Endocrinology and Adolescence: aerobic exercise reduces insulin resistance markers in obese youth: a meta-analysis of randomized controlled trials.

abstract：BACKGROUND:Lithium, clinically used in the treatment of bipolar disorders, is well known to induce thyroid growth. However, the mechanism involved is only incompletely characterized. Although it is conventionally believed that thyroid proliferation depends on the thyroid-stimulating hormone (TSH)/cAMP/cAMP response ele...

journal_title：European journal of endocrinology

authors： Rao AS,Kremenevskaja N,Resch J,Brabant G

更新日期：2005-12-01 00:00:00

abstract：:There is increasing evidence that ovarian steroids inhibit vascular responsiveness to the neurohypophysial hormone vasopressin. The present study examined the recovery of the arterial blood pressure following a single (2 ml/100 g body weight) haemorrhage in ovariectomized (OVX) Brattleboro rats with hereditary hypotha...

journal_title：European journal of endocrinology

authors： Morrissey SE,Edwards TJ,Wilson KJ,Whitehead SA,Laycock JF

更新日期：1997-03-01 00:00:00

abstract：:Over the last 5 years, new actors involved in the pathogenesis of combined pituitary hormone deficiency in humans have been reported: they included a member of the immunoglobulin superfamily glycoprotein and ciliary G protein-coupled receptors, as well as new transcription factors and signalling molecules. New modes o...

journal_title：European journal of endocrinology

authors： Castinetti F,Reynaud R,Saveanu A,Jullien N,Quentien MH,Rochette C,Barlier A,Enjalbert A,Brue T

更新日期：2016-06-01 00:00:00

abstract：:Human growth hormone (GH) exists in a variety of isoforms. In the pituitary, the most abundant isoform is 22-kD GH (22 K GH), while other isoforms (non-22 K GH) are present in variable amounts. In human plasma, the GH heterogeneity contributes to the wide variability in GH levels measured by different immunoassays. Th...

journal_title：European journal of endocrinology

authors： Boguszewski CL,Hynsjö L,Johannsson G,Bengtsson BA,Carlsson LM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated a high prevalence of thyroperoxidase antibodies (TPOAb) and autoimmune hypothyroidism in breast cancer (BC). These studies have been performed in BC patients generally 20-30 days after mastectomy. It is known that stress may have an influence on the immune system and a rela...

journal_title：European journal of endocrinology

authors： Giustarini E,Pinchera A,Fierabracci P,Roncella M,Fustaino L,Mammoli C,Giani C

更新日期：2006-05-01 00:00:00

abstract：:The objective of the present study was to compare fasting levels of free IGF-I in serum from patients with adult onset growth hormone deficiency (GHD) and from healthy volunteers, and to examine the effect of GH replacement therapy in GHD on serum free IGF-I. Free IGF-I was measured using separation of free IGF-I by u...

journal_title：European journal of endocrinology

authors： Skjaerbaek C,Vahl N,Frystyk J,Hansen TB,Jørgensen JO,Hagen C,Christiansen JS,Orskov H

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:Modest elevations in circulating IGF-I levels have been suggested to protect against the development of glucose intolerance in insulin-resistant subjects. To further understand the interactions of GH and IGF-I on beta-cell function and post-load glucose tolerance in glucose-intolerant subjects predisposed to ...

journal_title：European journal of endocrinology

authors： Yuen K,Wareham N,Frystyk J,Hennings S,Mitchell J,Fryklund L,Dunger D

更新日期：2004-07-01 00:00:00

abstract：:Rituximab (RTX) use in open-label series has been associated with very encouraging responses in patients with active and moderate-to-severe Graves' orbitopathy (GO). Recently, randomized controlled trials of RTX have been performed in such patients to answer the question of clinical efficacy and the safety profile of ...

journal_title：European journal of endocrinology

authors： Stan MN,Salvi M

更新日期：2017-02-01 00:00:00

abstract：:Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-gener...

