Radiotherapy for non-functioning pituitary adenomas.

Abstract:

:The initial management of large non-functioning pituitary adenomas is surgical debulking. In some cases, postoperative radiotherapy (RT) is administered in order to reduce the likelihood of tumour regrowth. Historically, there have been concerns surrounding a number of potentially significant complications of pituitary RT. Recent contributions to the literature, however, suggest that pituitary RT may be less hazardous than was originally thought. This article reviews the evidence relating to the potential side-effects of RT and weighs these risks against the clinically beneficial effects of preventing pituitary tumour regrowth.

journal_name

Eur J Endocrinol

authors

Boelaert K,Gittoes NJ

doi

10.1530/eje.0.1440569

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

569-75

issue

6

eissn

0804-4643

issn

1479-683X

pii

1440569

journal_volume

144

pub_type

杂志文章,评审
  • Associations between subcutaneous fat density and systemic inflammation differ by HIV serostatus and are independent of fat quantity.

    abstract:Objectives:Adipose tissue (AT) density measurement may provide information about AT quality among people living with HIV. We assessed AT density and evaluated relationships between AT density and immunometabolic biomarker concentrations in men with HIV. Design:Cross-sectional analysis of men enrolled in the Multicente...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/EJE-19-0296

    authors: Lake JE,Debroy P,Ng D,Erlandson KM,Kingsley LA,Palella FJ,Budoff MJ,Post WS,Brown TT

    更新日期:2019-10-01 00:00:00

  • Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis.

    abstract::To investigate a possible association between vitamin D receptor genotype and development of postmenopausal osteoporosis, a longitudinal study from 1977 to 1995 was carried out on women living in Oslo, Norway. One hundred and eighteen premenopausal women born in 1930 were included in a study of pre- and postmenopausal...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1350096

    authors: Berg JP,Falch JA,Haug E

    更新日期:1996-07-01 00:00:00

  • Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome.

    abstract:Objectives:We investigated the clinical significance of ACTH stimulation during adrenal venous sampling (AVS) by surgical outcome of primary aldosteronism (PA). Design:Multicenter retrospective study by Japan PA study. Method:We allocated 314 patients with both basal and ACTH-stimulated AVS data who underwent adrenal...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/EJE-19-0860

    authors: Kobayashi H,Nakamura Y,Abe M,Kurihara I,Itoh H,Ichijo T,Takeda Y,Yoneda T,Katabami T,Tsuiki M,Wada N,Ogawa Y,Sakamoto R,Kawashima J,Sone M,Inagaki N,Yoshimoto T,Yamada T,Okamoto R,Matsuda Y,Fujita M,Watanabe M,

    更新日期:2020-03-01 00:00:00

  • New perspectives for gene therapy in endocrinology.

    abstract::Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.1430447

    authors: Barzon L,Bonaguro R,Palù G,Boscaro M

    更新日期:2000-10-01 00:00:00

  • Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty.

    abstract:OBJECTIVE:Makorin ring finger protein 3 (MKRN3) gene restrains the hypothalamic-pituitary-gonadal axis. In girls, peripheral levels of MKRN3 decline prior to the onset of puberty. We described longitudinal changes in serum MKRN3 levels in boys before and during puberty and assessed the effect of inhibition of estrogen ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,随机对照试验

    doi:10.1530/EJE-15-1193

    authors: Varimo T,Dunkel L,Vaaralahti K,Miettinen PJ,Hero M,Raivio T

    更新日期:2016-06-01 00:00:00

  • Withdrawn: Case detection, diagnosis, and treatment of patients with primary aldosteronism: an Endocrine Society clinical practice guideline.

    abstract::Ahead of Print article withdrawn by publisher. ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-09-0870

    authors: Funder J,Carey R,Fardella C,Gomez-Sanchez C,Mantero F,Stowasser M,Young W,Montori VM

    更新日期:2009-09-30 00:00:00

  • Serum leptin and habitual fatty acid dietary intake in patients with type 1 diabetes mellitus.

