当前位置： SCI文献检索 > EUROPEAN JOURNAL OF ENDOCRINOLOGY期刊下所有文献 > Pharmacokinetics and tolerability of a bioadhesive buccal testosterone tablet in hypogonadal men.

Pharmacokinetics and tolerability of a bioadhesive buccal testosterone tablet in hypogonadal men.

Abstract：

OBJECTIVE:A phase I single centre, open label study of the pharmacokinetics and tolerability of a buccal testosterone tablet (COL 1621) was carried out. DESIGN:Twelve testosterone-deficient males were treated with the buccal tablet twice daily for 7 consecutive days. Multiple blood samples were drawn for testosterone, dihydrotestosterone (DHT), bioavailable testosterone and sex hormone-binding globulin (SHBG). RESULTS:After COL 1621, means+/-S.D. serum testosterone level increased to a peak concentration of 26.6+/-5.8 nmol/l (7.7+/-1.7 ng/ml) at 4.8+/-5.8 h and stayed in the eugonadal range. Steady state was achieved within the first 24 h and was maintained in the normal range. The bioavailable testosterone, DHT and free testosterone index followed a pattern very similar to that of testosterone. The mean serum testosterone to DHT ratio was within the normal male range throughout treatment. There was only one treatment-related adverse event (headache). Two-thirds of patients indicated that treatment with COL 1621 was acceptable and that the tablet was convenient to use. Six patients (50.0%) preferred COL 1621 to their previous testosterone replacement therapy, two patients gave preference to their previous treatment and three patients found both treatments to be equally acceptable. Data for one patient was not available. CONCLUSION:We conclude that COL 1621 can efficiently elevate serum testosterone and DHT levels in hypogonadal men within the first day of application, achieve a steady state within 24 h and maintain serum testosterone in the normal range with a twice-daily treatment regimen. COL 1621 provides an effective alternative oral testosterone replacement therapy that gives physiological levels of testosterone and is well tolerated by the patients.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Ross RJ,Jabbar A,Jones TH,Roberts B,Dunkley K,Hall J,Long A,Levine H,Cullen DR

doi

10.1530/eje.0.1500057

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

57-63

issue

1

eissn

0804-4643

issn

1479-683X

journal_volume

150

pub_type

临床试验,杂志文章

相关文献

EUROPEAN JOURNAL OF ENDOCRINOLOGY文献大全
  • Growth modelling of non-functioning pituitary adenomas in patients referred for surgery.

    abstract：OBJECTIVE:Recent observational studies have established progression and recurrence rates of pituitary adenomas. However, it is still unknown how individual pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. The objective of this study was to define a growth model for non-func...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0502

    authors： Honegger J,Zimmermann S,Psaras T,Petrick M,Mittelbronn M,Ernemann U,Reincke M,Dietz K

    更新日期：2008-03-01 00:00:00

  • Changes in the management and comorbidities of acromegaly over three decades: the French Acromegaly Registry.

    abstract：CONTEXT:Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN:The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and pro...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究

    doi：10.1530/EJE-16-1064

    authors： Maione L,Brue T,Beckers A,Delemer B,Petrossians P,Borson-Chazot F,Chabre O,François P,Bertherat J,Cortet-Rudelli C,Chanson P,French Acromegaly Registry Group.

    更新日期：2017-05-01 00:00:00

  • Female gonadal development in XX patients with distal 9p monosomy.

    abstract：OBJECTIVE:A sex determining gene(s) has been mapped to a approximately 700 kb region distal to the exons of DMRT1 on 9p. The aim of this study was to examine gonadal developmental status in XX patients hemizygous for the 9p sex determining region. DESIGN:Clinical and molecular studies were performed in an 8-year-old g...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1450613

    authors： Ogata T,Muroya K,Ohashi H,Mochizuki H,Hasegawa T,Kaji M

    更新日期：2001-11-01 00:00:00

  • Short-term low-dose growth hormone administration in subjects with impaired glucose tolerance and the metabolic syndrome: effects on beta-cell function and post-load glucose tolerance.

    abstract：OBJECTIVE:Modest elevations in circulating IGF-I levels have been suggested to protect against the development of glucose intolerance in insulin-resistant subjects. To further understand the interactions of GH and IGF-I on beta-cell function and post-load glucose tolerance in glucose-intolerant subjects predisposed to ...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1510039

    authors： Yuen K,Wareham N,Frystyk J,Hennings S,Mitchell J,Fryklund L,Dunger D

    更新日期：2004-07-01 00:00:00

  • Pegvisomant and Pasireotide LAR as second line therapy in acromegaly: clinical effectiveness and predictors of response.

