Abstract：
OBJECTIVE:The role of preoperative localisation of abnormal parathyroid glands remains controversial but is particularly relevant to the management of patients with recurrent or persistent hyperparathyroidism and familial syndromes. We report our experience of the use of selective parathyroid venous sampling (PVS) in the localisation of parathyroid disease in such patients. DESIGN:We report a retrospective 10-year experience (n = 27) of the use of PVS in complicated primary hyperparathyroidism and contrast the use of PVS with neck ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) and sestamibi imaging modalities. RESULTS:In 14 out of 25 patients who underwent surgery PVS results were completely concordant with surgical and histological findings and 88% of patients achieved post-operative cure. Out of 13 patients referred after previous failed surgery, 12 underwent further surgery which was curative in 9. In total PVS yielded useful positive (n = 13) and/or negative information (n = 6) in 19 out of 25 patients undergoing surgery. Using histology as the gold standard, 59% of PVS studies were entirely consistent with histology, as compared with 39% of ultrasound scans, 36% of sestamibi scans and 17% of MRI/CT scans. CONCLUSIONS:PVS is a valuable adjunct to MRI/CT and sestamibi scanning in selected patients with complicated hyperparathyroidism when performed in an experienced unit.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Ogilvie CM,Brown PL,Matson M,Dacie J,Reznek RH,Britton K,Carpenter R,Berney D,Drake WM,Jenkins PJ,Chew SL,Monson JPdoi
10.1530/eje.1.02304subject
Has Abstractpub_date
2006-12-01 00:00:00pages
813-21issue
6eissn
0804-4643issn
1479-683Xpii
155/6/813journal_volume
155pub_type
杂志文章abstract：OBJECTIVE:A phase I single centre, open label study of the pharmacokinetics and tolerability of a buccal testosterone tablet (COL 1621) was carried out. DESIGN:Twelve testosterone-deficient males were treated with the buccal tablet twice daily for 7 consecutive days. Multiple blood samples were drawn for testosterone,...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
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更新日期：2004-01-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
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journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
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更新日期：2002-07-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,多中心研究
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更新日期：2013-02-15 00:00:00
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pub_type： 杂志文章
doi：10.1530/eje.0.1410585
更新日期：1999-12-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0441
更新日期：2009-09-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1530/EJE-11-1047
更新日期：2012-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2003-10-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1420263
更新日期：2000-03-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2015-08-01 00:00:00
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更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章,meta分析,评审
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更新日期：2017-01-01 00:00:00
abstract：BACKGROUND AND AIM:Several basic science studies support the existence of non-genomic glucocorticoid signaling in pancreas, liver, and adipocytes, but its clinical relevance has not yet been elucidated. This study aimed at investigating the rapid effects of hydrocortisone on the human metabolic response to glucose. SU...
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doi：10.1530/EJE-10-0282
更新日期：2010-08-01 00:00:00
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更新日期：1996-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1530/EJE-09-0234
更新日期：2009-10-01 00:00:00
abstract：:With the use of two central health registries in Sweden, the Hospital Discharge Registry and the Medical Birth Registry, we identified 100 infants born of women who had been hospitalized for diabetes insipidus. By checking the medical records of these women, 29 infants were identified whose mothers had diabetes insipi...
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pub_type： 杂志文章
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更新日期：1995-02-01 00:00:00
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pub_type： 共识发展会议,杂志文章,评审
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更新日期：2014-08-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1530/EJE-20-0473
更新日期：2020-07-01 00:00:00
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pub_type： 杂志文章,多中心研究
doi：10.1530/EJE-08-0573
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVE:Cases of men with estrogen resistance and aromatase deficiency have highlighted the effects of estrogens on bone metabolism, the cardiovascular system and biochemical variables of the metabolic syndrome. In eugonadal men, administration of an aromatase inhibitor induces a substantial elevation of LH and testo...
journal_title：European journal of endocrinology
pub_type： 杂志文章,随机对照试验
doi：10.1530/eje.1.02126
更新日期：2006-04-01 00:00:00
