Childhood thyroid function, body composition and cardiovascular function.

abstract：OBJECTIVE:Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim wa...

journal_title：European journal of endocrinology

authors： Gallo M,Aragno M,Gatto V,Tamagno E,Brignardello E,Manti R,Danni O,Boccuzzi G

更新日期：1999-07-01 00:00:00

abstract：:Skeletal anabolic agents enhance bone formation, which is determined by the number and function of osteoblasts. Signals that influence the differentiation and function of cells of the osteoblast lineage play a role in the mechanism of action of anabolic agents in the skeleton. Wnts induce the differentiation of mesenc...

journal_title：European journal of endocrinology

authors： Canalis E

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of long-term GH in GH-deficient adults, as predicted by IGF-I levels. METHODS:Patients received GH, 5 microg/kg per day for 1 Month and 10 microg/kg per day for another 12-30 Months. Changes in body composition, cardiac structure/function, serum lipids and quality of life were meas...

journal_title：European journal of endocrinology

authors： Ezzat S,Fear S,Gaillard RC,Gayle C,Marcovitz S,Mattioni T,Nussey S,Rees A,Svanberg E

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:Surgery remains a common form of treatment for sellar and parasellar tumors involving the pituitary gland and adjacent structures. Studies have suggested that pituitary surgery procedures performed at high-volume centers are associated with less adverse outcomes, yet it remains unclear which types of patients...

journal_title：European journal of endocrinology

authors： Mukherjee D,Zaidi HA,Kosztowski T,Chaichana KL,Salvatori R,Chang DC,Quiñones-Hinojosa A

更新日期：2009-08-01 00:00:00

abstract：Objectives:Inoperable or metastatic paragangliomas (PGLs) and malignant pheochromocytomas (PCCs) are rare tumours with limited options for systemic treatment. Aim of this study was to assess the safety and efficacy of the radiolabelled somatostatin analogue (177LutetiumDOTA0-Tyr3)octreotate (177Lu-DOTATATE) for the tre...

journal_title：European journal of endocrinology

authors： Zandee WT,Feelders RA,Smit Duijzentkunst DA,Hofland J,Metselaar RM,Oldenburg RA,van Linge A,Kam BLR,Teunissen JJM,Korpershoek E,Hendriks JM,Abusaris H,Slagter C,Franssen GJH,Brabander T,De Herder WW

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Non-thyroidal illness (NTI) is associated with alterations in thyroid hormone metabolism. Whether morphological changes of the thyroid gland accompany NTI is unknown. The aim of the present study was to describe thyroid morphology in patients with lethal non-thyroidal disease. DESIGN:In an autopsy study 267 ...

journal_title：European journal of endocrinology

authors： De Jongh FE,Jöbsis AC,Elte JW

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:The current guidelines for the management of adrenal incidentaloma advise hormonal and radiological follow-up of patients for 2-5 years after the initial diagnosis. However, the vast majority of adrenal incidentaloma are non-functional benign cortical adenomas that require no treatment, so the routine applica...

journal_title：European journal of endocrinology

authors： Kastelan D,Kraljevic I,Dusek T,Knezevic N,Solak M,Gardijan B,Kralik M,Poljicanin T,Skoric-Polovina T,Kastelan Z

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND/AIM:Our previous studies showed that administration of dexamethasone plus food increased serum leptin levels 100% more than dexamethasone alone. We hypothesized that this increase in leptin from the meal could result directly from the provision of fuel metabolites rather than from the meal-induced rise in in...

journal_title：European journal of endocrinology

authors： Garcia-Lorda P,Nash W,Roche A,Pi-Sunyer FX,Laferrere B

更新日期：2003-06-01 00:00:00

abstract：:For patients with neuroendocrine tumours (NETs) of the gastrointestinal tract and pancreas (GEP) (GEP-NETs), excellent care should ideally be provided by a multidisciplinary team of skilled health care professionals. In these patients, a combination of nuclear medicine imaging and conventional radiological imaging tec...

journal_title：European journal of endocrinology

authors： de Herder WW

更新日期：2014-04-10 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the influence of age on the association between thyroid function and mortality. DESIGN:The Nijmegen Biomedical Study is a population-based study, comprising 5816 randomly selected adults of all age groups without previously known thyroid disease. METHODS:TSH, free th...

