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Interaction between malnutrition and ovarian hormones on the systemic IGF-I axis.

Abstract：

OBJECTIVE:In malnutrition both the GH-IGF and reproductive axes are greatly affected. Because the actions of IGF and sex steroids are inter-dependent in many tissues, we have examined how ovariectomy modulates the response of the systemic IGF system to undernutrition. DESIGN AND METHODS:Peripubertal (30 days of age) female rats were either sham operated or ovariectomized. Five days later half of each group was submitted to a protein-caloric restriction diet. All rats were killed at 60 days of age. RESULTS:Growth was decreased in all rats submitted to calorie restriction and this was consistent with a decrease in circulating IGF-I concentrations and liver IGF-I mRNA expression. While in normally fed rats ovariectomy had no significant effect on serum IGF-I concentrations, ovariectomized and underfed rats had significantly higher levels than intact underfed rats. In undernourished rats, serum IGF-binding proteins (IGFBP)-1, -2 and -3 concentrations were significantly reduced and this was not modified by ovariectomy. In contrast, liver mRNA concentrations of IGFBP-1 and -2 were increased and IGFBP-3 unchanged in intact undernourished animals, suggesting that undernutrition could be affecting the proteolysis of these binding proteins, and this response was significantly modulated by ovariectomy. CONCLUSION:These results indicate that the presence of circulating ovarian hormones significantly affects the response of the IGF system to undernutrition.

journal_name

Eur J Endocrinol

journal_title

European journal of endocrinology

authors

Goya L,García-Segura LM,Ramos S,Pascual-Leone AM,Argente J,Martín MA,Chowen JA

doi

10.1530/eje.0.1470417

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

417-24

issue

3

eissn

0804-4643

issn

1479-683X

pii

1470417

journal_volume

147

pub_type

杂志文章

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