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Exploring the use of recombinant human TSH in the diagnosis of central hypothyroidism.

Abstract：

CONTEXT:The diagnosis of central hypothyroidism (CH) is often difficult to establish as serum TSH levels may be low, normal, or slightly increased. OBJECTIVE:To explore the use of recombinant human TSH (rhTSH) in the diagnosis of CH. DESIGN:Randomized single-blind clinical trial. SETTING:Outpatient clinic of a tertiary care referral center. INTERVENTION:A single intramuscular injection of 0.1 and 0.9 mg rhTSH in random order with 1-week interval. PARTICIPANTS:Eighteen adult patients with pituitary insufficiency and six healthy age-, sex-, and body mass index-matched controls. Six patients had untreated CH (newCH), six had treated CH (CH), and six patients were TSH sufficient (nonCH). Five weeks before TSH stimulation, levothyroxine was replaced with tri-iodothyronine (T(3)) for 4 weeks. One week before stimulation, treatment was withdrawn. MAIN OUTCOME MEASURES:Thyroid hormones and thyroglobulin (Tg) before and 2, 3(1/2), 7, 24, 48, and 72 h after each injection. RESULTS:In the newCH group, basal free thyroxine (FT(4)) levels were lower than in controls (P<0.05). After 0.9 mg rhTSH, the increases in FT(4) and reverse T(3) (rT(3)) were less marked in the newCH group than in controls (FT(4)+/-s.e.m. 9.2+/-0.5 to 19.7+/-1.2 vs 11.3+/-0.5 to 27.8.2+/-2.4 pmol/l, P<0.05). The CH group exhibited reduced basal and stimulated FT(4) compared with the TSH-sufficient groups. Tg increased similarly among all study groups after rhTSH injection. CONCLUSION:In this pilot study, patients with untreated CH had lower response to 0.9 mg rhTSH in FT(4) and rT(3) than controls. An rhTSH test may be useful in the diagnosis of CH, but further studies are required.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Filipsson H,Nyström E,Johannsson G

doi

10.1530/EJE-08-0151

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

153-60

issue

2

eissn

0804-4643

issn

1479-683X

pii

EJE-08-0151

journal_volume

159

pub_type

杂志文章,随机对照试验

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