MANAGEMENT OF ENDOCRINE DISEASE: Personalized medicine in the treatment of acromegaly.

abstract：OBJECTIVE:In the absence of widely available measures of determining free and/or bioavailable testosterone (BioT) physicians may use formulae such as the free androgen index (FAI) to estimate free testosterone. We compared the efficacy of calculated markers of androgen status in predicting serum BioT and hypogonadism. ...

journal_title：European journal of endocrinology

authors： Morris PD,Malkin CJ,Channer KS,Jones TH

更新日期：2004-08-01 00:00:00

abstract：:The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is ac...

journal_title：European journal of endocrinology

authors： Ghigo E,Arvat E,Rizzi G,Goffi S,Grottoli S,Mucci M,Boghen MF,Camanni F

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim wa...

journal_title：European journal of endocrinology

authors： Gallo M,Aragno M,Gatto V,Tamagno E,Brignardello E,Manti R,Danni O,Boccuzzi G

更新日期：1999-07-01 00:00:00

abstract：:Low levels of insulin-like growth factor I (IGF-I) in critical illness are observed despite increased or normal levels of growth hormone (GH). The mechanisms for this apparent GH resistance have not been elucidated. As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cyt...

journal_title：European journal of endocrinology

authors： Wolf M,Böhm S,Brand M,Kreymann G

更新日期：1996-12-01 00:00:00

abstract：Objective:Retrospective studies suggest that women have more active brown adipose tissue (BAT) than men, but little is known of the effect of fluctuating sex steroids across the menstrual cycle on thermogenesis in women. Design:To characterise the effects of sex and sex steroids on BAT activity we recruited healthy we...

journal_title：European journal of endocrinology

authors： Fuller-Jackson JP,Dordevic AL,Clarke IJ,Henry BA

更新日期：2020-09-01 00:00:00

abstract：:Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from either the adrenals and/or the ovaries, clinically manifested as the appearance and/or increase in terminal hair growth or the development of symptoms/signs of virilization. In either settings, physicians need to evalua...

journal_title：European journal of endocrinology

authors： Markopoulos MC,Kassi E,Alexandraki KI,Mastorakos G,Kaltsas G

更新日期：2015-02-01 00:00:00

abstract：:Osteopetrosis is a rare metabolic bone disease characterized by a generalized increase in skeletal mass. It is inherited in a number of mammalian species, including man, and results from a congenital defect in the development or function of the osteoclasts. The consequent impairment of bone resorption prevents formati...

journal_title：European journal of endocrinology

authors： Felix R,Hofstetter W,Cecchini MG

更新日期：1996-02-01 00:00:00

abstract：:In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be repor...

journal_title：European journal of endocrinology

authors： Saeger W,Lüdecke DK,Buchfelder M,Fahlbusch R,Quabbe HJ,Petersenn S

更新日期：2007-02-01 00:00:00

abstract：CONTEXT:The TIMES2 (testosterone replacement in hypogonadal men with either metabolic syndrome or type 2 diabetes) study reported beneficial effects of testosterone replacement therapy (TRT) on insulin resistance and other variables in men with diabetes or metabolic syndrome. The androgen receptor CAG repeat polymorphi...

journal_title：European journal of endocrinology

authors： Stanworth RD,Akhtar S,Channer KS,Jones TH

更新日期：2013-12-21 00:00:00

abstract：INTRODUCTION:Patients with craniopharyngioma (CP) have disturbances of the hypothalamic-pituitary axis and serious comorbidities such as obesity. We hypothesized that the secretion of hormones regulating the nutritional status is altered in adult patients with CP compared with patients with non-functioning pituitary ad...

journal_title：European journal of endocrinology

authors： Roemmler-Zehrer J,Geigenberger V,Störmann S,Losa M,Crippa V,Otto B,Bidlingmaier M,Dimopoulou C,Stalla GK,Schopohl J

更新日期：2014-03-13 00:00:00

abstract：OBJECTIVE:KLF7 encodes Krüppel-like factor (KLF) 7, a member of the KLF family of transcription factors, initially shown to play important roles in cellular development and differentiation, and reported to be specifically involved in adipogenesis. Several single nucleotide polymorphisms (SNPs) have been identified in K...

