Anthropometric factors have significant influence on the outcome of the GHRH-arginine test: establishment of normative data for an automated immunoassay specifically measuring 22 kDa human growth hormone.

abstract：BACKGROUND:Phytosterolaemia (sitosterolaemia) is a rare autosomal recessive condition caused by mutations on the ABCG5 and ABCG8 gut transporter proteins. This leads to accumulation of plant-derived cholesterol-like molecules in blood and tissues. CASE:We describe a family of Bangladesh origin, where three siblings (t...

journal_title：European journal of endocrinology

authors： Mushtaq T,Wales JK,Wright NP

更新日期：2007-08-01 00:00:00

abstract：:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...

journal_title：European journal of endocrinology

authors： Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

更新日期：2012-07-01 00:00:00

abstract：Objective:The challenge of finding patients with the rare conditon of diabetes insipidus in need of vasopressin treatment is demanding. The guidelines for performing the fluid deprivation test and interpreting the results are abundant. We evaluated the discriminative capacity of the fluid deprivation test in patients w...

journal_title：European journal of endocrinology

authors： Sjöström A,Bartuseviciene I,Höybye C

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:This study evaluated the short- and long-term cardiovascular- and cancer-related morbidities during cross-sex hormone therapy in a large sample of trans persons. SUBJECTS AND METHODS:A specialist center cross-sectional study compared 214 trans women (male-to-female transsexual persons) and 138 trans men (fem...

journal_title：European journal of endocrinology

authors： Wierckx K,Elaut E,Declercq E,Heylens G,De Cuypere G,Taes Y,Kaufman JM,T'Sjoen G

更新日期：2013-09-13 00:00:00

abstract：BACKGROUND:Familial neurohypophyseal (central) diabetes insipidus (DI) is caused by mutations in the arginine vasopressin-neurophysin II (AVP-NPII) gene. The majority of cases is inherited in an autosomal dominant way. In this study, we present the clinical features of a mother and her son with autosomal dominant neuro...

journal_title：European journal of endocrinology

authors： de Fost M,van Trotsenburg AS,van Santen HM,Endert E,van den Elzen C,Kamsteeg EJ,Swaab DF,Fliers E

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:In view of their different actions on thyroid hormone receptor (TR) isoforms we set out to investigate whether amiodarone (AM) and dronedarone (Dron) have different and/or component-specific effects on cardiac gene expression. DESIGN:Rats were treated with AM or Dron and the expression of TRalpha 1, TRalpha ...

journal_title：European journal of endocrinology

authors： Stoykov I,van Beeren HC,Moorman AF,Christoffels VM,Wiersinga WM,Bakker O

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. DESIGN AND METHODS:Study cohort included 8...

journal_title：European journal of endocrinology

authors： Vierimaa O,Ebeling TM,Kytölä S,Bloigu R,Eloranta E,Salmi J,Korpi-Hyövälti E,Niskanen L,Orvola A,Elovaara E,Gynther A,Sane T,Välimäki M,Ignatius J,Leisti J,Salmela PI

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:11beta-Hydroxylase and aldosterone synthase are two highly homologous genes involved in different forms of human hypertension and in different animal models of hypertension. It has been shown that the conservative substitution D147E in the human CYP11B2 gene results in an increased production of corticosteron...

journal_title：European journal of endocrinology

authors： Mulatero P,Glorioso N,Fallo F,Soro A,Morra di Cella S,Carra R,Filigheddu F,Veglio F

更新日期：2001-04-01 00:00:00

abstract：:Context Abnormalities in the hypothalamo-pituitary-gonadal axis have long been reported in Noonan syndrome (NS) males with only few data available in prepubertal children. Objective The aim of this study was to describe the gonadal function of NS males from childhood to adulthood. Design It is a retrospective chart re...

journal_title：European journal of endocrinology

authors： Moniez S,Pienkowski C,Lepage B,Hamdi S,Daudin M,Oliver I,Jouret B,Cartault A,Diene G,Verloes A,Cavé H,Salles JP,Tauber M,Yart A,Edouard T

更新日期：2018-12-01 00:00:00

abstract：:Low levels of insulin-like growth factor I (IGF-I) in critical illness are observed despite increased or normal levels of growth hormone (GH). The mechanisms for this apparent GH resistance have not been elucidated. As many of the acute inflammatory responses in critical illness are mediated by the proinflammatory cyt...

