当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Regulation of the sodium iodide symporter by iodide in FRTL-5 cells.

Regulation of the sodium iodide symporter by iodide in FRTL-5 cells.

Abstract：

OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses of iodide given to rats chronically decrease the sodium/iodide symporter (NIS) mRNA and protein, suggesting that escape is due to a decrease in NIS and subsequent iodide transport. We have now studied the effect of excess iodide on NIS in FRTL-5 cells to further explore the mechanisms whereby excess iodide decreases NIS. DESIGN:FRTL-5 cells were employed and were incubated in the presence or absence of various concentrations of iodide. NIS mRNA and protein and the turnover of NIS were assessed. METHODS:NIS mRNA was measured by Northern analysis, NIS protein by Western analysis and NIS turnover by pulse-chase labeling experiments. RESULTS:Iodide (10(-) mol/l) had no effect on NIS mRNA in FRTL-5 cells at 24 and 48 h compared with cells cultured in the absence of iodide. However, excess iodide decreased NIS protein by 50% of control values at 24 h and by 70% at 48 h. This effect of iodide was dose dependent. Pulse-chase experiments demonstrated that there was no effect of iodide on new NIS protein synthesis and that the turnover of NIS protein in the presence of iodide was 27% faster than in the absence of added iodide. CONCLUSIONS:Excess iodide does not decrease NIS mRNA in FRTL-5 cells but does decrease NIS protein, suggesting that in this in vitro thyroid cell model iodide modulates NIS, at least in part, at a post-transcriptional level. This iodide-induced decrease in NIS protein appears to be due, at least partially, to an increase in NIS protein turnover.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Eng PH,Cardona GR,Previti MC,Chin WW,Braverman LE

doi

10.1530/eje.0.1440139

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

139-44

issue

2

eissn

0804-4643

issn

1479-683X

pii

1440139

journal_volume

144

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study.

    abstract：CONTEXT AND OBJECTIVE:High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0662

    authors： Nin JW,Ferreira I,Schalkwijk CG,Prins MH,Chaturvedi N,Fuller JH,Stehouwer CD,EURODIAB Prospective Complications Study Group.

    更新日期：2012-02-01 00:00:00

  • Increased prevalence of polycystic ovary syndrome in premenopausal women with nonalcoholic fatty liver disease.

    abstract：OBJECTIVE:Limited data exist concerning the presence of polycystic ovary syndrome (PCOS) in premenopausal women with nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prevalence of PCOS in overweight and obese premenopausal women with NAFLD. DESIGN:Prospective, observational, and cross-sectional st...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-15-0567

    authors： Vassilatou E,Vassiliadi DA,Salambasis K,Lazaridou H,Koutsomitopoulos N,Kelekis N,Kassanos D,Hadjidakis D,Dimitriadis G

    更新日期：2015-12-01 00:00:00

  • Regulation of neuropeptide Y mRNA expression in cultured human pheochromocytoma cells.

    abstract：:The expression of the neuropeptide Y (NPY) gene varies considerably in human pheochromocytomas, but the mechanisms for this variation have not been clarified. To investigate the regulation pattern of the NPY gene in human pheochromocytomas, we screened 16 pheochromocytomas and 9 normal adrenal tissues with Northern bl...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1410431

    authors： Liu J,Kahri AI,Heikkilä P,Voutilainen R

    更新日期：1999-10-01 00:00:00

  • Functional glucocorticoid receptor gene variants do not underlie the high variability of 17-hydroxyprogesterone screening values in healthy newborns.

    abstract：OBJECTIVE:17-Hydroxyprogesterone (17-OHP) screening for classical congenital adrenal hyperplasia (CAH) is part of many newborn screening programs worldwide. Cut-off values are relatively high, and screening sensitivity does not reach 100%. Recently, the glucocorticoid receptor (GR) N363S-variant has been linked to rela...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-08-0639

    authors： Schreiner F,Tozakidou M,Maslak R,Holtkamp U,Peter M,Gohlke B,Woelfle J

    更新日期：2009-04-01 00:00:00

  • Bone mineral density in middle-aged women with Turner's syndrome.

    abstract：:Bone mineral density (BMD), bone mineral content and body composition were determined in 47 middle-aged (mean age 47.9 +/- 1.1 years) women with Turner's syndrome. Bone mineral density was measured in the forearm, femoral neck and total body. The women investigated had a BMD lower than the normal mean. When expressed ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1320047

    authors： Sylvén L,Hagenfeldt K,Ringertz H

    更新日期：1995-01-01 00:00:00

  • Renal impairment is closely associated with plasma aldosterone concentration in patients with primary aldosteronism.

