Circulating vascular endothelial growth factor and active renin concentrations and prostaglandin E2 urinary excretion in patients with adrenal tumours.

Abstract:

OBJECTIVES:The aim of the present study was to determine vascular endothelial growth factor (VEGF), prostaglandin E(2) (PGE(2)) and active renin levels in patients with hormonally active adrenal tumours. DESIGN:The study was comprised of 16 patients with primary aldosteronism, 13 patients with active Cushing's syndrome due to adrenal adenomas, 8 patients with adrenal carcinomas, 19 patients with phaeochromocytoma and 19 healthy volunteers. METHODS:Active renin in plasma was determined by a two-site immunoradiometric assay. VEGF in sera samples and PGE(2) in 24-h urine were measured by ELISA. RESULTS:VEGF was significantly elevated in all the four groups of patients as compared with the controls. VEGF levels in patients with Cushing's syndrome were higher than those in patients with primary aldosteronism. Patients with adrenal carcinomas had the highest VEGF levels and the differences reached significance as compared with patients with primary aldosteronism and phaeochromocytoma. PGE(2) levels were not significantly different among groups. Active renin was significantly the lowest in patients with primary aldosteronism and significantly the highest in patients with phaeochromocytoma compared with the controls. Active renin in patients with primary aldosteronism was significantly lower than in those with Cushing's syndrome, phaeochromocytoma and adrenal carcinoma. CONCLUSIONS:Our data indicated that the mean level of VEGF in patients with all investigated adrenal tumours was significantly higher than in healthy controls. The cortisol-producing tumours appear to have increased angiogenic potential. Angiogenesis is probably associated not only with malignancy but also with functional activity of the adrenal tumors.

journal_name

Eur J Endocrinol

authors

Zacharieva S,Atanassova I,Orbetzova M,Nachev E,Kalinov K,Kirilov G,Shigarminova R,Ivanova R,Dashev G

doi

10.1530/eje.0.1500345

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

345-9

issue

3

eissn

0804-4643

issn

1479-683X

journal_volume

150

pub_type

杂志文章
  • Osteogenesis imperfecta: an update on clinical features and therapies.

    abstract::Osteogenesis imperfecta (OI) is an inherited skeletal dysplasia characterized by bone fragility and skeletal deformities. While the majority of cases are associated with pathogenic variants in COL1A1 and COL1A2, the genes encoding type I collagen, up to 25% of cases are associated with other genes that function within...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-20-0299

    authors: Marom R,Rabenhorst BM,Morello R

    更新日期:2020-10-01 00:00:00

  • A carnivore species (Canis familiaris) expresses circadian melatonin rhythm in the peripheral blood and melatonin receptors in the brain.

    abstract::Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1310191

    authors: Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

    更新日期:1994-08-01 00:00:00

  • TSH-suppressive doses of levothyroxine are required to achieve preoperative native serum triiodothyronine levels in patients who have undergone total thyroidectomy.

    abstract:OBJECTIVE:Thyroidal production of triiodothyronine (T(3)) is absent in patients who have undergone total thyroidectomy. Therefore, relative T(3) deficiency may occur during postoperative levothyroxine (L-T(4)) therapy. The objective of this study was to evaluate how the individual serum T(3) level changes between preop...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-11-1029

    authors: Ito M,Miyauchi A,Morita S,Kudo T,Nishihara E,Kihara M,Takamura Y,Ito Y,Kobayashi K,Miya A,Kubota S,Amino N

    更新日期:2012-09-01 00:00:00

  • Cross-sectional area of the median nerve is increased in primary autoimmune hypothyroidism and decreases upon treatment with thyroxine.

    abstract:BACKGROUND:The purpose of this study was to assess changes in the cross-sectional area (CSA) of nervus medianus by ultrasound in newly diagnosed primary hypothyroid patients after thyroxine replacement treatment. PATIENTS AND METHODS:The cohort comprised 30 patients with newly diagnosed primary autoimmune hypothyroidi...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-16-0397

    authors: Holováčová D,Kužma M,Killinger Z,Payer J

    更新日期:2016-10-01 00:00:00

  • Novel inactivating mutations in the GH secretagogue receptor gene in patients with constitutional delay of growth and puberty.