journal_title：European journal of endocrinology

authors： Zobel DP,Andreasen CH,Burgdorf KS,Andersson EA,Sandbaek A,Lauritzen T,Borch-Johnsen K,Jørgensen T,Maeda S,Nakamura Y,Eiberg H,Pedersen O,Hansen T

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:This study aimed to analyze the autonomic control of heart rate variability (HRV) in subjects receiving chronic l-thyroxine (l-T4) treatment after total thyroidectomy and (131)I therapy for differentiated thyroid carcinoma. METHODS:Blood pressure (BP) and sympatho-vagal activity (evaluated by power spectral ...

journal_title：European journal of endocrinology

authors： Casu M,Cappi C,Patrone V,Repetto E,Giusti M,Minuto F,Murialdo G

更新日期：2005-06-01 00:00:00

abstract：:The secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is regulated by gonadotropin-releasing hormone (GnRH). As men age, mean serum concentrations of immunoreactive gonadotropic hormones tend to increase, while serum testosterone concentrations tend to decline. To evaluate age-related change...

journal_title：European journal of endocrinology

authors： Zwart AD,Urban RJ,Odell WD,Veldhuis JD

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:The role of preoperative localisation of abnormal parathyroid glands remains controversial but is particularly relevant to the management of patients with recurrent or persistent hyperparathyroidism and familial syndromes. We report our experience of the use of selective parathyroid venous sampling (PVS) in t...

journal_title：European journal of endocrinology

authors： Ogilvie CM,Brown PL,Matson M,Dacie J,Reznek RH,Britton K,Carpenter R,Berney D,Drake WM,Jenkins PJ,Chew SL,Monson JP

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Pubertal onset is usually defined by breast development in girls and testicular growth in boys. Pubarche is defined as the attainment of pubic hair and is considered as a sign of pubertal transition. Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and Δ4-androstenedione (A...

journal_title：European journal of endocrinology

authors： Mouritsen A,Aksglaede L,Soerensen K,Hagen CP,Petersen JH,Main KM,Juul A

更新日期：2012-12-31 00:00:00

abstract：OBJECTIVE:To test further the hypothesis that autosomal dominant neurohypophyseal diabetes insipidus (adFNDI) is caused by heterozygous mutations in the vasopressin-neurophysin II (AVP-NPII) gene that exert a dominant negative effect by producing a precursor that misfolds, accumulates and eventually destroys the neuros...

journal_title：European journal of endocrinology

authors： Rutishauser J,Kopp P,Gaskill MB,Kotlar TJ,Robertson GL

更新日期：2002-05-01 00:00:00

abstract：Context:The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required f...

journal_title：European journal of endocrinology

authors： Wright C,O'Day P,Alyamani M,Sharifi N,Auchus RJ

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance...

journal_title：European journal of endocrinology

authors： le Roux CW,Jenkins PJ,Chew SL,Camacho-Hübner C,Grossman AB,Besser GM,Monson JP

更新日期：2002-07-01 00:00:00

abstract：:We report one patient with 21-hydroxylase deficiency and associated bilateral macro-orchidism caused by nodular hyperplasia of testicular adrenal rests (TAR). The boy, referred to us when 10 years old, was born with bilateral cryptorchidism that was treated unsuccessfully with i.m. injections of human chorionic gonado...

journal_title：European journal of endocrinology

authors： Benvenga S,Smedile G,Lo Giudice F,Trimarchi F

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:Biallelic TSHR mutations cause congenital hypothyroidism (CH). Serum TSH levels of monoallelic mutation carriers range from normal to mildly elevated, and thus the size of its effect remains unclear. The objectives were to examine the association between monoallelic TSHR mutations and positivity at newborn sc...

journal_title：European journal of endocrinology

authors： Abe K,Narumi S,Suwanai AS,Adachi M,Muroya K,Asakura Y,Nagasaki K,Abe T,Hasegawa T

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative genes has been limited. DESIGN AND METHODS:One hundred ten patients with primary CH w...

journal_title：European journal of endocrinology

authors： Sun F,Zhang JX,Yang CY,Gao GQ,Zhu WB,Han B,Zhang LL,Wan YY,Ye XP,Ma YR,Zhang MM,Yang L,Zhang QY,Liu W,Guo CC,Chen G,Zhao SX,Song KY,Song HD

