Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death.

Abstract:

BACKGROUND:To examine the relationship between maternal TSH and free thyroxine (FT(4)) concentrations in early pregnancy and the risk of miscarriage, fetal or neonatal death. METHOD:Cohort study of 2497 Dutch women. TSH, FT(4), and thyroid peroxidase antibodies concentrations were determined at first booking. Child loss was operationalized as miscarriage, fetal or neonatal death. Women with overt thyroid dysfunction were excluded. RESULTS:Twenty-seven cases of child loss were observed. The mean TSH and FT(4) level in the women with child loss was 1.48 mU/l and 9.82 pmol/l compared with 1.11 mU/l and 9.58 pmol/l in women without child loss. The incidence of child loss increased by 60% (OR=1.60 (95% confidence interval (CI): 1.04-2.47)) for every doubling in TSH concentration. This association remained after adjustment for smoking, age, parity, diabetes mellitus, hypertension, previous preterm deliveries, and previous preterm stillbirth/miscarriage (adjusted odds ratio=1.80 (95% CI: 1.07-3.03)). This was not true for FT(4) concentrations (OR=1.41 (95% CI: 0.21-9.40); P=0.724). CONCLUSION:In a cohort of pregnant women without overt thyroid dysfunction, the risk of child loss increased with higher levels of maternal TSH. Maternal FT(4) concentrations and child loss were not associated.

journal_name

Eur J Endocrinol

authors

Benhadi N,Wiersinga WM,Reitsma JB,Vrijkotte TG,Bonsel GJ

doi

10.1530/EJE-08-0953

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

985-91

issue

6

eissn

0804-4643

issn

1479-683X

pii

EJE-08-0953

journal_volume

160

pub_type

杂志文章
  • Long-term effects of cranial irradiation for childhood malignancy on sleep in adulthood.

    abstract:BACKGROUND:Cranial radiation therapy (CRT) is required for successful treatment of a variety of brain tumours in childhood. OBJECTIVE:To investigate whether childhood CRT leads to altered sleep-wakefulness organization in adulthood, and to identify the determinants of such alterations. SUBJECTS AND METHODS:Subjective...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1500503

    authors: Van Someren EJ,Swart-Heikens J,Endert E,Bisschop PH,Swaab DF,Bakker PJ,Romijn JA,Fliers E

    更新日期:2004-04-01 00:00:00

  • Impact of sleep behavior on glycemic control in type 1 diabetes: the role of social jetlag.

    abstract:BACKGROUND:Sleep behavior is changing toward shorter sleep duration and a later chronotype. It results in a sleep debt that is acquitted on work-free days, inducing a small but recurrent sleep misalignment each week, referred to as "social jetlag". These sleep habits could affect health through misalignment with circad...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-16-0188

    authors: Larcher S,Gauchez AS,Lablanche S,Pépin JL,Benhamou PY,Borel AL

    更新日期:2016-11-01 00:00:00

  • Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors.

    abstract::Regulatory actions of angiotensin II (AngII), which is involved in the pathophysiology of hypertension and also participates in cell proliferation and cell differentiation, are mainly mediated by AngII type 1 (AT1) receptor. Recently, activating mutations of receptors causing hyperfunctioning endocrine diseases have b...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1370262

    authors: Sachse R,Shao XJ,Rico A,Finckh U,Rolfs A,Reincke M,Hensen J

    更新日期:1997-09-01 00:00:00

  • The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.

    abstract:OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1530/eje.0.1460339

    authors: Wickman S,Saukkonen T,Dunkel L

    更新日期:2002-03-01 00:00:00

  • New perspectives for gene therapy in endocrinology.

    abstract::Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1430447

    authors: Barzon L,Bonaguro R,Palù G,Boscaro M

    更新日期:2000-10-01 00:00:00

  • Skeletal muscle mitochondrial function in polycystic ovarian syndrome.

    abstract:OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-11-0419

    authors: Rabøl R,Svendsen PF,Skovbro M,Boushel R,Schjerling P,Nilas L,Madsbad S,Dela F

    更新日期:2011-10-01 00:00:00

  • Factors controlling testis descent.

    abstract::Descent of the testis from an intra-abdominal site in foetal life to an extracorporeal location after birth is a mandatory developmental process to ensure that the mature testis promotes normal spermatogenesis. The two phases of transabdominal and inguinoscrotal descent occur approximately during the first and last th...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-08-0458

    authors: Hughes IA,Acerini CL

    更新日期:2008-12-01 00:00:00

  • Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA).

    abstract:OBJECTIVE:The somatic point mutation in the BRAF gene, which results in a valine-to-glutamate substitution at residue 600 (BRAF(V600E)), is an ideal hallmark of papillary thyroid carcinoma (PTC). However, its prevalence is varyingly reported in different studies, and its expression in the follicular variant PTC is cont...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.02072

    authors: Sapio MR,Posca D,Troncone G,Pettinato G,Palombini L,Rossi G,Fenzi G,Vitale M

