Endocrine and metabolic responses to extreme altitude and physical exercise in climbers.

abstract：:Several converging lines of evidence obtained over the last years in a wide variety of experimental model organisms suggest that the ageing process is regulated by genes that encode proteins from the somatotroph axis: longevity genes like daf-2, which were identified using mutant Caenorhabditis elegans strains, turned...

journal_title：European journal of endocrinology

authors： Holzenberger M

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Autoimmune polyendocrine syndrome type I (APS I) is a monogenic disease affecting endocrine glands and other organs due to mutations of the autoimmune regulator (AIRE) gene. There is a wide variability in clinical phenotypes in patients with APS I, which makes the diagnosis a challenge. OBJECTIVE:To screen ...

journal_title：European journal of endocrinology

authors： F Magitta N,Pura M,S Bøe Wolff A,Vanuga P,Meager A,M Knappskog P,Husebye ES

更新日期：2008-05-01 00:00:00

abstract：:The objective was to compare the changes in prostaglandin synthesis and metabolism occurring within the fetal membranes that are associated with the onset of parturition and to study the effect of steroid hormones on prostaglandin metabolism. A tissue explant study was made of discs of amnion and chorion obtained from...

journal_title：European journal of endocrinology

authors： Brennand JE,Leask R,Kelly RW,Greer IA,Calder AA

更新日期：1995-11-01 00:00:00

abstract：:The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

journal_title：European journal of endocrinology

authors： Gründker C,Günthert AR,Westphalen S,Emons G

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The presence of virilizing signs associated with high serum androgen levels in postmenopausal women is rare. Virilizing ovarian tumors (VOTs) and ovarian stromal hyperthecosis (OH) are the most common etiologies in virilized postmenopausal women. The differential diagnosis between these two conditions is oft...

journal_title：European journal of endocrinology

authors： Yance VRV,Marcondes JAM,Rocha MP,Barcellos CRG,Dantas WS,Avila AFA,Baroni RH,Carvalho FM,Hayashida SAY,Mendonca BB,Domenice S

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Leptin secretion is reduced by low temperatures in experimental animals, and this effect has been explained as an adaptive mechanism to cold environments. This study investigated the in vitro effects of cold exposure on human white adipose tissue. DESIGN:To understand whether the low temperature action is a ...

journal_title：European journal of endocrinology

authors： Peinó R,Piñeiro V,Gualillo O,Menéndez C,Brenlla J,Casabiell X,Diéguez C,Casanueva FF

更新日期：2000-02-01 00:00:00

abstract：:Growth in neuroblastoma cells is regulated by insulin-like growth factors (IGFs) whose action is modulated by IGF binding proteins (IGFBPs). In this study, SK-N-SH neuroblastoma cells were shown to produce IGF-II, IGFBP-2, IGFBP-4 and small quantities of IGFBP-6. We have studied the effects of a natural morphogen, ret...

journal_title：European journal of endocrinology

authors： Babajko S,Binoux M

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:The alpha(2)-adrenergic receptors are involved in the effects of catecholamines on energy metabolism. Of three known subtypes with differential expression, alpha(2A)-adrenergic receptors are also localized in adipose tissue where they counteract the lipolytic activity of beta-adrenergic receptors. This study ...

journal_title：European journal of endocrinology

authors： Hamann A,Brieske C,Tafel J,Buttron P,Schwarzloh B,Münzberg H,Hinney A,Mayer H,Siegfried W,Hebebrand J,Greten H,Algenstaedt P,Ziegler R

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Glucocorticoids are the mainstay of immunosuppression for active moderate-severe Graves' orbitopathy (GO). AIM:To analyze the response to therapy and the contribution of glucocorticoid receptor (GR) gene polymorphisms to the therapeutic outcome of intravenous glucocorticoids (IVGC) in active moderate-severe...

journal_title：European journal of endocrinology

authors： Vannucchi G,Covelli D,Campi I,Origo D,Currò N,Cirello V,Dazzi D,Beck-Peccoz P,Salvi M

更新日期：2013-11-22 00:00:00

abstract：OBJECTIVE:Patients with primary aldosteronism (PA) have a high prevalence of osteoporosis (OP) and fractures (Fx). We evaluated the presence of PA in patients admitted to our metabolic bone disease outpatient clinic. DESIGN:Study conducted on an in- and outpatient basis in a referral Italian endocrinology unit. METHO...

