Abstract:
OBJECTIVE:Most studies on treatment of microprolactinoma have focused on clinical and biochemical outcome rather than on functional and mental well-being. We evaluated this topic in female patients with microprolactinoma, because other pituitary adenomas are associated with decreased quality of life. DESIGN:We conducted a cross-sectional study. PATIENTS AND METHODS:To assess the impact of treatment for microprolactinoma on subjective well-being, quality of life was investigated in 55 female patients (mean age 45 +/- 10 years), treated for microprolactinoma in our center, using four validated, health-related questionnaires: Short-Form-36 (SF-36), Nottingham Health Profile (NHP), Multidimensional Fatigue Inventory (MFI-20), and Hospital Anxiety and Depression Scale (HADS). Patient outcomes were compared with those of 183 female controls with equal age distributions. RESULTS:Anxiety and depression scores were increased when compared with controls for all subscales as measured by HADS, and fatigue for all but one subscale as measured by MFI-20. Patients treated for microprolactinoma had worse scores on social functioning, role limitations due to physical problems (SF-36), energy, emotional reaction, and social isolation (NHP) when compared with control subjects. Important independent predictors of quality of life were reproductive status and anxiety and depression scores according to the HADS. CONCLUSION:Quality of life is impaired in female patients treated for microprolactinoma, especially due to increased anxiety and depression. These increased anxious and depressive feelings might be due to possible effects of hyperprolactinemia on the central nervous system. Failure to recognize this association may adversely affect patient-doctor relationships.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Kars M,van der Klaauw AA,Onstein CS,Pereira AM,Romijn JAdoi
10.1530/EJE-07-0259subject
Has Abstractpub_date
2007-08-01 00:00:00pages
133-9issue
2eissn
0804-4643issn
1479-683Xpii
157/2/133journal_volume
157pub_type
杂志文章abstract:Objective:Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponecti...
journal_title:European journal of endocrinology
pub_type: 杂志文章
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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doi:10.1530/eje.0.1460519
更新日期:2002-04-01 00:00:00
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journal_title:European journal of endocrinology
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abstract::Little is known about patients with malignant digestive neuroendocrine tumours (MD-NETs). Although their incidence is increasing, MD-NETs remain a rare cancer, representing 1% of digestive cancers. Most MD-NETs are well-differentiated. MD-NET poorly differentiated carcinomas account for 20% of cases on average. Anatom...
journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0732
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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journal_title:European journal of endocrinology
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doi:10.1530/eje.0.1460209
更新日期:2002-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-10-21 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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更新日期:1998-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-09-0202
更新日期:2009-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.1.02279
更新日期:2006-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
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更新日期:2002-01-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0014
更新日期:2011-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-08-0639
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journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.0.1370209
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journal_title:European journal of endocrinology
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更新日期:2015-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0286
更新日期:2007-11-01 00:00:00
abstract::The episodicity of 24 h GH release was studied in 18 patients with active acromegaly, 12 patients 7-10 days after pituitary surgery, 14 patients long after operation (3-17 years), and 21 healthy gender- and age-matched control subjects, using a recently introduced scale- and model-independent regularity statistic, app...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1380164
更新日期:1998-02-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-07-0061
更新日期:2007-07-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1480481
更新日期:2003-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.01891
更新日期:2005-04-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1360157
更新日期:1997-02-01 00:00:00