journal_title：European journal of endocrinology

authors： van de Ven AC,Netea-Maier RT,de Vegt F,Ross HA,Sweep FC,Kiemeney LA,Smit JW,Hermus AR,den Heijer M

更新日期：2014-08-01 00:00:00

abstract：:Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) micrograms/l [median (standard error of m...

journal_title：European journal of endocrinology

authors： Marek J,Hána V,Krsek M,Justová V,Catus F,Thomas F

更新日期：1994-07-01 00:00:00

abstract：Objective:Several clinical studies have reported that renal impairments are sometimes observed in patients with primary aldosteronism (PA). We analyzed the prevalence of renal impairments in PA patients and identified parameters that increase the risk for them. Design:This is a retrospective cross-sectional study. We ...

journal_title：European journal of endocrinology

authors： Kawashima A,Sone M,Inagaki N,Takeda Y,Itoh H,Kurihara I,Umakoshi H,Ichijo T,Katabami T,Wada N,Ogawa Y,Kawashima J,Fujita M,Miyauchi S,Okamura S,Fukuoka T,Yanase T,Izawa S,Yoshikawa Y,Hashimoto S,Yamada M,Kai T,

更新日期：2019-09-01 00:00:00

abstract：:123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy scanning is commonly used in the imaging of phaeochromocytoma (and paraganglioma) to confirm the site of disease and whether any spread has occurred. However, 123I-MIBG imaging is negative in 15% of cases of benign phaeochromocytoma and around 50% of cases of malig...

journal_title：European journal of endocrinology

authors： Mackenzie IS,Gurnell M,Balan KK,Simpson H,Chatterjee K,Brown MJ

更新日期：2007-10-01 00:00:00

abstract：:Nitric oxide mediates a wide array of cellular functions in many tissues. It is generated by three known isoforms of nitric oxide synthases (NOS). Recently, the endothelial isoform, NOSIII, was shown to be abundantly expressed in the rat thyroid gland and its expression increased in goitrous glands. In this study, we ...

journal_title：European journal of endocrinology

authors： Colin IM,Kopp P,Zbären J,Häberli A,Grizzle WE,Jameson JL

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:The purpose of this population-based prospective cohort study was to examine the effect of hormone therapy (HT) on incidence of diabetes mellitus (DM). DESIGN AND METHODS:Eight thousand four hundred and eighty-three DM-free post-menopausal women aged 52-62 from the population-based Kuopio osteoporosis risk ...

journal_title：European journal of endocrinology

authors： Pentti K,Tuppurainen MT,Honkanen R,Sandini L,Kröger H,Alhava E,Saarikoski S

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Circulating IGF1 declines with age while ill-health increases. Controversy remains whether differences in the levels of IGF1 and its binding proteins 1 and 3 (IGFBP1 and IGFBP3) determine health outcomes during ageing. We examined associations of IGF1, IGFBP1 and IGFBP3 with all-cause and cardiovascular morta...

journal_title：European journal of endocrinology

authors： Yeap BB,Chubb SA,McCaul KA,Ho KK,Hankey GJ,Norman PE,Flicker L

更新日期：2011-05-01 00:00:00

abstract：:Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack ...

journal_title：European journal of endocrinology

authors： Chanson P,Dormoy A,Dekkers OM

更新日期：2019-07-01 00:00:00

abstract：:Puberty is the result of increasing pulsatile secretion of the hypothalamic gonadotropin releasing hormone (GnRH), which stimulates the release of gonadotropins and in turn gonadal activity. In general in females, development of secondary sex characteristics due to the activity of the gonadal axis, i.e., the growth of...

journal_title：European journal of endocrinology

authors： Delemarre EM,Felius B,Delemarre-van de Waal HA

更新日期：2008-12-01 00:00:00

abstract：Objective:Retrospective studies suggest that women have more active brown adipose tissue (BAT) than men, but little is known of the effect of fluctuating sex steroids across the menstrual cycle on thermogenesis in women. Design:To characterise the effects of sex and sex steroids on BAT activity we recruited healthy we...

journal_title：European journal of endocrinology

authors： Fuller-Jackson JP,Dordevic AL,Clarke IJ,Henry BA

更新日期：2020-09-01 00:00:00

abstract：:The relationship between calcitrophic hormones and blood pressure has been investigated in 583 elderly subjects who were untreated for hypertension. Univariate analysis demonstrated that serum parathyroid hormone, calcitriol, albumin and calcium were correlated significantly with mean blood pressure (r = +0.15, +0.10,...

