Abstract:
OBJECTIVE:To compare baseline characteristics in adult patients with growth hormone (GH) deficiency (GHD) who had previously been treated for Cushing's disease or acromegaly with data from patients with GHD of other aetiologies. To study the effects of GH therapy in those patients who had completed at least 6 months of GH replacement. DESIGN:Data from a large outcomes research database (KIMS (Pharmacia International Metabolic Database)). METHODS:135 patients were identified with previous Cushing's disease, 40 had had acromegaly, and 1392 had GHD of other aetiologies. The number of additional hormone deficiencies, and the mean age of the patients were similar in the three groups. Similar proportions of patients in each group were treated using surgery, but radiotherapy was used more often in patients with acromegaly than those with other diagnoses. RESULTS:At baseline, the prevalence of diabetes mellitus and hypertension were significantly higher in the group treated for Cushing's disease, and the prevalence of stroke was significantly higher in the group treated for acromegaly. The incidence of coronary heart disease and claudication were similar in all three groups. Patients treated for Cushing's disease had lower bone mineral density and suffered fractures more often than other GHD adults. Body mass index, waist-hip ratio, serum concentrations of lipids and standard deviation scores of serum concentrations of insulin-like-growth factor-I were similar in the three groups. The dose of GH administered was comparable in the three groups and the effects of GH replacement on waist circumference, blood pressure and quality of life were also similar across the groups. The numbers and types of adverse events reported were not different between the groups. CONCLUSIONS:These data suggest that the characteristics of patients in these diagnostic groups depend on the primary disease which resulted in GHD, and that the clinical expression of GHD does not differ between the groups. Patients with previous hypercortisolism showed more long-term effects of their disease, such as diabetes mellitus, hypertension and fractures. A benefit from GH replacement was evident in patients previously treated for acromegaly and Cushing's disease particularly in relation to quality of life.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Feldt-Rasmussen U,Abs R,Bengtsson BA,Bennmarker H,Bramnert M,Hernberg-Ståhl E,Monson JP,Westberg B,Wilton P,Wüster C,KIMS International Study Board of KIMS Study Group.doi
10.1530/eje.0.1460067subject
Has Abstractpub_date
2002-01-01 00:00:00pages
67-74issue
1eissn
0804-4643issn
1479-683Xpii
14667journal_volume
146pub_type
杂志文章abstract:Objective:Fetal exposure to gestational diabetes mellitus (GDM) increases the risk of metabolic diseases in the offspring. Leptin, adiponectin, and fibroblast growth factor 21 (FGF21) may play potential roles in the underlying disease mechanisms. We investigated the impact of fetal exposure to GDM on leptin, adiponecti...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-19-0658
更新日期:2019-12-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
doi:10.1530/eje.0.1390304
更新日期:1998-09-01 00:00:00
abstract::For many years, it has been well documented that combined hormonal contraceptives increase the risk of venous thromboembolism (VTE). The third-generation pill use (desogestrel or gestodene (GSD)) is associated with an increased VTE risk as compared with second-generation (levonorgestrel) pill use. Other progestins suc...
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pub_type: 杂志文章,评审
doi:10.1530/EJE-14-0527
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:Many reports demonstrate improvements in cardiovascular risk factors during GH replacement (rhGH) in adult GH deficiency (GHD). However, it remains to be determined to what extent these changes translate into a reduction of increased cardiovascular morbidity and mortality. The aim of this study was to evalua...
journal_title:European journal of endocrinology
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doi:10.1530/EJE-06-0699
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Fetal growth restriction (FGR) has been related to several health risks, which have been generally identified in small-for-gestational age (SGA) individuals. OBJECTIVE:To evaluate the impact of FGR on body composition and hormonal status in infants born either small- or appropriate-for-gestational age (AGA)...
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pub_type: 杂志文章
doi:10.1530/EJE-07-0286
更新日期:2007-11-01 00:00:00
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更新日期:2006-11-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 共识发展会议,杂志文章,评审
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更新日期:2014-08-01 00:00:00
abstract::Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-gener...
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更新日期:2018-03-01 00:00:00
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更新日期:2002-10-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-10-0192
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1320206
更新日期:1995-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0577
更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EJE-11-0512
更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1410231
更新日期:1999-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1370040
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pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-19-0082
更新日期:2019-06-01 00:00:00
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doi:10.1530/EJE-07-0502
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1410585
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更新日期:2002-09-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1320502
更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/EJE-16-0668
更新日期:2017-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.1.02047
更新日期:2005-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1380562
更新日期:1998-05-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-02-20 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1320144
更新日期:1995-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1530/eje.0.1300446
更新日期:1994-05-01 00:00:00
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journal_title:European journal of endocrinology
pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-09-01 00:00:00