journal_title：European journal of endocrinology

authors： Wolf M,Böhm S,Brand M,Kreymann G

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular mortality and morbidity. Little is known about hemostatic features of patients with PHPT. To our knowledge, plasma tissue factor pathway inhibitor (TFPI) and thrombin-activatable fibrinolysis inhibitor (TAFI) levels...

journal_title：European journal of endocrinology

authors： Erem C,Kocak M,Nuhoglu I,Yilmaz M,Ucuncu O

更新日期：2009-05-01 00:00:00

abstract：Objective:With increasing migration to Europe, diabetes diagnosis and treatment of refugees became challenging. To describe the current experience with pediatric refugees in Germany and Austria. Design and Methods:43,137 patients (<21 years) with type 1 diabetes from the diabetes patient follow-up registry (DPV) were ...

journal_title：European journal of endocrinology

authors： Prinz N,Konrad K,Brack C,Hahn E,Herbst A,Icks A,Grulich-Henn J,Jorch N,Kastendieck C,Mönkemöller K,Razum O,Steigleder-Schweiger C,Witsch M,Holl RW

更新日期：2019-07-01 00:00:00

abstract：:X-linked adrenoleucodystrophy (ALD) has been shown to be one of the most frequent causes of Addison's disease in men. It is characterized by an impaired peroxisomal beta-oxidation of very long chain fatty acids and is associated with mutations of the ALD gene resulting in a defective peroxisomal membrane transport pro...

journal_title：European journal of endocrinology

authors： Korenke GC,Roth C,Krasemann E,Hüfner M,Hunneman DH,Hanefeld F

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of thyroid dysfunction (TD) and IgG subclasses of thyroid autoantibodies (TAs) and to determine the predictive factors of TD in chronic hepatitis C (CHC) patients. DESIGN:Three hundred and twelve untreated hepatitis C virus-infected patients without a history of TD or treatment ...

journal_title：European journal of endocrinology

authors： Shao C,Huo N,Zhao L,Gao Y,Fan X,Zheng Y,Wang L,Lu H,Xu X,Guo X

更新日期：2013-04-15 00:00:00

abstract：:In the last few years, molecular studies on pituitary adenomas have yielded evidence supporting a primary pituitary origin of these tumors. Although the existence of genomic alterations in tumoral cells is strongly suggested by the fact that almost all pituitary adenomas are monoclonal in origin, structural genetic ab...

journal_title：European journal of endocrinology

authors： Spada A,Vallar L,Faglia G

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE:The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematolog...

journal_title：European journal of endocrinology

authors： Vivanco M,Dalle JH,Alberti C,Lescoeur B,Yakouben K,Carel JC,Baruchel A,Léger J

更新日期：2012-08-01 00:00:00

abstract：:Acromegaly is associated with high morbidity and elevated mortality when not adequately treated. Surgery is the first-line treatment for most patients as it is the only one that can lead to immediate cure. In patients who are not cured by surgery, treatment is currently based on a trial-and-error approach. First-gener...

journal_title：European journal of endocrinology

authors： Kasuki L,Wildemberg LE,Gadelha MR

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:We have studied the effect of tryptophan on cellular [(125)I]tri-iodothyronine (T3) uptake by mouse thymocytes. MATERIALS AND METHODS:Mouse thymocytes (20 x 10(6 )cells/ml) were suspended in Krebs-Ringer solution buffered by Tris-HCl and incubation (23 degrees C at pH7.45+/-0.6), in the presence or absence o...

journal_title：European journal of endocrinology

authors： Centanni M,Canettieri G,Viceconti N,Sibilla R,Bei A,Andreoli M

更新日期：2000-07-01 00:00:00

abstract：:Sex steroids are important for the growth and maintenance of both the female and the male skeleton. However, the relative contribution of androgens versus estrogens in the regulation of the male skeleton is unclear. Experiments using mice with inactivated sex steroid receptors demonstrated that both activation of the ...

journal_title：European journal of endocrinology

authors： Ohlsson C,Vandenput L

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:The kisspeptin/GPR54 pathway has been proven to be crucial in the process of puberty onset, yet the polymorphisms in the KISS1 gene and their relationships with central precocious puberty (CPP) have not been investigated. This study was performed to reveal the relationship between the gene and the disease. D...