    abstract：Background:The treatment of acromegaly resistant to first-generation somatostatin receptor ligands (SRLs) is often difficult. Pegvisomant and Pasireotide LAR are mostly used in these subset of patients, as second line therapies. Choice of the type of second line therapies is difficult, since predictors of response are ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-20-0767

    authors： Chiloiro S,Giampietro A,Mirra F,Donfrancesco F,Tartaglione T,Mattogno PP,Angelini F,Liverana L,Gessi M,Carmelo A,Rindi G,Giustina A,Fleseriu M,Pontecorvi A,De Marinis L,Bianchi A

    更新日期：2021-02-01 00:00:00

  • Distinct effects of pioglitazone and metformin on circulating sclerostin and biochemical markers of bone turnover in men with type 2 diabetes mellitus.

    abstract：OBJECTIVE:Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures and thiazolidinediones (TZDs) increase this risk. TZDs stimulate the expression of sclerostin, a negative regulator of bone formation, in vitro. Abnormal sclerostin production may, therefore, be involved in the pathogenesis of i...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1530/EJE-11-1061

    authors： van Lierop AH,Hamdy NA,van der Meer RW,Jonker JT,Lamb HJ,Rijzewijk LJ,Diamant M,Romijn JA,Smit JW,Papapoulos SE

    更新日期：2012-04-01 00:00:00

  • Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review.

    abstract：:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-12-0167

    authors： Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

    更新日期：2012-07-01 00:00:00

  • Evaluation for roles of nitric oxide generated in the anteroventral third ventricular region in controlling vasopressin secretion and cardiovascular system of conscious rats.

    abstract：OBJECTIVE:To examine local actions of nitric oxide (NO) on the neural mechanisms controlling the release of vasopressin (AVP) and the cardiovascular system in the anteroventral third ventricular region (AV3V), a pivotal area for autonomic functions, and to pursue the problem of whether it may have any role in the AVP a...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430523

    authors： Yamaguchi K,Watanabe K,Yamaya K

    更新日期：2000-10-01 00:00:00

  • Sympatho-vagal control of heart rate variability in patients treated with suppressive doses of L-thyroxine for thyroid cancer.

    abstract：OBJECTIVE:This study aimed to analyze the autonomic control of heart rate variability (HRV) in subjects receiving chronic l-thyroxine (l-T4) treatment after total thyroidectomy and (131)I therapy for differentiated thyroid carcinoma. METHODS:Blood pressure (BP) and sympatho-vagal activity (evaluated by power spectral ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.01918

    authors： Casu M,Cappi C,Patrone V,Repetto E,Giusti M,Minuto F,Murialdo G

    更新日期：2005-06-01 00:00:00

  • Impaired growth and intracranial calcifications in autosomal dominant hypocalcemia caused by a GNA11 mutation.

    abstract：OBJECTIVE:Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia and inappropriately low PTH concentrations. ADH type 1 is caused by activating mutations in the calcium-sensing receptor (CASR), a G-protein-coupled receptor signaling through α11 (Gα11) and αq (Gαq) subunits. Heterozygous activating mutat...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0109

    authors： Tenhola S,Voutilainen R,Reyes M,Toiviainen-Salo S,Jüppner H,Mäkitie O

    更新日期：2016-09-01 00:00:00

  • Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function.

    abstract：OBJECTIVE:Adiponectin and resistin have been linked to inflammation, endothelial dysfunction, and/or insulin secretion or resistance. It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfun...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-09-0555

    authors： Fargnoli JL,Sun Q,Olenczuk D,Qi L,Zhu Y,Hu FB,Mantzoros CS

    更新日期：2010-02-01 00:00:00

  • Modulating effect of human growth hormone on tumour necrosis factor-alpha and interleukin-1beta.

    abstract：:We measured serum tumour necrosis factor-alpha (TNF-alpha) as well as interleukin-1betta (IL-1beta) and GH concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1-13.9 years, before and 4 and 24h after the first GH injection (0.1 IU/kg s.c.). No differences were found in basal concen...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1380640

    authors： Bozzola M,De Amici M,Zecca M,Schimpff RM,Rapaport R

    更新日期：1998-06-01 00:00:00

  • Polymorphisms in the endocannabinoid receptor 1 in relation to fat mass distribution.