    更新日期:2006-02-01 00:00:00

  • Role of gamma probes in performing minimally invasive parathyroidectomy in patients with primary hyperparathyroidism: optimization of preoperative and intraoperative procedures.

    abstract:OBJECTIVE:In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN:To define the role of intraoperati...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1530/eje.0.1490007

    authors: Rubello D,Piotto A,Casara D,Muzzio PC,Shapiro B,Pelizzo MR

    更新日期:2003-07-01 00:00:00

  • Contrasts in the gonadotropin-releasing hormone dose-response relationships for luteinizing hormone, follicle-stimulating hormone and alpha-subunit release in young versus older men: appraisal with high-specificity immunoradiometric assay and deconvolutio

    abstract::The secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is regulated by gonadotropin-releasing hormone (GnRH). As men age, mean serum concentrations of immunoreactive gonadotropic hormones tend to increase, while serum testosterone concentrations tend to decline. To evaluate age-related change...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1530/eje.0.1350399

    authors: Zwart AD,Urban RJ,Odell WD,Veldhuis JD

    更新日期:1996-10-01 00:00:00

  • Fractionated radiotherapy and radiosurgery in acromegaly: analysis of 352 patients from the German Acromegaly Registry.

    abstract:Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-19-0784

    authors: Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.

    更新日期:2020-03-01 00:00:00

  • The presence of thyroid peroxidase antibody of IgG2 subclass is a risk factor for thyroid dysfunction in chronic hepatitis C patients.

    abstract:OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-12-0775

    authors: Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

    更新日期:2013-04-15 00:00:00

  • Influence of renal function on clinico-pathological features of primary hyperparathyroidism.

    abstract:OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480597

    authors: Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

    更新日期:2003-06-01 00:00:00

  • Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?

    abstract:OBJECTIVE:The androgen receptor (AR) gene contains a CAG repeat polymorphism coding for a polyglutamine chain, the length of which is inversely correlated with AR transcriptional activity. We explored whether this polymorphism modulates the activities of testosterone (T) related to body composition in elderly men. DES...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-06-0607

    authors: Lapauw B,Goemaere S,Crabbe P,Kaufman JM,Ruige JB

    更新日期:2007-03-01 00:00:00

  • Absence of regular pulsatile LH secretion during pre- and post-implantation periods in sheep.

    abstract::Two experiments were conducted to determine the patterns of LH secretion and to evaluate the LH responses to pulsatile administration of GnRH during early pregnancy in ewes. In experiment 1, pregnant ewes (n=16) were used to determine the concentration of LH in plasma of jugular blood samples collected every 15 min fo...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1410521

    authors: Al-Gubory KH

    更新日期:1999-11-01 00:00:00

  • Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases.

    abstract::Serum thyroid parameters show substantial inter-individual variability, in which genetic variation is a major factor. Findings in patients with subclinical hyper- and hypothyroidism illustrate that even minor alterations in serum thyroid function tests can have important consequences for a variety of thyroid hormone-r...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.1.02279

    authors: Peeters RP,van der Deure WM,Visser TJ

    更新日期:2006-11-01 00:00:00

  • PRE-TERM BIRTH IN WOMEN EXPOSED TO CUSHING'S DISEASE: THE BABY-CUSH STUDY.

    abstract::Design Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing's disease (and being eu-, hypo- or hypercortiso...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-20-1224

    authors: Hochman C,Cristante J,Geslot A,Salenave S,Sonnet E,Briet C,Bachelot A,Chevalier N,Gilly O,Brue T,Hadjadj S,Kerlan V,Chanson P,Vezzosi D,Chabre O,Drui DD,Castinetti FF

    更新日期:2021-01-01 00:00:00

  • Effect of supplemental vitamin D and calcium on serum sclerostin levels.

    abstract:OBJECTIVE:Serum sclerostin levels have been reported to be inversely associated with serum 25OHD levels, but the effect of vitamin D and calcium supplementation on serum sclerostin levels is unknown. This study was carried out to determine whether vitamin D and calcium supplementation altered serum sclerostin levels in...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1530/EJE-13-0862

    authors: Dawson-Hughes B,Harris SS,Ceglia L,Palermo NJ

    更新日期:2014-03-13 00:00:00

  • Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche.

    abstract:OBJECTIVE:To determine if uterine and ovarian measurements can significantly distinguish between precocious puberty (PP) and premature thelarche (PT) and whether ultrasound has any advantage over the gonadotropin-releasing hormone (GnRH) stimulation test. DESIGN:Prospective. METHODS:One hundred and three girls referr...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.02151

    authors: de Vries L,Horev G,Schwartz M,Phillip M

    更新日期:2006-06-01 00:00:00

  • Treatment of Graves' disease by carbimazole: high dose with thyroxine compared to titration dose.

