Partial restoration of GH responsiveness to ghrelin in Cushing's disease after 6 months of ketoconazole treatment: comparison with GHRP-6 and GHRH.

abstract：OBJECTIVE:To analyse trends in diagnostic practices of thyroid diseases and to relate them to the increase in thyroid cancer incidence in France over time. DESIGN:From 1980 to 2000, a French retrospective multicentric (three endocrinology and three nuclear medicine centres) study of thyroid diseases was conducted on 2...

journal_title：European journal of endocrinology

authors： Leenhardt L,Bernier MO,Boin-Pineau MH,Conte Devolx B,Maréchaud R,Niccoli-Sire P,Nocaudie M,Orgiazzi J,Schlumberger M,Wémeau JL,Chérie-Challine L,De Vathaire F

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Chromosomal rearrangements of the RET proto-oncogene is one of the most common molecular events in papillary thyroid carcinoma (PTC). However, their pathogenic role and clinical significance are still debated. This study aimed to investigate the prevalence of RET/PTC rearrangement in a cohort of BRAF WT PTCs ...

journal_title：European journal of endocrinology

authors： Colato C,Vicentini C,Cantara S,Pedron S,Brazzarola P,Marchetti I,Di Coscio G,Chilosi M,Brunelli M,Pacini F,Ferdeghini M

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD). SUBJECTS AND METHODS:In this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with...

journal_title：European journal of endocrinology

authors： Nobili V,Giorgio V,Liccardo D,Bedogni G,Morino G,Alisi A,Cianfarani S

更新日期：2014-03-08 00:00:00

abstract：OBJECTIVE:Anti-inflammatory glucocorticoid (GC) therapy often induces hyperglycemia due to insulin resistance and islet-cell dysfunction. Incretin-based therapies may preserve glucose tolerance and pancreatic islet-cell function. In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase...

journal_title：European journal of endocrinology

authors： van Genugten RE,van Raalte DH,Muskiet MH,Heymans MW,Pouwels PJ,Ouwens DM,Mari A,Diamant M

更新日期：2014-02-04 00:00:00

abstract：OBJECTIVES:Women with polycystic ovary syndrome (PCOS) frequently suffer from metabolic disturbances, in particular from insulin resistance. Accumulating evidence suggests that vitamin D deficiency may contribute to the development of the metabolic syndrome (MS). Hence, the aim of our study was to investigate the assoc...

journal_title：European journal of endocrinology

authors： Wehr E,Pilz S,Schweighofer N,Giuliani A,Kopera D,Pieber TR,Obermayer-Pietsch B

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia. DESIGN:Clinical evaluation and genetic analysis of CASR gene. Functional characterization of mutated CASRs. METHODS:Direct sequencing of CASR gene in...

journal_title：European journal of endocrinology

authors： Cetani F,Lemmi M,Cervia D,Borsari S,Cianferotti L,Pardi E,Ambrogini E,Banti C,Brown EM,Bagnoli P,Pinchera A,Marcocci C

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Mutations in HESX1 represent a rare cause of GH deficiency (GHD) associated with a broad spectrum of other anomalies. We searched for causative mutations in a cohort of 244 Italian patients affected by combined and isolated GHD (IGHD). METHODS:The HESX1 gene-coding region and exon-intron boundaries were scre...

journal_title：European journal of endocrinology

authors： Vivenza D,Godi M,Faienza MF,Mellone S,Moia S,Rapa A,Petri A,Bellone S,Riccomagno S,Cavallo L,Giordano M,Bona G

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:In type I diabetes mellitus, early markers of beta cell damage are needed in order to detect the infraclinical development of the disease. The reg protein may be a good candidate, as the reg gene has been proposed to play a role in the pancreatic beta cell destruction/regeneration process during diabetogenesi...

journal_title：European journal of endocrinology

authors： Christofilis MA,Carrere J,Atlan-Gepner C,Zevaco-Mattei C,Thivolet C,Baeza N,Figarella C,Vialettes B

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:The purpose of this population-based prospective cohort study was to examine the effect of hormone therapy (HT) on incidence of diabetes mellitus (DM). DESIGN AND METHODS:Eight thousand four hundred and eighty-three DM-free post-menopausal women aged 52-62 from the population-based Kuopio osteoporosis risk ...

journal_title：European journal of endocrinology

authors： Pentti K,Tuppurainen MT,Honkanen R,Sandini L,Kröger H,Alhava E,Saarikoski S

