Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution.

abstract：OBJECTIVE:Epigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET) development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene silencing is a well-established oncogenic mechanism that is potentially reversible and therefore an interesting therapeutic target. Multiple endocrine neo...

journal_title：European journal of endocrinology

authors： Conemans EB,Lodewijk L,Moelans CB,Offerhaus GJA,Pieterman CRC,Morsink FH,Dekkers OM,de Herder WW,Hermus AR,van der Horst-Schrivers AN,Drent ML,Bisschop PH,Havekes B,Brosens LAA,Dreijerink KMA,Borel Rinkes IHM,Timmers HTM

更新日期：2018-09-01 00:00:00

abstract：:Klinefelter syndrome, 47,XXY (KS), is the most frequent sex chromosome aberration in males, affecting 1 in 660 newborn boys. The syndrome is characterized by testicular destruction with extensive fibrosis and hyalinization of the seminiferous tubules resulting in small testes, hypergonadotropic hypogonadism, and azoos...

journal_title：European journal of endocrinology

authors： Aksglaede L,Juul A

更新日期：2013-03-15 00:00:00

abstract：OBJECTIVE:In a preliminary cross-sectional study, we discovered that DNA topoisomerase II autoantibodies (anti-TopII) were detected in 49.2% of 195 Chinese type 1 diabetes mellitus (type 1 DM) patients with a mean age of 14.5 years and a mean duration of disease of 4.6 years. In order to demonstrate the relationship be...

journal_title：European journal of endocrinology

authors： Shiau MY,Tsai ST,Hwang J,Wu CY,Chang YH

更新日期：2000-06-01 00:00:00

abstract：:An increased calcitonin serum level is suggestive of a medullary thyroid cancer (MTC), but is not pathognomonic. The possibility of false positives or other calcitonin-secreting neuroendocrine neoplasms (NENs) should be considered. Serum calcitonin levels are generally assessed by immunoradiometric and chemiluminescen...

journal_title：European journal of endocrinology

authors： Giannetta E,Guarnotta V,Altieri B,Sciammarella C,Guadagno E,Malandrino P,Puliani G,Feola T,Isidori AM,Colao AAL,Faggiano A

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Subclinical hypothyroidism occurs in a number of children with Down's syndrome (DS). The reason for the mildly elevated plasma thyrotropin (TSH) concentrations is not known. The present study investigated whether decreased TSH bioactivity plays a role in this phenomenon. DESIGN:A retrospective study of plasm...

journal_title：European journal of endocrinology

authors： Konings CH,van Trotsenburg AS,Ris-Stalpers C,Vulsma T,Wiedijk BM,de Vijlder JJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:In female adrenal insufficiency, dehydroepiandrosterone (DHEA) secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological DHEA substitution on substrate metabolism. DESIGN:We studied nine females with adrenal insufficiency after 9 days ...

journal_title：European journal of endocrinology

authors： Christiansen JJ,Gravholt CH,Fisker S,Møller N,Andersen M,Svenstrup B,Bennett P,Ivarsen P,Christiansen JS,Jørgensen JO

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Investigation of small numbers of parathyroid tumours by X-chromosome inactivation analysis suggests that the majority of them are monoclonal lesions most likely caused by a somatic mutation. Somatic mutations in the MEN1 gene located on chromosome 11q13 have recently been identified in 12-17% of solitary pa...

journal_title：European journal of endocrinology

authors： Miedlich S,Krohn K,Lamesch P,Müller A,Paschke R

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs). METHODS:Fourteen sporadic PAs were studied by comparative genomic hybridization (CGH). RESULTS:The fourteen studied PAs showed chromosomal imbalances. All cases except one exhibited two or more abnormalities. Chromosomal gains ...

journal_title：European journal of endocrinology

authors： Garcia JL,Tardio JC,Gutierrez NC,Gonzalez MB,Polo JR,Hernandez JM,Menarguez J

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:Clinical presentation of pituitary adenomas frequently involves pain, particularly headache, due to structural and functional properties of the tumour. Our aim was to investigate the clinical characteristics of pain in a large cohort of patients with pituitary disease. DESIGN:In a cross-sectional study, we a...

