Abstract:
:Maintenance of fluid homeostasis during periods of heightened physical stress can be best evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the potential contributions of other related endocrine factors, such as oxytocin (OT) and brain natriuretic peptide (BNP), have not been well described during exercise. Seven endurance-trained runners completed three separate running trials: a maximal test to exhaustion (high intensity), a 60-min treadmill run (steady state), and a 56 km ultramarathon (prolonged endurance exercise). Statistically significant pre- to post-run increases were found only following the ultramarathon in [AVP](p) (1.9 vs 6.7 pg/ml; P<0.05), [OT](p) (1.5 vs 3.5 pg/ml; P<0.05), [NT-proBNP](p) (23.6 vs 117.9 pg/ml; P<0.01), [interleukin 6](p) (4.0 vs 59.6 pg/ml; P<0.05), [cortisol](p) (14.6 vs 32.6 microg/ml; P<0.01), [corticosterone](p) (652.8 vs 3491.4 ng/ml; P<0.05) and [11-deoxycortisol](p) (0.1 vs 0.5 microg/ml; P<0.05) while a significant post-run increase in [aldosterone](p) was documented after high-intensity (4.9 vs 12.5 ng/ml; P<0.05), steady-state (6.1 vs 16.9 ng/ml; P<0.05) and prolonged endurance running (2.6 vs 19.7 ng/ml; P<0.05). Similarly, changes in fluid balance parameters were significantly different between the ultramarathon versus high-intensity and steady-state running with regard to plasma volume contraction (less % contraction), body weight loss (increased % weight loss), plasma [Na(+)] Delta (decreased from baseline), and urine osmolality Delta (increase from baseline). Hypothetically driven relationships between [OT](p) and [AVP](p) (r=0.69; P<0.01) and between [NT-proBNP](p) Delta and plasma [Na(+)] Delta (r=-0.79; P<0.001)--combined with the significant and unexpected pre- to post-race increases after prolonged endurance exercise--allows for possible speculation that OT and BNP may assist their better known companion hormones (AVP and ANP) in the regulation of fluid balance during conditions of extreme physical stress.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Hew-Butler T,Noakes TD,Soldin SJ,Verbalis JGdoi
10.1530/EJE-08-0064subject
Has Abstractpub_date
2008-12-01 00:00:00pages
729-37issue
6eissn
0804-4643issn
1479-683Xpii
EJE-08-0064journal_volume
159pub_type
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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doi:10.1530/eje.1.02072
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pub_type: 杂志文章,随机对照试验
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journal_title:European journal of endocrinology
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pub_type: 杂志文章
doi:10.1530/EJE-14-1140
更新日期:2015-08-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
doi:10.1530/eje.0.1310499
更新日期:1994-11-01 00:00:00
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journal_title:European journal of endocrinology
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doi:10.1530/EJE-06-0699
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1410368
更新日期:1999-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2016-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0555
更新日期:2010-02-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,多中心研究
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更新日期:2003-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00