    abstract：OBJECTIVE:Both animal and human studies have associated the endocannabinoid system with obesity and markers of metabolic dysfunction. Blockade of the cannabinoid receptor 1 (CB1) caused weight loss and reduction in waist size in both obese and type II diabetics. Recent studies on common variants of the CB1 receptor gen...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,随机对照试验

    doi：10.1530/EJE-10-0192

    authors： Frost M,Nielsen TL,Wraae K,Hagen C,Piters E,Beckers S,De Freitas F,Brixen K,Van Hul W,Andersen M

    更新日期：2010-09-01 00:00:00

  • Growth hormone-releasing activity of growth hormone-releasing peptide-6 is maintained after short-term oral pretreatment with the hexapeptide in normal aging.

    abstract：:The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is ac...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1310499

    authors： Ghigo E,Arvat E,Rizzi G,Goffi S,Grottoli S,Mucci M,Boghen MF,Camanni F

    更新日期：1994-11-01 00:00:00

  • Downregulation of long-form prolactin receptor mRNA during prolactin-induced luteal regression.

    abstract：OBJECTIVE:Prolactin is capable of both trophic and lytic actions in rat corpora lutea. In corpora lutea responding to a trophic prolactin signal, the long form of the prolactin receptor is the dominant form and is upregulated by prolactin. We investigated whether mRNA for the short form of the prolactin receptor was do...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1430285

    authors： Bowen JM,Telleria CM,Towns R,Keyes PL

    更新日期：2000-08-01 00:00:00

  • An alternative spliced variant of circulating soluble tumor necrosis factor-alpha receptor-2 is paradoxically associated with insulin action.

    abstract：OBJECTIVE:Serum concentrations of soluble tumor necrosis factor-alpha (TNF-alpha) receptor 2 (sTNFR2) are associated with insulin resistance. In a recent study, we provided evidence for the existence of a biologically active form of sTNFR2 produced by alternative splicing (DS-TNFR2). We aimed to evaluate whether this c...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.1.02145

    authors： Fernández-Real JM,Straczkowski M,Lainez B,Chacón MR,Kowalska I,López-Bermejo A,García-España A,Nikolajuk A,Kinalska I,Ricart W

    更新日期：2006-05-01 00:00:00

  • A carnivore species (Canis familiaris) expresses circadian melatonin rhythm in the peripheral blood and melatonin receptors in the brain.

    abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1310191

    authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

    更新日期：1994-08-01 00:00:00

  • C-peptide and the risk for incident complications and mortality in type 2 diabetic patients: a retrospective cohort study after a 14-year follow-up.

    abstract：OBJECTIVE:C-peptide, a cleavage product of insulin, exerts biological effects in patients with type 1 diabetes mellitus, but its role in type 2 diabetes mellitus is controversial. Our aim was to examine the associations between fasting C-peptide levels and all-cause mortality, specific-cause mortality and the incidence...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-12-0085

    authors： Bo S,Gentile L,Castiglione A,Prandi V,Canil S,Ghigo E,Ciccone G

    更新日期：2012-08-01 00:00:00

  • Circulating vascular endothelial growth factor and active renin concentrations and prostaglandin E2 urinary excretion in patients with adrenal tumours.

    abstract：OBJECTIVES:The aim of the present study was to determine vascular endothelial growth factor (VEGF), prostaglandin E(2) (PGE(2)) and active renin levels in patients with hormonally active adrenal tumours. DESIGN:The study was comprised of 16 patients with primary aldosteronism, 13 patients with active Cushing's syndrom...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1500345

    authors： Zacharieva S,Atanassova I,Orbetzova M,Nachev E,Kalinov K,Kirilov G,Shigarminova R,Ivanova R,Dashev G

    更新日期：2004-03-01 00:00:00

  • The clinical, pathological, and genetic features of familial isolated pituitary adenomas.

    abstract：:Pituitary adenomas occur in a familial setting in multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC), which occur due to mutations in the genes MEN1 and PRKAR1A respectively. Isolated familial somatotropinoma (IFS) is also a well-described clinical syndrome related only to patients with acrogigantis...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-07-0348

    authors： Beckers A,Daly AF

    更新日期：2007-10-01 00:00:00

  • DIAGNOSIS OF ENDOCRINE DISEASE: Mosaic disorders of FGF23 excess: Fibrous dysplasia/McCune-Albright syndrome and cutaneous skeletal hypophosphatemia syndrome.