    abstract:OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1420263

    authors: Rojo-Martínez G,Soriguer FJ,González-Romero S,Tinahones F,Moreno F,de Adana SR,Garriga MJ,Esteva I,García-Arnés J,Gómez-Zumaquero JM,García-Almeida JM

    更新日期:2000-03-01 00:00:00

  • Prolactin and breast increase during pregnancy in PCOS: linked to long-term metabolic health?

    abstract::Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria (n = 239), former participants of the randomized controlled trial (RCT) PregMet were invited, 131 p...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-19-0002

    authors: Underdal MO,Salvesen Ø,Schmedes A,Andersen MS,Vanky E

    更新日期:2019-06-01 00:00:00

  • Fractionated radiotherapy and radiosurgery in acromegaly: analysis of 352 patients from the German Acromegaly Registry.

    abstract:Background:If biochemical control of acromegaly is not achieved by operation and medication, radiotherapy may be indicated. Objective:To describe fractionated radiotherapy (FRT) and stereotactic radiosurgery (SRS) regarding excess of IGF-1 and pituitary function. Design and methods:A retrospective analysis of 352 pat...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-19-0784

    authors: Knappe UJ,Petroff D,Quinkler M,Schmid SM,Schöfl C,Schopohl J,Stieg MR,Tönjes A,participants of the German Acromegaly Registry.

    更新日期:2020-03-01 00:00:00

  • Effects of N-methyl-D-aspartate and kainic acid on prolactin secretion in prepubertal female rats.

    abstract::The control of prolactin (PRL) secretion by N-methyl-D-aspartate (NMDA) and kainic acid (KA), agonists of NMDA and kainate receptors, and the interactions between NMDA and KA with nitric oxide (NO) were analysed in prepubertal female rats. For this purpose, serum PRL concentrations and hypothalamic and pituitary dopam...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1350464

    authors: Pinilla L,González D,Tena-Sempere M,Aguilar R,Aguilar E

    更新日期:1996-10-01 00:00:00

  • The octreotide test dose is not a reliable predictor of the subsequent response to somatostatin analogue therapy in patients with acromegaly.

    abstract::In many centres, a test dose (TD) of octreotide is administered before commencing somatostatin analogue therapy (SAT), although the merits of this procedure are uncertain. We have analysed the value of the GH response to a TD in predicting the efficacy of subsequent SAT in 47 patients with acromegaly (25 male, median ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.02073

    authors: Pokrajac A,Claridge AG,Shakoor SK,Trainer PJ

    更新日期:2006-02-01 00:00:00

  • Binding of heparin to human thyroglobulin (Tg) involves multiple binding sites including a region corresponding to a binding site of rat Tg.

    abstract:OBJECTIVE:Binding of thyroglobulin (Tg) to heparin allows efficient Tg interaction with its endocytic receptor, megalin. Rat Tg (rTg) binds to heparin using an exposed carboxyl terminal region (RELPSRRLKRPLPVK, Arg2489-Lys2503) rich in positively charged residues which is, however, not entirely conserved in human Tg (h...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460591

    authors: Lisi S,Pinchera A,McCluskey RT,Chiovato L,Marinò M

    更新日期:2002-04-01 00:00:00

  • Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis.

    abstract:OBJECTIVE:In malnutrition both the GH-IGF and reproductive axes are greatly affected. Because the actions of IGF and sex steroids are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. DESIGN AND METHODS:Peripubertal (30 days of age) f...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470417

    authors: Goya L,García-Segura LM,Ramos S,Pascual-Leone AM,Argente J,Martín MA,Chowen JA

    更新日期:2002-09-01 00:00:00

  • Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes.

    abstract:OBJECTIVE:Glucocorticoid excess leads to insulin resistance. This study explores the effects of glucocorticoids on the glucose transport system and insulin signalling in rat adipocytes. The interaction between glucocorticoids and high levels of insulin and glucose is also addressed. DESIGN AND METHODS:Isolated rat adi...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1460419

    authors: Burén J,Liu HX,Jensen J,Eriksson JW

    更新日期:2002-03-01 00:00:00

  • Reduced microvascular perfusion and reactivity in adult GH deficient patients is restored by GH replacement.

