2DM from the German/Austrian multicenter Diabetes Patienten Verlaufsdokumentation database were analyzed based on chronological age or age at diagnosis (0-1...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0143

    authors： Awa WL,Fach E,Krakow D,Welp R,Kunder J,Voll A,Zeyfang A,Wagner C,Schütt M,Boehm B,de Souza M,Holl RW,DPV Initiative.,German BMBF Competence Networks Diabetes mellitus and Obesity.

    更新日期：2012-08-01 00:00:00

  • Diabetes insipidus and use of desmopressin (Minirin) during pregnancy.

    abstract：:With the use of two central health registries in Sweden, the Hospital Discharge Registry and the Medical Birth Registry, we identified 100 infants born of women who had been hospitalized for diabetes insipidus. By checking the medical records of these women, 29 infants were identified whose mothers had diabetes insipi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1320144

    authors： Källén BA,Carlsson SS,Bengtsson BK

    更新日期：1995-02-01 00:00:00

  • Interactions of insulin-like growth factor-I, insulin and estradiol with GnRH-stimulated luteinizing hormone release from female rat gonadotrophs.

    abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1440073

    authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

    更新日期：2001-01-01 00:00:00

  • Intralipid/heparin infusion suppresses serum leptin in humans.

    abstract：BACKGROUND/AIM:Our previous studies showed that administration of dexamethasone plus food increased serum leptin levels 100% more than dexamethasone alone. We hypothesized that this increase in leptin from the meal could result directly from the provision of fuel metabolites rather than from the meal-induced rise in in...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1480669

    authors： Garcia-Lorda P,Nash W,Roche A,Pi-Sunyer FX,Laferrere B

    更新日期：2003-06-01 00:00:00

  • Decreased expression of thyrotropin receptor gene suggests a high-risk subgroup for oncocytic adenoma.

    abstract：OBJECTIVE:The malignancy of thyroid oncocytic tumours, or oncocytomas, is higher than that of follicular tumours. The aim of this study was to investigate the role of thyroid-specific genes in oncocytic tumours and papillary carcinomas. DESIGN AND METHODS:We compared 29 oncocytic tumours with 12 papillary carcinomas. ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500269

    authors： Mirebeau-Prunier D,Guyétant S,Rodien P,Franc B,Baris O,Rohmer V,Reynier P,Tourmen Y,Malthièry Y,Savagner F

    更新日期：2004-03-01 00:00:00

  • Growth hormone deficiency and replacement in hypopituitary patients previously treated for acromegaly or Cushing's disease.

    abstract：OBJECTIVE:To compare baseline characteristics in adult patients with growth hormone (GH) deficiency (GHD) who had previously been treated for Cushing's disease or acromegaly with data from patients with GHD of other aetiologies. To study the effects of GH therapy in those patients who had completed at least 6 months of...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1460067

    authors： Feldt-Rasmussen U,Abs R,Bengtsson BA,Bennmarker H,Bramnert M,Hernberg-Ståhl E,Monson JP,Westberg B,Wilton P,Wüster C,KIMS International Study Board of KIMS Study Group.

    更新日期：2002-01-01 00:00:00

  • Could different treatment approaches in acromegaly influence life expectancy? A comparative study between Bulgaria and Campania (Italy).

    abstract：BACKGROUND:Mortality in acromegaly strictly depends on optimal control of GH and IGF1 levels. Modern medical therapy with somatostatin analogs (SSAs) and GH receptor antagonists (GHRAs) is not available in many countries due to funding restrictions. This retrospective, comparative, cohort study investigated the impact ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-13-1022

    authors： Colao A,Vandeva S,Pivonello R,Grasso LF,Nachev E,Auriemma RS,Kalinov K,Zacharieva S

    更新日期：2014-08-01 00:00:00

  • Inhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH.

    abstract：OBJECTIVE:The DAZ (deleted in azoospermia) gene family on the Y chromosome long arm is the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility and it is expressed only in germ cells. The aim of the study was to assess Sertoli cell function in subjects with AZFc deletions. DESIGN:Case-cont...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1460801

    authors： Foresta C,Bettella A,Moro E,Rossato M,Merico M,Garolla A,Ferlin A

    更新日期：2002-06-01 00:00:00

  • Impaired glucagon suppression and reduced insulin sensitivity in subjects with prediabetes undergoing atorvastatin therapy.

    abstract：Objective:Statin therapy has been linked to an increased risk of type 2 diabetes in high-risk populations; however, the pathophysiology of this association remains to be clarified. We investigated glucagon suppression and its relationship with insulin resistance in prediabetic subjects undergoing atorvastatin therapy; ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0173

    authors： Urbano F,Di Pino A,Scicali R,Filippello A,Di Mauro S,Scamporrino A,Marchisello S,Rabuazzo AM,Purrello F,Piro S

    更新日期：2019-12-01 00:00:00

  • Anthropometric, haemodynamic, humoral and hormonal evaluation in patients with incidental adrenocortical adenomas before and after surgery.

    abstract：OBJECTIVE:To compare clinical and humoral parameters before and after surgery in patients with incidental adrenocortical adenomas. DESIGN:Six patients with subclinical Cushing's syndrome and nine with non-functioning adenomas were investigated before and 12 Months after removal of the mass. METHODS:Anthropometric (bo...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1480213

    authors： Bernini G,Moretti A,Iacconi P,Miccoli P,Nami R,Lucani B,Salvetti A

    更新日期：2003-02-01 00:00:00

  • Transsphenoidal surgery in acromegaly investigated by intraoperative high-field magnetic resonance imaging.

