DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment.

abstract：OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is defined as hereditary primary hyperparathyroidism without the association of other diseases or tumors. Linkage analyses suggest that different genotypes can lead to the same phenotype of primary hyperparathyroidism. Hereditary syndromes associated with p...

journal_title：European journal of endocrinology

authors： Miedlich S,Lohmann T,Schneyer U,Lamesch P,Paschke R

更新日期：2001-08-01 00:00:00

abstract：:Amiodarone (AMD) is a powerful anti-arrhythmic drug used for the treatment of a wide variety of cardiac arrhythmias and its most striking feature is its high iodine content. Thyroid dysfunction is a limiting side-effect of the drug and both AMD-induced hypothyroidism (AIH) and AMD-induced thyrotoxicosis (AIT) are repo...

journal_title：European journal of endocrinology

authors： Pitsiavas V,Smerdely P,Boyages SC

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:The antagonism of Agouti protein (AP) and Agouti-related protein on melanocortin receptors suggests an inhibitory role in the regulation of steroidogenesis. However, we have previously demonstrated that ectopic AP overexpression increased restraint-induced corticosterone release and adrenal reactivity to ACTH...

journal_title：European journal of endocrinology

authors： Shevchenko AY,Bazhan NM,Makarova EN,Yakovleva TV,Karkaeva NR

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

journal_title：European journal of endocrinology

authors： Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Iodine deficiency has re-emerged in New Zealand, while selenium status has improved. The aim of this study was to investigate the effects of excess iodine intake as iodate on thyroid and selenium status. METHODS:In a randomized controlled trial on older people (mean±s.d. 73±4.8 years; n=143), two groups rece...

journal_title：European journal of endocrinology

authors： Thomson CD,Campbell JM,Miller J,Skeaff SA

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:GH deficiency (GHD) and glucocorticoid excess are associated with increased risk of fragility fractures. We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD. DESIGN:Cross-sectional study. METHODS:Fifty-one ad...

journal_title：European journal of endocrinology

authors： Mazziotti G,Porcelli T,Bianchi A,Cimino V,Patelli I,Mejia C,Fusco A,Giampietro A,De Marinis L,Giustina A

更新日期：2010-07-01 00:00:00

abstract：:Objective To investigate how weight loss by different diets impacts postprandial levels of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon. Methods In this single-centre, parallel group 2-year trial, 70 healthy postmenopausal obese women were randomised to the Paleolith...

journal_title：European journal of endocrinology

authors： Otten J,Ryberg M,Mellberg C,Andersson T,Chorell E,Lindahl B,Larsson C,Holst JJ,Olsson T

更新日期：2019-06-01 00:00:00

abstract：:There is increasing evidence that ovarian steroids inhibit vascular responsiveness to the neurohypophysial hormone vasopressin. The present study examined the recovery of the arterial blood pressure following a single (2 ml/100 g body weight) haemorrhage in ovariectomized (OVX) Brattleboro rats with hereditary hypotha...

journal_title：European journal of endocrinology

authors： Morrissey SE,Edwards TJ,Wilson KJ,Whitehead SA,Laycock JF

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVE:Vitamin D insufficiency is common in primary hyperparathyroidism (pHPT). Patients with pHPT frequently have a reduced health-related quality of life (HRQoL). Our objectives were to evaluate whether HRQoL in pHPT is associated with vitamin D insufficiency and whether vitamin D supplementation after parathyroid...

journal_title：European journal of endocrinology

authors： Åberg V,Norenstedt S,Zedenius J,Sääf M,Nordenström J,Pernow Y,Nilsson IL

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To determine the frequency of mutations of the gonadotropin-releasing hormone receptor (GnRHR) and of the G protein-coupled receptor 54 (GPR54) genes in normosmic idiopathic hypogonadotropic hypogonadism (IHH). METHODS:In a retrospective study we analyzed the GnRHR and the GPR54 genes of 45 IHH patients and ...

journal_title：European journal of endocrinology

authors： Lanfranco F,Gromoll J,von Eckardstein S,Herding EM,Nieschlag E,Simoni M

更新日期：2005-12-01 00:00:00

abstract：:The experimental model of chronic inhibition of nitric oxide (NO) production has proven to be a useful tool to study cardiovascular and renal lesions produced by this type of hypertension, which are similar to those found in human hypertension. It also offers a unique opportunity to study the interaction of NO with th...