    abstract：Objective:Several clinical studies have reported that renal impairments are sometimes observed in patients with primary aldosteronism (PA). We analyzed the prevalence of renal impairments in PA patients and identified parameters that increase the risk for them. Design:This is a retrospective cross-sectional study. We ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-19-0047

    authors： Kawashima A,Sone M,Inagaki N,Takeda Y,Itoh H,Kurihara I,Umakoshi H,Ichijo T,Katabami T,Wada N,Ogawa Y,Kawashima J,Fujita M,Miyauchi S,Okamura S,Fukuoka T,Yanase T,Izawa S,Yoshikawa Y,Hashimoto S,Yamada M,Kai T,

    更新日期：2019-09-01 00:00:00

  • The clinical, pathological, and genetic features of familial isolated pituitary adenomas.

    abstract：:Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome related only to patients with acrogigantis...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-07-0348

    authors： Beckers A,Daly AF

    更新日期：2007-10-01 00:00:00

  • Effects of growth hormone replacement therapy on levels of cortisol and cortisol-binding globulin in hypopituitary adults.

    abstract：OBJECTIVE:To determine if human growth hormone (hGH) replacement therapy alters pharmacokinetics of hydrocortisone (CS) substitution in hypopituitary adults. DESIGN:To this aim, we analysed serum and salivary CS profiles 270 min after oral CS administration at baseline and 6 and 12 months after initiation of hGH repla...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430769

    authors： Tschöp M,Lahner H,Feldmeier H,Grasberger H,Morrison KM,Janssen OE,Attanasio AF,Strasburger CJ

    更新日期：2000-12-01 00:00:00

  • Macroprolactinaemia: a biological diagnostic strategy from the study of 222 patients.

    abstract：OBJECTIVES:Gel filtration chromatography (GFC), the gold standard for macroprolactinaemia (MPRL) diagnosis, is a slow, costly and labour-intensive method. To limit the number of GFC required, we evaluated two screening tests for MPRL: prolactin (PRL) recovery after polyethylene glycol (PEG) precipitation and PRL concen...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-14-1073

    authors： Parlant-Pinet L,Harthé C,Roucher F,Morel Y,Borson-Chazot F,Raverot G,Raverot V

    更新日期：2015-06-01 00:00:00

  • Gamma knife radiosurgery is a successful adjunctive treatment in Cushing's disease.

    abstract：OBJECTIVE:Though transsphenoidal surgery remains the first-line treatment of Cushing's disease, recurrence occurs frequently. Conventional radiotherapy and anticortisolic drugs both have adverse effects. Stereotactic radiosurgery needs to be evaluated more precisely. The aim of this study was to determine long-term hor...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02323

    authors： Castinetti F,Nagai M,Dufour H,Kuhn JM,Morange I,Jaquet P,Conte-Devolx B,Regis J,Brue T

    更新日期：2007-01-01 00:00:00

  • Catecholamine production in patients with gastroenteropancreatic neuroendocrine tumors.

    abstract：OBJECTIVE:Amine precursor uptake and decarboxylation is a classical feature of gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Production of catecholamines was studied in GEP NET and non-NET patients. DESIGN:A cross-sectional study was undertaken. METHODS:We studied catecholamine and metabolite secretion in...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1400434

    authors： Ciofu A,Baudin E,Chanson P,Cailleux AF,Comoy E,Sabourin JC,Ducreux M,Schaison G,Schlumberger M

    更新日期：1999-05-01 00:00:00

  • Gene therapy of thyroid cancer via retrovirally-driven combined expression of human interleukin-2 and herpes simplex virus thymidine kinase.

    abstract：OBJECTIVE AND DESIGN:Based on our clinical experience with combined gene therapy of glioblastoma, we developed a retroviral vector expressing two therapeutic genes (i.e. thymidine kinase of herpes simplex virus, HSV-TK, and interleukin-2, IL-2) and evaluated its efficiency in vitro and in vivo. METHODS:Expression of t...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1480073

    authors： Barzon L,Bonaguro R,Castagliuolo I,Chilosi M,Franchin E,Del Vecchio C,Giaretta I,Boscaro M,Palù G

    更新日期：2003-01-01 00:00:00

  • Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe.

    abstract：BACKGROUND:Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. OBJECTIVES:i) To review current management of AI and the unmet medica...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0450

    authors： Grossman A,Johannsson G,Quinkler M,Zelissen P

    更新日期：2013-10-21 00:00:00

  • Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty.