journal_title：European journal of endocrinology

authors： Kasuki L,Wildemberg LE,Gadelha MR

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies have shown an increased risk for prostate carcinoma in men with serum IGF-I in the upper part of the age-related reference range. Recombinant human GH (rhGH) is widely used in patients with GH deficiency, usually raising the serum IGF-I levels into the normal range: safety surveillance...

journal_title：European journal of endocrinology

authors： le Roux CW,Jenkins PJ,Chew SL,Camacho-Hübner C,Grossman AB,Besser GM,Monson JP

更新日期：2002-07-01 00:00:00

abstract：CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...

journal_title：European journal of endocrinology

authors： Maione L,Brue T,Beckers A,Delemer B,Petrossians P,Borson-Chazot F,Chabre O,François P,Bertherat J,Cortet-Rudelli C,Chanson P,French Acromegaly Registry Group.

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Both animal and human studies have associated the endocannabinoid system with obesity and markers of metabolic dysfunction. Blockade of the cannabinoid receptor 1 (CB1) caused weight loss and reduction in waist size in both obese and type II diabetics. Recent studies on common variants of the CB1 receptor gen...

journal_title：European journal of endocrinology

authors： Frost M,Nielsen TL,Wraae K,Hagen C,Piters E,Beckers S,De Freitas F,Brixen K,Van Hul W,Andersen M

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:A phase I single centre, open label study of the pharmacokinetics and tolerability of a buccal testosterone tablet (COL 1621) was carried out. DESIGN:Twelve testosterone-deficient males were treated with the buccal tablet twice daily for 7 consecutive days. Multiple blood samples were drawn for testosterone,...

journal_title：European journal of endocrinology

authors： Ross RJ,Jabbar A,Jones TH,Roberts B,Dunkley K,Hall J,Long A,Levine H,Cullen DR

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:GHRH is secreted by the hypothalamus and, upon binding to specific GHRH receptors in the pituitary, stimulates growth hormone (GH) production and release from the pituitary. In addition to this neuroendocrine action, accumulated evidence implies additional roles for GHRH in carcinogenesis in non-pituitary tis...

journal_title：European journal of endocrinology

authors： Chatzistamou I,Schally AV,Kiaris H,Politi E,Varga J,Kanellis G,Kalofoutis A,Pafiti A,Koutselini H

更新日期：2004-09-01 00:00:00

abstract：:We measured serum concentrations of insulin-like growth factors I and II (IGF-I and IGF-II) by radioimmunoassay in 107 healthy women aged 28-78 years and in 116 women with established osteoporosis. The women with established osteoporosis were randomized to a 1-year double-blind, placebo-controlled treatment with conti...

journal_title：European journal of endocrinology

authors： Ravn P,Overgaard K,Spencer EM,Christiansen C

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:The relationship between thyroid function and the risk of venous thromboembolism (VTE) has not been addressed in population-based cohorts. We investigated the association between TSH levels and the risk of VTE in a general adult population. DESIGN:Population-based cohort study. METHODS:TSH was measured in 1...

journal_title：European journal of endocrinology

authors： Lerstad G,Enga KF,Jorde R,Brodin EE,Svartberg J,Brækkan SK,Hansen JB

更新日期：2015-07-01 00:00:00

abstract：:There are close interactions between the adipocyte-derived hormone, leptin, and the anterior pituitary, especially the hypothalamic-pituitary-adrenal (HPA) axis. We investigated the relationship between the sympathetic adrenergic system and serum leptin levels, dependent on the function of anterior pituitary hormone a...

journal_title：European journal of endocrinology

authors： Schafroth U,Godang K,Ueland T,Bollerslev J

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...

journal_title：European journal of endocrinology

authors： Romero-Kusabara IL,Filho JV,Scalissi NM,Melo KC,Demartino G,Longui CA,Melo MR,Cury AN

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...

journal_title：European journal of endocrinology

authors： Rojo-Martínez G,Soriguer FJ,González-Romero S,Tinahones F,Moreno F,de Adana SR,Garriga MJ,Esteva I,García-Arnés J,Gómez-Zumaquero JM,García-Almeida JM

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Flushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying orga...

