Abstract：
Objective:The challenge of finding patients with the rare conditon of diabetes insipidus in need of vasopressin treatment is demanding. The guidelines for performing the fluid deprivation test and interpreting the results are abundant. We evaluated the discriminative capacity of the fluid deprivation test in patients with polyuria to define a cut off for a more effective discrimination between diabetes insipidus and other polyuria syndromes. Research design and methods:Retrospective review and data collection of all ambulatory fluid deprivation tests, of patients with mild polyuria and polydipsia (< 3 L/day), performed between 2000 and 2018. Serum osmolality, urine osmolality, urine volumes and clinical information of diagnosis were retrieved from the patient's medical records. Results:The study group consisted of 153 patients, 123 were diagnosed with non-diabetes insipidus and 30 with diabetes insipidus. After 12 h fasting (baseline) median duration of the fluid deprivation test was 5 h (fasting range: 12-21 h). At baseline, there was a significant difference between median serum and urine osmolality between the groups (P < 0.05). The best cut-off for the diagnosis of diabetes insipidus, was the combination of < 400 mosmol/kg in urine and > 302 mosmol/kg in serum. With this cut-off a sensitivity of 90% and specificity of 98% was achieved. Conclusion:After 12 h fasting our proposed cut off clearly differentiated between diabetes insipidus, and non-diabetes insipidus suggesting a possibility to considerably reduce the duration of the fluid deprivation test.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Sjöström A,Bartuseviciene I,Höybye Cdoi
10.1530/EJE-20-0759subject
Has Abstractpub_date
2021-01-01 00:00:00pages
123-131issue
1eissn
0804-4643issn
1479-683Xpii
EJE-20-0759journal_volume
184pub_type
杂志文章abstract：:Previous work has examined potential links between the etiology of GH deficiency (GHD) and the baseline characteristics of the patients including biochemical and psychometric parameters. Using an update of the KIMS pharmaco-epidemiological database (Pfizer International Metabolic Database), we addressed the question h...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0273
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1480597
更新日期：2003-06-01 00:00:00
abstract：:We compared two highly specific markers for bone resorption-pyridinium cross-links (pyridinoline (PYR) and deoxypyridinoline (DPR)) in urine and carboxy-terminal telopeptide of type I collagen (ICTP) in serum-in 63 healthy postmenopausal women and 63 women with osteoporosis characterized by more bone resorption than b...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1310258
更新日期：1994-09-01 00:00:00
abstract：OBJECTIVE:This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM). DESIGN AND METHODS:A prospective study design was used to evaluate 34 TED patients a...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0945
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abstract：:Fifty-five patients with adult-onset GH deficiency (mean age, 49 years) were enrolled in a placebo-controlled, crossover study to investigate the effects of GH therapy on exercise capacity, body composition, and quality of life (QOL). GH and placebo were administered for 9 months each, separated by a 4-month washout p...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1530/eje.1.01971
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Ki-67 labeling index (LI) is currently regarded as a useful prognostic marker of pituitary adenoma (PA) clinical behavior, although its relevance as a reliable clinical indicator is far from being universally accepted, since both validations and criticisms are found in the literature. Minichromosome maintena...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-15-0586
更新日期：2016-03-01 00:00:00
abstract：:The initial management of large non-functioning pituitary adenomas is surgical debulking. In some cases, postoperative radiotherapy (RT) is administered in order to reduce the likelihood of tumour regrowth. Historically, there have been concerns surrounding a number of potentially significant complications of pituitar...
journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/eje.0.1440569
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:An inherited profile of genes related to the response to aggressive environmental factors such as viruses and chemicals may be related to an increased susceptibility to Graves' disease (GD). DESIGN AND METHODS:This prospective case-control study was designed to examine the relationship between human herpesvi...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-09-0719
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances parturition, blocks lactation and changes several hormone receptors in mammary gland and liver. Since IGFs are implicated i...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460729
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVE:In hyperthyroidism, tissue glucose disposal is increased to adapt to high energy demand. Our aim was to examine the regulation of glucose transporter (GLUT) isoforms by IGF-I in monocytes from patients with hyperthyroidism. DESIGN AND METHODS:Blood (20 ml) was drawn from 21 healthy and 10 hyperthyroid subjec...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-07-0532
更新日期：2008-03-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1440653
更新日期：2001-06-01 00:00:00
abstract：:X-linked adrenoleucodystrophy (ALD) has been shown to be one of the most frequent causes of Addison's disease in men. It is characterized by an impaired peroxisomal beta-oxidation of very long chain fatty acids and is associated with mutations of the ALD gene resulting in a defective peroxisomal membrane transport pro...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1370040
更新日期：1997-07-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
doi：10.1530/EJE-15-0066
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Lithium, clinically used in the treatment of bipolar disorders, is well known to induce thyroid growth. However, the mechanism involved is only incompletely characterized. Although it is conventionally believed that thyroid proliferation depends on the thyroid-stimulating hormone (TSH)/cAMP/cAMP response ele...
journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.1.02038
更新日期：2005-12-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1460067
更新日期：2002-01-01 00:00:00
abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1420042
更新日期：2000-01-01 00:00:00
abstract：:We measured serum tumour necrosis factor-alpha (TNF-alpha) as well as interleukin-1betta (IL-1beta) and GH concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1-13.9 years, before and 4 and 24h after the first GH injection (0.1 IU/kg s.c.). No differences were found in basal concen...
journal_title：European journal of endocrinology
pub_type： 临床试验,杂志文章
doi：10.1530/eje.0.1380640
更新日期：1998-06-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-16-0701
更新日期：2017-02-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-11-0490
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journal_title：European journal of endocrinology
pub_type： 杂志文章
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更新日期：2015-07-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：European journal of endocrinology
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更新日期：2017-11-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/EJE-08-0818
更新日期：2009-03-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1470755
更新日期：2002-12-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
doi：10.1530/eje.0.1380501
更新日期：1998-05-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：European journal of endocrinology
pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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journal_title：European journal of endocrinology
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更新日期：2002-01-01 00:00:00