    abstract：BACKGROUND:A limited number of mutations in the GH secretagogue receptor gene (GHSR) have been described in patients with short stature. Objective To analyze GHSR in idiopathic short stature (ISS) children including a subgroup of constitutional delay of growth and puberty (CDGP) patients. SUBJECTS AND METHODS:The GHSR...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-11-0168

    authors： Pugliese-Pires PN,Fortin JP,Arthur T,Latronico AC,Mendonca BB,Villares SM,Arnhold IJ,Kopin AS,Jorge AA

    更新日期：2011-08-01 00:00:00

  • EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?

    abstract：:AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions, such as low energy, increasing energy production and reducing energy waste. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, wi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-16-0927

    authors： López M

    更新日期：2017-05-01 00:00:00

  • Anionic iodotyrosine residues are required for iodothyronine synthesis.

    abstract：:Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxida...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380227

    authors： de Vijlder JJ,den Hartog MT

    更新日期：1998-02-01 00:00:00

  • Autosomal dominant osteopetrosis revisited: lessons from recent studies.

    abstract：:Systematic studies of autosomal dominant osteopetrosis (ADO) were followed by the identification of underlying mutations giving unique possibilities to perform translational studies. What was previously designated ADO1 turned out to be a high bone mass phenotype caused by a missense mutation in the first propeller of ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-13-0136

    authors： Bollerslev J,Henriksen K,Nielsen MF,Brixen K,Van Hul W

    更新日期：2013-07-13 00:00:00

  • Changes in prostaglandin synthesis and metabolism associated with labour, and the influence of dexamethasone, RU 486 and progesterone.

    abstract：:The objective was to compare the changes in prostaglandin synthesis and metabolism occurring within the fetal membranes that are associated with the onset of parturition and to study the effect of steroid hormones on prostaglandin metabolism. A tissue explant study was made of discs of amnion and chorion obtained from...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1330527

    authors： Brennand JE,Leask R,Kelly RW,Greer IA,Calder AA

    更新日期：1995-11-01 00:00:00

  • High IGFBP2 levels are not only associated with a better metabolic risk profile but also with increased mortality in elderly men.

    abstract：OBJECTIVE:Serum IGF-binding protein 2 (IGFBP2) concentrations are reduced in obese humans and increase after a prolonged period of fasting. We investigated the association between IGFBP2 levels and mortality together with other factors that are related to IGFBP2, including the metabolic syndrome and physical function. ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0160

    authors： van den Beld AW,Blum WF,Brugts MP,Janssen JA,Grobbee DE,Lamberts SW

    更新日期：2012-07-01 00:00:00

  • Cross-sectional area of the median nerve is increased in primary autoimmune hypothyroidism and decreases upon treatment with thyroxine.

    abstract：BACKGROUND:The purpose of this study was to assess changes in the cross-sectional area (CSA) of nervus medianus by ultrasound in newly diagnosed primary hypothyroid patients after thyroxine replacement treatment. PATIENTS AND METHODS:The cohort comprised 30 patients with newly diagnosed primary autoimmune hypothyroidi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0397

    authors： Holováčová D,Kužma M,Killinger Z,Payer J

    更新日期：2016-10-01 00:00:00

  • Effect of tryptophan on the early tri-iodothyronine uptake in mouse thymocytes.

    abstract：OBJECTIVE:We have studied the effect of tryptophan on cellular [(125)I]tri-iodothyronine (T3) uptake by mouse thymocytes. MATERIALS AND METHODS:Mouse thymocytes (20 x 10(6 )cells/ml) were suspended in Krebs-Ringer solution buffered by Tris-HCl and incubation (23 degrees C at pH7.45+/-0.6), in the presence or absence o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430119

    authors： Centanni M,Canettieri G,Viceconti N,Sibilla R,Bei A,Andreoli M

    更新日期：2000-07-01 00:00:00

  • Regressive liver adenomatosis following androgenic progestin therapy withdrawal: a case report with a 10-year follow-up and a molecular analysis.

    abstract：OBJECTIVE:The relationship between sex hormones and hepatocellular adenoma development is well established. On the contrary, their contribution to liver adenomatosis (LA) development is still a debatable issue. Recently, inactivating mutations of hepatocyte nuclear factor-1alpha (HNF-1alpha) transcription factor gene o...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0020

    authors： Svrcek M,Jeannot E,Arrivé L,Poupon R,Fromont G,Fléjou JF,Zucman-Rossi J,Bouchard P,Wendum D

