Abstract:
CONTEXT:The TIMES2 (testosterone replacement in hypogonadal men with either metabolic syndrome or type 2 diabetes) study reported beneficial effects of testosterone replacement therapy (TRT) on insulin resistance and other variables in men with diabetes or metabolic syndrome. The androgen receptor CAG repeat polymorphism (AR CAG) is known to affect stimulated AR activity and has been linked to various clinically relevant variables. OBJECTIVE:To assess the role of AR CAG in the alteration of clinical response to TRT in the TIMES2 study. DESIGN:Subgroup analysis from a multicentre, randomised, double-blind, placebo-controlled and parallel group study. SETTING:Outpatient study recruiting from secondary and primary care. PATIENTS:A total of 139 men with hypogonadism and type 2 diabetes or metabolic syndrome, of which 73 received testosterone during the TIMES2 study. INTERVENTION:Testosterone 2% transdermal gel vs placebo. MAIN OUTCOME MEASURE:Regression coefficient of AR CAG from linear regression models for each variable. RESULTS:AR CAG was independently positively associated with change in fasting insulin, triglycerides and diastolic blood pressure during TRT with a trend to association with HOMA-IR - the primary outcome variable. There was a trend to negative association between AR CAG and change in PSA. There was no association of AR CAG with change in other glycaemic variables, other lipid variables or obesity. CONCLUSION:AR CAG affected the response of some variables to TRT in the TIMES2 study, although the association with HOMA-IR did not reach significance. Various factors may have limited the power of our study to detect the significant associations between AR CAG, testosterone levels and change in variables with testosterone treatment. Analysis of similar data sets from other clinical trials is warranted.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Stanworth RD,Akhtar S,Channer KS,Jones THdoi
10.1530/EJE-13-0703subject
Has Abstractpub_date
2013-12-21 00:00:00pages
193-200issue
2eissn
0804-4643issn
1479-683Xpii
EJE-13-0703journal_volume
170pub_type
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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abstract:BACKGROUND:Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. OBJECTIVE:To identify predictors of the PEGV dose requ...
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:European journal of endocrinology
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pub_type: 杂志文章,随机对照试验
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更新日期:2002-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
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更新日期:2018-08-01 00:00:00
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更新日期:2012-12-01 00:00:00
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更新日期:2012-02-01 00:00:00
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更新日期:2010-08-01 00:00:00
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更新日期:1998-05-01 00:00:00