journal_title：European journal of endocrinology

authors： Dimopoulou C,Athanasoulia AP,Hanisch E,Held S,Sprenger T,Toelle TR,Roemmler-Zehrer J,Schopohl J,Stalla GK,Sievers C

更新日期：2014-11-01 00:00:00

abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

journal_title：European journal of endocrinology

authors： Canalis E

更新日期：2018-02-01 00:00:00

abstract：:We measured serum concentrations of insulin-like growth factors I and II (IGF-I and IGF-II) by radioimmunoassay in 107 healthy women aged 28-78 years and in 116 women with established osteoporosis. The women with established osteoporosis were randomized to a 1-year double-blind, placebo-controlled treatment with conti...

journal_title：European journal of endocrinology

authors： Ravn P,Overgaard K,Spencer EM,Christiansen C

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Elevated levels of circulating fibroblast growth factor 21 (FGF21) are commonly encountered in type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, all of which share exaggerated postprandial lipemia as a common proatherogenic feature. How FGF21 responds to an oral fat load in man is unknown...

journal_title：European journal of endocrinology

authors： Matikainen N,Taskinen MR,Stennabb S,Lundbom N,Hakkarainen A,Vaaralahti K,Raivio T

更新日期：2012-03-01 00:00:00

abstract：:Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

journal_title：European journal of endocrinology

authors： Barzon L,Bonaguro R,Palù G,Boscaro M

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Pubertal onset is usually defined by breast development in girls and testicular growth in boys. Pubarche is defined as the attainment of pubic hair and is considered as a sign of pubertal transition. Pubarche is preceded by a gradual increase in production of adrenal androgens, DHEA and Δ4-androstenedione (A...

journal_title：European journal of endocrinology

authors： Mouritsen A,Aksglaede L,Soerensen K,Hagen CP,Petersen JH,Main KM,Juul A

更新日期：2012-12-31 00:00:00

abstract：:Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders resulting from deficiency of one of the five enzymes required for synthesis of cortisol in the adrenal cortex. The most common form of the disease is classic 21-hydroxylase deficiency, which is characterized by decreased synthesis of gluc...

journal_title：European journal of endocrinology

authors： Charmandari E,Brook CG,Hindmarsh PC

更新日期：2004-11-01 00:00:00

abstract：:Two experiments were conducted to determine the patterns of LH secretion and to evaluate the LH responses to pulsatile administration of GnRH during early pregnancy in ewes. In experiment 1, pregnant ewes (n=16) were used to determine the concentration of LH in plasma of jugular blood samples collected every 15 min fo...

journal_title：European journal of endocrinology

authors： Al-Gubory KH

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The intrarenal renin-angiotensin system (RAS) activation plays a pivotal role in immunoglobulin A nephropathy (IgAN) pathogenesis, which is still largely undefined. Recently, vasopressin (AVP) has been advocated to contribute to the genesis and progression of chronic kidney diseases (CKD) directly, and indire...

journal_title：European journal of endocrinology

authors： Rocchetti MT,Tamma G,Lasorsa D,Suriano IV,D'Apollo A,Papale M,Mastrofrancesco L,Grandaliano G,Svelto M,Valenti G,Gesualdo L,Di Paolo S

更新日期：2011-10-01 00:00:00

abstract：:Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome related only to patients with acrogigantis...

journal_title：European journal of endocrinology

authors： Beckers A,Daly AF

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this meta-analysis was to examine the evidence for the effectiveness of aerobic exercise interventions on reducing insulin resistance markers in obese children and/or adolescents. A secondary outcome was change in percentage of body fat. METHODS:A computerized search was made from seven databa...

journal_title：European journal of endocrinology

authors： García-Hermoso A,Saavedra JM,Escalante Y,Sánchez-López M,Martínez-Vizcaíno V

更新日期：2014-10-01 00:00:00

abstract：:Serum thyrotropin (TSH) concentration circadian rhythm is abolished in many endocrine and non-endocrine diseases. In the present study we have measured serum TSH concentration over 24 h every 2 h in second and third trimester pregnant women. During the 24-h period, serum free thyroxine and free triiodothyronine concen...

journal_title：European journal of endocrinology

authors： Roti E,Bartalena L,Minelli R,Salvi M,Gardini E,Pistolesi A,Martino E,Braverman LE