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Individuals carrying a heterozygous inactivating PAX8 mutation are affected by congenital hypothyroidism (CH), although heterozygous Pax8 knockout mice are not. It has remained unclear whether CH in PAX8 mutation carriers is caused by haploinsufficiency or a dominant negative mechanism. OBJECTIVE:To report ...

journal_title：European journal of endocrinology

authors： Narumi S,Araki S,Hori N,Muroya K,Yamamoto Y,Asakura Y,Adachi M,Hasegawa T

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:GH deficiency (GHD) and glucocorticoid excess are associated with increased risk of fragility fractures. We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD. DESIGN:Cross-sectional study. METHODS:Fifty-one ad...

journal_title：European journal of endocrinology

authors： Mazziotti G,Porcelli T,Bianchi A,Cimino V,Patelli I,Mejia C,Fusco A,Giampietro A,De Marinis L,Giustina A

更新日期：2010-07-01 00:00:00

abstract：DESIGN:In order to characterize whether different degrees of adipose tissue storage may be associated with markers of early atherosclerosis, we evaluated oxidant-antioxidant status and inflammatory markers and determined carotid intima-media thickness (cIMT) in healthy constitutional lean and obese pre-pubertal childre...

journal_title：European journal of endocrinology

authors： Giannini C,de Giorgis T,Scarinci A,Cataldo I,Marcovecchio ML,Chiarelli F,Mohn A

更新日期：2009-07-01 00:00:00

abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

journal_title：European journal of endocrinology

authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

更新日期：2000-01-01 00:00:00

abstract：:To know the role of sex hormone-binding globulin (SHBG) in the intracellular steroidal actions in human ovarian cancers, the expression of SHBG mRNA as a substitute for intracellular SHBG expression was investigated in normal ovarian tissues and ovarian tumors. In the present study, we used competitive reverse transcr...

journal_title：European journal of endocrinology

authors： Misao R,Nakanishi Y,Fujimoto J,Hori M,Ichigo S,Tamaya T

更新日期：1995-09-01 00:00:00

abstract：:The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal ...

journal_title：European journal of endocrinology

authors： Kubota T,Taguchi M,Kobayashi K,Masuda M,Aso T

更新日期：1997-08-01 00:00:00

abstract：:Objective Pituitary adenoma MRI T2 signal intensity associates with tumor characteristics including responsiveness to somatostatin analogs (SSAs). These analyses determined whether baseline T2 signal intensity predicts response to primary medical treatment with long-acting SSA. Design Post-hoc analyses of the prospect...

journal_title：European journal of endocrinology

authors： Bonneville F,Rivière LD,Petersenn S,Bevan J,Houchard A,Sert C,Caron PJ,PRIMARYS Study group.

更新日期：2018-12-01 00:00:00

abstract：:Low levels of insulin-like growth factor I (IGF-I) in critical illness are observed despite increased or normal levels of growth hormone (GH). The mechanisms for this apparent GH resistance have not been elucidated. As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cyt...

journal_title：European journal of endocrinology

authors： Wolf M,Böhm S,Brand M,Kreymann G

更新日期：1996-12-01 00:00:00

abstract：:Growth hormone (GH) is used by athletes like bodybuilders to increase muscle strength and weight gain. On the other hand, chronic hypersecretion of GH in active acromegaly may result in outwardly hypertrophied but functionally weaker muscles. As a model for studying long-term effects of GH on muscle strength, we analy...

journal_title：European journal of endocrinology

authors： Wolf E,Wanke R,Schenck E,Hermanns W,Brem G

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:Adrenocortical tumors may originate from the zona glomerulosa, zona fasciculata, or zona reticularis and be associated with syndromes due to overproduction of mineralocorticoids, glucocorticoids, or androgens respectively. We report an unusual case of recurrent adrenocortical carcinoma (ACC), which seems to c...

journal_title：European journal of endocrinology

authors： Barzon L,Masi G,Fincati K,Pacenti M,Pezzi V,Altavilla G,Fallo F,Palù G

更新日期：2005-11-01 00:00:00

abstract：:Pituitary adenomas are frequently occurring neoplasms that produce clinically significant disease in 1:1000 of the general population. The pathogenesis of pituitary tumors is a matter of interest as it could help to improve diagnosis and treatment. Until recently, however, disruptions in relatively few genes were know...

journal_title：European journal of endocrinology

authors： Vandeva S,Daly AF,Petrossians P,Zacharieva S,Beckers A

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Depot GnRH agonists are commonly used in the treatment of central precocious puberty (CPP). The triptorelin 11.25 mg 3-month depot, currently used in adult indications, had not previously been evaluated in CPP. DESIGN:This was a multicenter, open-label, 12 month trial conducted in 64 CPP children (54 girls a...

journal_title：European journal of endocrinology

authors： Carel JC,Blumberg J,Seymour C,Adamsbaum C,Lahlou N,Triptorelin 3-month CPP Study Group.

