Decreased expression of thyrotropin receptor gene suggests a high-risk subgroup for oncocytic adenoma.

abstract：OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of ...

journal_title：European journal of endocrinology

authors： Wu D,Li L,Yang M,Liu H,Yang G

更新日期：2011-10-01 00:00:00

abstract：:An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescen...

journal_title：European journal of endocrinology

authors： Giannetta E,Guarnotta V,Altieri B,Sciammarella C,Guadagno E,Malandrino P,Puliani G,Feola T,Isidori AM,Colao AAL,Faggiano A

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:The role of preoperative localisation of abnormal parathyroid glands remains controversial but is particularly relevant to the management of patients with recurrent or persistent hyperparathyroidism and familial syndromes. We report our experience of the use of selective parathyroid venous sampling (PVS) in t...

journal_title：European journal of endocrinology

authors： Ogilvie CM,Brown PL,Matson M,Dacie J,Reznek RH,Britton K,Carpenter R,Berney D,Drake WM,Jenkins PJ,Chew SL,Monson JP

更新日期：2006-12-01 00:00:00

abstract：:The p16INK4A and p15INK4B genes on chromosome 9p21 encode the p16 and p15 inhibitors of cyclin D/cyclin-dependent kinase 4 complexes respectively. Mutations and deletions of the p16INK4A gene have been found in melanomas and many other types of tumors. To assess the role of the p16INK4A and p15NK4B genes in tumorigene...

journal_title：European journal of endocrinology

authors： Yoshimoto K,Tanaka C,Yamada S,Kimura T,Iwahana H,Sano T,Itakura M

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN:To define the role of intraoperati...

journal_title：European journal of endocrinology

authors： Rubello D,Piotto A,Casara D,Muzzio PC,Shapiro B,Pelizzo MR

更新日期：2003-07-01 00:00:00

abstract：Context:The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required f...

journal_title：European journal of endocrinology

authors： Wright C,O'Day P,Alyamani M,Sharifi N,Auchus RJ

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:17-Hydroxyprogesterone (17-OHP) screening for classical congenital adrenal hyperplasia (CAH) is part of many newborn screening programs worldwide. Cut-off values are relatively high, and screening sensitivity does not reach 100%. Recently, the glucocorticoid receptor (GR) N363S-variant has been linked to rela...

journal_title：European journal of endocrinology

authors： Schreiner F,Tozakidou M,Maslak R,Holtkamp U,Peter M,Gohlke B,Woelfle J

更新日期：2009-04-01 00:00:00

abstract：UNLABELLED:Chronic exposure to hypercortisolism has significant impact on patient's health and health-related quality of life (HRQoL), as demonstrated with generic questionnaires. We have developed a disease-generated questionnaire to evaluate HRQoL in patients with Cushing's syndrome (CS; CushingQoL). OBJECTIVE:Valid...

journal_title：European journal of endocrinology

authors： Webb SM,Badia X,Barahona MJ,Colao A,Strasburger CJ,Tabarin A,van Aken MO,Pivonello R,Stalla G,Lamberts SW,Glusman JE

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To compare the presentation and clinical course of Graves' disease (GD) in two pediatric populations consisting of 28 patients with Down's syndrome (DS) and 109 controls without DS respectively. DESIGN AND METHODS:The evolution over time of GD was determined in both groups according to the clinical changes a...

journal_title：European journal of endocrinology

authors： De Luca F,Corrias A,Salerno M,Wasniewska M,Gastaldi R,Cassio A,Mussa A,Aversa T,Radetti G,Arrigo T

更新日期：2010-03-01 00:00:00

abstract：:As differentiated (follicular and papillary) thyroid cancer (DTC) may recur years after initial treatment, follow-up of patients with DTC is long term. However, this population has changed, with more individuals being discovered at an earlier stage of disease, so that previous follow-up protocols based mostly on data ...

