Abstract：
:An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescent assays with high sensitivity and specificity; however, slightly moderately elevated levels could be attributable to various confounding factors. Calcitonin values >100 pg/mL are strongly suspicious of malignancy, whereas in patients with moderately elevated values (10-100 pg/mL) a stimulation test may be applied to improve diagnostic accuracy. Although the standard protocol and the best gender-specific cut-offs for calcium-stimulated calcitonin are still controversial, the fold of the calcitonin increase after stimulation seems to be more reliable. Patients with MTC show stimulated calcitonin values at least three to four times higher than the basal values, whereas calcitonin-secreting NENs can be distinguished from a C-cell disease by the absence of or journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract：BACKGROUND:Previous studies have suggested that infections are an important cause of death in patients with Addison's disease, but epidemiological studies on the frequency of infections in this population are lacking. OBJECTIVE:To assess and compare the incidence risk of infections in patients with primary adrenal ins...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-12-0879
更新日期：2013-03-15 00:00:00
abstract：:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-12-0167
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia. DESIGN:Clinical evaluation and genetic analysis of CASR gene. Functional characterization of mutated CASRs. METHODS:Direct sequencing of CASR gene in...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0798
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-produci...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0201
更新日期：2011-07-01 00:00:00
abstract：:The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1370200
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVE:According to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim o...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-18-0253
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1490343
更新日期：2003-10-01 00:00:00
abstract：:Vasoactive and angiogenic factors are involved in the autocrine/paracrine thyroid regulation of microvascular bed during goiter development. In the thyroid of old mice, the presence of slowly functioning ('cold') follicles allowed us to study the microvascular regulation of each follicle in correlation with the immuno...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1420651
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:Smaller size at birth has been associated with an increased risk of metabolic and cardiovascular disorders in adult life. Fetal programming of the hypothalamic-pituitary-adrenal axis has been suggested as a possible explanation. Fetal glucocorticoid (GC) overexposure has effects that suggest a role of GCs in ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-10-0718
更新日期：2010-12-01 00:00:00
abstract：:Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-gener...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-17-1006
更新日期：2018-03-01 00:00:00
abstract：OBJECTIVE:C-peptide, a cleavage product of insulin, exerts biological effects in patients with type 1 diabetes mellitus, but its role in type 2 diabetes mellitus is controversial. Our aim was to examine the associations between fasting C-peptide levels and all-cause mortality, specific-cause mortality and the incidence...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-12-0085
更新日期：2012-08-01 00:00:00
abstract：:The initial management of large non-functioning pituitary adenomas is surgical debulking. In some cases, postoperative radiotherapy (RT) is administered in order to reduce the likelihood of tumour regrowth. Historically, there have been concerns surrounding a number of potentially significant complications of pituitar...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.1440569
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:Flushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying orga...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-17-0295
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN:To define the role of intraoperati...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1490007
更新日期：2003-07-01 00:00:00
abstract：:For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging tec...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-14-0077
更新日期：2014-04-10 00:00:00
abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1300151
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:The first aim of this work was to investigate, under basal conditions in adult male rats, the long-term consequences of perinatal maternal food restriction on the plasma concentrations of vasopressin (VP), aldosterone and atrial natriuretic peptide (ANP) and on plasma renin activity (PRA). Furthermore, under ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1470835
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the influence of age on the association between thyroid function and mortality. DESIGN:The Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known thyroid disease. METHODS:TSH, free th...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-13-1070
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:In view of their different actions on thyroid hormone receptor (TR) isoforms we set out to investigate whether amiodarone (AM) and dronedarone (Dron) have different and/or component-specific effects on cardiac gene expression. DESIGN:Rats were treated with AM or Dron and the expression of TRalpha 1, TRalpha ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-07-0017
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances parturition, blocks lactation and changes several hormone receptors in mammary gland and liver. Since IGFs are implicated i...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460729
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVE:17-Hydroxyprogesterone (17-OHP) screening for classical congenital adrenal hyperplasia (CAH) is part of many newborn screening programs worldwide. Cut-off values are relatively high, and screening sensitivity does not reach 100%. Recently, the glucocorticoid receptor (GR) N363S-variant has been linked to rela...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0639
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVES:Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D(3) (25(OH)D(3)) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0545
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-10-0245
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:The iodine supply of the population in Berlin has normalized during the last 5 Years. Therefore autoimmune thyroiditis has become the most important differential diagnosis in children and adolescents with goiter. OBJECTIVE:The aim of the present study was to define the prevalence of anti-thyroid peroxidase ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1480301
更新日期：2003-03-01 00:00:00
abstract：:A 27-year-old woman with no previous personal or family history of thyroid disease was referred to us for the evaluation of thyroid nodule, five months postpartum. Thyroid scintigraphy demonstrated a left cold nodule. Fine needle aspiration cytology of the nodule showed a mixture of colloid, follicular cells and lymph...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1380562
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:In polycystic ovary syndrome (PCOS), insulin resistance (IR) appears with high prevalence and represents the major cause of cardiometabolic complications. Lipin 1beta regulates lipid metabolism and augments insulin sensitivity. The impact of lipin 1beta expression in visceral and subcutaneous adipose tissue o...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0387
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:Chromosomal rearrangements of the RET proto-oncogene is one of the most common molecular events in papillary thyroid carcinoma (PTC). However, their pathogenic role and clinical significance are still debated. This study aimed to investigate the prevalence of RET/PTC rearrangement in a cohort of BRAF WT PTCs ...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-14-0930
更新日期：2015-05-01 00:00:00
abstract：:Glucose transporter-1 (GLUT1) has been found in high abundance in human placentas. The purpose of this study was to analyze the changes in the level of GLUT1 during pregnancy. We have analyzed the gestational changes in human placental GLUT1 by [3H]cytochalasin B binding assay, immunoblot analysis and Northern blot an...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1320206
更新日期：1995-02-01 00:00:00
abstract：Objective:Hypertension and symptoms of catecholamine excess are features of pheochromocytomas and paragangliomas (PPGLs). This prospective observational cohort study assessed whether differences in presenting features in patients tested for PPGLs might assist establishing likelihood of disease. Design and methods:Pati...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1530/EJE-19-0159
更新日期：2019-10-01 00:00:00
abstract：:The best test for the assessment of the hypothalamic-pituitary-adrenal (HPA) axis remains a matter of controversy. We compared the performance of the short synacthen test (SST, 250 microg) with the insulin stress test (IST) to assess the reliability of the former as a first line test. Patients with pituitary disease u...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1390580
更新日期：1998-12-01 00:00:00
