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Negative correlation between thyroperoxidase and dual oxidase H2O2-generating activities in thyroid nodular lesions.

Abstract：

:Iodine incorporation into thyroglobulin is dependent on the activities of both thyroperoxidase (TPO) and thyroid dual oxidase 2 (DuOx2). Although TPO expression is decreased in some thyroid nodular lesions, DuOx1 and 2 mRNA expressions are maintained, but DuOx H2O2-generating activity has never been evaluated in such tumors. Our goal was to determine DuOx activity in hypofunctioning lesions of the thyroid. We evaluated H2O2 generation by DuOx in 12 paranodular to cold nodule samples, 17 non-toxic multinodular goiters (MNG; 33 samples), 3 papillary carcinomas (PC; 4 samples), 3 follicular carcinomas (FC; 4 samples), and 10 follicular adenomas. DuOx activity was detected in all paranodular tissues (121+/-23 nmol H2O2/h per mg protein), but was undetectable (<1 nmol H2O2 generated) in all PC, two out of four FC samples and seven out of ten adenomas. In 11 MNG at least two different areas of the goiter have been evaluated, and in 5 of these goiters one of the samples had DuOx activity below the limit of detection. The coefficient of variation in MNG samples ranged from 11.3 to 57.2%. Interestingly, in all the adenomas studied, TPO activity (486+/-142 U/g protein, n=8) was well within the range found in paranodular tissues (414+/-116 U/g protein, n=3). We found a significant negative correlation between DuOx and TPO activities, suggesting that these enzymes are regulated in opposite directions, at least in thyroid tumors.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Ginabreda MG,Cardoso LC,Nobrega FM,Ferreira AC,Gonçalves MD,Vaisman M,Carvalho DP

doi

10.1530/EJE-07-0602

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

223-7

issue

2

eissn

0804-4643

issn

1479-683X

pii

158/2/223

journal_volume

158

pub_type

杂志文章

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