    abstract:BACKGROUND:An increased cardiovascular risk and mortality in hypopituitary patients receiving conventional hormonal treatment without GH replacement have been shown in several studies. Various atherogenic risk factors including endothelial dysfunction - an early event in the atherogenesis - are more expressed in adults...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1470333

    authors: Hána V,Prázný M,Marek J,Skrha J,Justová V

    更新日期:2002-09-01 00:00:00

  • Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT.

    abstract:OBJECTIVE:To i) compare incretin responses to oral glucose and mixed meal of diabetic patients with the normoglycaemic population and ii) to investigate whether incretin responses are associated with hypertriglyceridaemia and alanine aminotransferase (ALT) as liver fat marker. DESIGN:A population-based study. METHODS...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-13-0487

    authors: Alssema M,Rijkelijkhuizen JM,Holst JJ,Teerlink T,Scheffer PG,Eekhoff EM,Gastaldelli A,Mari A,Hart LM,Nijpels G,Dekker JM

    更新日期:2013-09-12 00:00:00

  • Long-term clinical data and molecular defects in the STAR gene in five Greek patients.

    abstract:CONTEXT:Steroidogenic acute regulatory (STAR) gene mutations lead to adrenal and gonadal failure. Interesting, though as yet unexplained, features are the formation of ovarian cysts and the potential presence of CNS findings. OBJECTIVE:To report biochemical, genetic, and long-term clinical data in five Greek patients ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-12-0600

    authors: Sertedaki A,Dracopoulou M,Voutetakis A,Stefanaki K,Rontogianni D,Magiakou AM,Kanaka-Gantenbein C,Chrousos G,Dacou-Voutetakis C

    更新日期:2013-02-15 00:00:00

  • Tumor necrosis factor-alpha decreases thyrotropin-induced 5'-deiodinase activity in FRTL-5 thyroid cells.

    abstract::Tumor necrosis factor-alpha (TNF-alpha) exerts various effects on many cell types. Acute administration of TNF-alpha to rats decrease hepatic 5'-deiodinase activity (5'D-I) and TNF-alpha has been implicated in the pathogenesis of the low triiodothyronine syndrome in non-thyroidal illness in humans. The thyroid, liver ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1300502

    authors: Ongphiphadhanakul B,Fang SL,Tang KT,Patwardhan NA,Braverman LE

    更新日期:1994-05-01 00:00:00

  • Modulation by retinoic acid of insulin-like growth factor (IGF) and IGF binding protein expression in human SK-N-SH neuroblastoma cells.

    abstract::Growth in neuroblastoma cells is regulated by insulin-like growth factors (IGFs) whose action is modulated by IGF binding proteins (IGFBPs). In this study, SK-N-SH neuroblastoma cells were shown to produce IGF-II, IGFBP-2, IGFBP-4 and small quantities of IGFBP-6. We have studied the effects of a natural morphogen, ret...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1340474

    authors: Babajko S,Binoux M

    更新日期:1996-04-01 00:00:00

  • Commentary-FSH and bone 2010: evolving evidence.

    abstract::Bone loss due to menopause, natural or artificial, has been attributed solely to low estrogen. However, in a woman's life, the most precipitous bone loss begins 2 years prior to the last menstrual period, during which time estrogen levels are unperturbed whereas FSH is elevated. Our cell-based and mouse genetic studie...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-10-0397

    authors: Iqbal J,Sun L,Zaidi M

    更新日期:2010-07-01 00:00:00

  • Anionic iodotyrosine residues are required for iodothyronine synthesis.

    abstract::Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxida...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1380227

    authors: de Vijlder JJ,den Hartog MT

    更新日期:1998-02-01 00:00:00

  • Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma.

    abstract:CONTEXT:Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) and head and neck paragangliomas (HNPGLs), but utility for screening beyond that achieved using standard measurements of normetanephrine and...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1530/EJE-17-0077

    authors: Rao D,Peitzsch M,Prejbisz A,Hanus K,Fassnacht M,Beuschlein F,Brugger C,Fliedner S,Langton K,Pamporaki C,Gudziol V,Stell A,Januszewicz A,Timmers HJLM,Lenders JWM,Eisenhofer G

