Abstract:
AIM:To describe volumes of orbital fat (FV) and extraocular muscles (MV) in Graves' orbitopathy (GO) as a function of the duration of GO. PATIENTS:i) Cross-sectional survey among 95 consecutive patients with untreated GO who had been referred to the combined thyroid-eye clinics of our university hospital. ii) Longitudinal survey among 39 of the 95 patients who did not receive any therapeutic intervention and were followed for 1 year. METHODS:A computed tomography (CT)-based and well-validated method for calculating orbital soft tissues. In order to neutralize sex differences, results are expressed as ratios of FV:orbital volume (OV) and MV:OV. RESULTS:i) Patients with GO duration of >1 year had greater FV:OV (0.65 vs 0.55, P=0.004), similar MV:OV (0.22 vs 0.21, not significant (NS)), and more proptosis (22 mm vs 21 mm, P=0.03) as compared to those with shorter duration. ii) As compared to baseline, after 1 year, FV:OV had increased (0.56 vs 0.63, P=0.000), MV:OV had not changed (0.19 vs 0.19, NS), proptosis was higher (20 mm vs 21 mm, P=0.003), and clinical activity scores had become lower (2 vs 1, P=0.02) (median values). CONCLUSION:CT images show that a longer duration of GO is associated with a higher orbital FV. Extraocular MV, however, is not associated with GO duration; rather, it is related to the severity of GO.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Potgieser PW,Wiersinga WM,Regensburg NI,Mourits MPdoi
10.1530/EJE-14-1140subject
Has Abstractpub_date
2015-08-01 00:00:00pages
149-53issue
2eissn
0804-4643issn
1479-683Xpii
173/2/149journal_volume
173pub_type
杂志文章abstract:OBJECTIVE:Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia. DESIGN:Clinical evaluation and genetic analysis of CASR gene. Functional characterization of mutated CASRs. METHODS:Direct sequencing of CASR gene in...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-08-0798
更新日期:2009-03-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02011
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journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure. Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vi...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1470671
更新日期:2002-11-01 00:00:00
abstract::Objective Chronic hypoparathyroidism and its treatment may lead to symptoms and complications affecting quality of life. We determined complications in chronic hypoparathyroid patients. Design Retrospective cross-sectional study of patients with chronic hypoparathyroidism treated with active vitamin D supplements in a...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-18-0580
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1420263
更新日期:2000-03-01 00:00:00
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doi:10.1530/eje.1.01889
更新日期:2005-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1340326
更新日期:1996-03-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-10-0718
更新日期:2010-12-01 00:00:00
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journal_title:European journal of endocrinology
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更新日期:2005-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1390217
更新日期:1998-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-16-0188
更新日期:2016-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-13-0703
更新日期:2013-12-21 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:European journal of endocrinology
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doi:10.1530/eje.0.1310086
更新日期:1994-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02105
更新日期:2006-03-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-19-0299
更新日期:2019-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:European journal of endocrinology
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更新日期:2012-12-01 00:00:00
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更新日期:2004-10-01 00:00:00
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journal_title:European journal of endocrinology
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更新日期:2015-02-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1380562
更新日期:1998-05-01 00:00:00
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更新日期:2018-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-08-0365
更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00