Abstract:
:The episodicity of 24 h GH release was studied in 18 patients with active acromegaly, 12 patients 7-10 days after pituitary surgery, 14 patients long after operation (3-17 years), and 21 healthy gender- and age-matched control subjects, using a recently introduced scale- and model-independent regularity statistic, approximate entropy (ApEn). Blood samples were taken at 10-min intervals for 24 h, and plasma GH concentrations were measured by immunofluorometric assay (detection limit 11.5 ng/l). For this study we selected operated patients who were biochemically in remission, defined by normal circulating IGF-I and insulin-like growth factor-binding protein-3 (IGFBP-3) concentrations, normal glucose-suppressed plasma GH concentration (<0.38 microg/l), and the normalization of the paradoxical rise of GH to TRH or GnRH. In patients with active acromegaly ApEn was 1.23+/-0.04, with no overlap with the control subjects (P = 1.2 x 10[-16]), who had an ApEn of 0.40+/-0.04. ApEn in patients shortly after surgery was 0.71+/-0.09 (P < 0.001 vs controls), and long after surgery 0.56+/-0.05 (P < 0.011 vs controls). ApEn values in treated and untreated patients correlated significantly with the plasma concentration of IGF-I (r=0.531) and IGFBP-3 (r=0.598), and the log-transformed 24h GH secretion rate (r=0.749). Shortly after surgery only one-third of the patients had a normal ApEn value, whereas long after surgery about 70% of the patients had a normal ApEn value. Although ApEn eventually normalized in about 70% of the operated patients, the cause of the persistence of abnormal GH release in the remainder of the subjects is not known, and might reflect permanent hypothalamic-pituitary dysfunction or a very early recurrence of the somatotroph adenoma.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
van den Berg G,Pincus SM,Frölich M,Veldhuis JD,Roelfsema Fdoi
10.1530/eje.0.1380164subject
Has Abstractpub_date
1998-02-01 00:00:00pages
164-9issue
2eissn
0804-4643issn
1479-683Xjournal_volume
138pub_type
杂志文章abstract:OBJECTIVE:This study evaluated the short- and long-term cardiovascular- and cancer-related morbidities during cross-sex hormone therapy in a large sample of trans persons. SUBJECTS AND METHODS:A specialist center cross-sectional study compared 214 trans women (male-to-female transsexual persons) and 138 trans men (fem...
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更新日期:2008-12-01 00:00:00
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更新日期:2021-01-01 00:00:00
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更新日期:2004-04-01 00:00:00
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更新日期:2018-12-01 00:00:00
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更新日期:2016-06-01 00:00:00
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更新日期:1995-08-01 00:00:00
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更新日期:2011-03-01 00:00:00
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更新日期:2001-05-01 00:00:00
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更新日期:2002-12-01 00:00:00
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更新日期:1997-07-01 00:00:00
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