Inducing puberty.

abstract：:In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA...

journal_title：European journal of endocrinology

authors： Gharib H,Papini E,Paschke R

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Differences in circulating steroid hormone levels have been hypothesized to explain ethnic differences in steroid-related diseases. The aim of this study was to determine the serum levels of a wide panel of steroid hormones, both androgens and estrogens, in healthy middle-aged African-Caribbean and European ...

journal_title：European journal of endocrinology

authors： Giton F,Fiet J,Cornu JN,Cussenot O,Bélanger A,Urien S,Oliva A,Blanchet P,Multigner L

更新日期：2011-12-01 00:00:00

abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

journal_title：European journal of endocrinology

authors： Das S,Fahmy NW,Bourne GA

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...

journal_title：European journal of endocrinology

authors： Tani Y,Inoshita N,Sugiyama T,Kato M,Yamada S,Shichiri M,Hirata Y

更新日期：2010-10-01 00:00:00

abstract：CONTEXT:Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia. OBJECTIVE:To further investigate the endocrine and metabolic responses to extreme HA. METHODS:We studied nine male elite climbers at sea level and at 5200 m after climbing Mt. ...

journal_title：European journal of endocrinology

authors： Benso A,Broglio F,Aimaretti G,Lucatello B,Lanfranco F,Ghigo E,Grottoli S

更新日期：2007-12-01 00:00:00

abstract：:Several cytokines have been shown to be expressed in normal and adenomatous pituitary tissue. Recently, interleukin-8 (IL-8) mRNA was identified by reverse transcription (RT)-PCR in each of a series of 17 pituitary tumours examined. We have investigated further the presence of IL-8 mRNA, using in situ hybridisation in...

journal_title：European journal of endocrinology

authors： Suliman ME,Royds JA,Baxter L,Timperley WR,Cullen DR,Jones TH

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Ghrelin is a peptide mainly secreted by gastric mucosa and has been implicated in the regulation of eating behavior and weight balance. Obesity and Helicobacter pylori infection are associated with changes in plasma ghrelin levels. OBJECTIVE:This study was designed to evaluate the density of ghrelin-produci...

journal_title：European journal of endocrinology

authors： Maksud FA,Alves JS,Diniz MT,Barbosa AJ

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. DESIGN:Population-based cohort study. METHODS:TSH was measured in 1...

journal_title：European journal of endocrinology

authors： Lerstad G,Enga KF,Jorde R,Brodin EE,Svartberg J,Brækkan SK,Hansen JB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Previously, it has been demonstrated that receptor protein tyrosine phosphatase sigma (RPTPsigma) is involved in glucose homeostasis and insulin signaling in several animal models. The aim of this study was to evaluate whether polymorphisms in this gene influence the development of type 2 diabetes (T2D) in hu...

journal_title：European journal of endocrinology

authors： Långberg EC,Gu HF,Nordman S,Efendic S,Ostenson CG

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:To determine if functional imaging using 11C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHOD...

journal_title：European journal of endocrinology

authors： Koulouri O,Kandasamy N,Hoole AC,Gillett D,Heard S,Powlson AS,O'Donovan DG,Annamalai AK,Simpson HL,Akker SA,Aylwin SJ,Brooke A,Buch H,Levy MJ,Martin N,Morris D,Parkinson C,Tysome JR,Santarius T,Donnelly N,Buscombe

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:In Cushing's disease (CD), GH responsiveness to several stimuli, including ghrelin, GHRP-6, and GHRH, is blunted. Recovery of GH secretion after remission of hypercortisolism after transsphenoidal surgery, radiotherapy, or adrenalectomy is controversial. There are no studies evaluating the effect of primary c...

journal_title：European journal of endocrinology

authors： Correa-Silva SR,Nascif SO,Molica P,Sá LB,Vieira JG,Lengyel AM

更新日期：2009-11-01 00:00:00

abstract：:Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from either the adrenals and/or the ovaries, clinically manifested as the appearance and/or increase in terminal hair growth or the development of symptoms/signs of virilization. In either settings, physicians need to evalua...

journal_title：European journal of endocrinology

authors： Markopoulos MC,Kassi E,Alexandraki KI,Mastorakos G,Kaltsas G

更新日期：2015-02-01 00:00:00

abstract：:With the use of two central health registries in Sweden, the Hospital Discharge Registry and the Medical Birth Registry, we identified 100 infants born of women who had been hospitalized for diabetes insipidus. By checking the medical records of these women, 29 infants were identified whose mothers had diabetes insipi...

journal_title：European journal of endocrinology

authors： Källén BA,Carlsson SS,Bengtsson BK

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess changes in the cross-sectional area (CSA) of nervus medianus by ultrasound in newly diagnosed primary hypothyroid patients after thyroxine replacement treatment. PATIENTS AND METHODS:The cohort comprised 30 patients with newly diagnosed primary autoimmune hypothyroidi...

journal_title：European journal of endocrinology

authors： Holováčová D,Kužma M,Killinger Z,Payer J

更新日期：2016-10-01 00:00:00

abstract：:Hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (OPG) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. The present study was designed to examine whether hypothyroidism causes...

journal_title：European journal of endocrinology

authors： Nagasaki T,Inaba M,Jono S,Hiura Y,Tahara H,Shirakawa K,Onoda N,Ishikawa T,Ishimura E,Nishizawa Y

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Betaglycan is a membrane-anchored proteoglycan involved in mediating the passage of transforming growth factor-beta (TGF-beta), inhibin and activin activities into cells. TGF-beta and inhibin-related proteins are growth factors that are expressed by several tIssues and in pregnancy. They have a function in m...