journal_title：European journal of endocrinology

authors： Luan X,Zhou Y,Wang W,Yu H,Li P,Gan X,Wei D,Xiao J

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...

journal_title：European journal of endocrinology

authors： Fahlbusch R,Keller Bv,Ganslandt O,Kreutzer J,Nimsky C

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:While anti-pituitary antibodies (APAs) were detected in some patients with Sheehan's syndrome (SS) suggesting an autoimmune pituitary involvement in the development of their hypopituitarism, hypothalamic cell anti-hypothalamus antibodies (AHAs) have not been investigated so far. DESIGN:The aim of this study ...

journal_title：European journal of endocrinology

authors： De Bellis A,Kelestimur F,Sinisi AA,Ruocco G,Tirelli G,Battaglia M,Bellastella G,Conzo G,Tanriverdi F,Unluhizarci K,Bizzarro A,Bellastella A

更新日期：2008-02-01 00:00:00

abstract：Objective:Several clinical studies have reported that renal impairments are sometimes observed in patients with primary aldosteronism (PA). We analyzed the prevalence of renal impairments in PA patients and identified parameters that increase the risk for them. Design:This is a retrospective cross-sectional study. We ...

journal_title：European journal of endocrinology

authors： Kawashima A,Sone M,Inagaki N,Takeda Y,Itoh H,Kurihara I,Umakoshi H,Ichijo T,Katabami T,Wada N,Ogawa Y,Kawashima J,Fujita M,Miyauchi S,Okamura S,Fukuoka T,Yanase T,Izawa S,Yoshikawa Y,Hashimoto S,Yamada M,Kai T,

更新日期：2019-09-01 00:00:00

abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

journal_title：European journal of endocrinology

authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

更新日期：1994-08-01 00:00:00

abstract：:Nelson's syndrome is a potentially life-threatening condition that does not infrequently develop following total bilateral adrenalectomy (TBA) for the treatment of Cushing's disease. In this review article, we discuss some controversial aspects of Nelson's syndrome including diagnosis, predictive factors, aetiology, p...

journal_title：European journal of endocrinology

authors： Barber TM,Adams E,Ansorge O,Byrne JV,Karavitaki N,Wass JA

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Lithium, clinically used in the treatment of bipolar disorders, is well known to induce thyroid growth. However, the mechanism involved is only incompletely characterized. Although it is conventionally believed that thyroid proliferation depends on the thyroid-stimulating hormone (TSH)/cAMP/cAMP response ele...

journal_title：European journal of endocrinology

authors： Rao AS,Kremenevskaja N,Resch J,Brabant G

更新日期：2005-12-01 00:00:00

abstract：:Recombinant human GH has been licensed for use in adult patients with GH deficiency (GHD) for over 15 years. Early weight- and surface area-based dosing regimens were effective but resulted in supraphysiological levels of IGF1 and increased incidence of side effects. Current practice has moved towards individualised r...

journal_title：European journal of endocrinology

authors： Gasco V,Prodam F,Grottoli S,Marzullo P,Longobardi S,Ghigo E,Aimaretti G

更新日期：2013-02-20 00:00:00

abstract：CONTEXT AND OBJECTIVE:Arterial stimulation and venous sampling (ASVS) is an important technique for localizing insulinoma. The principle behind ASVS is that insulin secretion is promoted from insulinoma cells by the injection of calcium into the insulinoma-feeding artery. However, the mechanism for ASVS-induced insulin...

journal_title：European journal of endocrinology

authors： Ono Y,Oda N,Ishihara S,Shimomura A,Hayakawa N,Suzuki A,Horiguchi A,Senda T,Miyakawa S,Itoh M

更新日期：2008-07-01 00:00:00

abstract：:Male age-related bone loss is caused, at least in part, by hypogonadism that occurs with advancing age. The study of the effects of sex steroids on bone physiology in men has recently highlighted the central role of estrogens on bone pathophysiology. This review focuses on particular aspects of bone physiology and pat...

journal_title：European journal of endocrinology

authors： Rochira V,Balestrieri A,Madeo B,Zirilli L,Granata AR,Carani C

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. DESIGN:Population based, cross-sectional study. METHODS:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical his...

journal_title：European journal of endocrinology

authors： Kamycheva E,Sundsfjord J,Jorde R

更新日期：2004-08-01 00:00:00