    abstract:BACKGROUND:A limited number of mutations in the GH secretagogue receptor gene (GHSR) have been described in patients with short stature. Objective To analyze GHSR in idiopathic short stature (ISS) children including a subgroup of constitutional delay of growth and puberty (CDGP) patients. SUBJECTS AND METHODS:The GHSR...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-11-0168

    authors: Pugliese-Pires PN,Fortin JP,Arthur T,Latronico AC,Mendonca BB,Villares SM,Arnhold IJ,Kopin AS,Jorge AA

    更新日期:2011-08-01 00:00:00

  • Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates.

    abstract::The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cort...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1440319

    authors: Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri F

    更新日期:2001-04-01 00:00:00

  • Effects of leptin on secretion of LH and FSH from primary cultured female rat pituitary cells.

    abstract:BACKGROUND:Leptin, which is the product of the obese gene, is believed to play important roles in pubertal development and reproductive function in females. In a study using adult male rats, it was found that leptin stimulated secretion of gonadotropin from the pituitary in a dose-related manner. However, there has bee...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1440653

    authors: Ogura K,Irahara M,Kiyokawa M,Tezuka M,Matsuzaki T,Yasui T,Kamada M,Aono T

    更新日期:2001-06-01 00:00:00

  • Influence of gender, age and renal function on plasma adiponectin level: the Tanno and Sobetsu study.

    abstract:DESIGN:The aim of this study was to determine the association between aging and adiponectin level from the aspect of the influence of renal function and sex hormones in humans. METHODS:Serum adiponectin and blood urea nitrogen (BUN) levels were measured in 964 subjects (372 males) aged 60.3+/-12.5 years. Testosterone ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.01930

    authors: Isobe T,Saitoh S,Takagi S,Takeuchi H,Chiba Y,Katoh N,Shimamoto K

    更新日期:2005-07-01 00:00:00

  • Postablation (131)I scintigraphy with neck and thorax SPECT-CT and stimulated serum thyroglobulin level predict the outcome of patients with differentiated thyroid cancer.

    abstract:OBJECTIVE:Neck and thorax single photon emission computed tomography with computed tomography (SPECT-CT) improves the reliability of postablation (131)I whole-body scan (WBS) for differentiated thyroid cancer (DTC). The aim of this study was to assess the prognostic value for persistent or recurrent disease of postabla...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-11-0156

    authors: Ciappuccini R,Heutte N,Trzepla G,Rame JP,Vaur D,Aide N,Bardet S

    更新日期:2011-06-01 00:00:00

  • Pituitary-ovarian dysfunction in rats with induced nephrotic syndrome.

    abstract::The reproductive hormonal profile was evaluated in female rats with experimental nephrotic syndrome induced with a single subcutaneous dose of puromycin aminonucleoside (PAN). Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P4), testosterone and 17 beta-estradiol (E2...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1320502

    authors: Menjívar M,Vilchis F,Cárdenas M,Cruz C,Merchant H,Pérez-Palacios G,Pedraza-Chaverri J

    更新日期:1995-04-01 00:00:00

  • The impact of levothyroxine sodium treatment on oxidative stress in Hashimoto's thyroiditis.

    abstract:OBJECTIVE:Although several studies reported increased oxidative stress in Hashimoto's thyroiditis (HT), the effect of levothyroxine treatment on oxidative status is not studied extensively. Therefore, we conducted this study to investigate the effects of levothyroxine replacement on oxidative stress in HT. DESIGN AND ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-15-1061

    authors: Ates I,Altay M,Yilmaz FM,Topcuoglu C,Yilmaz N,Berker D,Guler S

    更新日期:2016-06-01 00:00:00

  • Anti-hypothalamus and anti-pituitary antibodies may contribute to perpetuate the hypopituitarism in patients with Sheehan's syndrome.

    abstract:OBJECTIVE:While anti-pituitary antibodies (APAs) were detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far. DESIGN:The aim of this study ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-07-0647

    authors: De Bellis A,Kelestimur F,Sinisi AA,Ruocco G,Tirelli G,Battaglia M,Bellastella G,Conzo G,Tanriverdi F,Unluhizarci K,Bizzarro A,Bellastella A

