Abstract:
:We compared two highly specific markers for bone resorption-pyridinium cross-links (pyridinoline (PYR) and deoxypyridinoline (DPR)) in urine and carboxy-terminal telopeptide of type I collagen (ICTP) in serum-in 63 healthy postmenopausal women and 63 women with osteoporosis characterized by more bone resorption than bone formation. The ICTP, PYR and DPR levels were all higher, by 24% (p = 0.001), 16% (p = 0.05) and 25% (p = 0.004), respectively, in the osteoporotic women. For the merged groups, there were significant correlations between serum ICTP concentration and urinary PYR (r = 0.667, p < 0.0001) and DPR (r = 0.452, p < 0.0001) excretion; for the osteoporotic and normal women separately, the r values were 0.73 (p < 0.01) and 0.45 (p < 0.01) for PYR and 0.51 (p < 0.01) and 0.22 (p = 0.08) for DPR versus ICTP respectively. Weak correlations in linear regression between ICTP and various indices of bone formation (osteocalcin, bone-specific alkaline phosphatase and carboxy-terminal propeptide of type I procollagen) disappeared when the correlation between ICTP and pyridinolines was accounted for by calculation of partial correlation coefficients in multiple regression analysis. Serum ICTP concentration appears to discriminate between groups of normal and osteoporotic women as well as urinary pyridinium cross-links, which is thus far the most sensitive method for assessing bone resorption.
journal_name
Eur J Endocrinoljournal_title
European journal of endocrinologyauthors
Välimäki MJ,Tähtelä R,Jones JD,Peterson JM,Riggs BLdoi
10.1530/eje.0.1310258subject
Has Abstractpub_date
1994-09-01 00:00:00pages
258-62issue
3eissn
0804-4643issn
1479-683Xjournal_volume
131pub_type
杂志文章abstract:OBJECTIVE:The first aim of this work was to investigate, under basal conditions in adult male rats, the long-term consequences of perinatal maternal food restriction on the plasma concentrations of vasopressin (VP), aldosterone and atrial natriuretic peptide (ANP) and on plasma renin activity (PRA). Furthermore, under ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1470835
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:Very few previous studies have compared the degree of health-related quality of life (HRQL), depression and anxiety of differentiated thyroid cancer patients (DTC) under short-term hypothyroid-ism and levothyroxine treatment. METHODS:Using patient-completed instruments, we examined the frequency of physical ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02047
更新日期:2005-12-01 00:00:00
abstract::In non-functioning pituitary macroadenoma (NFMA), hyperprolactinaemia (hyperPRL) is considered to be a sign of hypothalamic-pituitary dysregulation, but it is unknown whether hyperPRL is associated with an increased frequency of pituitary hormone deficiencies. Forty consecutive patients with histology-proven NFMA were...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1350299
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:Cardiovascular disease (CVD) occurs frequently and may progress more rapidly in overt hypothyroidism (OVH). However, the role of mild thyroid failure as a risk factor for CVD is not clear. This study is aimed at exploring the association between subclinical hypothyroidism (SCH) and coronary artery disease (CA...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0014
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:We measured the total and nonphosphorylated insulin-like growth factor-binding protein (IGFBP)-1 concentrations in obese children to determine the effect of obesity on the status of IGFBP-1 phosphorylation. We also measured the serum levels of insulin, total and free IGF-I, and IGFBP-3 to investigate their re...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1410585
更新日期:1999-12-01 00:00:00
abstract::Prediction models are of a great assistance for predicting the development of a disease, detecting or screening undiagnosed patients, predicting the effectiveness of a treatment and helping toward better decision-making. Recently, three predictive scores in the field of autoimmune thyroid disease (AITD) have been intr...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-19-0234
更新日期:2019-09-01 00:00:00
abstract::Bone loss due to menopause, natural or artificial, has been attributed solely to low estrogen. However, in a woman's life, the most precipitous bone loss begins 2 years prior to the last menstrual period, during which time estrogen levels are unperturbed whereas FSH is elevated. Our cell-based and mouse genetic studie...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-10-0397
更新日期:2010-07-01 00:00:00
abstract::Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders resulting from deficiency of one of the five enzymes required for synthesis of cortisol in the adrenal cortex. The most common form of the disease is classic 21-hydroxylase deficiency, which is characterized by decreased synthesis of gluc...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.0.151u077
更新日期:2004-11-01 00:00:00
abstract::The reduced activity of the growth hormone (GH)-insulin-like growth factor I (IGF-I) axis in aging may contribute to changes in body composition. As this GH insufficiency is due to hypothalamic pathogenesis, the availability of GH-releasing peptides (GHRPs), such as GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) which is ac...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
doi:10.1530/eje.0.1310499
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:To study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications. DESIGN:Cross-sectional. MATERIALS AND METHODS:All patients (n=177) undergoing diagnostic evaluation and ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-12-0032
更新日期:2012-06-01 00:00:00
abstract::Fibrous dysplasia/McCune-Albright Syndrome (FD/MAS), arising from gain-of-function mutations in Gαs, and cutaneous skeletal hypophosphatemia syndrome (CSHS), arising from gain-of-function mutations in the Ras/MAPK pathway, are strikingly complex, mosaic diseases with overlapping phenotypes. Both disorders are defined ...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-19-0969
更新日期:2020-05-01 00:00:00
abstract::As differentiated (follicular and papillary) thyroid cancer (DTC) may recur years after initial treatment, follow-up of patients with DTC is long term. However, this population has changed, with more individuals being discovered at an earlier stage of disease, so that previous follow-up protocols based mostly on data ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1510539
