Abstract:
OBJECTIVES:Evidence of the association between vitamin D and cardiovascular risk factors in the young is limited. We therefore assessed the relationships between circulating 25-hydroxyvitamin D(3) (25(OH)D(3)) and metabolic syndrome (MetS), its components, and early atherosclerotic changes in 452 (304 overweight/obese and 148 healthy, normal weight) Caucasian children. METHODS:We determined serum 25(OH)D(3) concentrations in relation to MetS, its components (central obesity, hypertension, low high-density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, glucose impairment, and/or insulin resistance (IR)), and impairment of flow-mediated vasodilatation (FMD) and increased carotid intima-media thickness (cIMT) - two markers of subclinical atherosclerosis. RESULTS:Higher 25(OH)D(3) was significantly associated with a reduced presence of MetS. Obesity, central obesity, hypertension, hypertriglyceridemia, low HDL-cholesterol, IR, and MetS were all associated with increased odds of having low 25(OH)D(3) levels, after adjustment for age, sex, and Tanner stage. After additional adjustment for SDS-body mass index, elevated blood pressure (BP) and MetS remained significantly associated with low vitamin D status. The adjusted odds ratio (95% confidence interval) for those in the lowest (<17 ng/ml) compared with the highest tertile (>27 ng/ml) of 25(OH)D(3) for hypertension was 1.72 (1.02-2.92), and for MetS, it was 2.30 (1.20-4.40). A similar pattern of association between 25(OH)D(3), high BP, and MetS was observed when models were adjusted for waist circumference. No correlation was found between 25(OH)D(3) concentrations and either FMD or cIMT. CONCLUSIONS:Low 25(OH)D(3) levels in Caucasian children are inversely related to total adiposity, MetS, and hypertension.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Pacifico L,Anania C,Osborn JF,Ferraro F,Bonci E,Olivero E,Chiesa Cdoi
10.1530/EJE-11-0545subject
Has Abstractpub_date
2011-10-01 00:00:00pages
603-11issue
4eissn
0804-4643issn
1479-683Xpii
EJE-11-0545journal_volume
165pub_type
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更新日期:2002-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1995-04-01 00:00:00
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更新日期:1997-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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更新日期:2013-10-01 00:00:00
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更新日期:2008-02-01 00:00:00
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更新日期:2002-06-01 00:00:00
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更新日期:2020-05-01 00:00:00
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更新日期:2012-07-01 00:00:00
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更新日期:2001-06-01 00:00:00
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更新日期:2013-12-21 00:00:00