journal_title：European journal of endocrinology

authors： Huguet I,Grossman A

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Chronic exposure to elevated glucocorticoid (GC) concentrations induces detrimental effects in several tissues. In the skin, GCs provoke intense alterations on various parameters of the physiology of fibroblasts, cumulatively leading to skin atrophy and impaired wound healing. As there are concerns that GCs m...

journal_title：European journal of endocrinology

authors： Zervolea I,Pratsinis H,Tsagarakis S,Karavitaki N,Stathakos D,Thalassinos N,Kletsas D

更新日期：2005-06-01 00:00:00

abstract：:Deflazacort is an oxazoline derivative of cortisone with presumably less serious side effects, but its effects on growth factors are unknown. The present experiments in Long Evans rats were carried out to investigate how deflazacort administration affected the growing rat, especially in relation to hepatic insulin-lik...

journal_title：European journal of endocrinology

authors： Latta K,Krieg RJ Jr,Chan W,Hisano S,Chan JC

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Thyroid hormone (TH) transporters are expressed in thyrocytes and most play a role in TH release. We asked whether expression of the monocarboxylate transporter 8 (MCT8) and the L-type amino acid transporters LAT2 and LAT4 is changed with thyrocyte dedifferentiation and in hyperfunctioning thyroid tissues. D...

journal_title：European journal of endocrinology

authors： Badziong J,Ting S,Synoracki S,Tiedje V,Brix K,Brabant G,Moeller LC,Schmid KW,Fuhrer D,Zwanziger D

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:This open label, multicentre study was designed to evaluate the efficacy and tolerability of lanreotide Autogel (L-Autogel) in acromegalic patients over a 24-week period. The outcome of treatment with this new, long-acting, aqueous formulation of lanreotide was also compared with the patients' previous treatm...

journal_title：European journal of endocrinology

authors： Alexopoulou O,Abrams P,Verhelst J,Poppe K,Velkeniers B,Abs R,Maiter D

更新日期：2004-09-01 00:00:00

abstract：:Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or le...

journal_title：European journal of endocrinology

authors： Dumoulin SC,Perret BP,Bennet AP,Caron PJ

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:Binding of thyroglobulin (Tg) to heparin allows efficient Tg interaction with its endocytic receptor, megalin. Rat Tg (rTg) binds to heparin using an exposed carboxyl terminal region (RELPSRRLKRPLPVK, Arg2489-Lys2503) rich in positively charged residues which is, however, not entirely conserved in human Tg (h...

journal_title：European journal of endocrinology

authors： Lisi S,Pinchera A,McCluskey RT,Chiovato L,Marinò M

更新日期：2002-04-01 00:00:00

abstract：:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...

journal_title：European journal of endocrinology

authors： Tsourdi E,Rachner TD,Rauner M,Hamann C,Hofbauer LC

更新日期：2011-12-01 00:00:00

abstract：:Orthodenticle homolog 2 (OTX2) is a homeobox family transcription factor required for brain and eye formation. Various genetic alterations in OTX2 have been described, mostly in patients with severe ocular malformations. In order to expand the knowledge of the spectrum of OTX2 mutation, we performed OTX2 mutation scre...

journal_title：European journal of endocrinology

authors： Gorbenko Del Blanco D,Romero CJ,Diaczok D,de Graaff LC,Radovick S,Hokken-Koelega AC

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

journal_title：European journal of endocrinology

authors： Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

更新日期：2003-06-01 00:00:00

abstract：Objective:To evaluate the prevalence and natural course of autoimmune and non-autoimmune subclinical hypothyroidism (SH) in Down syndrome (DS) children and adolescents. Design:Prospective multicenter study. Methods:For the study, 101 DS patients with SH (TSH 5-10 mIU/L; FT4 12-22 pmol/L), aged 2-17 years at SH diagno...

journal_title：European journal of endocrinology

authors： Pepe G,Corica D,De Sanctis L,Salerno M,Faienza MF,Tessaris D,Tuli G,Scala I,Penta L,Alibrandi A,Pajno GB,Aversa T,Wasniewska M,Thyroid Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED).

更新日期：2020-04-01 00:00:00