更新日期：1995-07-01 00:00:00

abstract：:Several lines of evidence suggest that tumor necrosis factor-alpha (TNFalpha) may contribute to the pathogenesis of autoimmune thyroid disease. It is not known, however, whether increased thyroidal TNFalpha levels are associated with changes in thyroid function. The purpose of the present study was to utilize in situ ...

journal_title：European journal of endocrinology

authors： Mori K,Mori M,Stone S,Braverman LE,DeVito WJ

更新日期：1998-11-01 00:00:00

abstract：:Exogenous growth hormone (hGH) administration in humans attenuates the endogenous growth hormone (GH) response to some pharmacological stimuli; in particular, pretreatment with hGH completely blocks the serum GH response to growth hormone-releasing hormone. In order to evaluate the mechanism(s) whereby opiods induce G...

journal_title：European journal of endocrinology

authors： Fanciulli G,Oliva O,Tomasi PA,Pala A,Bertoncelli A,Dettori A,Delitala G

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Gastric carcinoid tumours type 1 (GCA1) originate from hyperplastic enterochromaffin-like (ECL) cells secondary to hypergastrinaemia. Treatment with somatostatin analogues (SSA) might impede ECL-cell hyperplasia by suppressing gastrin secretion and/or by a direct anti-proliferative effect on ECL cells. We co...

journal_title：European journal of endocrinology

authors： Grozinsky-Glasberg S,Kaltsas G,Gur C,Gal E,Thomas D,Fichman S,Alexandraki K,Barak D,Glaser B,Shimon I,Gross DJ

更新日期：2008-10-01 00:00:00

abstract：:Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack ...

journal_title：European journal of endocrinology

authors： Chanson P,Dormoy A,Dekkers OM

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:While anti-pituitary antibodies (APAs) were detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far. DESIGN:The aim of this study ...

journal_title：European journal of endocrinology

authors： De Bellis A,Kelestimur F,Sinisi AA,Ruocco G,Tirelli G,Battaglia M,Bellastella G,Conzo G,Tanriverdi F,Unluhizarci K,Bizzarro A,Bellastella A

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in o...

journal_title：European journal of endocrinology

authors： Yeap BB,Alfonso H,Hankey GJ,Flicker L,Golledge J,Norman PE,Chubb SA

更新日期：2013-09-12 00:00:00

abstract：:Stem cell terminology has entered the lexicon of medical practitioners even though the application of harvesting stem cells to treat diseases other than haematological disorders is not yet a reality in clinical practice. All branches of medicine will be affected by the new technology, more so those related to regenera...

journal_title：European journal of endocrinology

authors： Hughes IA

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:There are limited data on cardiometabolic risk factors and the prevalence of metabolic syndrome (MetS) across the different PCOS phenotypes in Caucasian population. Lipid accumulation product (LAP) is a clinical surrogate marker that could be used for evaluation of MetS in clinical practice. The aim of the st...

journal_title：European journal of endocrinology

authors： Božić-Antić I,Ilić D,Bjekić-Macut J,Bogavac T,Vojnović-Milutinović D,Kastratovic-Kotlica B,Milić N,Stanojlović O,Andrić Z,Macut D

更新日期：2016-12-01 00:00:00

abstract：:Human growth hormone (GH) exists in a variety of isoforms. In the pituitary, the most abundant isoform is 22-kD GH (22 K GH), while other isoforms (non-22 K GH) are present in variable amounts. In human plasma, the GH heterogeneity contributes to the wide variability in GH levels measured by different immunoassays. Th...

journal_title：European journal of endocrinology

authors： Boguszewski CL,Hynsjö L,Johannsson G,Bengtsson BA,Carlsson LM

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of long-term, non-suppressive levothyroxine (L-T(4)) treatment on quantitative ultrasonometry in women. DESIGN:This was a case-control study. SUBJECTS AND METHODS:Altogether 667 women (mean age+/-s.d., 49.5+/-13.1 years) were studied. Of these, 156 (23%) had non-toxic goitre or hypoth...

journal_title：European journal of endocrinology

authors： Hadji P,Hars O,Sturm G,Bauer T,Emons G,Schulz KD

更新日期：2000-05-01 00:00:00