    更新日期:2008-02-01 00:00:00

  • Possible delayed diagnosis and treatment of metastatic differentiated thyroid cancer by adopting the 2015 ATA guidelines.

    abstract:OBJECTIVE:According to the 2015 American Thyroid Association (ATA) guidelines, thyroid ablation by iodine-131 (I-131) therapy is absolutely recommended only in patients with high-risk differentiated thyroid cancer (DTC). Often distant metastases are not recognized early and they can stay silent for long time. The aim o...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-18-0253

    authors: Albano D,Bertagna F,Bonacina M,Durmo R,Cerudelli E,Gazzilli M,Panarotto MB,Formenti AM,Mazziotti G,Giustina A,Giubbini R

    更新日期:2018-09-01 00:00:00

  • Radiotherapy for non-functioning pituitary adenomas.

    abstract::The initial management of large non-functioning pituitary adenomas is surgical debulking. In some cases, postoperative radiotherapy (RT) is administered in order to reduce the likelihood of tumour regrowth. Historically, there have been concerns surrounding a number of potentially significant complications of pituitar...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1440569

    authors: Boelaert K,Gittoes NJ

    更新日期:2001-06-01 00:00:00

  • Cellular alterations in pituitary tumors.

    abstract::In the last few years, molecular studies on pituitary adenomas have yielded evidence supporting a primary pituitary origin of these tumors. Although the existence of genomic alterations in tumoral cells is strongly suggested by the fact that almost all pituitary adenomas are monoclonal in origin, structural genetic ab...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1300043

    authors: Spada A,Vallar L,Faglia G

    更新日期:1994-01-01 00:00:00

  • Biology of the gonadotropin-releasing hormone system in gynecological cancers.

    abstract::The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1460001

    authors: Gründker C,Günthert AR,Westphalen S,Emons G

    更新日期:2002-01-01 00:00:00

  • Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study.

    abstract:AIM:It is widely known that inflammation is related to type 2 diabetes (T2D), but few studies have shown a direct relationship between the immune system and T2D using a reliable biomarker. Neutrophil:lymphocyte ratio (NLR) is an easy-to-analyze inflammation biomarker, but few studies have assessed the relationship betw...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1530/EJE-15-0176

    authors: Guo X,Zhang S,Zhang Q,Liu L,Wu H,Du H,Shi H,Wang C,Xia Y,Liu X,Li C,Sun S,Wang X,Zhou M,Huang G,Jia Q,Zhao H,Song K,Niu K

    更新日期:2015-08-01 00:00:00

  • Relationship between calcitrophic hormones and blood pressure in elderly subjects.

    abstract::The relationship between calcitrophic hormones and blood pressure has been investigated in 583 elderly subjects who were untreated for hypertension. Univariate analysis demonstrated that serum parathyroid hormone, calcitriol, albumin and calcium were correlated significantly with mean blood pressure (r = +0.15, +0.10,...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1300446

    authors: St John A,Dick I,Hoad K,Retallack R,Welborn T,Prince R

    更新日期:1994-05-01 00:00:00

  • Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women.

    abstract:BACKGROUND:Adaptive alterations in maternal physiology cause changes in thyroid hormone levels throughout pregnancy, and precise biochemical evaluation is thus highly dependent on gestation-specific reference intervals and expected intra-individual variation. OBJECTIVE:The aim of the study was the assessment of the in...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-09-0579

    authors: Boas M,Forman JL,Juul A,Feldt-Rasmussen U,Skakkebaek NE,Hilsted L,Chellakooty M,Larsen T,Larsen JF,Petersen JH,Main KM

    更新日期:2009-12-01 00:00:00

  • Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities.

    abstract:OBJECTIVE:Aldosterone binds the mineralocorticoid receptor (MR) and is involved in the regulation of ionic transport, mainly sodium retention. MR is encoded by one single gene transcribed into various messengers that are thought to be translated into a unique 107 kDa protein. The aim of this study was to identify and c...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1500585

    authors: Pascual-Le Tallec L,Demange C,Lombès M

    更新日期:2004-04-01 00:00:00

  • Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review.

    abstract::Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-12-0167

    authors: Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

    更新日期:2012-07-01 00:00:00

  • The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.