    abstract::A comparative study of high-dose (HD, carbimazole 60 mg plus thyroxine 100-150 micrograms daily) and titration-dose (TD) regimens of carbimazole was carried out in 70 patients with Graves' disease, the patients being assigned randomly to one or other regimen. The treatment was given for 1 year and follow-up was for 2 ...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1530/eje.0.1310120

    authors: Edmonds CJ,Tellez M

    更新日期:1994-08-01 00:00:00

  • Cognition in the adult with childhood-onset GH deficiency.

    abstract::The GH/IGF1 axis may play an important role in cognitive function. This theory is supported by the finding that both GH and IGF1 receptors are located in several brain areas such as the hippocampus, a brain area that is known to play an essential role in cognitive processes, especially memory and learning. However, th...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-08-0279

    authors: van Nieuwpoort IC,Drent ML

    更新日期:2008-12-01 00:00:00

  • MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms.

    abstract::The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the LH receptor ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-18-0396

    authors: Huhtaniemi I

    更新日期:2018-09-01 00:00:00

  • Pregnancy and pituitary disorders.

    abstract::Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to physiological changes in the pituitary and target hormone levels, binding globulins, and placental ho...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-09-0923

    authors: Karaca Z,Tanriverdi F,Unluhizarci K,Kelestimur F

    更新日期:2010-03-01 00:00:00

  • DIAGNOSIS OF ENDOCRINE DISEASE: Diagnostic approach to TSH-producing pituitary adenoma.

    abstract::Thyrotropin (TSH)-secreting adenomas (TSHomas) are the rarest form of pituitary adenomas, and most endocrinologists will see few cases in a lifetime, if any. In most cases, the diagnostic approach is complicated and cases may be referred after being presented as a syndrome of inappropriate TSH secretion or as a pituit...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-16-1029

    authors: Tjörnstrand A,Nyström HF

    更新日期:2017-10-01 00:00:00

  • Nelson's syndrome.

    abstract::Nelson's syndrome is a potentially life-threatening condition that does not infrequently develop following total bilateral adrenalectomy (TBA) for the treatment of Cushing's disease. In this review article, we discuss some controversial aspects of Nelson's syndrome including diagnosis, predictive factors, aetiology, p...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-10-0466

    authors: Barber TM,Adams E,Ansorge O,Byrne JV,Karavitaki N,Wass JA

    更新日期:2010-10-01 00:00:00

  • Coadministration of lanreotide Autogel and pegvisomant normalizes IGF1 levels and is well tolerated in patients with acromegaly partially controlled by somatostatin analogs alone.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of coadministered lanreotide Autogel (LA; 120  mg/month) and pegvisomant (40-120  mg/week) in acromegaly. DESIGN:This is a 28-week, multicenter, open-label, single-arm sequential study. METHODS:Patients (n=92) biochemically uncontrolled, on somatostatin analogs (SSAs) or ...

    journal_title:European journal of endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1530/EJE-10-0867

    authors: van der Lely AJ,Bernabeu I,Cap J,Caron P,Colao A,Marek J,Neggers S,Birman P

    更新日期:2011-03-01 00:00:00

  • Expression of sex hormone-binding globulin mRNA in human ovarian cancers.

    abstract::To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1330327

    authors: Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

    更新日期:1995-09-01 00:00:00

  • Diagnostic 131I whole body scanning after thyroidectomy and ablation for differentiated thyroid cancer.

    abstract:OBJECTIVE:To assess the value of the diagnostic whole body (131)I scan after thyroidectomy and (131)I ablation. DESIGN:Retrospective analysis of all patients with differentiated thyroid cancer treated in one centre between 1990 and 2000. RESULTS:A total of 153 consecutive patients who underwent diagnostic scanning fo...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1500649

    authors: Taylor H,Hyer S,Vini L,Pratt B,Cook G,Harmer C

    更新日期:2004-05-01 00:00:00

  • Retrospective analysis of the association of nodular goiter with primary and secondary hyperparathyroidism.

    abstract:BACKGROUND:The association of hyperparathyroidism (HPT) with thyroid disease has long been known, but the mechanisms underlying such an association have not yet been clarified. OBJECTIVE:To elucidate the main factors determining this combination of endocrine diseases, in a retrospective multicenter study. METHODS:We ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/eje.0.1450429

    authors: dell'Erba L,Baldari S,Borsato N,Bruno G,Calò-Gabrieli G,Carletto M,Ciampolillo A,Dondi M,Erba P,Gerundini P,Lastoria S,Marinelli P,Santoro M,Scarano B,Zagni P,Bagnasco M,Mariani G

    更新日期:2001-10-01 00:00:00

  • Tumor necrosis factor-alpha decreases thyrotropin-induced 5'-deiodinase activity in FRTL-5 thyroid cells.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) exerts various effects on many cell types. Acute administration of TNF-alpha to rats decrease hepatic 5'-deiodinase activity (5'D-I) and TNF-alpha has been implicated in the pathogenesis of the low triiodothyronine syndrome in non-thyroidal illness in humans. The thyroid, liver ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1300502

    authors: Ongphiphadhanakul B,Fang SL,Tang KT,Patwardhan NA,Braverman LE

    更新日期:1994-05-01 00:00:00