journal_title：European journal of endocrinology

authors： Salcuni AS,Carnevale V,Battista C,Palmieri S,Eller-Vainicher C,Guarnieri V,Pugliese F,Guglielmi G,Desina G,Minisola S,Chiodini I,Scillitani A

更新日期：2017-11-01 00:00:00

abstract：:Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...

journal_title：European journal of endocrinology

authors： Fanciulli G,Oliva O,Tomasi PA,Pala A,Bertoncelli A,Dettori A,Delitala G

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure. Active vitamin D, 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)), with the vi...

journal_title：European journal of endocrinology

authors： Correa P,Akerstrom G,Westin G

更新日期：2002-11-01 00:00:00

abstract：Objective:To evaluate the prevalence and natural course of autoimmune and non-autoimmune subclinical hypothyroidism (SH) in Down syndrome (DS) children and adolescents. Design:Prospective multicenter study. Methods:For the study, 101 DS patients with SH (TSH 5-10 mIU/L; FT4 12-22 pmol/L), aged 2-17 years at SH diagno...

journal_title：European journal of endocrinology

authors： Pepe G,Corica D,De Sanctis L,Salerno M,Faienza MF,Tessaris D,Tuli G,Scala I,Penta L,Alibrandi A,Pajno GB,Aversa T,Wasniewska M,Thyroid Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms of TSH receptor (TSHR) activation and intramolecular signal transduction are largely unknown. Deletion of the extracellular domain (ECD) of the TSHR results in increased constitutive activity, which suggests a self-inhibitory interaction between the ECD and the extracellular loops (EC...

journal_title：European journal of endocrinology

authors： Neumann S,Claus M,Paschke R

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:An increased tendency towards thromboembolic events is observed in patients with Cushing's syndrome. There are much fewer publications available about thromboembolic complications in patients with subclinical Cushing's syndrome (SCS). Therefore, a question arises whether hemostatic disturbances appear in this...

journal_title：European journal of endocrinology

authors： Swiatkowska-Stodulska R,Kaniuka-Jakubowska S,Wisniewski P,Skibowska-Bielinska A,Sworczak K

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Pretibial myxedema (PM) is a manifestation of Graves' disease (GD). Currently, its diagnosis depends on physicians' observation and biopsy. No satisfactory, objective, and non-invasive tool is available to record and investigate lesions. Digital infrared thermal imaging (DITI) detects surface temperature, and...

journal_title：European journal of endocrinology

authors： Shih SR,Lin MS,Li HY,Yang HY,Hsiao YL,Chang MT,Chen CM,Chang TC

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinase-9 (MMP-9) have been considered as important mediators of vascular remodeling and plaque instability. The formation of a complex with NGAL and MMP-9 is crucial for atherotic plaque erosion and thrombus formation. In women with poly...

journal_title：European journal of endocrinology

authors： Diamanti-Kandarakis E,Livadas S,Kandarakis SA,Margeli A,Papassotiriou I

更新日期：2008-04-01 00:00:00

abstract：:Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to physiological changes in the pituitary and target hormone levels, binding globulins, and placental ho...

journal_title：European journal of endocrinology

authors： Karaca Z,Tanriverdi F,Unluhizarci K,Kelestimur F

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...

journal_title：European journal of endocrinology

authors： Peterhoff M,Sieg A,Brede M,Chao CM,Hein L,Ullrich S

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To detect exogenous recombinant human GH (rhGH) abuse in female athletes. DESIGN:GH-dependent markers were assayed in serum of 100 female athletes (control group) and in a subgroup of nine female subjects treated with rhGH (0.09 IU/kg body weight, 6 days/week for 3 weeks). METHODS:Cut-off values (mean+2 s.d...

journal_title：European journal of endocrinology

authors： Di Luigi L,Rigamonti AE,Agosti F,Mencarelli M,Sgrò P,Marazzi N,Cella SG,Müller EE,Sartorio A

更新日期：2009-05-01 00:00:00

abstract：Objective:Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponecti...

journal_title：European journal of endocrinology

authors： Kampmann FB,Thuesen ACB,Hjort L,Bjerregaard AA,Chavarro JE,Frystyk J,Bjerre M,Tetens I,Olsen SF,Vaag AA,Damm P,Grunnet LG