journal_title：European journal of endocrinology

authors： Vargas F,Moreno JM,Wangensteen R,Rodríguez-Gómez I,García-Estañ J

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Individuals carrying a heterozygous inactivating PAX8 mutation are affected by congenital hypothyroidism (CH), although heterozygous Pax8 knockout mice are not. It has remained unclear whether CH in PAX8 mutation carriers is caused by haploinsufficiency or a dominant negative mechanism. OBJECTIVE:To report ...

journal_title：European journal of endocrinology

authors： Narumi S,Araki S,Hori N,Muroya K,Yamamoto Y,Asakura Y,Adachi M,Hasegawa T

更新日期：2012-11-01 00:00:00

abstract：Objective:Hypertension and symptoms of catecholamine excess are features of pheochromocytomas and paragangliomas (PPGLs). This prospective observational cohort study assessed whether differences in presenting features in patients tested for PPGLs might assist establishing likelihood of disease. Design and methods:Pati...

journal_title：European journal of endocrinology

authors： Geroula A,Deutschbein T,Langton K,Masjkur J,Pamporaki C,Peitzsch M,Fliedner S,Timmers HJLM,Bornstein SR,Beuschlein F,Stell A,Januszewicz A,Prejbisz A,Fassnacht M,Lenders JWM,Eisenhofer G

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:Many investigators believe that basal adrenal venous sampling (AVS) should be done simultaneously, whereas others opt for sequential AVS for simplicity and reduced cost. This study aimed to evaluate the concordance of sequential and simultaneous AVS methods. DESIGN AND METHODS:Between 1989 and 2015, bilatera...

journal_title：European journal of endocrinology

authors： Almarzooqi MK,Chagnon M,Soulez G,Giroux MF,Gilbert P,Oliva VL,Perreault P,Bouchard L,Bourdeau I,Lacroix A,Therasse E

更新日期：2017-02-01 00:00:00

abstract：:We measured serum tumour necrosis factor-alpha (TNF-alpha) as well as interleukin-1betta (IL-1beta) and GH concentrations in 15 children with isolated growth hormone deficiency (GHD), age range 5.1-13.9 years, before and 4 and 24h after the first GH injection (0.1 IU/kg s.c.). No differences were found in basal concen...

journal_title：European journal of endocrinology

authors： Bozzola M,De Amici M,Zecca M,Schimpff RM,Rapaport R

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:Slow-release (SR) lanreotide is a long-acting somatostatin analog that has been developed in order to overcome the inconvenience of multiple daily subcutaneous injections of octreotide, required for metabolic control in acromegaly. Lanreotide SR has been found to be well tolerated and effective in reducing GH...

journal_title：European journal of endocrinology

authors： Verhelst JA,Pedroncelli AM,Abs R,Montini M,Vandeweghe MV,Albani G,Maiter D,Pagani MD,Legros JJ,Gianola D,Bex M,Poppe K,Mockel J,Pagani G

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Ki-67 labeling index (LI) is currently regarded as a useful prognostic marker of pituitary adenoma (PA) clinical behavior, although its relevance as a reliable clinical indicator is far from being universally accepted, since both validations and criticisms are found in the literature. Minichromosome maintena...

journal_title：European journal of endocrinology

authors： Coli A,Asa SL,Fadda G,Scannone D,Chiloiro S,De Marinis L,Lauretti L,Ranelletti FO,Lauriola L

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Inactivating mutations of the GH-releasing hormone receptor (GHRHR) gene (GHRHR) cause familial isolated GH deficiency (IGHD) type IB. The GH response to physical exercise (PE) in patients lacking GHRHR has never been studied. We hypothesized that subjects lacking functional GHRHR may be a model to study GH r...

journal_title：European journal of endocrinology

authors： Salvatori R,Fan X,Veldhuis JD,Couch R

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies have shown that more than 50% of patients with congestive heart failure (CHF) have decreased bone mineral density (BMD). There is limited knowledge about the longitudinal changes of BMD and how to treat bone loss in patients with CHF. METHODS:The present study was a prospective, long...

journal_title：European journal of endocrinology

authors： Frost RJ,Sonne C,Wehr U,Stempfle HU

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:An increased cardiovascular risk and mortality in hypopituitary patients receiving conventional hormonal treatment without GH replacement have been shown in several studies. Various atherogenic risk factors including endothelial dysfunction - an early event in the atherogenesis - are more expressed in adults...

journal_title：European journal of endocrinology

authors： Hána V,Prázný M,Marek J,Skrha J,Justová V

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated a high prevalence of thyroperoxidase antibodies (TPOAb) and autoimmune hypothyroidism in breast cancer (BC). These studies have been performed in BC patients generally 20-30 days after mastectomy. It is known that stress may have an influence on the immune system and a rela...