    更新日期:2017-08-01 00:00:00

  • The prevalence of anti-thyroid peroxidase antibodies and autoimmune thyroiditis in children and adolescents in an iodine replete area.

    abstract:BACKGROUND:The iodine supply of the population in Berlin has normalized during the last 5 Years. Therefore autoimmune thyroiditis has become the most important differential diagnosis in children and adolescents with goiter. OBJECTIVE:The aim of the present study was to define the prevalence of anti-thyroid peroxidase ...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1480301

    authors: Kabelitz M,Liesenkötter KP,Stach B,Willgerodt H,Stäblein W,Singendonk W,Jäger-Roman E,Litzenbörger H,Ehnert B,Grüters A

    更新日期:2003-03-01 00:00:00

  • Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.

    abstract:OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1490343

    authors: Peterhoff M,Sieg A,Brede M,Chao CM,Hein L,Ullrich S

    更新日期:2003-10-01 00:00:00

  • Macroprolactinaemia: a biological diagnostic strategy from the study of 222 patients.

    abstract:OBJECTIVES:Gel filtration chromatography (GFC), the gold standard for macroprolactinaemia (MPRL) diagnosis, is a slow, costly and labour-intensive method. To limit the number of GFC required, we evaluated two screening tests for MPRL: prolactin (PRL) recovery after polyethylene glycol (PEG) precipitation and PRL concen...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/EJE-14-1073

    authors: Parlant-Pinet L,Harthé C,Roucher F,Morel Y,Borson-Chazot F,Raverot G,Raverot V

    更新日期:2015-06-01 00:00:00

  • GH improves growth and clinical status in children with cystic fibrosis -- a review of published studies.

    abstract::Children with cystic fibrosis (CF) have problems with poor linear growth and inadequate weight gain. Nutritional augmentation has been the mainstay of therapy for improving both weight and height in CF; however, inadequate growth continues to be a problem. Furthermore, protein catabolism has been documented even in no...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/eje.0.151s081

    authors: Hardin DS

    更新日期:2004-08-01 00:00:00

  • ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome.

    abstract::Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-15-0605

    authors: Tavares C,Melo M,Cameselle-Teijeiro JM,Soares P,Sobrinho-Simões M

    更新日期:2016-04-01 00:00:00

  • GH therapy in adult GH deficiency: a review of treatment schedules and the evidence for low starting doses.

    abstract::Recombinant human GH has been licensed for use in adult patients with GH deficiency (GHD) for over 15 years. Early weight- and surface area-based dosing regimens were effective but resulted in supraphysiological levels of IGF1 and increased incidence of side effects. Current practice has moved towards individualised r...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/EJE-12-0563

    authors: Gasco V,Prodam F,Grottoli S,Marzullo P,Longobardi S,Ghigo E,Aimaretti G

    更新日期:2013-02-20 00:00:00

  • Ultrasonographic and clinical parameters for early differentiation between precocious puberty and premature thelarche.

    abstract:OBJECTIVE:To determine if uterine and ovarian measurements can significantly distinguish between precocious puberty (PP) and premature thelarche (PT) and whether ultrasound has any advantage over the gonadotropin-releasing hormone (GnRH) stimulation test. DESIGN:Prospective. METHODS:One hundred and three girls referr...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.1.02151

    authors: de Vries L,Horev G,Schwartz M,Phillip M

    更新日期:2006-06-01 00:00:00

  • Trans-sphenoidal surgery for microprolactinoma: an acceptable alternative to dopamine agonists?

    abstract:AIMS:Reported cure rates following trans-sphenoidal surgery for microprolactinoma are variable and recurrence rates in some series are high. We wished to examine the cure rate of trans-sphenoidal surgery for microprolactinoma, and to assess the long-term complications and recurrence rate. DESIGN:A retrospective review...

    journal_title:European journal of endocrinology

    pub_type: 杂志文章

    doi:10.1530/eje.0.1400043

    authors: Turner HE,Adams CB,Wass JA

    更新日期:1999-01-01 00:00:00