更新日期：2018-06-01 00:00:00

abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

journal_title：European journal of endocrinology

authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Epigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET) development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene silencing is a well-established oncogenic mechanism that is potentially reversible and therefore an interesting therapeutic target. Multiple endocrine neo...

journal_title：European journal of endocrinology

authors： Conemans EB,Lodewijk L,Moelans CB,Offerhaus GJA,Pieterman CRC,Morsink FH,Dekkers OM,de Herder WW,Hermus AR,van der Horst-Schrivers AN,Drent ML,Bisschop PH,Havekes B,Brosens LAA,Dreijerink KMA,Borel Rinkes IHM,Timmers HTM

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To make the specificity of fluorodesoxyglucose ((18)FDG) positron emission tomography (PET) precise, in the follow-up of patients with adrenal cancer. DESIGN:This single centre retrospective study assessed the frequency and outcome of (18)FDG uptake in the remaining adrenal glands after adrenalectomy for adr...

journal_title：European journal of endocrinology

authors： Leboulleux S,Deandreis D,Escourrou C,Al Ghuzlan A,Bidault F,Aupérin A,Travagli JP,Lumbroso J,Schlumberger M,Baudin E

更新日期：2011-01-01 00:00:00

abstract：:Glycoprotein hormone alpha-subunit (alpha SU) is a recognized product of clinically non-functioning, glycoprotein hormone-secreting and somatotroph adenomas but has not been studied systematically in corticotroph tumours. We have performed immunohistochemistry for alpha SU in a consecutive series of four corticotroph ...

journal_title：European journal of endocrinology

authors： Desai B,Burrin JM,Nott CA,Geddes JF,Lamb EJ,Aylwin SJ,Wood DF,Thakkar C,Monson JP

更新日期：1995-07-01 00:00:00

abstract：:The relationship between calcitrophic hormones and blood pressure has been investigated in 583 elderly subjects who were untreated for hypertension. Univariate analysis demonstrated that serum parathyroid hormone, calcitriol, albumin and calcium were correlated significantly with mean blood pressure (r = +0.15, +0.10,...

journal_title：European journal of endocrinology

authors： St John A,Dick I,Hoad K,Retallack R,Welborn T,Prince R

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:In view of their different actions on thyroid hormone receptor (TR) isoforms we set out to investigate whether amiodarone (AM) and dronedarone (Dron) have different and/or component-specific effects on cardiac gene expression. DESIGN:Rats were treated with AM or Dron and the expression of TRalpha 1, TRalpha ...

journal_title：European journal of endocrinology

authors： Stoykov I,van Beeren HC,Moorman AF,Christoffels VM,Wiersinga WM,Bakker O

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is oft...

journal_title：European journal of endocrinology

authors： Yance VRV,Marcondes JAM,Rocha MP,Barcellos CRG,Dantas WS,Avila AFA,Baroni RH,Carvalho FM,Hayashida SAY,Mendonca BB,Domenice S

更新日期：2017-07-01 00:00:00

abstract：:Human growth hormone (GH) exists in a variety of isoforms. In the pituitary, the most abundant isoform is 22-kD GH (22 K GH), while other isoforms (non-22 K GH) are present in variable amounts. In human plasma, the GH heterogeneity contributes to the wide variability in GH levels measured by different immunoassays. Th...

journal_title：European journal of endocrinology

authors： Boguszewski CL,Hynsjö L,Johannsson G,Bengtsson BA,Carlsson LM

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:Short stature caused by point mutations or deletions of the short stature homeobox (SHOX) gene (SHOX haploinsufficiency (SHI)) is a registered indication for GH treatment. Patients with a SHOX enhancer deletion (SED) have a similar phenotype, but their response to GH is unknown. It is uncertain if duplication...

journal_title：European journal of endocrinology

authors： Donze SH,Meijer CR,Kant SG,Zandwijken GR,van der Hout AH,van Spaendonk RM,van den Ouweland AM,Wit JM,Losekoot M,Oostdijk W

更新日期：2015-11-01 00:00:00