    abstract：OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.1.01970

    authors： Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

    更新日期：2005-08-01 00:00:00

  • Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trial.

    abstract：OBJECTIVE:We conducted a prospective phase II clinical trial to determine the efficacy of sorafenib in patients with advanced radio-iodine refractory differentiated thyroid cancer. In this article, the long-term results are presented. PATIENTS AND METHODS:Thirty-one patients with progressive metastatic or locally adva...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0405

    authors： Schneider TC,Abdulrahman RM,Corssmit EP,Morreau H,Smit JW,Kapiteijn E

    更新日期：2012-11-01 00:00:00

  • Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry.

    abstract：:In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be repor...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/eje.1.02326

    authors： Saeger W,Lüdecke DK,Buchfelder M,Fahlbusch R,Quabbe HJ,Petersenn S

    更新日期：2007-02-01 00:00:00

  • MANAGEMENT OF ENDOCRINE DISEASE: Personalized medicine in the treatment of acromegaly.

    abstract：:Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-gener...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-17-1006

    authors： Kasuki L,Wildemberg LE,Gadelha MR

    更新日期：2018-03-01 00:00:00

  • Downregulation of long-form prolactin receptor mRNA during prolactin-induced luteal regression.

    abstract：OBJECTIVE:Prolactin is capable of both trophic and lytic actions in rat corpora lutea. In corpora lutea responding to a trophic prolactin signal, the long form of the prolactin receptor is the dominant form and is upregulated by prolactin. We investigated whether mRNA for the short form of the prolactin receptor was do...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430285

    authors： Bowen JM,Telleria CM,Towns R,Keyes PL

    更新日期：2000-08-01 00:00:00

  • Testicular adrenal rests: evidence for luteinizing hormone receptors and for distinct types of testicular nodules differing for their autonomization.

    abstract：:We report one patient with 21-hydroxylase deficiency and associated bilateral macro-orchidism caused by nodular hyperplasia of testicular adrenal rests (TAR). The boy, referred to us when 10 years old, was born with bilateral cryptorchidism that was treated unsuccessfully with i.m. injections of human chorionic gonado...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410231

    authors： Benvenga S,Smedile G,Lo Giudice F,Trimarchi F

    更新日期：1999-09-01 00:00:00

  • Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?

    abstract：OBJECTIVE:The androgen receptor (AR) gene contains a CAG repeat polymorphism coding for a polyglutamine chain, the length of which is inversely correlated with AR transcriptional activity. We explored whether this polymorphism modulates the activities of testosterone (T) related to body composition in elderly men. DES...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-06-0607

    authors： Lapauw B,Goemaere S,Crabbe P,Kaufman JM,Ruige JB

    更新日期：2007-03-01 00:00:00

  • Calcium mobilization is a prerequisite for the expression of phorbol ester-stimulated luteinizing hormone secretion from pituitaries of male and acutely ovariectomized rats.

    abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1300151

    authors： Das S,Fahmy NW,Bourne GA

    更新日期：1994-02-01 00:00:00

  • Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation.

    abstract：OBJECTIVE:The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. DESIGN AND METHODS:Study cohort included 8...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0195

    authors： Vierimaa O,Ebeling TM,Kytölä S,Bloigu R,Eloranta E,Salmi J,Korpi-Hyövälti E,Niskanen L,Orvola A,Elovaara E,Gynther A,Sane T,Välimäki M,Ignatius J,Leisti J,Salmela PI

    更新日期：2007-09-01 00:00:00

  • Skeletal muscle mitochondrial function in polycystic ovarian syndrome.

    abstract：OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0419

    authors： Rabøl R,Svendsen PF,Skovbro M,Boushel R,Schjerling P,Nilas L,Madsbad S,Dela F

    更新日期：2011-10-01 00:00:00

  • Low-dose GH improves exercise capacity in adults with GH deficiency: effects of a 22-month placebo-controlled, crossover trial.

    abstract：:Fifty-five patients with adult-onset GH deficiency (mean age, 49 years) were enrolled in a placebo-controlled, crossover study to investigate the effects of GH therapy on exercise capacity, body composition, and quality of life (QOL). GH and placebo were administered for 9 months each, separated by a 4-month washout p...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1530/eje.1.01971

    authors： Bollerslev J,Hallén J,Fougner KJ,Jørgensen AP,Kristo C,Fagertun H,Gudmundsen O,Burman P,Schreiner T

    更新日期：2005-09-01 00:00:00

  • The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome.

    abstract：OBJECTIVE:Chronic exposure to elevated glucocorticoid (GC) concentrations induces detrimental effects in several tissues. In the skin, GCs provoke intense alterations on various parameters of the physiology of fibroblasts, cumulatively leading to skin atrophy and impaired wound healing. As there are concerns that GCs m...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01913

    authors： Zervolea I,Pratsinis H,Tsagarakis S,Karavitaki N,Stathakos D,Thalassinos N,Kletsas D

    更新日期：2005-06-01 00:00:00

  • Quality of life is decreased in female patients treated for microprolactinoma.

    abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0259

    authors： Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JA

    更新日期：2007-08-01 00:00:00