    abstract:OBJECTIVE:Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative genes has been limited. DESIGN AND METHODS:One hundred ten patients with primary CH w...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-17-1017

    authors: Sun F,Zhang JX,Yang CY,Gao GQ,Zhu WB,Han B,Zhang LL,Wan YY,Ye XP,Ma YR,Zhang MM,Yang L,Zhang QY,Liu W,Guo CC,Chen G,Zhao SX,Song KY,Song HD

    更新日期:2018-06-01 00:00:00

  • Association between an IGF-I gene polymorphism and body fatness: differences between generations.

    abstract:OBJECTIVE:A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations. DESIGN:Observati...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.02101

    authors: Voorhoeve PG,van Rossum EF,Te Velde SJ,Koper JW,Kemper HC,Lamberts SW,de Waal HA

    更新日期:2006-03-01 00:00:00

  • PRE-TERM BIRTH IN WOMEN EXPOSED TO CUSHING'S DISEASE: THE BABY-CUSH STUDY.

    abstract::Design Hypercortisolism during pregnancy is a risk factor for prematurity. Long-term exposure to hypercortisolism may lead to permanent comorbidities, such as hypertension or diabetes, even after remission. Our aim was to determine whether women with a history of Cushing's disease (and being eu-, hypo- or hypercortiso...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-20-1224

    authors: Hochman C,Cristante J,Geslot A,Salenave S,Sonnet E,Briet C,Bachelot A,Chevalier N,Gilly O,Brue T,Hadjadj S,Kerlan V,Chanson P,Vezzosi D,Chabre O,Drui DD,Castinetti FF

    更新日期:2021-01-01 00:00:00

  • Regulation of the sodium iodide symporter by iodide in FRTL-5 cells.

    abstract:OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1440139

    authors: Eng PH,Cardona GR,Previti MC,Chin WW,Braverman LE

    更新日期:2001-02-01 00:00:00

  • Recommended evaluation of adrenal incidentalomas is costly, has high false-positive rates and confers a risk of fatal cancer that is similar to the risk of the adrenal lesion becoming malignant; time for a rethink?

    abstract:OBJECTIVE:To assess the performance of current clinical recommendations for the evaluation of an adrenal incidentaloma. DESIGN AND METHODS LITERATURE REVIEW: Electronic databases (Pubmed, Ovid and citation searches from key articles) from 1980 to 2008 were searched. Eligible studies were those deemed most applicable to...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-09-0234

    authors: Cawood TJ,Hunt PJ,O'Shea D,Cole D,Soule S

    更新日期:2009-10-01 00:00:00

  • In Reply: The MELAS phenotype may not only be determined by heteroplasmy of causative mtDNA variants.

    abstract::none. ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-20-1426

    authors: Chae HW,Lee YM

    更新日期:2021-01-01 00:00:00

  • Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.

    abstract:OBJECTIVE:Anti-inflammatory glucocorticoid (GC) therapy often induces hyperglycemia due to insulin resistance and islet-cell dysfunction. Incretin-based therapies may preserve glucose tolerance and pancreatic islet-cell function. In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1530/EJE-13-0610

    authors: van Genugten RE,van Raalte DH,Muskiet MH,Heymans MW,Pouwels PJ,Ouwens DM,Mari A,Diamant M

    更新日期:2014-02-04 00:00:00

  • Increased expression of tumor necrosis factor-alpha and decreased expression of thyroglobulin and thyroid peroxidase mRNA levels in the thyroids of iodide-treated BB/Wor rats.

    abstract::Several lines of evidence suggest that tumor necrosis factor-alpha (TNFalpha) may contribute to the pathogenesis of autoimmune thyroid disease. It is not known, however, whether increased thyroidal TNFalpha levels are associated with changes in thyroid function. The purpose of the present study was to utilize in situ ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1390539

    authors: Mori K,Mori M,Stone S,Braverman LE,DeVito WJ

    更新日期:1998-11-01 00:00:00

  • Hyperandrogenism after menopause.

    abstract::Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from either the adrenals and/or the ovaries, clinically manifested as the appearance and/or increase in terminal hair growth or the development of symptoms/signs of virilization. In either settings, physicians need to evalua...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-14-0468

    authors: Markopoulos MC,Kassi E,Alexandraki KI,Mastorakos G,Kaltsas G

    更新日期:2015-02-01 00:00:00