journal_title：European journal of endocrinology

authors： Schlumberger M,Pacini F,Wiersinga WM,Toft A,Smit JW,Sanchez Franco F,Lind P,Limbert E,Jarzab B,Jamar F,Duntas L,Cohen O,Berg G

更新日期：2004-11-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) exerts various effects on many cell types. Acute administration of TNF-alpha to rats decrease hepatic 5'-deiodinase activity (5'D-I) and TNF-alpha has been implicated in the pathogenesis of the low triiodothyronine syndrome in non-thyroidal illness in humans. The thyroid, liver ...

journal_title：European journal of endocrinology

authors： Ongphiphadhanakul B,Fang SL,Tang KT,Patwardhan NA,Braverman LE

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:This open label, multicentre study was designed to evaluate the efficacy and tolerability of lanreotide Autogel (L-Autogel) in acromegalic patients over a 24-week period. The outcome of treatment with this new, long-acting, aqueous formulation of lanreotide was also compared with the patients' previous treatm...

journal_title：European journal of endocrinology

authors： Alexopoulou O,Abrams P,Verhelst J,Poppe K,Velkeniers B,Abs R,Maiter D

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...

journal_title：European journal of endocrinology

authors： Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JA

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial growth factor (VEGF) exists in three main splice variants, characterized by 121, 165 and 189 amino acids (VEGF 121, VEGF 165 and VEGF 189) and acts via two specific receptors: VEGF-R1 or Flt-1 and VEGF-R2 or KDR. VEGF plays an important role in the pathogenesis of diabetic retinopathy. Th...

journal_title：European journal of endocrinology

authors： Bortoloso E,Del Prete D,Dalla Vestra M,Gambaro G,Saller A,Antonucci F,Baggio B,Anglani F,Fioretto P

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified. OBJECTIVE:To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study. METHODS:We ...

journal_title：European journal of endocrinology

authors： dell'Erba L,Baldari S,Borsato N,Bruno G,Calò-Gabrieli G,Carletto M,Ciampolillo A,Dondi M,Erba P,Gerundini P,Lastoria S,Marinelli P,Santoro M,Scarano B,Zagni P,Bagnasco M,Mariani G

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:A significant decrease in vitamin D receptor (VDR) and calcium-sensing receptor (CaSR) protein expression has been demonstrated recently in parathyroid (PT) adenomas. In this study, we investigated the relationships between the proliferative activity of parathyroid glands (PTGs) and the expression of VDR as w...

journal_title：European journal of endocrinology

authors： Yano S,Sugimoto T,Tsukamoto T,Chihara K,Kobayashi A,Kitazawa S,Maeda S,Kitazawa R

更新日期：2003-04-01 00:00:00

abstract：:Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet's effects in patien...

journal_title：European journal of endocrinology

authors： Kawata T,Imanishi Y,Kobayashi K,Kenko T,Wada M,Ishimura E,Miki T,Nagano N,Inaba M,Arnold A,Nishizawa Y

更新日期：2005-10-01 00:00:00

abstract：:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...

journal_title：European journal of endocrinology

authors： Tsourdi E,Rachner TD,Rauner M,Hamann C,Hofbauer LC

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To test further the hypothesis that autosomal dominant neurohypophyseal diabetes insipidus (adFNDI) is caused by heterozygous mutations in the vasopressin-neurophysin II (AVP-NPII) gene that exert a dominant negative effect by producing a precursor that misfolds, accumulates and eventually destroys the neuros...

journal_title：European journal of endocrinology

authors： Rutishauser J,Kopp P,Gaskill MB,Kotlar TJ,Robertson GL

更新日期：2002-05-01 00:00:00

abstract：:Puberty is the result of increasing pulsatile secretion of the hypothalamic gonadotropin releasing hormone (GnRH), which stimulates the release of gonadotropins and in turn gonadal activity. In general in females, development of secondary sex characteristics due to the activity of the gonadal axis, i.e., the growth of...