journal_title：European journal of endocrinology

authors： St John A,Dick I,Hoad K,Retallack R,Welborn T,Prince R

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:Smaller size at birth has been associated with an increased risk of metabolic and cardiovascular disorders in adult life. Fetal programming of the hypothalamic-pituitary-adrenal axis has been suggested as a possible explanation. Fetal glucocorticoid (GC) overexposure has effects that suggest a role of GCs in ...

journal_title：European journal of endocrinology

authors： Manenschijn L,van den Akker EL,Ester WA,Leunissen RW,Willemsen RH,van Rossum EF,Koper JW,Lamberts SW,Hokken-Koelega AC

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:To study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications. DESIGN:Cross-sectional. MATERIALS AND METHODS:All patients (n=177) undergoing diagnostic evaluation and ...

journal_title：European journal of endocrinology

authors： Starup-Linde J,Waldhauer E,Rolighed L,Mosekilde L,Vestergaard P

更新日期：2012-06-01 00:00:00

abstract：:Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet's effects in patien...

journal_title：European journal of endocrinology

authors： Kawata T,Imanishi Y,Kobayashi K,Kenko T,Wada M,Ishimura E,Miki T,Nagano N,Inaba M,Arnold A,Nishizawa Y

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:In genetically predisposed individuals, exogenous factors (including pollution) influence the development of Hashimoto's thyroiditis/chronic lymphocytic thyroiditis (CLT). CLT may also be a risk factor for associated thyroid cancer. Few data are available on the role of pollution from petrochemical complex...

journal_title：European journal of endocrinology

authors： Arena S,Latina A,Baratta R,Burgio G,Gullo D,Benvenga S

更新日期：2015-04-01 00:00:00

abstract：:The study was undertaken to investigate the interaction between the release of endothelin-1 (ET-1) and prolactin (PRL) from human decidualized endometrial cells, and the effects of transforming growth factor (TGF)-beta 1 on the release of ET-1 and PRL from human decidual cells in the early stage of pregnancy. Stromal ...

journal_title：European journal of endocrinology

authors： Kubota T,Taguchi M,Kobayashi K,Masuda M,Aso T

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:To control postprandial hyperglycemia in insulin-treated type 2 diabetic patients, prandial therapy with regular human insulin (HI) or fast acting insulin analogs is used. Postprandial hyperglycemia seems to be reduced more effectively with insulin analogs than with normal insulin, but there are no data conce...

journal_title：European journal of endocrinology

authors： Sourij H,Schmoelzer I,de Campo A,Tripolt NJ,Stojakovic T,Scharnagl H,Kettler-Schmut E,Forst T,Wascher TC

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Binding of thyroglobulin (Tg) to heparin allows efficient Tg interaction with its endocytic receptor, megalin. Rat Tg (rTg) binds to heparin using an exposed carboxyl terminal region (RELPSRRLKRPLPVK, Arg2489-Lys2503) rich in positively charged residues which is, however, not entirely conserved in human Tg (h...

journal_title：European journal of endocrinology

authors： Lisi S,Pinchera A,McCluskey RT,Chiovato L,Marinò M

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:The human androgen receptor (AR) gene contains two polymorphisms of CAG and GGN repeats respectively. The GGN repeat function is still largely unknown and to date there are no in vivo data on this segment with respect to the general population. METHODS:We investigated the impact of CAG and GGN repeats on ma...

journal_title：European journal of endocrinology

authors： Lundin KB,Giwercman YL,Rylander L,Hagmar L,Giwercman A

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Vitamin D insufficiency is common in primary hyperparathyroidism (pHPT). Patients with pHPT frequently have a reduced health-related quality of life (HRQoL). Our objectives were to evaluate whether HRQoL in pHPT is associated with vitamin D insufficiency and whether vitamin D supplementation after parathyroid...

journal_title：European journal of endocrinology

authors： Åberg V,Norenstedt S,Zedenius J,Sääf M,Nordenström J,Pernow Y,Nilsson IL

更新日期：2015-02-01 00:00:00

abstract：CONTEXT:Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE:To improve the diagnostic accuracy of GH-releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI and sex and established normative data for an automatic immunoassay sp...

journal_title：European journal of endocrinology

authors： Deutschbein T,Bidlingmaier M,Schopohl J,Strasburger CJ,Petersenn S

更新日期：2017-03-01 00:00:00