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:In hyperthyroidism, tissue glucose disposal is increased to adapt to high energy demand. Our aim was to examine the regulation of glucose transporter (GLUT) isoforms by IGF-I in monocytes from patients with hyperthyroidism. DESIGN AND METHODS:Blood (20 ml) was drawn from 21 healthy and 10 hyperthyroid subjec...

journal_title：European journal of endocrinology

authors： Dimitriadis G,Maratou E,Boutati E,Kollias A,Tsegka K,Alevizaki M,Peppa M,Raptis SA,Hadjidakis DJ

更新日期：2008-03-01 00:00:00

abstract：:The aim of this study was to investigate the frequencies of clinical diabetes and humoral markers of anti-pancreatic autoimmunity in a homogeneous population of 600 Caucasian patients with recently diagnosed Graves' disease (GD), in order to characterize the specific features of this group of endocrine patients among ...

journal_title：European journal of endocrinology

authors： Maugendre D,Vérité F,Guilhem I,Genetet B,Allannic H,Delamaire M

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:A sex determining gene(s) has been mapped to a approximately 700 kb region distal to the exons of DMRT1 on 9p. The aim of this study was to examine gonadal developmental status in XX patients hemizygous for the 9p sex determining region. DESIGN:Clinical and molecular studies were performed in an 8-year-old g...

journal_title：European journal of endocrinology

authors： Ogata T,Muroya K,Ohashi H,Mochizuki H,Hasegawa T,Kaji M

更新日期：2001-11-01 00:00:00

abstract：:Patients with adrenal insufficiency need lifelong glucocorticoid replacement, but many suffer from poor quality of life, and overall there is increased mortality. Moreover, it appears that use of glucocorticoids at the higher end of the replacement dose range is associated with increased risk for cardiovascular and me...

journal_title：European journal of endocrinology

authors： Debono M,Ross RJ,Newell-Price J

更新日期：2009-05-01 00:00:00

abstract：:In recent years, 2-[(18)F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) has emerged as an important tool for the postoperative management of patients with differentiated thyroid cancer (DTC) and it is widely used in selected clinical situations. The most valuable role that FDG...

journal_title：European journal of endocrinology

authors： Salvatori M,Biondi B,Rufini V

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:KLF7 encodes Krüppel-like factor (KLF) 7, a member of the KLF family of transcription factors, initially shown to play important roles in cellular development and differentiation, and reported to be specifically involved in adipogenesis. Several single nucleotide polymorphisms (SNPs) have been identified in K...

journal_title：European journal of endocrinology

authors： Zobel DP,Andreasen CH,Burgdorf KS,Andersson EA,Sandbaek A,Lauritzen T,Borch-Johnsen K,Jørgensen T,Maeda S,Nakamura Y,Eiberg H,Pedersen O,Hansen T

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:Platinum-based chemotherapy (PBC) is the most effective cytotoxic treatment for advanced adrenocortical carcinoma (ACC). Excision repair cross complementing group 1 (ERCC1) plays a critical role in the repair of platinum-induced DNA damage. Two studies investigating the role of ERCC1 immunostaining as a predi...

journal_title：European journal of endocrinology

authors： Laufs V,Altieri B,Sbiera S,Kircher S,Steinhauer S,Beuschlein F,Quinkler M,Willenberg HS,Rosenwald A,Fassnacht M,Ronchi CL

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:TSH-secreting pituitary tumors (TSH-omas) are a rare cause of hyperthyroidism and account for <1% of all pituitary adenomas. Failure to recognize the presence of a TSH-oma may result in dramatic consequences such as thyroid ablation that may cause further growth in pituitary tumor. The primary goal of the tre...

journal_title：European journal of endocrinology

authors： Kienitz T,Quinkler M,Strasburger CJ,Ventz M

更新日期：2007-07-01 00:00:00

abstract：:Over the last 5 years, new actors involved in the pathogenesis of combined pituitary hormone deficiency in humans have been reported: they included a member of the immunoglobulin superfamily glycoprotein and ciliary G protein-coupled receptors, as well as new transcription factors and signalling molecules. New modes o...

journal_title：European journal of endocrinology

authors： Castinetti F,Reynaud R,Saveanu A,Jullien N,Quentien MH,Rochette C,Barlier A,Enjalbert A,Brue T

更新日期：2016-06-01 00:00:00