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE:The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematolog...

journal_title：European journal of endocrinology

authors： Vivanco M,Dalle JH,Alberti C,Lescoeur B,Yakouben K,Carel JC,Baruchel A,Léger J

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID). DESIGN:A longitudinal population-based study (DanThyr). METHODS:...

journal_title：European journal of endocrinology

authors： Krejbjerg A,Bjergved L,Pedersen IB,Carlé A,Jørgensen T,Perrild H,Ovesen L,Rasmussen LB,Knudsen N,Laurberg P

更新日期：2014-03-08 00:00:00

abstract：:Design Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing's disease (and being eu-, hypo- or hypercortiso...

journal_title：European journal of endocrinology

authors： Hochman C,Cristante J,Geslot A,Salenave S,Sonnet E,Briet C,Bachelot A,Chevalier N,Gilly O,Brue T,Hadjadj S,Kerlan V,Chanson P,Vezzosi D,Chabre O,Drui DD,Castinetti FF

更新日期：2021-01-01 00:00:00

abstract：:Context Abnormalities in the hypothalamo-pituitary-gonadal axis have long been reported in Noonan syndrome (NS) males with only few data available in prepubertal children. Objective The aim of this study was to describe the gonadal function of NS males from childhood to adulthood. Design It is a retrospective chart re...

journal_title：European journal of endocrinology

authors： Moniez S,Pienkowski C,Lepage B,Hamdi S,Daudin M,Oliver I,Jouret B,Cartault A,Diene G,Verloes A,Cavé H,Salles JP,Tauber M,Yart A,Edouard T

更新日期：2018-12-01 00:00:00

abstract：:Stem cell terminology has entered the lexicon of medical practitioners even though the application of harvesting stem cells to treat diseases other than haematological disorders is not yet a reality in clinical practice. All branches of medicine will be affected by the new technology, more so those related to regenera...

journal_title：European journal of endocrinology

authors： Hughes IA

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To test further the hypothesis that autosomal dominant neurohypophyseal diabetes insipidus (adFNDI) is caused by heterozygous mutations in the vasopressin-neurophysin II (AVP-NPII) gene that exert a dominant negative effect by producing a precursor that misfolds, accumulates and eventually destroys the neuros...

journal_title：European journal of endocrinology

authors： Rutishauser J,Kopp P,Gaskill MB,Kotlar TJ,Robertson GL

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:This open label, multicentre study was designed to evaluate the efficacy and tolerability of lanreotide Autogel (L-Autogel) in acromegalic patients over a 24-week period. The outcome of treatment with this new, long-acting, aqueous formulation of lanreotide was also compared with the patients' previous treatm...

journal_title：European journal of endocrinology

authors： Alexopoulou O,Abrams P,Verhelst J,Poppe K,Velkeniers B,Abs R,Maiter D

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:We measured the total and nonphosphorylated insulin-like growth factor-binding protein (IGFBP)-1 concentrations in obese children to determine the effect of obesity on the status of IGFBP-1 phosphorylation. We also measured the serum levels of insulin, total and free IGF-I, and IGFBP-3 to investigate their re...

journal_title：European journal of endocrinology

authors： Kamoda T,Saitoh H,Nakahara S,Inudoh M,Hirano T,Matsui A

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:Various adjuvant therapies have been introduced along with intensive insulin therapy in patients with recent onset type 1 diabetes. Nicotinamide (NA), administered at diagnosis of the disease, can have beneficial effects on the clinical remission rate, improve metabolic control and preserve or slightly increa...

journal_title：European journal of endocrinology

authors： Crinò A,Schiaffini R,Manfrini S,Mesturino C,Visalli N,Beretta Anguissola G,Suraci C,Pitocco D,Spera S,Corbi S,Matteoli MC,Patera IP,Manca Bitti ML,Bizzarri C,Pozzilli P,IMDIAB group.

更新日期：2004-05-01 00:00:00