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Identification of a deletion variant in the gene encoding the human alpha(2A)-adrenergic receptor.

Abstract：

OBJECTIVE:The alpha(2)-adrenergic receptors are involved in the effects of catecholamines on energy metabolism. Of three known subtypes with differential expression, alpha(2A)-adrenergic receptors are also localized in adipose tissue where they counteract the lipolytic activity of beta-adrenergic receptors. This study was undertaken to assess whether variants in the alpha(2A)-adrenergic receptor gene are associated with body weight. DESIGN AND METHODS:Single strand conformation polymorphism (SSCP) screening and subsequent sequencing were applied to determine genetic variants in DNA samples from individuals with obesity, those of normal weight and those underweight. RESULTS:Analysis of the coding region resulted in the identification of an 18 bp deletion, with no other mutation found. Of 429 genotyped subjects, 7 carried the deletion, with no significant differences between lean and obese subjects. A previously identified polymorphism in the promoter of the alpha(2A)-adrenergic receptor gene also did not show an association with any of the tested body weight categories. CONCLUSION:Our data suggest that variants in the alpha(2A)-adrenergic receptor gene are unlikely to contribute to the predisposition for the lean or obese state.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Hamann A,Brieske C,Tafel J,Buttron P,Schwarzloh B,Münzberg H,Hinney A,Mayer H,Siegfried W,Hebebrand J,Greten H,Algenstaedt P,Ziegler R

doi

10.1530/eje.0.1440291

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

291-5

issue

3

eissn

0804-4643

issn

1479-683X

pii

1440291

journal_volume

144

pub_type

杂志文章

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