journal_title：European journal of endocrinology

authors： Giustarini E,Pinchera A,Fierabracci P,Roncella M,Fustaino L,Mammoli C,Giani C

更新日期：2006-05-01 00:00:00

abstract：:Ipilimumab (Yervoy; Medarex and Bristol-Myers Squibb) is a human MAB against cytotoxic T-lymphocyte antigen 4, which enhances co-stimulation of cytotoxic T-lymphocytes, resulting in their proliferation and an anti-tumour response. It is licensed for the treatment of unresectable or metastatic malignant melanoma, while...

journal_title：European journal of endocrinology

authors： Juszczak A,Gupta A,Karavitaki N,Middleton MR,Grossman AB

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVES:The purpose of this population-based prospective cohort study was to examine the effect of hormone therapy (HT) on incidence of diabetes mellitus (DM). DESIGN AND METHODS:Eight thousand four hundred and eighty-three DM-free post-menopausal women aged 52-62 from the population-based Kuopio osteoporosis risk ...

journal_title：European journal of endocrinology

authors： Pentti K,Tuppurainen MT,Honkanen R,Sandini L,Kröger H,Alhava E,Saarikoski S

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:The DAZ (deleted in azoospermia) gene family on the Y chromosome long arm is the major candidate for the AZFc (azoospermia factor c) phenotype of male infertility and it is expressed only in germ cells. The aim of the study was to assess Sertoli cell function in subjects with AZFc deletions. DESIGN:Case-cont...

journal_title：European journal of endocrinology

authors： Foresta C,Bettella A,Moro E,Rossato M,Merico M,Garolla A,Ferlin A

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:The aim of the present study was to determine vascular endothelial growth factor (VEGF), prostaglandin E(2) (PGE(2)) and active renin levels in patients with hormonally active adrenal tumours. DESIGN:The study was comprised of 16 patients with primary aldosteronism, 13 patients with active Cushing's syndrom...

journal_title：European journal of endocrinology

authors： Zacharieva S,Atanassova I,Orbetzova M,Nachev E,Kalinov K,Kirilov G,Shigarminova R,Ivanova R,Dashev G

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To compare clinical and humoral parameters before and after surgery in patients with incidental adrenocortical adenomas. DESIGN:Six patients with subclinical Cushing's syndrome and nine with non-functioning adenomas were investigated before and 12 Months after removal of the mass. METHODS:Anthropometric (bo...

journal_title：European journal of endocrinology

authors： Bernini G,Moretti A,Iacconi P,Miccoli P,Nami R,Lucani B,Salvetti A

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism (PA) is the most common form of secondary hypertension, while Gitelman's syndrome (GS) is the most common inherited renal tubular disease. However, coexistence of these two diseases has never been previously reported. AIM AND SUBJECTS: The aim of our study was to describe the associatio...

journal_title：European journal of endocrinology

authors： Miao Z,Gao Y,Bindels RJ,Yu W,Lang Y,Chen N,Ren H,Sun F,Li Y,Wang X,Shao L

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To detect exogenous recombinant human GH (rhGH) abuse in female athletes. DESIGN:GH-dependent markers were assayed in serum of 100 female athletes (control group) and in a subgroup of nine female subjects treated with rhGH (0.09 IU/kg body weight, 6 days/week for 3 weeks). METHODS:Cut-off values (mean+2 s.d...

journal_title：European journal of endocrinology

authors： Di Luigi L,Rigamonti AE,Agosti F,Mencarelli M,Sgrò P,Marazzi N,Cella SG,Müller EE,Sartorio A

更新日期：2009-05-01 00:00:00

abstract：:The expression of GnRH and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the breast, ovary and endometrium. Dose-dependent antiproliferative effects of GnRH agonists in cell lines derived from these cance...

journal_title：European journal of endocrinology

authors： Gründker C,Günthert AR,Westphalen S,Emons G

更新日期：2002-01-01 00:00:00

abstract：:The recent onslaught of mass spectrometry (MS) to measurements of steroid hormones, including demands that they should be the only acceptable method, has confused clinicians and scientists who have relied for more than 40 years on a variety of immunoassay (IA) methods in steroid hormone measurements. There is little d...

journal_title：European journal of endocrinology

authors： Taylor AE,Keevil B,Huhtaniemi IT

更新日期：2015-08-01 00:00:00