journal_title：European journal of endocrinology

authors： Ciarmela P,Florio P,Toti P,Grasso D,Santopietro R,Tosi P,Petraglia F

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:Prevalence of non-alcoholic fatty liver disease (NAFLD) among children is increasing dramatically. It is unclear why some patients develop steatohepatitis (NASH), fibrosis and cirrhosis from steatosis, and others do not. A role for leptin has been claimed. This study aims to evaluate the relationship between ...

journal_title：European journal of endocrinology

authors： Nobili V,Manco M,Ciampalini P,Diciommo V,Devito R,Piemonte F,Comparcola D,Guidi R,Marcellini M

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:The evidence that stress may provoke Graves' hyperthyroidism in genetically susceptible subjects is substantial. Whether exposure to stress is related to the severity of thyrotoxicosis has not been studied. Advancing age is associated with not only less severe Graves' hyperthyroidism but also self-reported st...

journal_title：European journal of endocrinology

authors： Vos XG,Smit N,Endert E,Brosschot JF,Tijssen JG,Wiersinga WM

更新日期：2009-02-01 00:00:00

abstract：:The aim of this study was to assess the usefulness of ketoconazole as a therapeutic alternative to polycystic ovary syndrome. The study group comprised 37 women with signs of hyperandrogenism (hirsutism, acne) and oligomenorrhea. A low dose (400 mg/day) of ketoconazole was tested in a 9-month prospective clinical stud...

journal_title：European journal of endocrinology

authors： Vidal-Puig AJ,Muñoz-Torres M,Jódar-Gimeno E,García-Calvente CJ,Lardelli P,Ruiz-Requena ME,Escobar-Jiménez F

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To determine the benefit of periodical clinical screening of carriers of a mutation in the multiple endocrine neoplasia type 1 (MEN-1) gene, because any useful discussion requires more concrete data. DESIGN AND METHODS:Our study population consisted of all the patients with MEN-1 (n=58) who were treated at t...

journal_title：European journal of endocrinology

authors： Geerdink EA,Van der Luijt RB,Lips CJ

更新日期：2003-12-01 00:00:00

abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

journal_title：European journal of endocrinology

authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

更新日期：2000-01-01 00:00:00

abstract：AIM:To describe volumes of orbital fat (FV) and extraocular muscles (MV) in Graves' orbitopathy (GO) as a function of the duration of GO. PATIENTS:i) Cross-sectional survey among 95 consecutive patients with untreated GO who had been referred to the combined thyroid-eye clinics of our university hospital. ii) Longitud...

journal_title：European journal of endocrinology

authors： Potgieser PW,Wiersinga WM,Regensburg NI,Mourits MP

更新日期：2015-08-01 00:00:00

abstract：:Prostate growth is known to be controlled by steroids such as androgens and estradiol. For this reason steroids (estradiol, adrenal androgens) or steroid inhibitors are commonly used as palliative treatments for prostate carcinoma. In view of the pivotal role played by Ca2+ ions in cell proliferation, we decided to in...

journal_title：European journal of endocrinology

authors： Audy MC,Vacher P,Duly B

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, due to structural and functional properties of the tumour. Our aim was to investigate the clinical characteristics of pain in a large cohort of patients with pituitary disease. DESIGN:In a cross-sectional study, we a...

journal_title：European journal of endocrinology

authors： Dimopoulou C,Athanasoulia AP,Hanisch E,Held S,Sprenger T,Toelle TR,Roemmler-Zehrer J,Schopohl J,Stalla GK,Sievers C

更新日期：2014-11-01 00:00:00

abstract：:Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoos...

journal_title：European journal of endocrinology

authors： Aksglaede L,Juul A

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:To examine the relationship between maternal TSH and free thyroxine (FT(4)) concentrations in early pregnancy and the risk of miscarriage, fetal or neonatal death. METHOD:Cohort study of 2497 Dutch women. TSH, FT(4), and thyroid peroxidase antibodies concentrations were determined at first booking. Child lo...

journal_title：European journal of endocrinology

authors： Benhadi N,Wiersinga WM,Reitsma JB,Vrijkotte TG,Bonsel GJ

更新日期：2009-06-01 00:00:00

abstract：:Puberty is the period during which we attain adult secondary sexual characteristics and reproductive capability. Its onset depends upon reactivation of pulsative GNRH, secretion from its relative quiescence during childhood, on the background of intact potential for pituitary-gonadal function. This review is intended:...

journal_title：European journal of endocrinology

authors： Dunkel L,Quinton R

更新日期：2014-06-01 00:00:00

abstract：:The reproductive hormonal profile was evaluated in female rats with experimental nephrotic syndrome induced with a single subcutaneous dose of puromycin aminonucleoside (PAN). Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P4), testosterone and 17 beta-estradiol (E2...

journal_title：European journal of endocrinology

authors： Menjívar M,Vilchis F,Cárdenas M,Cruz C,Merchant H,Pérez-Palacios G,Pedraza-Chaverri J

更新日期：1995-04-01 00:00:00

abstract：:Glucocorticoids are potent osteopenic agents, producing negative calcium and bone balance via actions at many sites. The most significant adverse effects of glucocorticoid drugs on the skeleton are probably a direct inhibition of matrix synthesis by the osteoblast, reductions in calcium absorption in both the gut and ...

journal_title：European journal of endocrinology

authors： Reid IR

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether patients with Addison's disease and polyendocrine syndromes have undiagnosed autoimmune polyendocrine syndrome type I (APS I). MATERIALS AND METHODS:Forty patients with clinical manifestations resembling APS I and with autoantibodies typical of this condition were screened for Norwegia...

journal_title：European journal of endocrinology

authors： Bøe AS,Knappskog PM,Myhre AG,Sørheim JI,Husebye ES

更新日期：2002-04-01 00:00:00