journal_title：European journal of endocrinology

authors： Delemarre EM,Felius B,Delemarre-van de Waal HA

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

journal_title：European journal of endocrinology

authors： Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

更新日期：2013-04-15 00:00:00

abstract：OBJECTIVE:Increased reverse tritiodothyronine (T(3)) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T(3) in non-severely ill subjects but its significance remains unclear. PA...

journal_title：European journal of endocrinology

authors： Forestier E,Vinzio S,Sapin R,Schlienger JL,Goichot B

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:The French Acromegaly Registry records data of acromegalic patients' since 1992 in French, Belgian (Liège), and Swiss (Lausanne) centers. We studied the prevalence of diabetes in this population looking for risk factors. Patients from one of the centers (Reims) were then analyzed more thoroughly. METHODS:Th...

journal_title：European journal of endocrinology

authors： Fieffe S,Morange I,Petrossians P,Chanson P,Rohmer V,Cortet C,Borson-Chazot F,Brue T,Delemer B,French Acromegaly Registry.

更新日期：2011-06-01 00:00:00

abstract：:Objective To investigate how weight loss by different diets impacts postprandial levels of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon. Methods In this single-centre, parallel group 2-year trial, 70 healthy postmenopausal obese women were randomised to the Paleolith...

journal_title：European journal of endocrinology

authors： Otten J,Ryberg M,Mellberg C,Andersson T,Chorell E,Lindahl B,Larsson C,Holst JJ,Olsson T

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:An increased cardiovascular risk and mortality in hypopituitary patients receiving conventional hormonal treatment without GH replacement have been shown in several studies. Various atherogenic risk factors including endothelial dysfunction - an early event in the atherogenesis - are more expressed in adults...

journal_title：European journal of endocrinology

authors： Hána V,Prázný M,Marek J,Skrha J,Justová V

更新日期：2002-09-01 00:00:00

abstract：:Several converging lines of evidence obtained over the last years in a wide variety of experimental model organisms suggest that the ageing process is regulated by genes that encode proteins from the somatotroph axis: longevity genes like daf-2, which were identified using mutant Caenorhabditis elegans strains, turned...

journal_title：European journal of endocrinology

authors： Holzenberger M

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Elevated levels of circulating fibroblast growth factor 21 (FGF21) are commonly encountered in type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, all of which share exaggerated postprandial lipemia as a common proatherogenic feature. How FGF21 responds to an oral fat load in man is unknown...

journal_title：European journal of endocrinology

authors： Matikainen N,Taskinen MR,Stennabb S,Lundbom N,Hakkarainen A,Vaaralahti K,Raivio T

更新日期：2012-03-01 00:00:00

abstract：:The expression of the neuropeptide Y (NPY) gene varies considerably in human pheochromocytomas, but the mechanisms for this variation have not been clarified. To investigate the regulation pattern of the NPY gene in human pheochromocytomas, we screened 16 pheochromocytomas and 9 normal adrenal tissues with Northern bl...

journal_title：European journal of endocrinology

authors： Liu J,Kahri AI,Heikkilä P,Voutilainen R

更新日期：1999-10-01 00:00:00

abstract：:We measured serum tumour necrosis factor-alpha (TNF-alpha) as well as interleukin-1betta (IL-1beta) and GH concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1-13.9 years, before and 4 and 24h after the first GH injection (0.1 IU/kg s.c.). No differences were found in basal concen...

journal_title：European journal of endocrinology

authors： Bozzola M,De Amici M,Zecca M,Schimpff RM,Rapaport R

更新日期：1998-06-01 00:00:00

abstract：:We investigated the ontogeny of melatonin synthesis during fetal maturation by measuring the melatonin (MLT) and 6-hydroxymelatonin sulfate (MLTS) excretion in the urine of male infants aged 2-7 days and gestational age 26-42 weeks. We found a negative correlation between advancing gestational age and the MLT and MLTS...

journal_title：European journal of endocrinology

authors： Commentz JC,Henke A,Dammann O,Hellwege HH,Willig RP

更新日期：1996-08-01 00:00:00