Serum levels of 3alpha-androstanediol glucuronide in hirsute and non hirsute women.

abstract：OBJECTIVE:An inherited profile of genes related to the response to aggressive environmental factors such as viruses and chemicals may be related to an increased susceptibility to Graves' disease (GD). DESIGN AND METHODS:This prospective case-control study was designed to examine the relationship between human herpesvi...

journal_title：European journal of endocrinology

authors： Leite JL,Bufalo NE,Santos RB,Romaldini JH,Ward LS

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:The somatic point mutation in the BRAF gene, which results in a valine-to-glutamate substitution at residue 600 (BRAF(V600E)), is an ideal hallmark of papillary thyroid carcinoma (PTC). However, its prevalence is varyingly reported in different studies, and its expression in the follicular variant PTC is cont...

journal_title：European journal of endocrinology

authors： Sapio MR,Posca D,Troncone G,Pettinato G,Palombini L,Rossi G,Fenzi G,Vitale M

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVES:High variability in clinical response to metformin is often observed in type 2 diabetes (T2D) patients, and it highlights the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this observational study is to evaluate the role of tagSNPs (tagging single nucleot...

journal_title：European journal of endocrinology

authors： Zaharenko L,Kalnina I,Geldnere K,Konrade I,Grinberga S,Židzik J,Javorský M,Lejnieks A,Nikitina-Zake L,Fridmanis D,Peculis R,Radovica-Spalvina I,Hartmane D,Pugovics O,Tkáč I,Klimčáková L,Pīrāgs V,Klovins J

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations. DESIGN:Observati...

journal_title：European journal of endocrinology

authors： Voorhoeve PG,van Rossum EF,Te Velde SJ,Koper JW,Kemper HC,Lamberts SW,de Waal HA

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Epidemiological studies suggest that hypopituitary patients have an increased risk for cardiovascular mortality. The dyslipidaemia associated with this condition is often characterised by an increase in total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol (LDL-C) and may contribute to these f...

journal_title：European journal of endocrinology

authors： Christ ER,Cummings MH,Stolinski M,Jackson N,Lumb PJ,Wierzbicki AS,Sönksen PH,Russell-Jones DL,Umpleby AM

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

journal_title：European journal of endocrinology

authors： Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

更新日期：2013-04-15 00:00:00

abstract：:We investigated the ontogeny of melatonin synthesis during fetal maturation by measuring the melatonin (MLT) and 6-hydroxymelatonin sulfate (MLTS) excretion in the urine of male infants aged 2-7 days and gestational age 26-42 weeks. We found a negative correlation between advancing gestational age and the MLT and MLTS...

journal_title：European journal of endocrinology

authors： Commentz JC,Henke A,Dammann O,Hellwege HH,Willig RP

更新日期：1996-08-01 00:00:00

abstract：:X-linked adrenoleucodystrophy (ALD) has been shown to be one of the most frequent causes of Addison's disease in men. It is characterized by an impaired peroxisomal beta-oxidation of very long chain fatty acids and is associated with mutations of the ALD gene resulting in a defective peroxisomal membrane transport pro...

journal_title：European journal of endocrinology

authors： Korenke GC,Roth C,Krasemann E,Hüfner M,Hunneman DH,Hanefeld F

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:Biallelic TSHR mutations cause congenital hypothyroidism (CH). Serum TSH levels of monoallelic mutation carriers range from normal to mildly elevated, and thus the size of its effect remains unclear. The objectives were to examine the association between monoallelic TSHR mutations and positivity at newborn sc...

journal_title：European journal of endocrinology

authors： Abe K,Narumi S,Suwanai AS,Adachi M,Muroya K,Asakura Y,Nagasaki K,Abe T,Hasegawa T

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Although fibroblast growth factor 23 (FGF23) has been implicated in the pathogenesis of cardiovascular disease, the relationship between FGF23 and cardiovascular disease has not been well characterized in the general population. The aim of this study was to determine whether serum FGF23 is independently assoc...

journal_title：European journal of endocrinology

authors： Dalal M,Sun K,Cappola AR,Ferrucci L,Crasto C,Fried LP,Semba RD

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To compare clinical and humoral parameters before and after surgery in patients with incidental adrenocortical adenomas. DESIGN:Six patients with subclinical Cushing's syndrome and nine with non-functioning adenomas were investigated before and 12 Months after removal of the mass. METHODS:Anthropometric (bo...

journal_title：European journal of endocrinology

authors： Bernini G,Moretti A,Iacconi P,Miccoli P,Nami R,Lucani B,Salvetti A

更新日期：2003-02-01 00:00:00

abstract：:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...

journal_title：European journal of endocrinology

authors： Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To correlate anthropometric, computed tomography and fat cell data from abdominal regions with the levels of serum insulin, C-peptide, leptin, tumor necrosis factor-alpha (TNF-alpha), testosterone, 17beta-estradiol, androstenedione, dehydroepiandrosterone sulphate (DHEA-S) and sex hormone-binding globulin (SH...

journal_title：European journal of endocrinology

authors： Garaulet M,Pérex-Llamas F,Fuente T,Zamora S,Tebar FJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of ...

journal_title：European journal of endocrinology

authors： Wu D,Li L,Yang M,Liu H,Yang G

更新日期：2011-10-01 00:00:00

abstract：:For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging tec...

journal_title：European journal of endocrinology

authors： de Herder WW

更新日期：2014-04-10 00:00:00

abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

journal_title：European journal of endocrinology

authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Individuals carrying a heterozygous inactivating PAX8 mutation are affected by congenital hypothyroidism (CH), although heterozygous Pax8 knockout mice are not. It has remained unclear whether CH in PAX8 mutation carriers is caused by haploinsufficiency or a dominant negative mechanism. OBJECTIVE:To report ...