    abstract：:Fibrous dysplasia/McCune-Albright Syndrome (FD/MAS), arising from gain-of-function mutations in Gαs, and cutaneous skeletal hypophosphatemia syndrome (CSHS), arising from gain-of-function mutations in the Ras/MAPK pathway, are strikingly complex, mosaic diseases with overlapping phenotypes. Both disorders are defined ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章,评审

    doi：10.1530/EJE-19-0969

    authors： de Castro LF,Ovejero D,Boyce AM

    更新日期：2020-05-01 00:00:00

  • Serum GH response to pharmacological stimuli and physical exercise in two siblings with two new inactivating mutations in the GH-releasing hormone receptor gene.

    abstract：OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1470591

    authors： Salvatori R,Fan X,Veldhuis JD,Couch R

    更新日期：2002-11-01 00:00:00

  • Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome.

    abstract：OBJECTIVE:To compare the influence of transdermal and peroral oestrogen treatments in conjunction with cyproterone acetate (CPA) on metabolic and hormonal parameters in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS:Twenty-four women with PCOS, aged 25.4+/-4.3 (mean+/-s.d.) years, body mass index 24...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1530/eje.0.1500215

    authors： Vrbíková J,Stanická S,Dvoráková K,Hill M,Vondra K,Bendlová B,Stárka L

    更新日期：2004-02-01 00:00:00

  • Quantification of urinary insulin-like growth factors (IGFs) and IGF binding protein 3 in healthy volunteers before and after stimulation with recombinant human growth hormone.

    abstract：:We examined excretion of urinary insulin-like growth factors I and II (IGF-I and IGF-II) and their major binding protein IGFBP-3 in comparison to their respective serum concentration in nine healthy female volunteers (median age 25 years, range 22-27) under baseline conditions and after stimulation with recombinant hu...

    journal_title：European journal of endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1530/eje.0.1320433

    authors： Tönshoff B,Blum WF,Vickers M,Kurilenko S,Mehls O,Ritz E

    更新日期：1995-04-01 00:00:00

  • Regulation of the sodium iodide symporter by iodide in FRTL-5 cells.

    abstract：OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1440139

    authors： Eng PH,Cardona GR,Previti MC,Chin WW,Braverman LE

    更新日期：2001-02-01 00:00:00

  • Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.

    abstract：OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1490343

    authors： Peterhoff M,Sieg A,Brede M,Chao CM,Hein L,Ullrich S

    更新日期：2003-10-01 00:00:00

  • Quality of life is decreased in female patients treated for microprolactinoma.

    abstract：OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conduct...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-07-0259

    authors： Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JA

    更新日期：2007-08-01 00:00:00

  • Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI.

    abstract：OBJECTIVE:To determine if functional imaging using 11C-methionine positron emission tomography co-registered with 3D gradient echo MRI (Met-PET/MRI), can identify sites of residual active tumour in treated acromegaly, and discriminate these from post-treatment change, to allow further targeted treatment. DESIGN/METHOD...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-16-0639

    authors： Koulouri O,Kandasamy N,Hoole AC,Gillett D,Heard S,Powlson AS,O'Donovan DG,Annamalai AK,Simpson HL,Akker SA,Aylwin SJ,Brooke A,Buch H,Levy MJ,Martin N,Morris D,Parkinson C,Tysome JR,Santarius T,Donnelly N,Buscombe

    更新日期：2016-11-01 00:00:00

  • Serum levels of 3alpha-androstanediol glucuronide in hirsute and non hirsute women.

    abstract：:This study has evaluated the behaviour of 3alpha-androstanediol glucuronide (3alpha-diol G) in 170 women of whom 85 had polycystic ovary syndrome (PCOS), 35 had idiopathic hirsutism (IH) and 50 had regular cycles (control group). Of the women with PCOS, 45 were hirsute (PCOS-H) and 40 were non hirsute (PCOS-NH). Women...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/eje.0.1380421

    authors： Falsetti L,Rosina B,De Fusco D

    更新日期：1998-04-01 00:00:00

  • Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas.

    abstract：OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...

    journal_title：European journal of endocrinology

    pub_type： 杂志文章

    doi：10.1530/EJE-10-0245

    authors： Tani Y,Inoshita N,Sugiyama T,Kato M,Yamada S,Shichiri M,Hirata Y

    更新日期：2010-10-01 00:00:00