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:Non-thyroidal illness (NTI) is associated with alterations in thyroid hormone metabolism. Whether morphological changes of the thyroid gland accompany NTI is unknown. The aim of the present study was to describe thyroid morphology in patients with lethal non-thyroidal disease. DESIGN:In an autopsy study 267 ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1440221
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD). SUBJECTS AND METHODS:In this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-13-0609
更新日期:2014-03-08 00:00:00
abstract:OBJECTIVE:Adrenocorticotropic hormone (ACTH) is the primary secretagogue stimulating secretion of adrenal androgens (AA). Yet, genetic and environmental factors are assumed to play a determining role in the regulation of their biosynthesis and thus might explain the high variability of AA levels. Here we investigate th...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02015
更新日期:2005-11-01 00:00:00
abstract::Several bone matrix protein constituents, including the major component collagen type I and the hydroxyapatite binding protein, osteocalcin, have been implicated in the regulation of bone turnover. Cortical bone osteocalcin, collagen and mineral content were studied in autosomal dominant osteopetrosis type I (ADO), a ...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1300592
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:Several factors either predisposing or protecting from the onset of diabetes mellitus type 2 (DM2) have been proposed. Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or r...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-11-0280
更新日期:2011-08-01 00:00:00
abstract::Serum thyroid parameters show substantial inter-individual variability, in which genetic variation is a major factor. Findings in patients with subclinical hyper- and hypothyroidism illustrate that even minor alterations in serum thyroid function tests can have important consequences for a variety of thyroid hormone-r...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/eje.1.02279
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To study whether serum parathyroid hormone (PTH) and serum calcium are associated with body mass index (BMI), and their predicting role in obesity. DESIGN:Population based, cross-sectional study. METHODS:In 2001 a population-based health survey was held in Tromsø, North Norway. Questionnaires on medical his...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1510167
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:Hyperthyroidism in rats produces organ hypertrophy and increases in circulating IGF-I and IGF-binding protein (IGFBP)-3. Chronic treatment with thyroxine (T(4)) during pregnancy advances parturition, blocks lactation and changes several hormone receptors in mammary gland and liver. Since IGFs are implicated i...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1460729
更新日期:2002-05-01 00:00:00
abstract::Giant prolactinomas are rare tumours, representing only 2-3% of all prolactin (PRL)-secreting tumours and raising special diagnostic and therapeutic challenges. Based on several considerations developed in this review, their definition should be restricted to pituitary adenomas with a diameter of 40 mm or more, signi...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-14-0013
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:Serum concentrations of soluble tumor necrosis factor-alpha (TNF-alpha) receptor 2 (sTNFR2) are associated with insulin resistance. In a recent study, we provided evidence for the existence of a biologically active form of sTNFR2 produced by alternative splicing (DS-TNFR2). We aimed to evaluate whether this c...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.1.02145
更新日期:2006-05-01 00:00:00
abstract:INTRODUCTION:Activating mutations of the BRAF oncogene are frequently detected in papillary thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid substitution V600E accounts for 90% of all oncogenic BRAF mutations and is typically detected in classic PTCs, whereas other less frequent B...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-08-0239
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas. METHODS:Twenty-three acromegalic patients (mean tumor size, 25 +/- 12 mm; untreated preoperative GH, 4.2...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章
doi:10.1530/eje.1.01970
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/eje.0.1420263
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Various adjuvant therapies have been introduced along with intensive insulin therapy in patients with recent onset type 1 diabetes. Nicotinamide (NA), administered at diagnosis of the disease, can have beneficial effects on the clinical remission rate, improve metabolic control and preserve or slightly increa...
journal_title:European journal of endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1530/eje.0.1500719
更新日期:2004-05-01 00:00:00
abstract::A pheochromocytoma in a pregnant patient is one of the most threatening medical conditions for mother, fetus, and physician. Although extraordinarily rare with a frequency of 0.002% of all pregnancies, this tumor is notorious for its devastating consequences. As in non-pregnant patients, the signs and symptoms are qui...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-11-0528
更新日期:2012-02-01 00:00:00
abstract::AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions, such as low energy, increasing energy production and reducing energy waste. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, wi...
journal_title:European journal of endocrinology
pub_type: 杂志文章,评审
doi:10.1530/EJE-16-0927
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Iodine deficiency has re-emerged in New Zealand, while selenium status has improved. The aim of this study was to investigate the effects of excess iodine intake as iodate on thyroid and selenium status. METHODS:In a randomized controlled trial on older people (mean±s.d. 73±4.8 years; n=143), two groups rece...
journal_title:European journal of endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1530/EJE-11-0575
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:To examine the relationship between maternal TSH and free thyroxine (FT(4)) concentrations in early pregnancy and the risk of miscarriage, fetal or neonatal death. METHOD:Cohort study of 2497 Dutch women. TSH, FT(4), and thyroid peroxidase antibodies concentrations were determined at first booking. Child lo...
journal_title:European journal of endocrinology
pub_type: 杂志文章
doi:10.1530/EJE-08-0953
更新日期:2009-06-01 00:00:00