journal_title：European journal of endocrinology

authors： Narumi S,Araki S,Hori N,Muroya K,Yamamoto Y,Asakura Y,Adachi M,Hasegawa T

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:HDLs have many diverse functions. The goal of this study was to determine the association of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) with the development of type 2 diabetes (T2D). In particular, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D. ...

journal_title：European journal of endocrinology

authors： Hwang YC,Ahn HY,Park SW,Park CY

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:IGF1 is essential for human growth and mediates its effects through the type 1 IGF receptor (IGF1R). Our objective was to determine the frequency of certain previously reported IGF1R gene variants in the normal population and their effect on stature. DESIGN:A cross-sectional study was conducted in a populati...

journal_title：European journal of endocrinology

authors： Kansra AR,Dolan LM,Martin LJ,Deka R,Chernausek SD

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Only a few studies have investigated variations of different markers for inflammatory processes during the physiological menstrual cycle. The results are conflicting, particularly concerning the correlation between the marker leptin and steroid hormones. The aim of the study was to investigate the inflammator...

journal_title：European journal of endocrinology

authors： Wunder DM,Yared M,Bersinger NA,Widmer D,Kretschmer R,Birkhäuser MH

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Somatostatin analogs (SA) are the cornerstone in the medical treatment of acromegaly, used as either primary or adjunctive therapy. In particular, SA are effective in inducing the biochemical remission of the disease and tumor shrinkage, although only few cases of complete disappearance of the pituitary tumo...

journal_title：European journal of endocrinology

authors： Auriemma RS,Galdiero M,Grasso LF,Vitale P,Cozzolino A,Lombardi G,Colao A,Pivonello R

更新日期：2010-05-01 00:00:00

abstract：CONTEXT:The TIMES2 (testosterone replacement in hypogonadal men with either metabolic syndrome or type 2 diabetes) study reported beneficial effects of testosterone replacement therapy (TRT) on insulin resistance and other variables in men with diabetes or metabolic syndrome. The androgen receptor CAG repeat polymorphi...

journal_title：European journal of endocrinology

authors： Stanworth RD,Akhtar S,Channer KS,Jones TH

更新日期：2013-12-21 00:00:00

abstract：OBJECTIVE:Various adjuvant therapies have been introduced along with intensive insulin therapy in patients with recent onset type 1 diabetes. Nicotinamide (NA), administered at diagnosis of the disease, can have beneficial effects on the clinical remission rate, improve metabolic control and preserve or slightly increa...

journal_title：European journal of endocrinology

authors： Crinò A,Schiaffini R,Manfrini S,Mesturino C,Visalli N,Beretta Anguissola G,Suraci C,Pitocco D,Spera S,Corbi S,Matteoli MC,Patera IP,Manca Bitti ML,Bizzarri C,Pozzilli P,IMDIAB group.

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:Chromosomal rearrangements of the RET proto-oncogene is one of the most common molecular events in papillary thyroid carcinoma (PTC). However, their pathogenic role and clinical significance are still debated. This study aimed to investigate the prevalence of RET/PTC rearrangement in a cohort of BRAF WT PTCs ...

journal_title：European journal of endocrinology

authors： Colato C,Vicentini C,Cantara S,Pedron S,Brazzarola P,Marchetti I,Di Coscio G,Chilosi M,Brunelli M,Pacini F,Ferdeghini M

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:McCune-Albright syndrome (MAS) is a disorder caused by a post-zygotic gain-of-function mutation in the gene encoding the Gs-alpha protein. Sexual precocity, common in girls, has been reported in only 15% of boys, and little is known on the long-term evolution of MAS in males. OBJECTIVE:In a boy with MAS, we st...

journal_title：European journal of endocrinology

authors： De Luca F,Mitchell V,Wasniewska M,Arrigo T,Messina MF,Valenzise M,de Sanctis L,Lahlou N

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Though transsphenoidal surgery remains the first-line treatment of Cushing's disease, recurrence occurs frequently. Conventional radiotherapy and anticortisolic drugs both have adverse effects. Stereotactic radiosurgery needs to be evaluated more precisely. The aim of this study was to determine long-term hor...

journal_title：European journal of endocrinology

authors： Castinetti F,Nagai M,Dufour H,Kuhn JM,Morange I,Jaquet P,Conte-Devolx B,Regis J,Brue T

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:This retrospective study describes the role of serum thyroglobulin (Tg) in relation to tumor characteristics in the prediction of persistent/recurrent disease in patients with differentiated thyroid cancer (DTC) with negative Tg at the time of ablation. DESIGN:Between 1989 and 2006, 94 out of 346 (27%) patie...

journal_title：European journal of endocrinology

authors： Phan HT,Jager PL,van der Wal JE,Sluiter WJ,Plukker JT,Dierckx RA,Wolffenbuttel BH,Links TP

更新日期：2008-01-01 00:00:00

abstract：:Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...

journal_title：European journal of endocrinology

authors： Tavares C,Melo M,Cameselle-Teijeiro JM,Soares P,Sobrinho-Simões M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms of TSH receptor (TSHR) activation and intramolecular signal transduction are largely unknown. Deletion of the extracellular domain (ECD) of the TSHR results in increased constitutive activity, which suggests a self-inhibitory interaction between the ECD and the extracellular loops (EC...

journal_title：European journal of endocrinology

authors： Neumann S,Claus M,Paschke R

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults. DESIGN:Randomized double blind clinical trial with 20,000 IU cholecalciferol twice a week, or 20,000 IU once a week plus placebo, or placebo twice a week, for 12 months. All subjects were given 500 mg cal...

journal_title：European journal of endocrinology

authors： Sneve M,Figenschau Y,Jorde R

更新日期：2008-12-01 00:00:00