    更新日期：2007-06-01 00:00:00

  • Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects.

    abstract：OBJECTIVE:Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN:Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg cal...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-08-0339

    authors： Sneve M,Figenschau Y,Jorde R

    更新日期：2008-12-01 00:00:00

  • The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area.

    abstract：BACKGROUND:The iodine supply of the population in Berlin has normalized during the last 5 Years. Therefore autoimmune thyroiditis has become the most important differential diagnosis in children and adolescents with goiter. OBJECTIVE:The aim of the present study was to define the prevalence of anti-thyroid peroxidase ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1480301

    authors： Kabelitz M,Liesenkötter KP,Stach B,Willgerodt H,Stäblein W,Singendonk W,Jäger-Roman E,Litzenbörger H,Ehnert B,Grüters A

    更新日期：2003-03-01 00:00:00

  • Soluble α-klotho: a novel serum biomarker for the activity of GH-producing pituitary adenomas.

    abstract：OBJECTIVE:Klotho is a lifespan-influencing gene expressed mainly in the kidneys. Soluble α-Klotho (αKL) is released into the circulation. In this study, we present baseline αKL serum levels of patients with acromegaly compared with controls with other pituitary adenomas and assess changes following transsphenoidal surg...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-1045

    authors： Neidert MC,Sze L,Zwimpfer C,Sarnthein J,Seifert B,Frei K,Leske H,Rushing EJ,Schmid C,Bernays RL

    更新日期：2013-03-15 00:00:00

  • Early post-transplantation hypophosphatemia is associated with elevated FGF-23 levels.

    abstract：BACKGROUND:We examined the hypothesis that high FGF-23 levels early after transplantation contribute to the onset of hypophosphatemia, independently of parathyroid hormone (PTH) and other factors regulating phosphate metabolism. METHODS:We measured serum phosphate levels (sPi), renal tubular reabsorption of Pi (TmPi/G...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-1150

    authors： Trombetti A,Richert L,Hadaya K,Graf JD,Herrmann FR,Ferrari SL,Martin PY,Rizzoli R

    更新日期：2011-05-01 00:00:00

  • Endocrinology and Adolescence: aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials.

    abstract：OBJECTIVE:The purpose of this meta-analysis was to examine the evidence for the effectiveness of aerobic exercise interventions on reducing insulin resistance markers in obese children and/or adolescents. A secondary outcome was change in percentage of body fat. METHODS:A computerized search was made from seven databa...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,meta分析

    doi：10.1530/EJE-14-0291

    authors： García-Hermoso A,Saavedra JM,Escalante Y,Sánchez-López M,Martínez-Vizcaíno V

    更新日期：2014-10-01 00:00:00

  • Somatic and germline mutations in the pathogenesis of pituitary adenomas.

    abstract：:Pituitary adenomas are frequently occurring neoplasms that produce clinically significant disease in 1:1000 of the general population. The pathogenesis of pituitary tumors is a matter of interest as it could help to improve diagnosis and treatment. Until recently, however, disruptions in relatively few genes were know...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-19-0602

    authors： Vandeva S,Daly AF,Petrossians P,Zacharieva S,Beckers A

    更新日期：2019-12-01 00:00:00

  • Glucocorticoid replacement therapy and vertebral fractures in hypopituitary adult males with GH deficiency.

    abstract：OBJECTIVE:GH deficiency (GHD) and glucocorticoid excess are associated with increased risk of fragility fractures. We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD. DESIGN:Cross-sectional study. METHODS:Fifty-one ad...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-0125

    authors： Mazziotti G,Porcelli T,Bianchi A,Cimino V,Patelli I,Mejia C,Fusco A,Giampietro A,De Marinis L,Giustina A

    更新日期：2010-07-01 00:00:00

  • Changes in the glycosylation pattern of circulating gonadotropins after acute administration of gonadotropin-releasing hormone in patients with anorexia nervosa.

    abstract：:To study the involvement of gonadotropin-releasing hormone (GnRH) in glycosylation of circulating gonadotropin isoforms in anorexia nervosa (AN), 14 amenorrhoic patients with AN, 14 age-matched volunteers in early follicular phase, and five normal-weight re-fed patients with AN were investigated under baseline conditi...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380076

    authors： Savastano S,Tommaselli AP,Valentino R,Luciano A,Gigante M,Randazzo G,Contaldo F,Scalfi L,Lombardi G

    更新日期：1998-01-01 00:00:00